A cikin watan Mayu 2021, wata tawaga karkashin jagorancin Mohammad Azizur Rahman, Mataimakin Farfesa na Sashen Kimiyyar Halittu da Halittar Halitta, Jami'ar Jahangirnagar, Bangladesh, da Cibiyar Ci gaban Naman kaza, Sashen Tsawaita Aikin Noma, Ma'aikatar Noma, Bangladesh tare sun buga wata takarda mai ma'ana. Jaridar International Journal of Mecinal Mushrooms don jagorantar mutane a ƙarƙashin cutar ta COVID-19 don yin amfani da kyau da "sanannen ilimi" da "albarkatun da ke wanzu" don neman kariyar kai a cikin dogon jiran ceto tare da sababbin magunguna.

Dangane da sakamakon da aka tabbatar ta kimiyance, ta hanyar kimanta la'akari masu amfani kamar amincin abinci da samun damar cin abinci da namomin kaza na magani da kuma nazarin rawar da suke takawa a cikin riga-kafi, tsarin rigakafi, rage kumburin da ke haifar da rashin daidaituwa na ACE / ACE2 da haɓaka na yau da kullun na yau da kullun. cututtuka irin su cututtukan zuciya da jijiyoyin jini, ciwon sukari, hyperlipidemia, da hauhawar jini a cikin marasa lafiya da ke fama da cutar coronavirus 2019 (COVID-19), takardar ta bayyana dalilan da ya sa ya kamata mutane su “ci namomin kaza don hana annoba”.

Jaridar ta nuna sau da yawa a cikin labarin cewaGanoderma lucidumBabu shakka shine mafi dacewa zaɓi don rigakafi da maganin novel coronavirus ciwon huhu a tsakanin yawancin naman gwari masu cin abinci da na magani saboda wadata da kayan aikin sa daban-daban.

WannanGanoderma lucidumyana hana kwafin ƙwayoyin cuta, yana sarrafa wuce kima da ƙarancin amsawar rigakafi (anti-ƙumburi da haɓaka juriya) ba baƙon abu bane ga kowa kuma an tattauna a cikin labarai da yawa:

Yana da sauƙin fahimtar hakanGanoderma lucidum, wanda ya riga ya yi kyau wajen kare zuciya da hanta, kare huhu da ƙarfafa koda, daidaita matakan hawan uku, da kuma hana tsufa, na iya inganta rashin daidaituwa na marasa lafiya da cututtuka masu tsanani da masu matsakaici da tsofaffi a cikin yaki da su. namoniyar sabuwar cutar coronavirus.

Amma menene rashin daidaituwa na ACE/ACE2?Menene alaka da kumburi?Ta yayaGanoderma lucidumshiga tsakani a daidaitawa?

Rashin daidaituwa na ACE / ACE2 na iya tsananta kumburi.

ACE2 (angiotensin yana canza enzyme 2) ba wai kawai mai karɓar SARS-CoV-2 bane don mamaye sel amma kuma yana da aikin haɓakar enzymes.Babban aikinsa shi ne daidaita wani ACE (angiotensin yana canza enzyme) wanda yayi kama da kama amma yana da ayyuka daban-daban.

Lokacin da koda ta gano raguwar ƙarar jini ko hawan jini (kamar zubar jini ko bushewa), takan ɓoye renin cikin jini.Enzyme da hanta ke ɓoye yana canzawa zuwa "angiotensin I" mara aiki.Lokacin da angiotensin na ke gudana tare da jini ta cikin huhu don musayar gas, ACE a cikin alveolar capillaries yana canza shi zuwa "angiotensin II" mai aiki da gaske wanda ke aiki a cikin jiki.

A wasu kalmomi, ACE tana taka muhimmiyar rawa a cikin "tsarin renin-angiotensin" wanda ke kula da hawan jini akai-akai da ƙarar jini (yayin da yake riƙe da ruwan jiki akai-akai da electrolytes).

Kawai don ba za ku iya kiyaye tasoshin jini a cikin matsatsi, yanayin hawan jini kamar wannan ba!Hakan na iya kara yawan aikin zuciya don tura jini da koda don tace jini.Menene ƙari, angiotensin II ba wai kawai yana haɓaka vasoconstriction ba har ma yana haɓaka kumburi, oxidation da fibrosis.Ci gaba da lalacewa ga jiki ba zai iyakance ga hawan jini ba!

Don haka, don samun ma'auni, jiki da wayo yana daidaita ACE2 akan saman sel endothelial na jijiyoyin jini, alveolar, zuciya, koda, ƙananan hanji, bile duct, testis da sauran ƙwayoyin nama, ta yadda zai iya juyar da angiotensin II zuwa ang. 1-7) wanda ke fadada hanyoyin jini, yana rage hawan jini kuma yana iya maganin kumburi, anti-oxidation da anti-fibrosis.

A wasu kalmomi, ACE2 lever ne da ake amfani da shi a cikin jiki don daidaita samar da angiotensin da yawa na II ta ACE.Koyaya, ACE2 ta zama tashar tashar jirgin ruwa don sabon coronavirus don mamaye sel.

Lokacin da aka haɗa ACE2 tare da furotin mai karu na novel coronavirus, za a jawo shi cikin tantanin halitta ko kuma a zubar da shi cikin jini saboda lalacewar tsarin, ta yadda ACE2 a saman tantanin halitta ya ragu sosai kuma ya kasa daidaita ma'aunin angiotensin. II ya kunna ta ACE.

A sakamakon haka, amsawar kumburin da kwayar cutar ta haifar yana haɗuwa tare da tasirin pro-mai kumburi na angiotensin II.Amsa mai zafi mai zafi zai hana haɗin ACE2 ta sel, yana sa lalacewar sarkar ta haifar da rashin daidaituwa na ACE/ACE2 mafi tsanani.Hakanan zai sa lalacewar oxidative da lalacewar fibrosis na kyallen takarda da gabobin jiki mafi tsanani.

Nazarin asibiti sun lura cewa angiotensin Ⅱ na marasa lafiya da cutar coronavirus 2019 (COVID-19) yana ƙaruwa sosai, kuma yana da alaƙa da alaƙa da adadin ƙwayar cuta, matakin raunin huhu, abin da ya faru na matsanancin ciwon huhu da matsanancin ciwo na numfashi. .Har ila yau, binciken ya yi nuni da cewa, yawan martanin kumburin kumburi, da yawan hawan jini, da yawan jinin da ke haifarwa sakamakon rashin daidaituwar ACE/ACE2, dalilai ne masu muhimmanci da ke kara nauyi a zuciya da koda na masu fama da ciwon huhu na coronavirus da kuma haifar da myocardial da koda. cuta.

Hana ACE na iya inganta rashin daidaituwa na ACE/ACE2

Yawancin sinadaran da ke cikinGanoderma lucidumna iya hana ACE

Tun da masu hana ACE da aka saba amfani da su wajen maganin hauhawar jini na iya hana ayyukan ACE, rage samar da angiotensin II da rage lalacewar sarkar da ke haifar da rashin daidaituwa na ACE/ACE2, ana ɗaukar su da taimako don maganin ciwon huhu na coronavirus. .

Malaman Bangladesh sun yi amfani da wannan hujja a matsayin ɗaya daga cikin dalilan da ya sa fungi masu cin abinci da na magani suka dace don rigakafi da magani na COVID-19.

Domin bisa ga binciken da ya gabata, yawancin fungi masu cin abinci da na magani suna da sinadarai masu aiki waɗanda ke hana ACE, daga cikinsuGanoderma lucidumyana da mafi yawan abubuwan da ke aiki.

Dukansu polypeptides dauke a cikin ruwa tsantsa naGanoderma lucidumJikin 'ya'yan itace da triterpenoids (kamar ganoderic acid, ganoderenic acid da ganederols) da ke cikin methanol ko cirewar ethanol naGanoderma lucidumJikunan 'ya'yan itace na iya hana ayyukan ACE (Table 1) kuma tasirin hana su yana da inganci a tsakanin yawancin fungi masu cin abinci da na magani (Table 2).

Mafi mahimmanci, tun farkon shekarun 1970, nazarin asibiti a China da Japan sun tabbatar da hakanGanoderma lucidumzai iya rage hawan jini yadda ya kamata, yana nuna hakanGanoderma lucidumHana ACE ba kawai "aiki mai yiwuwa" ba ne amma kuma yana iya aiki ta hanyar gastrointestinal tract.

Aikace-aikacen asibiti na masu hana ACE

Tunani don inganta rashin daidaituwa na ACE / ACE2

Ko yin amfani da masu hana ACE don magance novel coronavirus pneumonia ya taɓa sanya al'ummar likitocin shakku.

Domin hana ACE zai ƙara bayyanar ACE2 a kaikaice.Kodayake abu ne mai kyau don yaƙar kumburi, oxidation da fibrosis, ACE2 shine mai karɓar sabon coronavirus.Don haka ko hana ACE yana kare kyallen takarda ko yana ƙara kamuwa da cuta har yanzu yana cikin damuwa.

A zamanin yau, an yi karatun asibiti da yawa (duba Nassoshi 6-9 don cikakkun bayanai) cewa masu hana ACE ba sa cutar da yanayin marasa lafiya da ciwon huhu na coronavirus.Don haka, yawancin ƙungiyoyin zuciya ko hauhawar jini a Turai da Amurka sun ba da shawarar a fili marasa lafiya su ci gaba da amfani da mai hana ACE idan babu wani yanayi na asibiti mara kyau.

Amma ga marasa lafiya na COVID-19 waɗanda ba su yi amfani da masu hana ACE ba, musamman waɗanda ba tare da hauhawar jini ba, cututtukan zuciya ko alamun ciwon sukari, ko ƙarin masu hana ACE a halin yanzu bai dace ba musamman saboda kodayake binciken asibiti ya lura da fa'idodin amfani da masu hana ACE (kamar su. mafi girman adadin rayuwa), tasirin ba ze zama a bayyane isa ya zama shawarar jagorar likita ba.

MatsayinGanoderma lucidumya fi hana ACE

Ba abin mamaki ba ne cewa masu hana ACE ba za su iya yin tasiri mai mahimmanci ba yayin lokacin lura na asibiti (yawanci 1 rana zuwa wata 1).Cutar kumburin da ba a kula da ita ba sakamakon yaƙin da ke tsakanin ƙwayoyin cuta da tsarin garkuwar jiki shine tushen tabarbarewar novel coronavirus pneumonia.Tun da ba a kawar da mai laifin ba, ba shakka yana da wahala a sake juya abubuwa a karon farko ta hanyar murkushe ACE don magance masu laifi.

Matsalar ita ce rashin daidaituwar ACE/ACE2 na iya zama bambaro na ƙarshe don murkushe raƙumi, kuma yana iya zama abin tuntuɓe don murmurewa nan gaba.Don haka, idan kuna tunani daga hangen nesa na neman sa'a da guje wa bala'i, kyakkyawan amfani da masu hana ACE zai taimaka wa marasa lafiya da ke fama da ciwon huhu na coronavirus.

Koyaya, idan aka kwatanta da illolin da masu hana ACE na roba za su iya haifar da su, kamar busassun tari, allotriogeusti da haɓakar potassium na jini, masanin Bangladesh wanda ya rubuta wannan takarda ya yi imanin cewa abubuwan da ke hana ACE a cikin abubuwan da ke faruwa ta dabi'a da naman gwari na magani. baya haifar da nauyi na jiki.Musamman,Ganoderma lucidum, wanda ke da yawancin abubuwan hanawa na ACE da ingantacciyar tasiri mai hanawa, ya fi dacewa sa ido.

Menene ƙari, da yawaGanoderma lucidumtsantsa koGanoderma lucidumAbubuwan da ke hana ACE kuma suna iya hana kwafin ƙwayoyin cuta, daidaita kumburi (guje wa guguwar cytokine), haɓaka rigakafi, kare tsarin zuciya da jijiyoyin jini, daidaita sukarin jini, daidaita yanayin hawan jini, daidaita lipids na jini, rage raunin hanta, rage raunin koda, rage raunin huhu, karewa. na numfashi fili, kare hanji.Abubuwan da ke hana ACE na roba ko sauran abubuwan hana ACE waɗanda aka samo daga fungi masu ci da magani ba za a iya kwatanta su ba.Ganoderma lucidumdangane da haka.

Rage haɗarin rashin lafiya mai tsanani da mutuwa shine kawai rage rikicin.

Daga lokacin da novel coronavirus ya zaɓi ACE2 a matsayin mai karɓar mamayewa, an ƙaddara ya bambanta da sauran ƙwayoyin cuta a cikin mutuwa da rikitarwa.

Domin da yawa ƙwayoyin nama a jikin mutum suna da ACE2.Novel coronavirus na iya lalata alveoli kuma ya haifar da hypoxia a cikin jiki, bi jini don samun tushe mai dacewa a cikin jiki, jawo hankalin ƙwayoyin rigakafi a ko'ina don kai hari, lalata ma'aunin ACE / ACE2 a ko'ina, ƙara kumburi, oxidation da fibrosis, ƙara yawan jini. matsa lamba da ƙarar jini, ƙara nauyi a kan zuciya da koda, sanya ruwan jiki da rashin daidaituwa na electrolytes wanda ke shafar ayyukan sel, yana haifar da ƙarin tasirin domino.

Don haka, kamuwa da cutar ciwon huhu na coronavirus ba wata hanya ce ta "samun sanyi mai tsanani" wanda "yana shafar huhu kawai".Zai sami mabiyi na dogon lokaci zuwa kyallen jikin jiki, gabobin jiki da ayyukan ilimin lissafi.

Kodayake labari mai daɗi game da haɓaka sabbin magunguna daban-daban don rigakafi da jiyya na COVID-19 yana da ban sha'awa sosai, wasu bayanan ajizai suna kusa:

Alurar rigakafi (inducing antibodies) baya bada garantin cewa ba za a sami kamuwa da cuta ba;

Magungunan rigakafi (hana yin kwafin ƙwayoyin cuta) ba zai iya ba da tabbacin maganin cutar ba;

Steroid anti-kumburi (cutar rigakafi) takobi ne mai kaifi biyu;

Ba za a iya guje wa matsaloli ba ko da babu rashin lafiya mai tsanani;

Canjin gwajin kwayar cutar daga mai kyau zuwa mara kyau ba lallai ba ne yana nufin nasarar yaki da annobar;

Fita daga asibiti da rai ba yana nufin za ku iya samun cikakkiyar murmurewa nan gaba ba.

Lokacin da magungunan coronavirus da alluran rigakafin sun taimaka mana fahimtar “gaba ɗaya shugabanci” na rage haɗarin rashin lafiya mai tsanani, rage yiwuwar mutuwa da rage tsawon lokacin asibiti, kar ku manta cewa akwai “baki-daki” da yawa waɗanda dole ne mu dogara ga kanmu don mu'amala da.

Lokacin da ’yan Adam suka dogara da hankali da gogewa don haɗa takamaiman tsoffin magunguna da sabbin magunguna waɗanda ke da takamaiman tasiri don cimma sakamako mafi kyau, ya kamata mu koyi ɗaukar cikakkiyar salon salon hadaddiyar giyar don magance wannan hadaddun cuta.

Daga haɓaka juriya, hana kwafin ƙwayar cuta, sarrafa kumburi mara kyau, daidaita ACE / ACE2 don kare tsarin zuciya da jijiyoyin jini, daidaita matakan hawan uku da rage nauyin cututtukan cututtukan da ke cikin jiki, ana iya faɗi waɗannan a matsayin buƙatun asali na rage yawan kamuwa da cuta. COVID-19, hana tsananin COVID-19 da inganta murmurewa COVID-19.

Babu wanda ya san ko akwai bege nan gaba don biyan waɗannan buƙatun a lokaci guda.Wataƙila "abubuwan girke-girke na sirri" wanda ke da nisa a sararin sama yana daidai a gaban ku.Allah mai jinƙai ya daɗe yana shirya girke-girke na hadaddiyar giyar mai na halitta, mai amfani biyu don abinci da magani, samuwa a shirye, kuma ya dace da maza, mata da yara.Ya dogara kawai ko mun san yadda ake amfani da shi.

[Madogararsa]

1. Mohammad Azizur Rahman, et al.Int J Med Namomin kaza.2021; 23 (5): 1-11.

2. Aiko Morigiwa, et al.Chem Pharm Bull (Tokyo).1986;34 (7): 3025-3028.

3. Noorlidah Abdullah, et al.Evid Based Complement Alternat Med.2012;2012:464238.

4. Tran Hai-Bang, et al.Kwayoyin halitta.2014;19 (9): 13473-13485.

5. Tran Hai-Bang, et al.Phytochem Lett.2015; 12: 243-247.

6. Chirag Bavishi, et al.JAMA Cardiol.2020; 5 (7): 745-747.

7. Abhinav Grover, et al.15 ga Yuni 2020: pvaa064.doi:10.1093/ehjcvp/pvaa064.

8. Renato D. Lopes, et al.Am Heart J. 2020 Agusta; 226: 49–59.

9. Renato D. Lopes, et al.JAMA.2021 Janairu 19;325 (3): 254–264.

KARSHE

Game da marubucin / Ms. Wu Tingyao
Wu Tingyao tana ba da rahoto kan bayanan Ganoderma lucidum na farko tun daga 1999. Ita ce marubucin littafinWaraka tare da Ganoderma(an buga a The People's Medical Publishing House a Afrilu 2017).
 
★ An buga wannan labarin ne a ƙarƙashin izini na musamman na marubucin, kuma mallakin GANOHERB ne.

★ Ayyukan da ke sama ba za a iya sake su ba, cire su ko amfani da su ta wasu hanyoyi ba tare da izinin GanoHerb ba.

★ Idan an ba da izinin yin amfani da ayyukan, to a yi amfani da su cikin iyakar izini kuma a nuna tushen: GanoHerb.

★ Duk wani keta bayanin da ke sama, GanoHerb za ta bi alhakin shari'a masu alaƙa.

★ Asalin rubutun wannan labarin Wu Tingyao ne ya rubuta shi da Sinanci kuma Alfred Liu ya fassara shi zuwa Turanci.Idan akwai wani sabani tsakanin fassarar (Turanci) da na asali (China), asalin Sinanci zai yi nasara.Idan masu karatu suna da wasu tambayoyi, tuntuɓi marubuciyar asali, Ms. Wu Tingyao.
 

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