Muri Gicurasi 2021, itsinda riyobowe na Mohammad Azizur Rahman, umwarimu wungirije w’ishami ry’ibinyabuzima n’ibinyabuzima bya Molecular, kaminuza ya Jahangirnagar, Bangaladeshi, n’ikigo gishinzwe iterambere ry’ibihumyo, ishami ry’ubuhinzi n’ubuhinzi, Minisiteri y’ubuhinzi, Bangaladeshi bafatanije gusohora impapuro zisubiza inyuma muri Ikinyamakuru mpuzamahanga cy’ubuvuzi bw’ibihumyo kugira ngo kiyobore abantu bari mu cyorezo cya COVID-19 gukoresha neza “ubumenyi buzwi” n '“umutungo uhari” mu rwego rwo gushaka kwikingira mu gihe kirekire bategereje agakiza hamwe n’ibiyobyabwenge bishya.

Hashingiwe ku bisubizo byagenzuwe na siyansi, binyuze mu gusuzuma ibitekerezo bifatika nk’umutekano uribwa no kugera ku bihumyo biribwa n’imiti no gusesengura uruhare rwabo muri antivirus, kugenzura ubudahangarwa bw'umubiri, kugabanya ibicanwa biterwa n'ubusumbane bwa ACE / ACE2 no kunoza indwara zidakira indwara nk'indwara z'umutima n'imitsi, diyabete, hyperlipidemiya, na hypertension ku barwayi bafite indwara ya coronavirus 2019 (COVID-19), impapuro zasobanuye impamvu zituma abantu bagomba “kurya ibihumyo kugira ngo birinde icyorezo”.

Urupapuro rwerekanye inshuro nyinshi mu ngingo koGanoderma lucidumntagushidikanya ni amahitamo akwiye yo gukumira no kuvura umusonga wa coronavirus umusonga mu bihumyo byinshi biribwa kandi bivura imiti kubera ibintu byinshi bikungahaye kandi bitandukanye.

IbyoGanoderma lucidumibuza kwigana virusi, igenga ibisubizo birenze urugero kandi bidahagije (anti-inflammation and resistance resistance) ntabwo bidasanzwe kuri buri wese kandi byaganiriweho mu ngingo nyinshi:

Biroroshye kubyumvaGanoderma lucidum, isanzwe ari nziza kurinda umutima numwijima, kurinda ibihaha no gushimangira impyiko, kugenga uburebure butatu, no kurwanya gusaza, birashobora guteza imbere ibibazo by’abarwayi bafite indwara zidakira ndetse n’abasaza ndetse n’abasaza mu rugamba rwo kurwanya agashya coronavirus umusonga.

Ariko ubusumbane bwa ACE / ACE2 ni ubuhe?Bifitanye isano niki no gutwika?NiguteGanoderma lucidumkugira uruhare mu guhuza ibikorwa?

Ubusumbane bwa ACE / ACE2 burashobora kongera uburibwe.

ACE2 (angiotensin ihindura enzyme 2) ntabwo yakira gusa SARS-CoV-2 gutera selile ahubwo ifite ibikorwa bya catalitiki ya enzymes.Uruhare rwarwo nyamukuru ni ukuringaniza indi ACE (angiotensin ihindura enzyme) isa cyane ariko ifite imirimo itandukanye rwose.

Iyo impyiko ibonye igabanuka ryubwinshi bwamaraso cyangwa umuvuduko wamaraso (nko kuva amaraso cyangwa umwuma), isohora renin mumaraso.Enzyme isohorwa numwijima ihindurwamo "angiotensin I" idakora.Iyo angiotensin I itembera namaraso mu bihaha kugirango mpane gaze, ACE muri capillaries ya alveolar ihindura "angiotensin II" ikora rwose mumubiri.

Muyandi magambo, ACE igira uruhare runini muri "sisitemu ya renin-angiotensin" ikomeza umuvuduko wamaraso hamwe nubunini bwamaraso (mugihe ikomeza amazi yumubiri na electrolytite).

Ni uko udashobora kugumana imiyoboro yamaraso muburyo bukomeye, bwumuvuduko ukabije nkuyu!Ibyo birashobora kongera akazi k'umutima kugirango usunike amaraso n'impyiko gushungura amaraso.Ikirenzeho, angiotensin II ntabwo itera vasoconstriction gusa ahubwo itera no gutwika, okiside na fibrosis.Kwangirika kwayo kumubiri ntibizagarukira kumuvuduko ukabije wamaraso!

Kubwibyo, kugirango habeho kuringaniza, umubiri ubigiranye ubuhanga ushyiraho ACE2 hejuru yingirabuzimafatizo ya endoteliyale yimitsi, alveolar, umutima, impyiko, amara mato, umuyoboro wa bile, testis nizindi selile, kugirango ibashe guhindura angiotensin II muri ang ( 1-7) yagura imiyoboro yamaraso, igabanya umuvuduko wamaraso kandi irashobora kurwanya anti-inflammation, anti-okiside na anti-fibrosis.

Muyandi magambo, ACE2 ni leveri ikoreshwa mumubiri kugirango iringanize umusaruro wa angiotensin II ikabije na ACE.Ariko, ACE2 ibaye icyambu cya sally ya roman coronavirus yibasira selile.

Iyo ACE2 ihujwe na proteine ​​ya spike ya roman coronavirus, izakururwa mu kagari cyangwa isuke mu maraso kubera kwangirika kw’imiterere, ku buryo ACE2 hejuru y’akagari igabanuka cyane kandi ikaba idashobora kurwanya angiotensin II yakoreshejwe na ACE.

Kubera iyo mpamvu, igisubizo cyatewe na virusi kijyana ningaruka ziterwa na angiotensin II.Igisubizo kigenda gikomera cyane kizabuza synthesis ya ACE2 na selile, bigatuma urunigi rwangirika rwatewe nubusumbane bwa ACE / ACE2 rukomeye.Bizakora kandi kwangiza okiside na fibrosis yangiza ingirangingo ningingo zikomeye.

Ubushakashatsi ku mavuriro bwerekanye ko angiotensin Ⅱ y’abarwayi bafite indwara ya coronavirus 2019 (COVID-19) yiyongereye ku buryo bugaragara, kandi bifitanye isano neza n’ubwinshi bwa virusi, urugero rw’imvune z’ibihaha, kuba umusonga ukabije w’indwara zifata imyanya y'ubuhumekero. .Ubushakashatsi bwerekanye kandi ko igisubizo gikabije cy’umuriro, umuvuduko w’amaraso, ndetse no kongera umuvuduko w’amaraso uterwa n’ubusumbane bwa ACE / ACE2 nimpamvu zingenzi zongera umutwaro ku mutima nimpyiko z’abarwayi barwaye umusonga wa coronavirus kandi bigatera myocardial nimpyiko indwara.

Kubuza ACE birashobora kunoza ubusumbane bwa ACE / ACE2

Ibintu byinshi birimoGanoderma lucidumirashobora kubuza ACE

Kubera ko inzitizi za ACE zikoreshwa cyane mu kuvura hypertension zishobora guhagarika ibikorwa bya ACE, kugabanya umusaruro wa angiotensin II no kugabanya ibyangijwe n’urunigi byatewe n’ubusumbane bwa ACE / ACE2, bifatwa nk’ingirakamaro mu kuvura umusonga wa coronavirus umusonga. .

Intiti zo muri Bangaladeshi zakoresheje iyi ngingo nk'imwe mu mpamvu zituma ibihumyo biribwa n’imiti bikwiranye no gukumira no kuvura COVID-19.

Kuberako ukurikije ubushakashatsi bwashize, ibihumyo byinshi biribwa nubuvuzi bifite ibintu bifatika bibuza ACE, muribyoGanoderma lucidumifite ibintu byinshi bikora.

Polypeptide zombi zikubiye mumazi yaGanoderma lucidumimibiri yimbuto hamwe na triterpenoide (nka acide ganoderic, acide ganoderenic na ganederol) biriho muri methanol cyangwa Ethanol yaGanoderma lucidumimibiri yera imbuto irashobora guhagarika ibikorwa bya ACE (Imbonerahamwe 1) kandi ingaruka zayo zo kubuza ni nziza cyane mubihumyo byinshi biribwa kandi bivura (Imbonerahamwe 2).

Icy'ingenzi cyane, nko mu myaka ya za 70, ubushakashatsi ku mavuriro mu Bushinwa no mu Buyapani bwemeje koGanoderma lucidumirashobora kugabanya neza umuvuduko ukabije wamaraso, byerekana koGanoderma lucidum'kubuza ACE ntabwo ari "igikorwa gishoboka" gusa ariko nanone irashobora gukora binyuze mumitsi yo munda.

Gukoresha ivuriro rya ACE inhibitor

Ibitekerezo byo kunoza ubusumbane bwa ACE / ACE2

Niba wakoresha ACE inhibitori kugirango uvure umusonga wa coronavirus pneumonia wigeze gutuma abaganga batindiganya.

Kuberako guhagarika ACE bizongera mu buryo butaziguye imvugo ya ACE2.Nubwo ari ikintu cyiza cyo kurwanya umuriro, okiside na fibrosis, ACE2 niyakira igitabo cyitwa coronavirus.Niba rero kubuza ACE kurinda ingirangingo cyangwa kongera ubwandu byari bikomeje gutera impungenge.

Muri iki gihe, habaye ubushakashatsi bwinshi ku mavuriro (reba Reba 6-9 kugira ngo ubone ibisobanuro birambuye) ko inzitizi za ACE zitangiza ubuzima bw'abarwayi barwaye umusonga wa coronavirus.Kubera iyo mpamvu, amashyirahamwe menshi yumutima cyangwa hypertension mu Burayi no muri Amerika yasabye abarwayi gukomeza gukoresha imiti igabanya ubukana bwa ACE niba nta mavuriro mabi abaye.

Naho abarwayi ba COVID-19 batakoresheje inibitori ya ACE, cyane cyane abadafite hypertension, indwara z'umutima cyangwa ibimenyetso bya diyabete, niba hakwiye gutangwa izindi mitiweli ya ACE kuri ubu ntibishoboka cyane cyane kubera ko nubwo ubushakashatsi bw’amavuriro bwabonye ibyiza byo gukoresha inzitizi za ACE (nka igipimo cyo kubaho cyane), ingaruka ntabwo isa nkaho igaragara bihagije kugirango ube umurongo ngenderwaho wubuvuzi.

Uruhare rwaGanoderma lucidumni birenze kubuza ACE

Ntabwo bitangaje kuba inhibitori ya ACE idashobora kugira ingaruka zikomeye mugihe cyo kwitegereza kwa muganga (mubisanzwe umunsi 1 kugeza ukwezi).Indurwe itagenzuwe iterwa no kurwanya virusi na sisitemu y’umubiri niyo ntandaro yo kwangirika kw’umusonga coronavirus pneumonia.Kubera ko nyirabayazana atakuweho, birumvikana ko bigoye guhindura ibintu mugihe cyambere mukanda ACE kugirango ikemure ibyitso.

Ikibazo nuko ubusumbane bwa ACE / ACE2 bushobora kuba aribwo bwatsi bwa nyuma bwo kumenagura ingamiya, kandi birashoboka cyane ko bizahinduka igisitaza cyo gukira ejo hazaza.Kubwibyo, niba utekereza ukurikije gukurikirana amahirwe no kwirinda ibiza, gukoresha neza inhibitori ya ACE bizafasha gukira abarwayi bafite umusonga wa coronavirus umusonga.

Icyakora, ugereranije n'ingaruka zishobora guterwa na sintetike ya ACE inhibitor, nka inkorora yumye, allotriogeusti hamwe na potasiyumu y’amaraso yazamutse, intiti yo muri Bangaladeshi yanditse iyi mpapuro yizeraga ko ibice bya ACE bibuza ibihumyo bisanzwe biribwa kandi bivura imiti. ntutere umutwaro wumubiri.By'umwihariko,Ganoderma lucidum, ifite ibice byinshi bya ACE-ibuza hamwe ningaruka nziza yo kubuza, birakwiye ko tureba imbere.

Ikirenzeho, benshiGanoderma lucidumibice cyangwaGanoderma lucidumibirungo bibuza ACE birashobora kandi kubuza kwigana virusi, kugenzura umuriro (kwirinda umuyaga wa cytokine), kongera ubudahangarwa, kurinda sisitemu yimitsi yumutima, kugenga isukari yamaraso, kugenga umuvuduko wamaraso, kugabanya lipide yamaraso, kugabanya imvune yumwijima, kugabanya ibikomere byimpyiko, kurinda inzira y'ubuhumekero, urinde inzira y'amara.Ibikoresho bya sintetike ya ACE ibuza cyangwa ibindi bikoresho bya ACE bibuza ibikomoka ku bihumyo biribwa n’imiti ntibishobora kugereranywaGanoderma lucidumKuri iyi ngingo.

Kugabanya ibyago byindwara zikomeye nurupfu ni ukugabanya ibibazo gusa.

Kuva igihe igitabo cyitwa coronavirus gihisemo ACE2 nkuwakira igitero, giteganijwe kuba gitandukanye nizindi virusi zica kandi zigoye.

Kuberako ingirabuzimafatizo nyinshi mumubiri wumuntu zifite ACE2.Igitabo coronavirus kirashobora kwangiza alveoli kandi kigatera hypoxia mumubiri, gukurikira amaraso kugirango ubone umusingi ukwiye mumubiri, gukurura ingirabuzimafatizo z'umubiri ahantu hose gutera, gusenya uburinganire bwa ACE / ACE2 ahantu hose, kongera umuriro, okiside na fibrosis, kongera amaraso umuvuduko nubunini bwamaraso, byongera umutwaro kumutima nimpyiko, gukora amazi yumubiri hamwe nuburinganire bwa electrolytite bigira ingaruka kumikorere ya selile, kandi bigatera ingaruka nyinshi za domino.

Kubwibyo, kwandura umusonga wa coronavirus pneumonia ntabwo ari "ukonja cyane" "ifata ibihaha gusa".Bizaba bikurikiranye igihe kirekire kumubiri, ingingo nimirimo yumubiri.

Nubwo inkuru nziza yerekeye iterambere ryibiyobyabwenge bishya bigamije gukumira no kuvura COVID-19 birashimishije cyane, ibintu bimwe bidatunganye biri hafi:

Inkingo (itera antibodies) ntabwo yemeza ko nta kwandura kuzabaho;

Imiti igabanya ubukana (kubuza kwigana virusi) ntishobora kwemeza gukiza indwara;

Steroid anti-inflammation (suppression immune) ni inkota y'amaharakubiri;

Ingorane ntizishobora kwirindwa nubwo nta burwayi bukomeye;

Guhindura kwipimisha virusi kuva mubyiza bikagenda nabi ntabwo bivuze byanze bikunze kurwanya gutsinda icyorezo;

Gusohoka mu bitaro ari muzima ntibisobanura ko uzashobora gukira byimazeyo ejo hazaza.

Iyo imiti ninkingo za coronavirus byadufashije gusobanukirwa "icyerekezo rusange" cyo kugabanya ibyago byindwara zikomeye, kugabanya amahirwe yo gupfa no kugabanya igihe cyo gushyirwa mubitaro, ntuzibagirwe ko hariho "ibisobanuro" byinshi cyane tugomba kubikora twishingikirize ubwacu kugirango dukemure.

Iyo abantu bashingiye ku bwenge n'uburambe kugirango bahuze imiti itandukanye ishaje kandi mishya ifite ingaruka zihariye kugirango tugere ku ngaruka nziza, dukwiye kwiga gufata imiti yuzuye ya cocktail yubuvuzi bwuzuye kugirango duhangane niyi ndwara itoroshye.

Kuva mukongera imbaraga zo kurwanya, kubuza kwigana virusi, kugenzura umuriro udasanzwe, kuringaniza ACE / ACE2 kugeza kurinda sisitemu yumutima nimiyoboro y'amaraso, kugenga hejuru eshatu no kugabanya umutwaro windwara zidakira kumubiri, ibi birashobora kuvugwa nkibikenewe byibanze byo kugabanya umuvuduko wubwandu bwa COVID-19, ikumira COVID-19 ikabije no kunoza kugarura COVID-19.

Ntawe uzi niba hari ibyiringiro ejo hazaza kugirango duhuze ibyo bikenerwa icyarimwe.Ahari "resept y'ibanga" iri kure cyane mwijuru mubyukuri imbere yawe.Imana yimpuhwe yateguye kuva kera cocktail resept isanzwe, ikoreshwa kabiri kubiryo nubuvuzi, byoroshye kuboneka, kandi ibereye abagabo, abagore nabana.Gusa biterwa nuko tuzi kubikoresha.

[Inkomoko]

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2. Aiko Morigiwa, n'abandi.Chem Pharm Bull (Tokiyo).1986;34 (7): 3025-3028.

3. Noorlidah Abdullah, n'abandi.Ibimenyetso Bishingiye Kwuzuza Ubundi Med.2012; 2012: 464238.

4. Tran Hai-Bang, n'abandi.Molekile.2014;19 (9): 13473-13485.

5. Tran Hai-Bang, n'abandi.Phytochem Lett.2015; 12: 243-247.

6. Chirag Bavishi, n'abandi.JAMA Cardiol.2020; 5 (7): 745-747.

7. Abhinav Grover, n'abandi.2020 Jun 15: pvaa064.doi: 10.1093 / ehjcvp / pvaa064.

8. Renato D. Lopes, n'abandi.Amutima J. 2020 Kanama; 226: 49–59.

9. Renato D. Lopes, n'abandi.JAMA.2021 Mutarama 19;325 (3): 254-22.

IHEREZO

Ibyerekeye umwanditsi / Madamu Wu Tingyao
Wu Tingyao yagiye atanga amakuru ku makuru ya Ganoderma lucidum kuva mu 1999. Niwe mwanditsi waGukiza hamwe na Ganoderma(byasohotse mu gitabo cy’ubuvuzi cy’abaturage muri Mata 2017).
 
★ Iyi ngingo yasohowe uruhushya rwihariye rwumwanditsi, kandi nyirubwite ni GANOHERB.

Work Ibikorwa byavuzwe haruguru ntibishobora kubyara, gucibwa cyangwa gukoreshwa mubundi buryo utabiherewe uburenganzira na GanoHerb.

★ Niba imirimo yemerewe gukoreshwa, igomba gukoreshwa murwego rwo gutanga uburenganzira no kwerekana inkomoko: GanoHerb.

★ Ku kurenga ku magambo yavuzwe haruguru, GanoHerb azakomeza inshingano zijyanye n'amategeko.

Text Umwandiko wumwimerere wiyi ngingo wanditswe mu gishinwa na Wu Tingyao uhindurwa mu cyongereza na Alfred Liu.Niba hari itandukaniro riri hagati yubuhinduzi (icyongereza) numwimerere (igishinwa), igishinwa cyumwimerere kizatsinda.Niba abasomyi bafite ikibazo, nyamuneka hamagara umwanditsi wambere, Madamu Wu Tingyao.
 

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