Muna Chivabvu 2021, timu inotungamirwa naMohammad Azizur Rahman, Associate Purofesa weDhipatimendi reBiochemistry uye Molecular Biology, Jahangirnagar University, Bangladesh, uye Mushroom Development Institute, Dhipatimendi reKurima Kuwedzera, Bazi rezvekurima, Bangladesh vakabatana vakaburitsa bepa rekudzokorora mukati. International Journal of Medicinal Mushrooms kutungamira vanhu pasi peCOVID-19 denda kuti vashandise zvakanaka "ruzivo rwunozivikanwa" uye "zviwanikwa zviripo" kutsvaga kuzvidzivirira mukumirira kwenguva refu kuponeswa nemishonga mitsva.

Zvichienderana nemhedzisiro yakasimbiswa nesainzi, kuburikidza nekuongororwa kwezvinhu zvinoshanda sekuchengetedza uye kuwanikwa kwehowa hunodyiwa uye hwemishonga uye kuongororwa kwebasa ravo muantivirus, mutemo wekudzivirira muviri, kudzikiswa kwekuzvimba kunokonzerwa neACE / ACE2 kusaenzana uye kuvandudzwa kwezvakajairwa zvisingaperi. Zvirwere zvakaita sechirwere chemoyo, chirwere cheshuga, hyperlipidemia, uye hypertension muvarwere vane chirwere chekoronavirus 2019 (COVID-19), bepa rakatsanangura zvikonzero nei vanhu vachifanira "kudya howa kudzivirira denda".

Pepa racho rakaratidza kakawanda munyaya yacho kutiGanoderma lucidumhapana mubvunzo kuti ndiyo yakanyanya kufanirwa sarudzo yekudzivirira uye kurapwa kweinoveli coronavirus pneumonia pakati peakawanda anodyika uye emishonga fungi nekuda kwekupfuma kwayo uye kwakasiyana-siyana inoshanda.

IzvozvoGanoderma luciduminhibits kudzokororwa kwehutachiona, inogadzirisa yakawandisa uye isina kukwana mhinduro dzekudzivirira (anti-inflammation uye kusimudzira kurwisa) hazvishamisi kune wese munhu uye zvakakurukurwa mune zvakawanda zvinyorwa:

Zviri nyore kunzwisisa izvozvoGanoderma lucidum, iyo yakatove yakanaka pakudzivirira mwoyo nechiropa, kudzivirira mapapu uye kusimbisa itsvo, kugadzirisa hutatu hwepamusoro, uye kurwisa kukwegura, kunogona kuvandudza mikana yevarwere vane zvirwere zvisingaperi uye vanhu vane makore epakati uye vakwegura mukurwisana. coronavirus itsva inouya nemabayo.

Asi chii chinonzi ACE/ACE2 kusaenzana?Zvinei nechokuita nekuzvimba?Zvinoita seiGanoderma lucidumkupindira mukubatana?

ACE/ACE2 kusaenzana kunogona kuwedzera kuzvimba.

ACE2 (angiotensin inoshandura enzyme 2) haingori chete inogamuchira yeSARS-CoV-2 kuti ipinde mumasero asiwo ine catalytic chiitiko che enzymes.Basa rayo guru ndere kuenzanisa imwe ACE (angiotensin inoshandura enzyme) inotaridzika zvakafanana asi ine mabasa akasiyana zvachose.

Kana itsvo ikaona kuderera kwehuwandu hweropa kana BP (sekubuda ropa kana kupera mvura mumuviri), inoburitsa renin muropa.Iyo enzyme yakavanzwa nechiropa inoshandurwa kuita "angiotensin I" isingashande.Kana angiotensin I inoyerera neropa nemumapapu kuitira kuchinjanisa gasi, iyo ACE iri mualveolar capillaries inoishandura kuita "angiotensin II" inoshanda chaizvo iyo inoshanda mumuviri wese.

Mune mamwe mazwi, ACE inobata basa rinokosha mu "renin-angiotensin system" iyo inochengetedza nguva dzose yeropa uye huwandu hweropa (paine kuchengetedza nguva dzose mvura yemuviri uye electrolytes).

Kungoti haugone kuchengeta tsinga dzeropa dzakasimba, dzakasimba sezvizvi!Izvozvo zvinogona kuwedzera basa remoyo kusunda ropa neitsvo kusefa ropa.Uyezve, angiotensin II haingosimudziri vasoconstriction chete asi inosimudzira kuzvimba, oxidation uye fibrosis.Kukuvadza kwayo kunoramba kuripo kumuviri hakuzongori kukwira kweropa!

Naizvozvo, kuti uve nechiyero, muviri unogadzirisa zvine hungwaru ACE2 pamusoro pevascular endothelial masero, alveolar, moyo, itsvo, dumbu diki, bile duct, testis uye mamwe matishu masero, kuitira kuti ikwanise kushandura angiotensin II kuita ang. 1-7) iyo inowedzera tsinga dzeropa, inoderedza BP uye inokwanisa kurwisa-kuzvimba, anti-oxidation uye anti-fibrosis.

Mune mamwe mazwi, ACE2 chibatiso chinoshandiswa mumuviri kuenzanisa kugadzirwa kweakanyanya angiotensin II neACE.Nekudaro, ACE2 inoitika kunge sally chiteshi cheiyo novel coronavirus kuti ipinde mumasero.

Kana ACE2 yasanganiswa ne spike protein yenovel coronavirus, inodhonzerwa muchitokisi kana kudururirwa muropa nekuda kwekukuvara kwechimiro, kuitira kuti iyo ACE2 iri pamusoro pesero ideredze zvakanyanya uye isingakwanise kuenzanisa iyo angiotensin. II yakagadzirwa neACE.

Nekuda kweizvozvo, mhinduro yekuzvimba inokonzerwa nehutachiona inopindirana nepro-inflammatory effect yeangiotensin II.Kuwedzera kwakawedzera kuzvimba mhinduro inotadzisa kuumbwa kweACE2 nemaseru, zvichiita kuti kukuvara kweketani kunokonzerwa nekusaenzana kweACE / ACE2 zvakanyanya.Ichaitawo kuti oxidative kukuvara uye fibrosis kukuvara kwematishu uye nhengo zvakanyanya.

Zvidzidzo zvekiriniki zvakaona kuti angiotensin Ⅱ yevarwere vane chirwere chekoronavirus 2019 (COVID-19) yakawedzera zvakanyanya, uye inoenderana nehuwandu hwehutachiona, dhigirii rekukuvara kwemapapu, kuitika kweacute pneumonia uye acute kufema kusagadzikana syndrome. .Zvidzidzo zvakaratidzawo kuti yakawedzera kuzvimba kupindura, kuwedzera kweropa, uye kuwedzera kweropa kunokonzerwa nekusaenzana kweACE / ACE2 zvikonzero zvakakosha zvinowedzera mutoro pamwoyo neitsvo dzevarwere vane novel coronavirus pneumonia uye kukonzera myocardial neitsvo. chirwere.

Inhibition yeACE inogona kuvandudza ACE/ACE2 kusaenzana

Zvizhinji zvinosanganiswa zviri mukatiGanoderma luciduminogona kuvharidzira ACE

Sezvo ACE inhibitors inowanzo shandiswa mukurapa hypertension inogona kutadzisa kuita kweACE, kuderedza kugadzirwa kweangiotensin II uye kuderedza kukuvara kweketani kunokonzerwa nekusaenzana kweACE / ACE2, inoonekwa seyamuro mukurapa kwenovel coronavirus pneumonia. .

Nyanzvi dzeBangladeshi dzakashandisa gakava iri sechimwe chezvikonzero nei fungi inodyiwa uye yekurapa yakakodzera kudzivirira uye kurapwa kweCCIDID-19.

Nekuti maererano netsvagiridzo yapfuura, akawanda anodyika uye emishonga fungi ane anoshanda zvinomisa izvo zvinotadzisa ACE, pakati payo.Ganoderma lucidumine zvinhu zvakawanda zvinoshanda.

Ose ari maviri mapolypeptides ari mumvura inotorwa yeGanoderma lucidumMitumbi inobereka michero uye iyo triterpenoids (yakadai seganoderic acids, ganoderenic acids uye ganederols) iripo mumethanol kana ethanol yakabudiswa.Ganoderma lucidumMitumbi inobereka michero inogona kutadzisa ACE chiitiko (Tafura 1) uye inhibitory mhedzisiro yavo yakanakisa pakati peakawanda anodyika uye emishonga fungi (Table 2).

Zvinotonyanya kukosha, kubvira kuma1970, zvidzidzo zvekiriniki muChina neJapan zvakasimbisa izvozvoGanoderma luciduminogona kunyatsodzikisa high blood pressure, zvichiratidza izvozvoGanoderma lucidum's inhibition yeACE haisi "inogoneka chiitiko" chete asi inogona kushanda kuburikidza nemudumbu.

Clinical kushandiswa kweACE inhibitors

Mafungiro ekuvandudza ACE/ACE2 kusaenzana

Kunyangwe kushandisa ACE inhibitors kurapa novel coronavirus pneumonia yakamboita kuti vezvekurapa vazeze.

Nekuti inhibiting ACE kuchawedzera zvisina kunanga kutaura kweACE2.Kunyangwe chiri chinhu chakanaka kurwisa kuzvimba, oxidation uye fibrosis, ACE2 ndiyo inogamuchira yeinoveli coronavirus.Saka kana inhibition yeACE inodzivirira matishu kana kuwedzera hutachiona kwanga kuchiri kunetseka.

Mazuva ano, kwave nezvidzidzo zvekiriniki zvakawanda (ona References 6-9 kuti uwane ruzivo) kuti ACE inhibitors haiwedzere mamiriro evarwere vane coronavirus pneumonia.Naizvozvo, masangano mazhinji emwoyo kana hypertension muEurope neUnited States akakurudzira varwere kuti vaenderere mberi nekushandisa ACE inhibitor kana pasina mamiriro ekiriniki asina kunaka akaitika.

Kana vari varwere veCCIDID-19 vasina kushandisa ACE inhibitors, kunyanya avo vasina hypertension, chirwere chemoyo kana chirwere cheshuga, kana imwe ACE inhibitors ichifanirwa kupihwa parizvino haisati yanyatsoenderana nekuti kunyangwe zvidzidzo zvekiriniki zvakaona mabhenefiti ekushandisa ACE inhibitors (senge mwero wepamusoro wekupona), mhedzisiro yacho hairatidzike seyakajeka zvakakwana kuti ive kurudziro yenhungamiro yekurapa.

Basa reGanoderma luciduminopfuura inhibiting ACE

Hazvishamisi kuti ACE inhibitors inogona kusakwanisa kuita zvakakosha panguva yekuongorora kwekliniki (kazhinji zuva 1 kusvika kumwedzi 1).Kuzvimba kusingadzoreki kunokonzerwa nekurwa pakati pehutachiona uye immune system ndicho chikonzero chekuipa kweiyo novel coronavirus pneumonia.Sezvo mhosva isati yabviswa, zvakaoma kushandura zvinhu panguva yekutanga nekudzvanyirira ACE kuti igadzirise izvo zvinobatanidzwa.

Dambudziko nderekuti kusaenzana kweACE/ACE2 kungangove kwekupedzisira kupwanya ngamera, uye zvinokwanisika kuve chigumbuso chekupora mune ramangwana.Naizvozvo, kana iwe uchifunga kubva pamaonero ekutsvaga rombo rakanaka uye kudzivirira njodzi, kushandiswa kwakanaka kweACE inhibitors kuchabatsira kupora kwevarwere vane novel coronavirus pneumonia.

Nekudaro, zvichienzaniswa nemhedzisiro inogona kukonzerwa neyakagadzirwa ACE inhibitors, senge chikosoro chakaoma, allotriogeusti uye yakakwira potassium yeropa, nyanzvi yeBangladeshi yakanyora bepa rino yaitenda kuti ACE-inhibiting zvikamu mune zvechisikigo zvinodyiwa uye fungi dzemishonga. kwete kukonzera mutoro wepanyama.Zvikuru sei,Ganoderma lucidum, iyo ine akawanda ACE-inhibiting zvikamu uye yakanakisa inhibitory maitiro, inonyanya kukosha kutarisira.

Chii zvakare, vazhinjiGanoderma lucidumzvinyorwa kanaGanoderma lucidumzvinongedzo zvinodzivisa ACE zvinogonawo kurambidza kudzokororwa kwehutachiona, kugadzirisa kuzvimba (kudzivisa cytokine dutu), kuwedzera hutachiona, kudzivirira masystems emwoyo, kudzora shuga yeropa, kudzora BP, kudzora lipids yeropa, kuderedza kukuvara kwechiropa, kuderedza kukuvara kweitsvo, kuderedza kukuvara kwemapapu, kudzivirira. nzira yekufema, chengetedza intestinal turakiti.Synthetic ACE inhibitory ingredients kana imwe ACE inhibitory ingredients inotorwa kubva kune zvinodyika uye mishonga fungi haigoni kuenzaniswa neGanoderma lucidumpanyaya iyi.

Kuderedza njodzi yekurwara zvakanyanya uye kufa kuri kungoderedza dambudziko.

Kubva panguva iyo novel coronavirus inosarudza ACE2 seyekupinda receptor, inotarisirwa kuve yakasiyana nemamwe mavhairasi mukuuraya uye kuomarara.

Nekuti akawanda matishu masero ari mumuviri wemunhu ane ACE2.Iyo novel coronavirus inogona kukuvadza alveoli uye kukonzera hypoxia mumuviri wese, kutevera ropa kuti uwane hwaro hwakakodzera mumuviri, kukwezva maseru edziviriro kwese kwese kurwisa, kuparadza chiyero cheACE / ACE2 kwese kwese, kuwedzera kuzvimba, oxidation uye fibrosis, kuwedzera ropa. kudzvanywa uye uwandu hweropa, kuwedzera mutoro pamwoyo neitsvo, kuita mvura dzemuviri uye kusaenzana kwe electrolytes izvo zvinokanganisa kushanda kwesero, uye kukonzeresa mamwe madomino mhedzisiro.

Naizvozvo, kutapukirwa neinoveli coronavirus pneumonia hakusi "kuwana kutonhora kwakanyanya" uko "kunokanganisa mapapu chete".Ichange iine kwenguva yakareba sequelae kune matishu emuviri, nhengo uye physiological mabasa.

Kunyangwe nhau dzakanaka nezve kuvandudzwa kwemishonga mitsva yakasiyana-siyana yekudzivirira uye kurapwa kweCCIDID-19 inonakidza kwazvo, zvimwe zvinhu zvisina kukwana zviri pedyo:

Vaccination (inducing antibodies) haivimbisi kuti hapazovi nehutachiona;

Antiviral mishonga (inhibition of virus replication) haigoni kuvimbisa kurapwa kwechirwere;

Steroid anti-inflammation (kudzvinyirirwa kweimmune) munondo unocheka kaviri;

Zvinetso zvingasadziviswa kunyange kana pasina chirwere chakakomba;

Shanduko yekuongorora utachiona kubva kune yakanaka kuenda kune yakaipa hairevi hazvo kurwisa kunobudirira kurwisa denda;

Kubuda muchipatara uri mupenyu hazvirevi kuti uchakwanisa kupora zvizere mune ramangwana.

Kana mishonga yekoronavirus nemishonga yekudzivirira yatibatsira kubata "gwara" rekudzikisa njodzi yekurwara zvakanyanya, kuderedza mukana wekufa uye kupfupisa kureba kwekuchipatara, usakanganwe kuti kune "ruzivo" rwakawanda rwatinofanira. vimba isu pachedu kuti tibate nawo.

Kana vanhu vachivimba nehungwaru uye ruzivo kusanganisa mishonga yekare nemitsva yakasiyana-siyana ine mhedzisiro chaiyo kuti iite zvakanakisa, isu tinofanirwa kudzidza kutora cocktail-maitiro akazara kurapa kubata nechirwere ichi chakaoma.

Kubva pakusimudzira kuramba, kuvharidzira kudzokororwa kwehutachiona, kudzora kuzvimba, kuenzanisa ACE / ACE2 kuchengetedza iyo yemoyo vascular system, kudzora iyo mitatu yakakwirira uye kuderedza mutoro wezvirwere zvisingaperi pamuviri, izvi zvinogona kutaurwa sezvinodiwa zvakakosha zvekudzikisa huwandu hwehutachiona. COVID-19, kudzivirira yakanyanya COVID-19 uye kugadzirisa kupora kweCOVID-19.

Hapana anoziva kana kune tariro mune ramangwana yekuzadzisa izvi zvinodiwa panguva imwe chete.Zvichida "chikafu chakavanzika" chiri kure mudenga chiri pamberi pako chaipo.Mwari ane tsitsi kubvira kare akagadzira resipi yekudyira yemusikirwo, inoshandiswa paviri pakudya nemushonga, inowanikwa zviri nyore, uye yakakodzera varume, vakadzi nevana.Zvinongoenderana nekuti tinoziva mashandisirwo azvo here.

[Kwakabva]

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2. Aiko Morigiwa, nevamwe.Chem Pharm Bull (Tokyo).1986;34(7): 3025-3028.

3. Noorlidah Abdullah, nevamwe.Evid Based Complement Alternat Med.2012;2012:464238.

4. Tran Hai-Bang, nevamwe.Mamorekuru.2014;19(9):13473-13485.

5. Tran Hai-Bang, nevamwe.Phytochem Lett.2015;12: 243-247.

6. Chirag Bavishi, nevamwe.JAMA Cardiol.2020;5(7):745-747.

7. Abhinav Grover, nevamwe.2020 Jun 15 : pvaa064.doi:10.1093/ehjcvp/pvaa064.

8. Renato D. Lopes, nevamwe.Am Heart J. 2020 Aug;226: 49–59.

9. Renato D. Lopes, nevamwe.JAMA.2021 Jan 19;325(3):254–264.

END

Nezve munyori/ Ms. Wu Tingyao
Wu Tingyao anga achitaura nezvekutanga-ruoko Ganoderma lucidum ruzivo kubva 1999. Ndiye munyori weKuporesa neGanoderma(yakabudiswa muThe People's Medical Publishing House muna Kubvumbi 2017).
 
★ Chinyorwa ichi chakaburitswa pasi pemvumo yakasarudzika yemunyori, uye muridzi ndeweGANOHERB.

★ Mabasa ari pamusoro haagone kudhindwa, kutorwa kana kushandiswa nedzimwe nzira pasina mvumo yeGanoHerb.

★ Kana mabasa akabvumirwa kushandiswa, anofanirwa kushandiswa mukati mechikamu chemvumo uye kuratidza kwakabva: GanoHerb.

★ Pakutyorwa kwechirevo chiri pamusoro, GanoHerb ichatevera mabasa anoenderana nemutemo.

★ Manyoro ekutanga echinyorwa ichi akanyorwa neChinese naWu Tingyao uye akashandurirwa muchiRungu naAlfred Liu.Kana paine mutsauko pakati peshanduro (yeChirungu) neyekutanga (Chinese), iyo yekutanga Chinese ichakunda.Kana vaverengi vaine mibvunzo, tapota taura nemunyori wemabviro, Ms. Wu Tingyao.
 

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