Esihlokweni esithi “Imiphumela emithathu yomtholampilo yeI-Ganoderma lucidumekuthuthukiseni i-viral hepatitis”, sibone izifundo zomtholampilo ezifakazela lokhoI-Ganoderma lucidumingasetshenziswa yodwa noma ihlanganiswe nemithi evamile yokusekela kanye nezimpawu ukusiza iziguli ezine-viral hepatitis ukulwa nokuvuvukala kanye negciwane futhi zilawule ukuzivikela okungalingani.Ngakho, kungabaI-Ganoderma lucidumkanye nemithi elwa namagciwane esetshenziswa ngokuvamile nayo idlala indima ehambisanayo?

Ngaphambi kokungena kulesi sihloko, kufanele siqonde ukuthi izidakamizwa ezilwa namagciwane azikwazi ukulibulala igciwane kodwa zingavimbela ukuphindaphinda kwegciwane elingene “engqamuzaneni” futhi linciphise inani lokusabalala kwegciwane.

Ngamanye amazwi, izidakamizwa ezilwa namagciwane azinawo umthelela kumagciwane “asangaphandle kweseli” afuna okuhlosiwe okungatheleleka ngakho.Kumele bathembele emandleni ahlangene amasosha omzimba akhiqizwa amasosha omzimba namaseli omzimba okuhlanganisa nama-macrophage ukuze asuse igciwane.

Yingakho kunendawo yezidakamizwa ezilwa namagciwane kanyeI-Ganoderma lucidumukusebenza ngezandla - ngobaI-Ganoderma luciduminhle ekulawuleni amasosha omzimba, ingenza nje ukushoda kwezidakamizwa ezilwa namagciwane;futhiI-Ganoderma lucidumUmthelela ovimbelayo ekuphindaphindeni kwegciwane futhi uthuthukisa kakhulu imishanguzo elwa namagciwane.

Ngokwemibiko yomtholampilo eshicilelwe, kungakhathaliseki ukuthi isetshenziswe nezidakamizwa ezilwa namagciwane ezifana ne-Lamivudine, i-Entecavir noma i-Adefovir isikhathi esingaphezu konyaka,I-Ganoderma lucidumayiphazamisi ukusebenza kahle noma ibangele ukusabela okungekuhle.Ngokuphambene nalokho, kungasiza iziguli ze-hepatitis B ezingapheli ukuba zithole imiphumela "esheshayo" noma "engcono" yokulwa nokuvuvukala kanye ne-antiviral, ukunciphisa ukuvela kokuphikiswa kwezidakamizwa, nokuthuthukisa izifo ezivamile zokuzivikela komzimba.Umthelela wale plus one mukhulu kangangokuthi asikho isizathu sokungawasebenzisi ndawonye.

Enye yezinzuzo ze-“I-Ganoderma lucidum+ imishanguzo elwa namagciwane” akulula ukuthuthukisa ukumelana nemithi.

Ngokombiko womtholampilo owakhishwa yi-Second Clinical College yase-Guangzhou University of Chinese Medicine ngo-2007, phakathi kweziguli ezine-hepatitis B ezingapheli ezathola i-6.I-Ganoderma lucidumamaphilisi ngosuku afinyelela ku-1.62 amagremu (okulingana namagremu angu-9 we-I-Ganoderma lucidumfruiting body) kuhlanganiswe nomuthi ovimbela amagciwane i-lamivudine unyaka owodwa, abanye babo belashwa ngemithi esekelayo neyizimpawu kunezinye izidakamizwa ezilwa namagciwane.

Ngenxa yalokho, i-hepatitis yakhululeka ngokushesha, akukho DNA yegciwane eyatholwa egazini lesiguli (okubonisa ukuthi inani legciwane lehlisiwe ukuze lingasachitheki egazini lisuka esibindini), kanye nethuba lokuthi i-e antigen inyamalale/iphenduke ibe ne-negative. liphakeme kakhulu (igciwane alisakhiqizwa ngamandla).Ngesikhathi esifanayo, amathuba okuguqulwa kokumelana nomuthi ezakhini zofuzo zegciwane ancipha kakhulu.

Njengoba kwakungekho ukusabela okubi emtholampilo ngesikhathi sonke sokwelashwa, azikho izinguquko ezimbi esimisweni segazi kanye nokuhlolwa kokusebenza kwezinso, amacala e-2 ohudo eqenjini elihlanzekile le-antiviral kanye necala elilodwa kuphela lekhanda elithambile eqenjini eliphathwe i-Ganoderma, kodwa zonke lezi zimo ze-3 bonke bakwazi ukuzikhulula ngokuzenzakalelayo, kwabonisa ukuthi ukwelashwa kweI-Ganoderma lucidumkuhlanganiswe nezidakamizwa ezilwa namagciwane akusebenzi nje kuphela kodwa futhi kuphephile.

I-Ganoderma lucidum ayikwazi nje ukuthuthukisa ukusebenza kahle kwezidakamizwa ezilwa namagciwane kodwa futhi inikeze iziguli imiphumela yokuzivikela komzimba ezingenawo ama-antiviral.Umbiko womtholampilo owashicilelwa ngo-2016 yi-Clinical Laboratory Center yaseDolobheni lase-Huangshi, eSifundazweni sase-Hubei wathola ukuthi ngemva konyaka owodwa wokwelashwa kweziguli ze-hepatitis B ezingalapheki ezinama-capsules angu-6 e-Ganoderma lucidum enziwe nge-Ganoderma lucidum fruiting body extract ehlanganisa amagremu angu-1.62 (okulingana namagremu angu-9). yeGanoderma lucidum fruiting body) ngosuku kanye nesidakamizwa esilwa namagciwane i-Entecavir, inkomba ye-hepatitis ibuyela kokujwayelekile, igciwane liyancipha, amathuba okuphindaphinda kwegciwane aba buthakathaka, futhi amangqamuzana e-Th17 ahlobene nokuvuvukala egazini nawo ayancipha.Igciwane le-hepatitis B kubangela ukuvuvukala kwesibindi ngoba amasosha omzimba kufanele ahlasele amaseli esibindi ukuze akhiphe igciwane elicashe kumaseli.Lapho impi phakathi kwegciwane kanye nokuzivikela komzimba ingapheli, amasosha omzimba kancane kancane ayalahlekelwa indawo phakathi kokukhuthaza ukuvuvukala (anti-virus) nokucindezela ukuvuvukala (ukuvikela amangqamuzana).Enye yezinkomba zayo ezithile ukukhiqizwa ngokweqile kwamaseli e-Th17 kuma-T cell asizayo (Th cell) ayala amasosha omzimba ukuba alwe.

Amaseli e-Th17 asetshenziswa kakhulu ukukhuthaza ukuvuvukala nokulwa nokutheleleka.Uma inombolo yabo inkulu kakhulu, izonciphisa elinye iqembu lamaseli we-Regulatory T (TReg) anesibopho sokuvimbela ukuvuvukala.Ukusetshenziswa okuhlangene kwe-Ganoderma lucidum ne-Entecavir kunganciphisa kakhulu amangqamuzana e-Th17, okungangabazeki ukuthi kunomthelela ekuthuthukiseni ukuvuvukala kwesibindi - ngakho-ke inani lamacala lapho inkomba ye-hepatitis ibuyela evamile izoba ngaphezu kwe-Entecavir esetshenziswe yedwa.

Njengoba izidakamizwa ezilwa namagciwane zingavimbela kuphela ukuphindaphinda kwegciwane futhi zingenalo ikhono lokulawula ukungatheleleki, ukuncishiswa kwe-Th17 ngokusobala kuhlobene ne-Ganoderma lucidum;ngoba ukuncishiswa kwe-Th17 akuphazamisi umphumela wokucindezelwa kwegciwane, i-Ganoderma lucidum akufanele nje ilungise amaseli e-Th17 kodwa futhi ithuthukise ukungalingani kwamasosha omzimba kweziguli ze-hepatitis B.
Umbiko womtholampilo owanyatheliswa yiSibhedlela Sesithupha Sabantu saseShaoxing City, eSifundazweni saseZhejiang ngo-2011 wabuye wabona iziguli ezingapheli zesifo sokusha kwesibindi kohlobo B zelashwa nge-100 ml ye-Ganoderma lucidum decoction (eyenziwe ngamagremu angu-50 emizimba ye-Ganoderma lucidum fruiting kanye namagremu angu-10 wezinsuku ezibomvu namanzi) kuhlanganiswe nomuthi ovimbela amagciwane i-Adefovir iminyaka emibili ilandelana.Lokhu kwelashwa akugcini nje ngokuba nomphumela ongcono wokudambisa isifo sokusha kwesibindi noma ukucindezela igciwane lesifo sokusha kwesibindi kohlobo kodwa futhi kunomphumela wokulawula ukuzivikela komzimba, okuhlanganisa nokwandisa ingxenye yamangqamuzana abulalayo emvelo, ama-T cell kanye nama-CD4+ T-cell subsets kuma-lymphocyte, kanye nokwanda kwenani lamaseli abulalayo emvelo. I-CD4+ yokwandisa isilinganiso se-CD4+/CD8+ T-cell subset, okuyenza ibe seduze nesimo sezempilo esifanele.

Iziguli ezinesifo sokusha kwesibindi kohlobo B ezingapheli zivame ukuba nokuncipha kwawo wonke amaseli e-T, ukuncipha kwenani le-CD4+ nokwenyuka kwengxenye ye-CD8+ njengoba isikhathi sesifo siqhubeka, okuholela ekwehleni kwesilinganiso se-CD4+/CD8+.Amaseli e-CD4+ T anezimpawu zamangqamuzana e-CD4+ endaweni yengqamuzana ikakhulukazi aqukethe “ama-T cell angumsizi” noma “ama-T cell alawulayo”, angayala wonke amasosha omzimba ukuba alwe (okuhlanganisa nokuyala ama-B cell ukuthi akhiqize amasosha omzimba) futhi alamule ukuvuvukala ngesikhathi. ;kanye namaseli e-CD8+ T anezimpawu zamangqamuzana e-CD8+ endaweni yengqamuzana ikakhulukazi “amaseli T abulalayo” angawabulala mathupha amaseli anamagciwane (kanye nawomdlavuza).Womabili amaqembu ama-T cell ahlukaniswa kuma-primitive T cell, ngakho athintana ngenombolo.Uma leli gciwane liqhubeka nokuthelela amangqamuzana, lenza inani elikhulu lama-T cell ukuthi ahlukane abe amaseli T abulalayo (CD8+), okuthinta ngokwemvelo inani le-CD4+ kanye nemisebenzi yayo yokuyala kanye nokuhlanganisa.Ukuthuthukiswa okunjalo kuzothinta amandla omzimba wokulwa namagciwane kanye ne-anti-inflammatory, futhi kuyingozi ekwelapheni i-hepatitis B.

Ngakho-ke, ukusetshenziswa okuhlangene kwe-Ganoderma lucidum kanye ne-antiviral drug adefovir dipivoxil kungakhuphula inani lama-T cell kanye ne-CD4+ kuwo, ngaleyo ndlela kwandise isilinganiso se-CD4+/CD8+, futhi ngesikhathi esifanayo kwandise kancane amangqamuzana abulalayo emvelo anenzuzo i-anti-virus kanye ne-anti-tumor.Lezi yizinkomba zokuthuthuka ekusebenzeni kwamasosha omzimba ezigulini ezine-hepatitis B engapheli, futhi umphumela ungcono kakhulu kuneziguli ezelashwa ngemithi elwa namagciwane kuphela.
 
Ngaphezu kwalokho, umbiko womtholampilo uphinde wabhala ukuthi akukho ukuqubuka, ukusabela kwamathumbu, i-creatine kinase (creatinine) ukwanda kanye nokungajwayelekile komsebenzi wezinso okwenzeka kuzo zonke izifundo phakathi nenqubo yokwelashwa, okuqinisekisa nakakhulu ukuphepha kwe-Ganoderma lucidum ekwelapheni kwe-adjuvant antiviral.Izici ezilwa namagciwane kanye ne-anti-inflammatory zisiza ukuvimbela isibindi ekuqineni kancane kancane kanye nomdlavuza ngesikhathi sokuvuvukala okuphindaphindiwe nokulungiswa, okugqamisa ukubaluleka kwabo ezigulini ezine-hepatitis B engapheli. I-Liver fibrosis iyisandulela se-cirrhosis yesibindi.Uma izinkomba ezifanele ze-fibrosis yesibindi zingancishiswa ngesikhathi sokwelashwa kwe-hepatitis B, lokhu kungase kube obunye ubufakazi bokuthi ukwelashwa kuyasebenza.

Umbiko womtholampilo okhishwe yiSibhedlela Sabantu Sesine saseDolobheni lasePanzhihua, eSifundazweni SaseSichuan ngo-2013, ngokusebenzisa ukwelashwa okungamaviki angu-48 (cishe unyaka ongu-1) kweziguli zesifo sokusha kwesibindi kohlobo B esingamahlalakhona ezinamakhapsuli angu-9 e-Ganoderma lucidum afinyelela ku-2.43 amagremu ngosuku (okulingana no-13.5 g) yeGanoderma lucidum fruiting bodies) ehlanganiswe nesidakamizwa esilwa namagciwane i-Adefovir dipivoxil kanye nezidakamizwa ezivikela isibindi, izimpawu kanye nezisekelayo, kutholwe ukuthi izinkomba zesifo sokusha kwesibindi kwesiguli sezithuthuke kakhulu, futhi izinkomba ezine egazini lesiguli ezihlobene ne-liver fibrosis nazo zehlile zisuka ngale. evamile kuya kwejwayelekile noma esondele kokujwayelekile.Lezi zimo zibonise ukuthi imiphumela ehambisanayo ye-Ganoderma lucidum kanye nemithi elwa namagciwane ingavezwa futhi ekuvimbeleni isifo sesibindi.

Kuhle ukusho ukuthi phakathi kweziguli ezingama-60 ezathola ukwelashwa kwe-Ganoderma lucidum kanye ne-adefovir dipivoxil, iziguli ezi-3 (5%) zazingenalo igciwane le-hepatitis B elibonakalayo (ukuguqulwa kwe-HBsAg negative) futhi zakhiqiza amasosha omzimba egciwane (ukuguqulwa kwe-Anti-HBs positive) ngemva kwalokho. ukwelashwa kwaqedwa.Umthelela onjalo wokwelapha awutholakali kalula uma uqhathaniswa nomgomo wokuthi u-1% kuphela weziguli zesifo sokusha kwesibindi kohlobo B ezithola ukwelashwa kwemithi elwa namagciwane ezingakwazi ukubona ukuguqulwa okungeyikho kwamasosha omzimba minyaka yonke.I-Ganoderma lucidum ingathuthukisa ukusebenza kwezidakamizwa ezilwa namagciwane, okuphinde kwafakazelwa futhi.I-Ganoderma lucidum fruiting body extract yamanzi angakwazi ukulawula zonke izici zokuzivikela komzimba.Ukuzivikela okuhle kungavimbela ukutheleleka, ukugula okungapheli kanye nokuphindaphinda.

Le mibiko yomtholampilo emine engenhla ayibonisi nje kuphela izinzuzo ze-Ganoderma lucidum ekusizeni izidakamizwa ezilwa namagciwane ekwelapheni isifo sokusha kwesibindi kohlobo B esingamahlalakhona kodwa futhi ibonisa ukuthi kungenzeka ukusebenzisa i-Ganoderma lucidum nezinye izidakamizwa ezilwa namagciwane ngokuhlangene.

Ama-capsules e-Ganoderma lucidum kanye ne-Ganoderma lucidum decoction esetshenziswe ocwaningweni kokubili okukhishwe kwamanzi emizimba ye-Ganoderma lucidum fruiting.

Izithako ezisebenzayo ezitholwe ngokukhipha imizimba ethela izithelo ye-Ganoderma lucidum ngamanzi ngokuyinhloko i-polysaccharides kuhlanganise nama-polysaccharide peptides nama-glycoprotein, kanye ne-triterpenoids encane.Lezi zithako ziwumthombo osebenzayo weGanoderma lucidum ukulawula umsebenzi wokuzivikela komzimba.Inhlanganisela ye-triterpenoid engavimbela ukuvuvukala okungavamile futhi ivimbele ukuphindaphinda kwegciwane ngokungangabazeki izochaza ngokugcwele umphumela webhonasi we-Ganoderma lucidum ekusizeni izidakamizwa ezilwa namagciwane.

Eqinisweni, isihluthulelo esibaluleke kakhulu ekwelapheni izifo ezibangelwa amagciwane ngisho nokuvimbela izifo ezihlukahlukene ezibangelwa amagciwane yisimiso sokuzivikela komzimba.Lapho amasosha omzimba elawulwa kahle kuyo yonke inqubo kusukela ekutholakaleni kwegciwane, ukufakwa ohlwini kwegciwane njengoba lalifunwa, ukukhiqizwa kwamasosha omzimba, ukuqedwa kwegciwane… , singase singangenwa kalula yileli gciwane lapho sidonsa kanzima, futhi singaliqeda igciwane futhi sigweme ukuphindelela ngisho noma singenwa igciwane.

Ungakhohlwa, ngisho noma igciwane le-hepatitis B selisuliwe futhi lingatholakali emzimbeni (ukuguqulwa okunegethivu kwe-HBsAg), izakhi zalo zofuzo kusengenzeka zishunyekwe ku-nucleus yeseli yesibindi noma kuma-chromosome.Uma nje ibamba ithuba lokuvikeleka okubuthakathaka, ingase ibuye.Igciwane linobuqili kakhulu, singaqhubeka kanjani nokudla i-Ganoderma lucidum?Izithenjwa

1.Chen Peiqiong.Ukubhekwa komtholampilo kwe-Lamivudine kuhlanganiswe nama-capsules e-Ganoderma lucidum ekwelapheni izimo ezingu-30 zeziguli ezine-hepatitis B. Imithi Emisha YaseShayina.2007;39(3): 78-79.
2. U-Chen Duan et al.Umphumela we-entecavir ohlangene nama-capsules we-Ganoderma lucidum ekwelapheni amaseli e-Th17 egazini le-peripheral leziguli ezine-hepatitis B. Shizhen Guoyi Guoyao.2016;27(6): 1369-1371.
3. Shen Huajiang.I-decoction ye-Ganoderma lucidum ehlanganiswe ne-adefovir dipivoxil ekwelapheni i-hepatitis B engapheli kanye nomthelela wayo ekusebenzeni komzimba.I-Zhejiang Journal of Traditional Chinese Medicine.2011;46(5):320-321.
4. Li Yulong.Ucwaningo lomtholampilo lwe-adefovir dipivoxil oluhlanganiswe nama-capsules e-Ganoderma lucidum ekwelapheni i-hepatitis B. Sichuan Medical Journal.2013;34(9): 1386-1388.

PHELA

Mayelana nombhali/ Nks. Wu Tingyao
U-Wu Tingyao ubelokhu ebika ngolwazi lokuqala lwe-Ganoderma lucidum kusukela ngo-1999. Ungumbhali wencwadi ethi Healing with Ganoderma (eshicilelwe ku-People's Medical Publishing House ngo-Ephreli 2017).
 
★ Lesi sihloko sishicilelwe ngaphansi kokugunyazwa okukhethekile kombhali, futhi ubunikazi bungobe-GANOHERB.★ Imisebenzi engenhla ayikwazi ukukhiqizwa kabusha, ikhishwe noma isetshenziswe ngezinye izindlela ngaphandle kokugunyazwa kwe-GanoHerb.★ Uma imisebenzi igunyaziwe ukuthi isetshenziswe, kufanele isetshenziswe ngaphakathi kobubanzi bokugunyazwa futhi ibonise umthombo: GanoHerb.★ Kunoma yikuphi ukwephulwa kwesitatimende esingenhla, i-GanoHerb izolandela izibopho ezingokomthetho ezihlobene.★ Umbhalo wokuqala walesi sihloko ubhalwe ngesiShayina nguWu Tingyao futhi wahunyushelwa esiNgisini ngu-Alfred Liu.Uma kukhona ukungqubuzana phakathi kokuhumusha (isiNgisi) kanye nokwangempela (isiShayina), isiShayina sangempela siyonqoba.Uma abafundi benemibuzo, sicela uthinte umbhali wokuqala, uNksz. Wu Tingyao.

Dlulisa iMillennia Health Culture
Faka isandla Kwezempilo Yabo Bonke