M'nkhani yakuti "Zotsatira zitatu zachipatala zaGanoderma lucidumpokonza matenda a chiwindi a virus”, tawona maphunziro azachipatala omwe amatsimikizira iziGanoderma lucidumangagwiritsidwe ntchito payekha kapena osakaniza ochiritsira kuthandiza ndi symptomatic mankhwala kuthandiza odwala tizilombo chiwindi kulimbana kutupa ndi tizilombo toyambitsa matenda ndi kulamulira imbalanced chitetezo chokwanira.Kotero, mukhozaGanoderma lucidumndi mankhwala oletsa ma virus omwe amagwiritsidwa ntchito nthawi zambiri amagwiranso ntchito?

Tisanalowe pamutuwu, tiyenera kumvetsetsa kuti mankhwala oletsa tizilombo toyambitsa matenda sangaphe kachilomboka koma amatha kuletsa kubwereza kwa kachilombo komwe kalowa mu "selo" ndikuchepetsa kuchuluka kwa ma virus.

Mwa kuyankhula kwina, mankhwala oletsa tizilombo toyambitsa matenda alibe mphamvu pa mavairasi omwe adakali "kunja kwa selo" kufunafuna malo omwe angathe kutenga kachilomboka.Ayenera kudalira mphamvu yolumikizana ya ma antibodies opangidwa ndi chitetezo chamthupi ndi ma cell a chitetezo chamthupi kuphatikiza ma macrophages kuti achotse kachilomboka.

Ichi ndichifukwa chake pali malo a antiviral mankhwala ndiGanoderma lucidumkugwirana manja - chifukwaGanoderma lucidumali bwino pa chitetezo cha m'thupi, akhoza kungowonjezera kusowa kwa ma antiviral mankhwala;ndiGanoderma lucidumKulepheretsa kuchulukitsa kwa ma virus kumawonjezeranso kwambiri ma antivayirasi.

Malinga ndi malipoti azachipatala omwe adasindikizidwa, kaya amagwiritsidwa ntchito ndi mankhwala oletsa tizilombo toyambitsa matenda monga Lamivudine, Entecavir kapena Adefovir kwa nthawi yopitilira chaka chimodzi,Ganoderma lucidumsichimasokoneza mphamvu kapena kuyambitsa zovuta.M'malo mwake, zitha kuthandiza odwala matenda a hepatitis B kuti akwaniritse "mwachangu" kapena "bwino" anti-inflammatory and antiviral zotsatira, kuchepetsa kupezeka kwa mankhwala osakanizidwa ndi mankhwala, ndikuwongolera matenda omwe wamba.Zotsatira za imodzi iyi kuphatikiza imodzi ndi yayikulu kwambiri kotero kuti palibe chifukwa choti musagwiritse ntchito pamodzi.

Chimodzi mwazabwino za "Ganoderma lucidum+ mankhwala oletsa tizilombo toyambitsa matenda” sikophweka kukulitsa kukana mankhwala.

Malinga ndi lipoti lachipatala lomwe linaperekedwa ndi Second Clinical College of Guangzhou University of Chinese Medicine mu 2007, pakati pa odwala matenda a hepatitis B omwe adalandira 6.Ganoderma lucidummakapisozi patsiku okwana 1.62 magalamu (ofanana ndi 9 magalamu aGanoderma lucidummatupi a fruiting) pamodzi ndi mankhwala oletsa tizilombo toyambitsa matenda lamivudine kwa chaka chimodzi, ena mwa iwo ankathandizidwanso ndi mankhwala othandizira komanso zizindikiro kusiyana ndi mankhwala ena oletsa tizilombo toyambitsa matenda.

Zotsatira zake, matenda a chiwindi adatsitsimutsidwa mwachangu, palibe DNA ya viral yomwe idapezeka m'magazi a wodwalayo (zomwe zimayimira kuti kuchuluka kwa kachilomboka kudachepetsedwa kuti zisatayikenso m'magazi kuchokera pachiwindi), komanso mwayi wa e antigen kutha / kutembenuka kukhala wopanda pake. okwera kwambiri (kachilomboka sikamachulukanso mwamphamvu).Panthawi imodzimodziyo, kuthekera kwa kusintha kwa mankhwala kukana mankhwala mu majini a tizilombo kunachepetsedwa kwambiri.

Popeza panalibe matenda obwera chifukwa cha mankhwala pa nthawi yonse ya chithandizo, palibe kusintha chokhwima magazi chizolowezi ndi aimpso kuyezetsa, 2 milandu kutsekula m'mimba mu koyera sapha mavairasi oyambitsa gulu ndi 1 yekha mlandu wofatsa mutu mu Ganoderma mankhwala gulu, koma zonsezi 3 milandu. onse anatha mowiriza kumasuka, izo zinasonyeza kuti mankhwala aGanoderma lucidumkuphatikiza mankhwala sapha mavairasi oyambitsa si ogwira komanso otetezeka.

Ganoderma lucidum sikungowonjezera mphamvu ya mankhwala oletsa tizilombo toyambitsa matenda komanso kupatsa odwala mphamvu zowononga thupi zomwe mankhwala oletsa tizilombo toyambitsa matenda alibe.Lipoti lachipatala lofalitsidwa mu 2016 ndi Clinical Laboratory Center ya Huangshi City, Province la Hubei linapeza kuti patatha chaka chimodzi chochiza odwala matenda a chiwindi a B omwe ali ndi makapisozi 6 a Ganoderma lucidum opangidwa ndi madzi a Ganoderma lucidum fruiting okwana magalamu 1.62 (ofanana ndi 9 magalamu) wa Ganoderma lucidum fruiting body) patsiku ndi mankhwala oletsa tizilombo toyambitsa matenda Entecavir, chiwerengero cha chiwindi cha chiwindi chimabwerera mwakale, kachilomboka kamachepa, mwayi wa kachilombo ka HIV umakhala wofooka, ndipo maselo a Th17 okhudzana ndi kutupa m'magazi amatsitsidwanso. zimayambitsa kutupa kwa chiwindi chifukwa chitetezo cha mthupi chimayenera kulimbana ndi maselo a chiwindi kuti achotse kachilombo kobisala m'maselo.Nkhondo yapakati pa kachilomboka ndi chitetezo chamthupi ikatha, chitetezo cha mthupi chimatha pang'onopang'ono pakati pa kulimbikitsa kutupa (anti-virus) ndi kupondereza kutupa (kuteteza maselo).Chimodzi mwa zizindikiro zake ndi kupanga kwambiri kwa maselo a Th17 m'maselo a T (Th cell) omwe amalamulira chitetezo cha mthupi kumenyana.

Maselo a Th17 amagwiritsidwa ntchito makamaka kulimbikitsa kutupa ndi kulimbana ndi matenda.Chiwerengero chawo chikachuluka kwambiri, chidzachepetsa gulu lina la Regulatory T (TReg) maselo omwe ali ndi udindo woletsa kutupa.Kugwiritsiridwa ntchito kophatikizana kwa Ganoderma lucidum ndi Entecavir kungachepetse kwambiri maselo a Th17, omwe mosakayikira amathandizira kusintha kwa kutupa kwa chiwindi - kotero kuti chiwerengero cha matenda omwe chiwerengero cha hepatitis chimabwereranso chidzakhala chochuluka kuposa cha Entecavir chogwiritsidwa ntchito chokha.

Monga mankhwala oletsa tizilombo toyambitsa matenda amatha kulepheretsa kubwereza kwa kachilomboka ndipo alibe mphamvu yoyendetsera chitetezo, kuchepetsa Th17 mwachiwonekere kumagwirizana ndi Ganoderma lucidum;chifukwa kuchepetsa Th17 sikumakhudza HIV kupondereza kwenikweni, Ganoderma lucidum sayenera kukonza Th17 maselo komanso kusintha wonse chitetezo chokwanira cha matenda a chiwindi B odwala.
Lipoti lachipatala lofalitsidwa ndi Sixth People's Hospital of Shaoxing City, Province la Zhejiang mu 2011 linawonanso odwala matenda a hepatitis B omwe amachiritsidwa ndi 100 ml ya Ganoderma lucidum decoction (yopangidwa kuchokera ku 50 magalamu a matupi a Ganoderma lucidum fruiting ndi 10 magalamu a masiku ofiira ndi madzi) kuphatikizidwa ndi mankhwala ochepetsa ma virus a Adefovir kwa zaka ziwiri zotsatizana.Kuchiza kumeneku sikumangokhala ndi zotsatira zabwino zochepetsera matenda a chiwindi kapena kupondereza kachilombo ka chiwindi komanso kumapangitsa kuti chitetezo cha mthupi chitetezeke, kuphatikizapo kuonjezera chiwerengero cha maselo akupha, T cell ndi CD4 + T-cell subsets mu lymphocytes, ndi kuwonjezeka kwa CD4+ kuti achulukitse chiŵerengero cha CD4+/CD8+ T-cell subset, kuzipangitsa kukhala pafupi ndi thanzi labwino.

Odwala matenda a chiwindi a B nthawi zambiri amakhala ndi kuchepa kwa maselo onse a T, kuchepa kwa chiwerengero cha CD4 + ndi kuwonjezeka kwa chiwerengero cha CD8 + pamene matendawa akutalika, zomwe zimapangitsa kuchepa kwa chiŵerengero cha CD4 +/CD8 +.Ma CD4+ T okhala ndi zolembera za CD4+ pama cell amakhala ndi "ma cell T othandizira" kapena "maselo a T owongolera", omwe amatha kulamula gulu lonse lankhondo kuti limenyane (kuphatikiza kulamula B cell kuti apange ma antibodies) ndikuyimira kutupa munthawi yake. ;ndi ma CD8+ T okhala ndi zolembera za CD8+ pama cell ndi makamaka "ma cell T opha" omwe amatha kupha okha ma cell omwe ali ndi kachilombo (komanso khansa).Magulu onse a T maselo amasiyanitsidwa ndi maselo a T oyambilira, motero amakhudzana wina ndi mnzake.Kachilomboka kakapitirizabe kupatsira ma cell, kumapangitsa kuti ma T cell ambiri azisiyanitsidwa kukhala ma cell akupha T (CD8+), zomwe zimakhudza kuchuluka kwa CD4 + ndi udindo wake wolamula ndi kulumikizana.Kukula kotereku kudzakhudza mphamvu ya chitetezo chamthupi yolimbana ndi mavairasi ndi anti-yotupa, ndipo kumawononga kuchiza matenda a hepatitis B.

Choncho, kugwiritsidwa ntchito pamodzi kwa Ganoderma lucidum ndi mankhwala oletsa tizilombo toyambitsa matenda adefovir dipivoxil akhoza kuonjezera chiwerengero cha maselo a T ndi CD4 + mwa iwo, potero kuwonjezera chiwerengero cha CD4 +/CD8 +, ndipo nthawi yomweyo kuwonjezera pang'ono maselo akupha achilengedwe omwe ali opindulitsa anti-virus ndi anti-chotupa.Izi ndi zizindikiro za kusintha kwa chitetezo cha mthupi cha odwala omwe ali ndi matenda a chiwindi a B, ndipo zotsatira zake zimakhala zabwino kwambiri kuposa odwala omwe amathandizidwa ndi mankhwala oletsa tizilombo toyambitsa matenda okha.
 
Kuonjezera apo, lipoti lachipatala linalembanso kuti palibe zotupa, m'mimba, creatine kinase (creatinine) kuwonjezeka ndi kuwonongeka kwa impso kunachitika m'maphunziro onse panthawi ya chithandizo, zomwe zimatsimikiziranso chitetezo cha Ganoderma lucidum mu adjuvant antiviral therapy.Zinthu zotsutsana ndi mavairasi ndi zotupa zimathandiza kuti chiwindi chisawonongeke pang'onopang'ono ndi khansa panthawi yotupa ndi kukonzanso mobwerezabwereza, kuwonetsa kufunika kwawo kwa odwala matenda a hepatitis B. Liver fibrosis ndi chiyambi cha chiwindi cha chiwindi.Ngati zizindikiro zogwirizana za chiwindi fibrosis zikhoza kuchepetsedwa panthawi ya mankhwala a hepatitis B, izi zikhoza kukhala umboni wina wosonyeza kuti mankhwalawa ndi othandiza.

Lipoti lachipatala loperekedwa ndi Fourth People's Hospital ku Panzhihua City, Sichuan Province mu 2013, kupyolera mu chithandizo cha masabata 48 (pafupifupi chaka chimodzi) cha odwala matenda a hepatitis B omwe ali ndi makapisozi 9 a Ganoderma lucidum okwana magalamu 2.43 patsiku (ofanana ndi 13.5 g). a Ganoderma lucidum fruiting body) pamodzi ndi mankhwala oletsa tizilombo toyambitsa matenda Adefovir dipivoxil ndi mankhwala oteteza chiwindi, zizindikiro ndi zothandizira, anapeza kuti zizindikiro za matenda a chiwindi a wodwalayo zinali bwino kwambiri, ndipo zizindikiro zinayi za magazi a wodwalayo zokhudzana ndi chiwindi fibrosis zinatsikanso kuchokera kupitirira. wabwinobwino kapena woyandikira wamba.Izi zikusonyeza kuti zotsatira za Ganoderma lucidum ndi mankhwala oletsa tizilombo toyambitsa matenda zingathe kuwonetsedwanso popewa matenda a chiwindi.

Ndikoyenera kutchula kuti mwa odwala 60 omwe adalandira chithandizo cha Ganoderma lucidum ndi adefovir dipivoxil, odwala 3 (5%) analibe kachilombo ka hepatitis B (HBsAg negative conversion) ndipo anapanga ma antibodies ku kachilomboka (Anti-HBs positive conversion) pambuyo pake. mankhwala anamalizidwa.Kuchiza koteroko sikupezeka mosavuta poyerekeza ndi cholinga chakuti 1% yokha ya odwala matenda a chiwindi a B omwe amalandila chithandizo chamankhwala amatha kuzindikira kutembenuka koyipa kwa antibody chaka chilichonse.Ganoderma lucidum ikhoza kupititsa patsogolo mphamvu ya mankhwala oletsa tizilombo toyambitsa matenda, omwe atsimikiziridwanso kachiwiri.Madzi a Ganoderma lucidum fruiting a thupi amatha kuyendetsa mbali zonse za chitetezo chokwanira.

Malipoti anayi omwe ali pamwambawa samangosonyeza ubwino wa Ganoderma lucidum pothandizira mankhwala oletsa tizilombo toyambitsa matenda pochiza matenda a chiwindi a B komanso akuwonetsa kuthekera kwa kugwiritsa ntchito Ganoderma lucidum ndi mankhwala ena oletsa tizilombo toyambitsa matenda pamodzi.

Makapisozi a Ganoderma lucidum ndi Ganoderma lucidum decoction omwe amagwiritsidwa ntchito pofufuza zonsezi ndizomwe zimapangidwira m'madzi a matupi a zipatso a Ganoderma lucidum.

Zomwe zimagwiritsidwa ntchito pochotsa matupi a zipatso za Ganoderma lucidum ndi madzi makamaka ma polysaccharides kuphatikiza ma polysaccharide peptides ndi glycoproteins, ndi triterpenoids pang'ono.Zosakaniza izi ndizomwe zimagwira ntchito za Ganoderma lucidum kuti zithetse chitetezo cha mthupi.Kuphatikiza kwa ma triterpenoids omwe amatha kuletsa kutupa kosazolowereka ndikuletsa kubwereza kwa kachilomboka mosakayikira kumafotokoza bwino za bonasi ya Ganoderma lucidum pothandizira mankhwala oletsa ma virus.

M'malo mwake, chinsinsi chofunikira kwambiri chochizira matenda obwera chifukwa cha ma virus komanso kupewa matenda osiyanasiyana a virus ndi chitetezo chamthupi.Chitetezo cha mthupi chikalamuliridwa bwino munjira yonse kuyambira kupezeka kwa kachilomboka, mndandanda wa kachilomboka monga momwe amafunira, kupanga ma antibodies, kuchotsedwa kwa kachilomboka… , sitingatengedwe mosavuta ndi kachilomboka, ndipo tingathe kuchotsa kachilomboka ndikupewa kuyambiranso ngakhale titatenga kachilomboka.

Musaiwale, ngakhale kachilombo ka hepatitis B kachotsedwa ndipo sikapezeka m'thupi (HBsAg negative conversion), chibadwa chake chimakhalabe chokhazikika mu nucleus ya chiwindi kapena ma chromosomes.Malingana ngati ipeza mwayi wa chitetezo chofooka, ikhoza kubwereranso.Kachilomboka ndi kochenjera kwambiri, tingatani kuti tisapitirize kudya Ganoderma lucidum?Maumboni

1.Chen Peiqiong.Kuwunika kwachipatala kwa Lamivudine pamodzi ndi makapisozi a Ganoderma lucidum pochiza 30 milandu ya odwala matenda a chiwindi a B. New Chinese Medicine.2007;39(3): 78-79.
2. Chen Duan et al.Zotsatira za entecavir pamodzi ndi makapisozi a Ganoderma lucidum pochiza maselo a Th17 m'magazi ozungulira a odwala matenda a chiwindi a B. Shizhen Guoyi Guoyao.2016;27(6): 1369-1371.
3. Shen Huajiang.Ganoderma lucidum decoction pamodzi adefovir dipivoxil pa matenda a chiwindi B ndi zotsatira zake pa chitetezo ntchito.Zhejiang Journal of Traditional Chinese Medicine.2011;46(5):320-321.
4. Li Yulong.Kafukufuku wachipatala wa adefovir dipivoxil pamodzi ndi makapisozi a Ganoderma lucidum pochiza matenda a chiwindi a B. Sichuan Medical Journal.2013;34(9): 1386-1388.

TSIRIZA

Za wolemba/ Mayi Wu Tingyao
Wu Tingyao wakhala akufotokoza za chidziwitso cha Ganoderma lucidum kuyambira 1999. Iye ndi mlembi wa Healing with Ganoderma (yofalitsidwa mu The People's Medical Publishing House mu April 2017).
 
★ Nkhaniyi yasindikizidwa pansi pa chilolezo cha wolemba, ndipo umwini ndi wa GANOHERB.★ Ntchito zomwe zili pamwambazi sizingapangidwenso, kuchotsedwa kapena kugwiritsidwa ntchito m'njira zina popanda chilolezo cha GanoHerb.★ Ngati ntchitozo zaloledwa kugwiritsidwa ntchito, ziyenera kugwiritsidwa ntchito molingana ndi chilolezo ndikuwonetsa gwero: GanoHerb.★ Pakuphwanya kulikonse kwa mawu omwe ali pamwambapa, GanoHerb idzatsata maudindo okhudzana ndi zamalamulo.★ Zolemba zoyambirira za nkhaniyi zidalembedwa m'Chitchaina ndi Wu Tingyao ndikumasulira m'Chingerezi ndi Alfred Liu.Ngati pali kusiyana kulikonse pakati pa kumasulira (Chingerezi) ndi choyambirira (Chitchaina), Chitchaina choyambirira chidzapambana.Ngati owerenga ali ndi mafunso, lemberani wolemba woyamba, Mayi Wu Tingyao.

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