Kwinqaku elithi "Iziphumo ezintathu zeklinikhi zeI-Ganoderma lucidumekuphuculeni ihepatitis yentsholongwane”, sibone izifundo zeklinikhi ezingqina okoI-Ganoderma lucidumingasetyenziswa yodwa okanye idityaniswe kunye neyeza eziqhelekileyo ezixhasayo kunye neempawu zokunceda izigulane ezinentsholongwane ye-hepatitis yokulwa nokudumba kunye nentsholongwane kunye nokulawula ukungalungelelani komzimba.Ngoko, unakoI-Ganoderma lucidumkunye namachiza asetyenziswa ngokuqhelekileyo ekliniki nawo adlala indima encedisanayo?

Ngaphambi kokuba singene kwesi sihloko, kufuneka siqonde ukuba amachiza e-antiviral akakwazi ukuyibulala intsholongwane kodwa anokuthintela ukuphindaphinda kwentsholongwane engene "kwiseli" kwaye inciphise inani lokusasazeka kwentsholongwane.

Ngamanye amazwi, amachiza okuthomalalisa iintsholongwane azinampembelelo kwiintsholongwane “esele zingaphandle kweseli” zijonge iithagethi ezinokusuleleka.Kufuneka bathembele kumandla adibeneyo amajoni omzimba aveliswa yi-immune system kunye neeseli zokhuselo lomzimba kubandakanya i-macrophages ukulahla intsholongwane.

Yingakho kukho indawo yamachiza e-antiviral kunyeI-Ganoderma lucidumukusebenza ngezandla - kubaI-Ganoderma lucidumilungile kulawulo lwe-immune, inokwenza nje ukusilela kwamachiza okulwa neentsholongwane;kwayeI-Ganoderma lucidum's inhibitory effect kuphindaphindeko lwentsholongwane ikwalunyuso olukhulu lwamachiza antiviral.

Ngokweengxelo zeklinikhi ezipapashiweyo, nokuba zisetyenziswe ngamachiza e-antiviral afana neLamivudine, i-Entecavir okanye i-Adefovir ngaphezu konyaka,I-Ganoderma lucidumayiphazamisi ukusebenza kakuhle okanye ibangele ukusabela okubi.Ngokuchasene noko, kunokunceda izigulana ezingapheliyo ze-hepatitis B ukuba zifezekise "ngokukhawuleza" okanye "ngcono" imiphumo yokuchasana nokudumba kunye ne-antiviral, ukunciphisa ukwenzeka kokumelana neziyobisi, kunye nokuphucula ukuphazamiseka okuqhelekileyo komzimba.Isiphumo sale dibanisa nenye sikhulu kangangokuba akukho sizathu sokungazisebenzisi kunye.

Enye yeenzuzo ze “I-Ganoderma lucidum+ amachiza okuthomalalisa iintsholongwane” akukho lula ukuphuhlisa ukunganyangeki ngamachiza.

Ngokwengxelo yeklinikhi ekhutshwe yi-Second Clinical College yaseGuangzhou University of Chinese Medicine kwi-2007, phakathi kwezigulane ezine-hepatitis B ezingapheliyo ezifumene i-6.I-Ganoderma lucidumii-capsules ngosuku zizonke 1.62 grams (ilingana ne-9 grams yeI-Ganoderma lucidumfruiting body) kudityaniswe neyeza lokuthomalalisa i-lamivudine unyaka omnye, ezinye zazo ziye zanyangwa ngamachiza axhasayo kunye neempawu kunezinye amachiza okuthomalalisa iintsholongwane.

Ngenxa yoko, i-hepatitis yakhululeka ngokukhawuleza, akukho DNA yentsholongwane efunyenwe egazini lomguli (ebonisa ukuba inani lentsholongwane liye lancitshiswa ukuba lingaphinde lichitheke egazini lisuka esibindini), kunye nethuba lokuba i-antigen inyamalale / iguqule i-negative. iphezulu ngokwentelekiso (intsholongwane ayisaphindi iphinde yande ngamandla).Kwangaxeshanye, ukuba nokwenzeka kweenguqu zokuxhathisa ngamachiza kwiijene zentsholongwane zentsholongwane kwancitshiswa kakhulu.

Njengoko kwakungekho zithintelo ezibi zeklinikhi ngexesha lonyango lonke, akukho tshintsho olubi kwindlela yegazi kunye novavanyo lomsebenzi wezintso, iimeko ze-2 zohudo kwiqela elicocekileyo le-antiviral kunye ne-1 kuphela imeko yentloko ebuhlungu kwiqela eliphathwa nge-Ganoderma, kodwa zonke ezi ziganeko ze-3. bonke bakwazi ukuzikhulula ngokuzenzekelayo, kwabonisa ukuba unyango lweI-Ganoderma lucidumkudityaniswe namachiza e-antiviral ayisebenzi nje kuphela kodwa ikhuselekile.

I-Ganoderma lucidum ayinakuphucula kuphela ukusebenza kwamachiza e-antiviral kodwa ikwabonelela izigulana ngeziphumo ze-immunomodulatory ezingenayo i-antiviral drugs.Ingxelo yeklinikhi epapashwe kwi-2016 yi-Clinical Laboratory Centre yeSixeko sase-Huangshi, iPhondo laseHubei lifumene ukuba emva konyaka omnye unyango lwezigulane ezingapheliyo ze-hepatitis B kunye ne-6 Ganoderma lucidum capsules ezenziwe nge-Ganoderma lucidum fruiting body extract to 1.62 grams (elingana ne-9 grams) yeGanoderma lucidum fruiting body) ngosuku kunye neyeza le-antiviral Entecavir, i-hepatitis index ibuyela kwisiqhelo, intsholongwane iyancipha, amathuba okuphindaphinda intsholongwane iba buthathaka, kunye neeseli ze-Th17 ezinxulumene nokudumba egazini nazo ziyancipha.Intsholongwane ye-hepatitis B kubangela ukudumba kwesibindi kuba amajoni omzimba kufuneka ahlasele iiseli zesibindi ukuze asuse intsholongwane ezifihla kwiiseli.Xa imfazwe phakathi kwentsholongwane kunye nokhuselo lomzimba lungapheli, amajoni omzimba ngokuthe ngcembe aphulukana nomhlaba phakathi kokukhuthaza ukudumba (i-anti-virus) kunye nokucinezela ukudumba (ukukhusela iiseli).Esinye sezibonakaliso zayo ezithile kukuveliswa ngokugqithiseleyo kweeseli ze-Th17 kwiiseli ze-T ezincedisayo (iiseli zeT) eziyalela amajoni omzimba ukuba alwe.

Iiseli ze-Th17 zisetyenziselwa ukukhuthaza ukuvutha kunye nokulwa nosulelo.Xa inani labo likhulu kakhulu, liya kunciphisa elinye iqela le-Regulatory T (TReg) iiseli ezijongene nokuthintela ukuvuvukala.Ukusetyenziswa okudibeneyo kwe-Ganoderma lucidum kunye ne-Entecavir kunokunciphisa kakhulu iiseli ze-Th17, ezingathandabuzekiyo ezinegalelo ekuphuculeni ukuvuvukala kwesibindi - ngoko ke inani leemeko apho i-hepatitis index ibuyela ngokuqhelekileyo iya kuba ngaphezu kwe-Entecavir esetyenziswa yedwa.

Njengoko izidakamizwa ze-antiviral zingakwazi ukuthintela ukuphindaphinda kwentsholongwane kwaye zingabi namandla okulawula i-immunity, ukunciphisa i-Th17 ngokucacileyo kuhambelana ne-Ganoderma lucidum;ngenxa yokuba ukuncitshiswa kwe-Th17 akuchaphazeli umphumo wokunciphisa intsholongwane, i-Ganoderma lucidum ayifanele ilungise iiseli ze-Th17 kuphela kodwa iphucule ukungalingani kwe-immune yezigulane ze-hepatitis B.
Ingxelo yeklinikhi epapashwe yiSibhedlele seSithandathu seSibhedlele saseShaoxing, kwiPhondo laseZhejiang ngo-2011 kwakhona izigulane ezingapheliyo ze-hepatitis B ziphathwa nge-100 ml ye-Ganoderma lucidum decoction (eyenziwe kwi-50 grams ye-Ganoderma lucidum imizimba yeziqhamo kunye ne-10 grams yemihla ebomvu kunye namanzi) kudityaniswe neyeza le-antiviral i-Adefovir iminyaka emibini elandelelanayo.Olu nyango alunaziphumo ezingcono kuphela zokuphelisa i-hepatitis okanye ukucinezela intsholongwane ye-hepatitis kodwa lunempembelelo yokulawula ukhuseleko, kuquka nokwandisa umlinganiselo weeseli ezibulalayo zendalo, iiseli ze-T kunye ne-CD4 + T-cell subsets kwi-lymphocytes, kunye nokwandisa I-CD4+ yokunyusa umlinganiselo we-CD4+/CD8+ T-cell subset, iyenze isondele kwimeko yempilo efanelekileyo.

Izigulane ze-hepatitis B ezingapheliyo zihlala zifumana ukuhla kweeseli ze-T zizonke, ukuncipha kwenani le-CD4 + kunye nokunyuka kwe-CD8 + njengoko ixesha lesi sifo likhula, okubangelwa ukuhla komlinganiselo we-CD4 +/CD8 +.Iiseli ze-CD4+ T ezine-CD4+ iimpawu zemolekyuli kumphezulu weseli ikakhulu ziqulethe "iiseli ze-T ezincedisayo" okanye "iiseli ze-T ezilawulayo", ezinokuyalela wonke umkhosi wamajoni omzimba ukuba ulwe (kubandakanywa nokuyalela iiseli ze-B ukuba zivelise amajoni omzimba) kunye nokulamla ukudumba ngexesha elifanelekileyo. ;kunye neeseli ze-CD8+ T ezine-CD8+ iimpawu zemolekyuli kumphezulu weseli ikakhulu "ziiseli T ezibulalayo" ezinokuthi zibulale iiseli ezosulelwe yintsholongwane (kunye nezomhlaza).Omabini amaqela eeseli T ahlulwe kwiiseli ze-T zamandulo, ngoko ke achaphazela enye kwenye ngenani.Xa intsholongwane iqhubeka ukosulela iiseli, yenza ukuba inani elikhulu leeseli ze-T zohluke zibe ziiseli T ezibulalayo (CD8+), nto leyo echaphazela ngokwendalo inani le-CD4+ kunye nomyalelo kunye noxanduva lokulungelelanisa.Uphuhliso olunjalo luya kuchaphazela amandla omzimba wokuchasana nentsholongwane kunye ne-anti-inflammatory, kwaye luyingozi kunyango lwe-hepatitis B.

Ke ngoko, usetyenziso oludityanisiweyo lweGanoderma lucidum kunye neyeza le-antiviral i-adefovir dipivoxil inokunyusa inani leeseli ze-T kunye ne-CD4 + kuzo, ngaloo ndlela inyusa umlinganiselo we-CD4 +/CD8+, kwaye kwangaxeshanye inyuse kancinci iiseli ezibulalayo zendalo eziluncedo anti-virus kunye ne-anti-tumor.Ezi zizalathisi zokuphucula ukusebenza komzimba wezigulane ezine-hepatitis B engapheliyo, kwaye umphumo ungcono kakhulu kunezigulane eziphathwa ngamachiza e-antiviral kuphela.
 
Ukongeza, ingxelo yeklinikhi nayo yabhala ukuba akukho rhashalala, ukusabela kwesisu, ukwanda kwe-creatine kinase (i-creatinine) kunye nokungahambi kakuhle kwe-renal kwenzeka kuzo zonke izifundo ngexesha lenkqubo yonyango, eqinisekisa ngakumbi ukhuseleko lwe-Ganoderma lucidum kwi-adjuvant antiviral therapy.Izinto ezichasene ne-viral kunye ne-anti-inflammatory zinceda ukukhusela isibindi ngokuthe ngcembe kunye nomhlaza ngexesha lokuvuvukala okuphindaphindiweyo kunye nokulungiswa, ukugqamisa ukubaluleka kwabo kwizigulane ezine-hepatitis B engapheliyo.Ukuba izikhombisi ezifanelekileyo ze-fibrosis yesibindi zinokuncitshiswa ngexesha lokunyangwa kwe-hepatitis B, oku kunokuba nobunye ubungqina bokuba unyango luyasebenza.

Ingxelo yeklinikhi ekhutshwe yiSibhedlele seSine sabantu sasePanzhihua City, kwiPhondo laseSichuan kwi-2013, ngokusebenzisa i-48-iveki (malunga ne-1 iminyaka) unyango lwezigulane ezingapheliyo ze-hepatitis B kunye ne-9 Ganoderma lucidum capsules ezipheleleyo ze-2.43 grams ngosuku (ezilingana ne-13.5 g) yeGanoderma lucidum fruiting bodies) edityaniswe ne-antiviral drug Adefovir dipivoxil kunye nokukhusela isibindi, iimpawu kunye neziyobisi ezixhasayo, zifumanise ukuba iimpawu zesigulana se-hepatitis ziphuculwe kakhulu, kwaye izikhombisi ezine kwigazi lomguli ezinxulumene ne-fibrosis yesibindi nazo ziye zehla ukusuka ngaphaya. eqhelekileyo ukuya kweqhelekileyo okanye kufutshane nesiqhelo.Ezi meko zibonise ukuba iziphumo ezihambelanayo zeGanoderma lucidum kunye neziyobisi ezichasayo zinokubonakaliswa ekuthinteleni isifo sesibindi.

Kuyafaneleka ukukhankanya ukuba phakathi kwezigulane ze-60 ezifumene zombini i-Ganoderma lucidum kunye ne-adefovir dipivoxil unyango, izigulane ze-3 (5%) zazingenayo i-virus ye-hepatitis B ebonakalayo (ukuguqulwa kwe-HBsAg engalunganga) kwaye yavelisa amajoni omzimba kwintsholongwane (ukuguqulwa kwe-Anti-HBs positive) emva unyango lwagqitywa.Isiphumo esinjalo sonyango asifumaneki lula xa sithelekisa nenjongo yokuba yi-1% kuphela yezigulana ze-hepatitis B ezifumana unyango lwechiza le-antiviral ezinokuqaphela uguqulo olubi lwe-antibody olungaphezulu minyaka le.I-Ganoderma lucidum inokuphucula ukusebenza kwamachiza e-antiviral, ephinde yafakazelwa kwakhona.I-Ganoderma lucidum fruiting body extract yamanzi inokulawula yonke imiba ye-immunity.Ukhuseleko oluhle lunokuthintela usulelo, ukugula okungapheliyo kunye nokuphindaphinda.

Iingxelo ezine zeklinikhi ezingentla apha azibonisi nje inzuzo ye-Ganoderma lucidum ekuncedeni amachiza okulwa ne-antiviral kunyango lwe-hepatitis B engapheliyo kodwa ibonisa ukuba kunokwenzeka ukusebenzisa i-Ganoderma lucidum kunye namanye amachiza e-antiviral ngokudibeneyo.

I-capsules ye-Ganoderma lucidum kunye ne-Ganoderma lucidum decoction esetyenziswe kuphando zombini izicatshulwa zamanzi ze-Ganoderma lucidum imizimba yeziqhamo.

Izithako ezisebenzayo ezifunyenwe ngokukhupha imizimba yeziqhamo zeGanoderma lucidum ngamanzi ikakhulu iipolysaccharides eziquka i-polysaccharide peptides kunye ne-glycoproteins, kunye ne-triterpenoids encinci.Ezi zithako zingumthombo osebenzayo weGanoderma lucidum ukulawula ukusebenza komzimba.Indibaniselwano ye-triterpenoids enokuthintela ukudumba okungaqhelekanga kunye nokuthintela ukuphindaphinda kwentsholongwane ngokungathandabuzekiyo kuya kuchaza ngokupheleleyo isiphumo sebhonasi yeGanoderma lucidum ekuncedeni amachiza alwa neentsholongwane.

Enyanisweni, esona sitshixo sibalulekileyo ekunyangeni izifo ezibangelwa yintsholongwane kwanokuthintela usulelo olwahlukahlukeneyo lwentsholongwane yinkqubo yomzimba yokuzikhusela.Xa amajoni omzimba elawulwa kakuhle kuyo yonke inkqubo ukusuka ekufumaneni intsholongwane, ukudweliswa kwentsholongwane njengoko ifunwa, ukuveliswa kwezilwa-buhlungu, ukupheliswa kwentsholongwane… , sisenokungasuki lula ekutsaleni imfazwe nentsholongwane, yaye sinokuyiphelisa le ntsholongwane size siphephe ukuphinda siphinde sifumane intsholongwane.

Ungalibali, nokuba intsholongwane ye-hepatitis B isusiwe kwaye ayifumaneki emzimbeni (ukuguqulwa okungalunganga kwe-HBsAg), izinto zayo zofuzo zisenokuthi zifakwe kwi-nucleus yeseli yesibindi okanye iichromosomes.Ngethuba nje ibamba ithuba lokungakhuseleki okubuthathaka, inokwenza ukubuya.Intsholongwane inobuqhophololo, njani ukuba singaqhubeki nokutya iGanoderma lucidum?Iimbekiselo

1.Chen Peiqiong.Ukuqwalaselwa kweklinikhi yeLamivudine edibeneyo kunye neGanoderma lucidum capsules kunyango lweemeko ze-30 zezigulane ezine-hepatitis B. New Chinese Medicine.2007;39(3): 78-79.
2. UChen Duan et al.Umphumo we-entecavir udibene ne-Ganoderma lucidum capsules kunyango lweeseli ze-Th17 kwi-peripheral yegazi yezigulane ezine-hepatitis B. Shizhen Guoyi Guoyao.2016;27(6): 1369-1371.
3. UShen Huajiang.I-Ganoderma lucidum decoction idibene ne-adefovir dipivoxil kunyango lwe-hepatitis B engapheliyo kunye nefuthe layo ekusebenzeni komzimba.Zhejiang Journal of Traditional Chinese Medicine.2011;46(5):320-321.
4. uLi Yulong.Uphononongo lweklinikhi ye-adefovir dipivoxil edibene ne-Ganoderma lucidum capsules kunyango lwe-hepatitis B. Sichuan Medical Journal.2013;34(9): 1386-1388.

ISIPHELO

Malunga nombhali/ Nksz. Wu Tingyao
U-Wu Tingyao uye wabika malunga nolwazi lokuqala lwe-Ganoderma lucidum ukususela ngo-1999. Ungumbhali we-Healing with Ganoderma (epapashwe kwi-People's Medical Publishing House ngo-Ephreli 2017).
 
★ Eli nqaku lipapashwe phantsi kogunyaziso olulodwa lombhali, kwaye ubunini bobuka-GANOHERB.★ Le misebenzi ingentla ayinakuphinda iveliswe, ikhutshwe okanye isetyenziswe ngezinye iindlela ngaphandle kokugunyaziswa kweGanoHerb.★ Ukuba imisebenzi igunyazisiwe ukuba isetyenziswe, kufuneka isetyenziswe ngaphakathi kwendawo yogunyaziso kwaye ibonise umthombo: GanoHerb.★ Nakuphi na ukuphulwa kwengxelo engentla, i-GanoHerb iya kulandela uxanduva olusemthethweni olunxulumeneyo.★ Umbhalo wokuqala weli nqaku ubhalwe ngesiTshayina nguWu Tingyao waza waguqulelwa kwisiNgesi nguAlfred Liu.Ukuba kukho nakuphi na ukungangqinelani phakathi kwenguqulelo (isiNgesi) kunye neyoqobo (isiTshayina), isiTshayina sokuqala siya koyisa.Ukuba abafundi banayo nayiphi na imibuzo, nceda uqhagamshelane nombhali wokuqala, uNks. Wu Tingyao.

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