Muchinyorwa "Matatu ekiriniki mhedzisiro yeGanoderma lucidummukuvandudza viral hepatitis”, takaona zvidzidzo zvekiriniki zvinoratidza izvozvoGanoderma luciduminogona kushandiswa yoga kana kusanganiswa nemishonga yakajairwa inotsigira uye zviratidzo zvekubatsira varwere vane hutachiona hepatitis kurwisa kuzvimba uye hutachiona uye kugadzirisa kusagadzikana kwekudzivirira.Saka, unogonaGanoderma lucidumuye iyo inowanzo shandiswa yekiriniki antiviral mishonga inoitawo basa rekuwedzera?

Tisati tapinda munyaya iyi, tinofanira kunzwisisa kuti mishonga inorwisa utachiona haigoni kuuraya hutachiona asi inogona kutadzisa kudzokororwa kwehutachiona hwakapinda mu "sero" uye kuderedza huwandu hwehutachiona.

Mune mamwe mazwi, antiviral mishonga haina mhedzisiro pahutachiona huchiri "kunze kwesero" uchitsvaga zvinotapukira.Vanofanira kuvimba nesimba rakabatanidzwa remasoja ekudzivirira chirwere anogadzirwa nemasoja edziviriro uye masero emumuviri anosanganisira macrophages kubvisa hutachiona.

Ichi ndicho chikonzero kune nzvimbo yemishonga inorwisa mabhakitiriya uyeGanoderma lucidumkushanda maoko - nokutiGanoderma lucidumyakanaka pane immune regulation, inogona kungogadzirisa kushomeka kwemishonga inorwisa mavhairasi;uyeGanoderma lucidum's inhibitory effect pakudzokororwa kwehutachiona zvakare kukurudzira kukuru kwemishonga inorwisa mavhairasi.

Maererano nemishumo yekiriniki yakabudiswa, ingave yakashandiswa nemishonga inorwisa mabhakitiriya yakadai seLamivudine, Entecavir kana Adefovir kweanopfuura gore,Ganoderma lucidumhaikanganisi kushanda zvakanaka kana kukonzera maitiro akashata.Kusiyana neizvi, zvinogona kubatsira varwere vasingaperi vane hepatitis B kuti vasvike "nekukurumidza" kana "zvirinani" anti-kuzvimba uye antiviral mhedzisiro, kuderedza kuitika kwekupokana nemishonga, uye kugadzirisa zvakajairika immune immune kusagadzikana.Mhedzisiro yeiyi plus one yakakura zvekuti hapana chikonzero chekusashandisa pamwe chete.

Imwe yemabhenefiti e "Ganoderma lucidum+ antiviral drugs” hazvisi nyore kukudziridza kusanzwa nemishonga.

Sekureva kwemushumo wekiriniki wakapihwa neSecond Clinical College yeGuangzhou University yeChinese Medicine muna 2007, pakati pevarwere vane chisingaperi hepatitis B vakagamuchira 6.Ganoderma lucidumcapsules pazuva zvinokwana 1.62 gramu (yakaenzana ne9 gramu yeGanoderma lucidummichero yemichero) yakasanganiswa neantiviral drug lamivudine kwegore rimwe, mamwe acho airapwawo nemishonga inotsigira uye ine zviratidzo pane mamwe madhiragi.

Nekuda kweizvozvo, hepatitis yakasunungurwa nekukurumidza, hapana hutachiona hweDNA hwakaonekwa muropa remurwere (zvichimiririra kuti huwandu hwehutachiona hwakaderedzwa kuti husisadere muropa kubva pachiropa), uye mukana we e antigen inonyangarika / kutendeuka isina kunaka yaive. zvakati wedzerei (hutachiwana hauchabudiriri nesimba).Panguva imwecheteyo, mukana wekuchinja kwemishonga yekurwisa muhutachiona hwehutachiona hwakaderedzwa zvikuru.

Sezvo pakanga pasina kliniki yakashata yakashata panguva yose yekurapa, hapana kuchinja kwakashata muropa uye renal basa rekuongorora, 2 zviitiko zvemanyoka mune yakachena antiviral boka uye 1 chete nyaya yemusoro munyoro muGanoderma-yakarapwa boka, asi zvese izvi zviitiko zve3. vese vakakwanisa kuzvirerutsa, zvairatidza kuti kurapwa kweGanoderma lucidumyakasanganiswa nemishonga inorwisa mavhairasi haingoshandi chete asiwo yakachengeteka.

Ganoderma lucidum haingogone chete kuvandudza kushanda kwemishonga inorwisa mavhairasi asi inopawo varwere vane immunomodulatory mhedzisiro iyo antiviral mishonga isina.Chirevo chekiriniki chakaburitswa muna 2016 neClinical Laboratory Center yeHuangshi City, Hubei Province yakawana kuti mushure megore rimwe rekurapwa kwevarwere vane hepatitis B vasingaperi vane 6 Ganoderma lucidum capsules yakagadzirwa neGanoderma lucidum fruiting body extract yemvura inokwana 1.62 gramu (yakaenzana ne9 gramu). yeGanoderma lucidum fruiting body) pazuva uye antiviral drug Entecavir, hepatitis index inodzokera kune yakajairika, hutachiona hunoderera, mukana wekudzoka kwehutachiona hunova husina simba, uye masero eTh17 ane chokuita nekuputika muropa anoderedzwawo. kukonzera kuzvimba kwechiropa nekuti immune system inofanirwa kurwisa maseru echiropa kuitira kuti abvise hutachiona hwakahwanda mumaseru.Kana hondo pakati pehutachiona uye kusadzivirirwa kwezvirwere zvisingapere, immune system iri kurasikirwa zvishoma nezvishoma pakati pekusimudzira kuzvimba (anti-virus) nekudzvinyirira kuzvimba (kudzivirira masero).Imwe yezviratidzo zvayo ndeyekunyanya kugadzirwa kweTh17 masero mubatsiri T masero (Th masero) anorayira immune system kurwisa.

Th17 masero anonyanya kushandiswa kukurudzira kuzvimba uye kurwisa hutachiona.Kana nhamba yavo yakawandisa, inoderedza rimwe boka reRegulatory T (TReg) masero ane basa rekudzivisa kuzvimba.Kushandiswa pamwe chete kweGanoderma lucidum neEntecavir kunogona kuderedza zvakanyanya masero eT17, izvo pasina mubvunzo zvinobatsira pakuvandudzwa kwechiropa chechiropa - saka nhamba yezviitiko apo hepatitis index inodzokera kune yakajairika ichave yakawanda kupfuura yeEntecavir inoshandiswa yoga.

Sezvo mishonga inorwisa mabhakitiriya inogona kungodzivisa kudzokorora kwehutachiwana uye haina kukwanisa kugadzirisa hutachiona, kuderedzwa kweT17 zviri pachena kune chokuita neGanoderma lucidum;nokuti kuderedzwa kweT17 hakukanganisi hutachiona hwekudzvinyirira, Ganoderma lucidum haifaniri kungoruramisa masero eTh17 chete asiwo kuvandudza kusaenzana kwekudzivirira kwezvirwere zvevarwere vehepatitis B.
Chirevo chekiriniki chakabudiswa neChitanhatu chePeople's Hospital cheShaoxing City, Zhejiang Province muna 2011 zvakare vakaona varwere vasingaperi vane hepatitis B vakabatwa ne 100 ml yeGanoderma lucidum decoction (yakagadzirwa kubva pamagiramu makumi mashanu eGanoderma lucidum fruiting body uye 10 gramu yemazuva matsvuku nemvura) zvakasanganiswa nemushonga weAdefovir kwemakore maviri akatevedzana.Kurapa uku hakungove nemhedzisiro iri nani yekubvisa hepatitis kana kudzvanya hutachiona hwehepatitis asiwo kune mhedzisiro yekudzora hutachiona, kusanganisira kuwedzera chikamu chemasero anouraya echisikigo, T cell uye CD4 + T-cell subsets mu lymphocytes, uye kuburikidza nekuwedzera kwe CD4+ kuwedzera reshiyo yeCD4+/CD8+ T-cell subset, zvichiita kuti ive pedyo nehutano hwakanaka.

Varwere vasingaperi vane hepatitis B vanowanzoona kuderera kwemasero eT ose, kuderera kwechikamu cheCD4 + uye kuwedzera kwechikamu cheCD8 + sezvo nguva yechirwere ichireba, zvichiita kuti kuderera kwehuwandu hweCD4 +/CD8 +.CD4+ T masero ane CD4+ molecular markers pasero rinonyanya kuve ne "helper T cells" kana "regulatory T cells", anogona kuraira uto rose rekudzivirira zvirwere kuti rirwe (kusanganisira kuraira masero eB kuti abudise masoja ekudzivirira chirwere) uye kuyananisa kuzvimba panguva yakakodzera. ;uye maCD8+ T masero ane maCD8+ molecular markers pasero anonyanya "kuuraya T masero" anogona kuuraya ega masero ane utachiona (negomarara).Mapoka ese ari maviri emasero eT anosiyaniswa kubva kumasero ekutanga eT, saka anobatana muhuwandu.Kana hutachiwana huchiramba huchibata maseru, hunoita kuti nhamba huru yeT cell isiyane kuita mhondi T cell (CD8+), izvo zvinongokanganisa huwandu hweCD4+ uye kuraira kwayo uye kuronga mabasa.Kubudirira kwakadai kunozokanganisa immune system yeanti-viral uye anti-kuzvimba, uye zvinokanganisa kurapwa kwehepatitis B.

Nokudaro, kushandiswa kwakasanganiswa kweGanoderma lucidum uye antiviral drug adefovir dipivoxil inogona kuwedzera nhamba yemasero eT uye CD4 + mavari, nokudaro kuwedzera huwandu hweCD4 +/CD8 +, uye panguva imwechete kuwedzera zvishoma masero emuurayi echisikigo anobatsira anti-virus uye anti-tumor.Izvi zviratidzo zvekuvandudzwa kwehutano hwezvirwere zvevarwere vane chirwere chisingaperi chehepatitis B, uye mhedzisiro yacho iri nani zvakanyanya kupfuura yevarwere vanorapwa nemishonga inorwisa mabhakitiriya chete.
 
Mukuwedzera, mushumo wechipatara wakanyorawo kuti hapana kuputika, kuputika kwepamuviri, creatine kinase (creatinine) kuwedzera uye renal function abnormality yakaitika muzvidzidzo zvose panguva yekurapa, iyo inowedzera kusimbisa kuchengetedzwa kweGanoderma lucidum mu adjuvant antiviral therapy.Anti-viral uye anti-inflammatory zvinhu zvinobatsira kudzivirira chiropa kubva pakuoma zvishoma nezvishoma uye kenza panguva yekudzokorora kuputika nekugadzirisa, kuratidza kukosha kwavo kune varwere vane chirwere chisingaperi chehepatitis B. Chiropa fibrosis inotangira chiropa chechiropa.Kana zviratidzo zvakakodzera zvechiropa fibrosis zvinogona kuderedzwa panguva yekurapa hepatitis B, izvi zvinogonawo kuva humwe uchapupu hwokuti kurapwa kunoshanda.

Chirevo chekiriniki chakapihwa ne Fourth People's Hospital yePanzhihua City, Sichuan Province muna 2013, kuburikidza ne48-vhiki (inenge 1-gore) kurapwa kwevasingaperi hepatitis B varwere vane 9 Ganoderma lucidum capsules inokwana 2.43 gramu pazuva (yakaenzana ne13.5 g). yeGanoderma lucidum fruiting body) yakasanganiswa neantiviral drug Adefovir dipivoxil nemishonga inodzivirira chiropa, zviratidzo uye inotsigira, yakaona kuti zviratidzo zvechirwere chehepatitis zvakavandudzwa zvakanyanya, uye zviratidzo zvina muropa remurwere zvine chekuita nechiropa fibrosis zvakange zvadonhawo kubva mhiri. normal to normal or close to normal.Aya mamiriro airatidza kuti mhedzisiro yeGanoderma lucidum uye antiviral mishonga inogona zvakare kuratidzwa mukudzivirira chirwere chechiropa.

Zvakakosha kutaura kuti pakati pevarwere makumi matanhatu vakagamuchira zvose Ganoderma lucidum uye adefovir dipivoxil kurapwa, varwere ve3 (5%) vakanga vasina kuonekwa hutachiona hweH hepatitis B (HBsAg negative conversion) uye vakagadzira masoja ekudzivirira chirwere (Anti-HBs positive conversion) mushure. kurapwa kwakapedzwa.Kurapa kwakadai haawanikwe zviri nyore kana zvichienzaniswa nechinangwa chekuti 1% chete yevarwere vane hepatitis B vanowana kurapwa kwemishonga inorwisa mabhakitiriya vanogona kuona kutendeuka kwepamusoro-soro gore rega rega.Ganoderma lucidum inogona kuvandudza kushanda kwemishonga inorwisa mabhakitiriya, iyo yakaratidza zvakare zvakare.Ganoderma lucidum fruiting body extract yemvura inogona kugadzirisa zvinhu zvose zvekudzivirira.Kudzivirira kwakanaka kunogona kudzivirira utachiona, chirwere chisingaperi uye kudzokorora.

Mishumo yekiriniki iri pamusoro apa haingoratidzi kubatsira kweGanoderma lucidum mukubatsira zvinodhaka zvehutachiona mukurapa kwechirwere chehepatitis B chisingaperi asi zvakare chinoratidza kugona kwekushandisa Ganoderma lucidum nemimwe mishonga inorwisa hutachiona pamwe chete.

Iyo Ganoderma lucidum capsules uye Ganoderma lucidum decoction yakashandiswa mukutsvagisa ese ari maviri emvura akatorwa eGanoderma lucidum fruiting miviri.

Zvishandiso zvinoshandiswa zvakawanikwa nekubvisa michero yeGanoderma lucidum nemvura inonyanya kuve polysaccharides inosanganisira polysaccharide peptides uye glycoproteins, uye zvishoma triterpenoids.Izvi zvinongedzo ndizvo zvinoshanda sosi yeGanoderma lucidum kugadzirisa immune basa.Iko kusanganiswa kwetriterpenoids iyo inogona kumisa kuzvimba kusingaite uye kurambidza kudzokororwa kwehutachiona pasina mubvunzo inotsanangura zvizere bhonasi mhedzisiro yeGanoderma lucidum mukubatsira antiviral mishonga.

Muchokwadi, kiyi yakakosha pakurapa zvirwere zvehutachiona uye kunyange kudzivirira hutachiona hwakasiyana-siyana hwehutachiona ndiyo immune system.Kana immune system ikagadziriswa mukuita kwese kubva pakuwanikwa kwehutachiona, kunyorwa kwehutachiona sezvinodiwa, kugadzirwa kwemasoja ekudzivirira chirwere, kubviswa kwehutachiona… , tingasatapukirwa nyore nyore mukukweva kwehondo noutachiona, uye tinogona kubvisa utachiona hwacho ndokudzivisa kudzokazve kunyange kana tikatapukirwa.

Usakanganwa, kunyangwe hutachiona hweHepatitis B hukacheneswa uye husingawanikwe mumuviri (HBsAg negative conversion), iyo genetic material ichiri ingangove yakaiswa mukati mechiropa cell nucleus kana chromosomes.Chero bedzi iyo inobata mukana wekusagadzikana kwekudzivirira, inogona kuita kudzoka.Hutachiona hune hunyengeri, tingatadza sei kuramba tichidya Ganoderma lucidum?References

1.Chen Peiqiong.Clinical observation yeLamivudine yakasanganiswa neGanoderma lucidum capsules mukurapa kwezviitiko zve30 zvevarwere vane chirwere chisingaperi chehepatitis B. New Chinese Medicine.2007;39(3): 78-79.
2. Chen Duan et al.Mhedzisiro ye entecavir yakasanganiswa neGanoderma lucidum capsules mukurapa kweTh17 masero muropa reperipheral revarwere vane chirwere chisingaperi chehepatitis B. Shizhen Guoyi Guoyao.2016;27(6): 1369-1371.
3. Shen Huajiang.Ganoderma lucidum decoction yakasanganiswa neadefovir dipivoxil mukurapa kwechisingaperi hepatitis B uye mhedzisiro yayo pakudzivirira kwemuviri.Zhejiang Journal yeTraditional Chinese Medicine.2011;46(5):320-321.
4. Li Yulong.Chidzidzo chekiriniki yeadefovir dipivoxil yakasanganiswa neGanoderma lucidum capsules mukurapa kwechirwere chehepatitis B. Sichuan Medical Journal.2013;34(9): 1386-1388.

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Nezve munyori/ Ms. Wu Tingyao
Wu Tingyao anga achishuma nezvekutanga-ruoko Ganoderma lucidum ruzivo kubvira 1999. Ndiye munyori weHealing with Ganoderma (yakabudiswa muThe People's Medical Publishing House muna Kubvumbi 2017).
 
★ Chinyorwa ichi chakaburitswa pasi pemvumo yakasarudzika yemunyori, uye muridzi ndeweGANOHERB.★ Mabasa ari pamusoro haagone kudhindwa, kutorwa kana kushandiswa nedzimwe nzira pasina mvumo yeGanoHerb.★ Kana mabasa akabvumirwa kushandiswa, anofanirwa kushandiswa mukati mechikamu chemvumo uye kuratidza kwakabva: GanoHerb.★ Pakutyorwa kwechirevo chiri pamusoro, GanoHerb ichatevera mabasa anoenderana nemutemo.★ Manyoro ekutanga echinyorwa ichi akanyorwa neChinese naWu Tingyao uye akashandurirwa muchiRungu naAlfred Liu.Kana paine mutsauko pakati peshanduro (yeChirungu) neyekutanga (Chinese), iyo yekutanga Chinese ichakunda.Kana vaverengi vaine mibvunzo, tapota taura nemunyori wemabviro, Ms. Wu Tingyao.

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