◎ Lesi sihloko sanyatheliswa okokuqala ngesiShayina sendabuko kushicilelo 96 elithi “I-Ganoderma” (Disemba 2022), futhi yashicilelwa okokuqala ngesiShayina esenziwe lula ku-“ganodermanews.com” (Januwari 2023), futhi manje isikhiqizwa kabusha lapha ngemvume yombhali.

Esihlokweni esithi “Isisekelo seReishiukuvimbela umkhuhlane ─ I-qi eyanele enempilo ngaphakathi emzimbeni izovimbela ukuhlasela kwezici ze-pathogenic" kumagazini we-46 "I-Ganoderma” ngo-2009, ngishilo ukuthi inkolelo-mbono yemithi yendabuko yaseShayina ikholelwa ukuthi impilo nezifo zingokwezimo ezihlukene "zokungqubuzana phakathi kwe-qi enempilo ne-pathogenic".Phakathi kwazo, i-“qi enempilo” ibhekisela emandleni omzimba womuntu wokumelana nezifo, futhi “i-pathogenic qi” ngokuvamile ibhekisela kumagciwane namagciwane ahlasela umzimba womuntu noma izimila ezikhiqiza emzimbeni.

Okusho ukuthi, umuntu usesimweni esinempilo ngoba i-qi eyanele enempilo ngaphakathi emzimbeni ivimbela ukuhlasela kwezici ze-pathogenic, okungukuthi, umzimba womuntu unamandla amakhulu okumelana nezifo, okungasho ukuthi ayikho i-pathogenic qi. emzimbeni kodwa kusho ukuthi i-pathogenic qi emzimbeni ayikwazi ukudlula i-qi enempilo;umuntu usesimweni sokugula ngoba izici ze-pathogenic zihlasela umzimba ongenawo ku-qi enempilo, okungukuthi, ukuntuleka kwe-qi enempilo kunciphisa ukumelana nezifo zomzimba, futhi ukuqoqwa kwezinto ezibangela izifo emzimbeni kuholela ezifweni.Indlela efanelekile yokwelashwa ukuqeda ngokuphelele izici ze-pathogenic.Kodwa-ke, kuze kube manje, awekho umuthi waseNtshonalanga noma umuthi wendabuko waseShayina ongaqeda ngokuphelele ezinye izici ze-pathogenic.

Ingabe akunjalo ngokutheleleka kwe-coronavirus yanamuhla?Ngenxa yokuntuleka kwemithi ethile elwa namagciwane, awekho umuthi wasentshonalanga noma umuthi wendabuko waseShayina ongawabulala ngokuphelele amagciwane.Isizathu esenza abantu abangenwe yileli gciwane balulame ukuthembela ekuqiniseni amasosha omzimba (i-qi enempilo) ngesisekelo sokwelashwa okunezimpawu (ukukhululwa kwezimpawu ezingakhululekile) ukuze ekugcineni kusule igciwane (i-pathogenic qi).

Amasosha omzimba aqinile enza kube nzima ukuthi amagciwane abangele izifo. 

I-coronavirus yenoveli (i-SARS-CoV-2) ithelele futhi yacekela phansi umhlaba iminyaka emi-3.Ekupheleni kuka-2022, bangaphezu kwezigidi ezingama-600 abantu abangenwe yileli gciwane futhi bangaphezu kwezigidi eziyisi-6 abantu asebeshonile.Njengamanje, ukuhlukahluka kwe-Omicron ye-coronavirus yenoveli zisasabalala kakhulu emhlabeni jikelele.Nakuba i-pathogenicity yabo kanye nezinga lokufa kwehlisiwe kokubili, iyathelelana kakhulu futhi izinga layo lokutheleleka liphezulu kakhulu.

Imithi elwa namagciwane ekhona ayikwazi ukubulala amagciwane athile, kodwa inganqanda ukwanda kwamagciwane.Ngaphandle kwezinyathelo ezijwayelekile zokuvikela ezinjengokugqoka imaski, ukunaka inhlanzeko yezandla, ukugcina ukuqhelelana nomphakathi, nokugwema imibuthano, into ebaluleke kakhulu ayilutho ngaphandle “kokuqinisa i-qi enempilo”.

Ukuzivikela komzimba kubhekisela emandleni amasosha omzimba okumelana nokuqeda ukuhlasela kwamagciwane afana namagciwane namagciwane, ukususa ukuguga, amaseli afile noma aguqukile emzimbeni kanye nezinto ezibangela ukungezwani komzimba, nokugcina ukuzinza kwendawo yangaphakathi yomzimba kanye gcina umzimba unempilo.

Izinto eziningi ezinjengokucindezeleka kwengqondo, ukukhathazeka, ukusebenza ngokweqile, ukungondleki kahle, ukuphazamiseka kokulala, ukungawuvivinyi umzimba, ukuguga, izifo nezidakamizwa kungaphazamisa ukuzivikela komzimba futhi kungabangela ukungasebenzi kahle kwamasosha omzimba noma ukungasebenzi kahle kwamasosha omzimba.

Phakathi nalolu bhubhane, abanye abantu ababesondelene kakhulu nabantu abangenwe i-coronavirus yenoveli abazange bagule futhi baba amacala angabonakali;abanye abantu bagula kodwa babe nezimpawu ezithambile.

Isizathu esenza laba bantu bangabi nezimpawu noma babe nezimpawu ezithambile ukuthi ukuzivikela okuqinile komzimba (i-qi enempilo) kucindezela igciwane (i-pathogenic qi).Uma kune-qi eyanele enempilo emzimbeni, izici ze-pathogenic azinayo indlela yokuhlasela umzimba.

Umdwebo we-Schematic we-Reishi uqinisa i-qi enempilo futhi uqeda amagciwane

Reishiithuthukisa ukuzivikela komzimba futhi ivimbele izifo ezibangelwa amagciwane.

Reishiinomphumela wokuqinisa amasosha omzimba.Okokuqala, uReishi angakwazi ukuthuthukisa umsebenzi wokuzivikela komzimba ongaqondile, okuhlanganisa ukugqugquzela ukuvuthwa, ukuhlukaniswa kanye nokusebenza kwamaseli e-dendritic, ukuthuthukisa umsebenzi wokubulala ama-macrophages e-mononuclear namangqamuzana abulalayo emvelo, futhi angaqeda ngokuqondile amagciwane ahlaselayo.

Okwesibili,Reishikuthuthukisa imisebenzi yokugoma kwe-humoral nokuvikeleka kwamangqamuzana njengokugqugquzela ukwanda kwamaseli e-B, ukukhuthaza ukukhiqizwa kwe-immunoglobulin (antibody) IgM ne-IgG, kugqugquzelwe ukwanda kwama-T cell, kuthuthukise umsebenzi wokubulala wamaseli e-cytotoxic T (CTL), kanye ukugqugquzela ukukhiqizwa kwama-cytokines afana ne-interleukin-1 (IL-1), i-interleukin-2 (IL-2) ne-interferon-gamma (IFN-gamma).

Ucwaningo luye lwabonisa ukuthi uReishi angavimbela ukuphunyuka komzimba kwamangqamuzana e-tumor, kodwa ukuthi kunomthelela ofanayo ekuphunyukeni komzimba kwamagciwane kusazoqhutshekwa kufundwe.Kodwa-ke, ngenxa ye-hypofunction yomzimba ebangelwa yizizathu ezahlukahlukene ezinjengokucindezeleka kwengqondo, ukukhathazeka, ukusebenza ngokweqile, ukuguga, izifo nezidakamizwa,Reishikuye kwafakazelwa ukusiza ukubuyisela ukusebenza okujwayelekile kokuzivikela komzimba.

Umthelela wokuqinisa amasosha omzimba weReishi uhlinzeka ngesisekelo sethiyori sokuvikela ukutheleleka nge-coronavirus.

Reishiithulisa umoya, imelana nengcindezi futhi ithuthukisa amasosha omzimba.

Ngesikhathi sobhadane lwe-COVID-19, abanye abantu baba nokwesaba, ukushuba, ukukhathazeka, ukuphazamiseka kokulala, ngisho nokudangala ngenxa yokucindezeleka kwengqondo okubangelwa ukutheleleka nge-COVID-19 noma izinyathelo zokuvimbela nokulawula ubhubhane, konke okuzothinta ukungatheleleki.

Esihlokweni esithi “Ukuhlolwa Kwezilwane kanye Nokuhlolwa Komuntu kweI-Ganoderma LucidumAgainst Stress-Induced Immune Function Suppression” kumagazini wama-63 weI-Ganodermango-2014, ngakhuluma ngokuhlolwa kwemithi ukuthiI-Ganoderma lucidumngcono ukusebenza komzimba kwamagundane abangelwa ukucindezeleka.Leli phepha libonisa ukuthi ukucindezeleka ngokomzimba nangokwengqondo okukhiqizwa ukuqeqeshwa okuphezulu kungacindezela umsebenzi wokuzivikela wabadlali, kodwa i-Ganoderma lucidum ingathuthukisa ukusebenza komzimba.

Le miphumela ihlobene nezici zokuqinisa umzimba kanye nezici zokuthulisa umoyaReishi.Kwelinye igama, i-Reishi isiza ekudambiseni ukucindezelwa kwengqondo ngemiphumela yayo efana nokulalisa ingqondo, ukulwa nokukhathazeka, nokulwa nokudangala.Ngakho-ke, akunzima ukucabanga ukuthi ukusebenza kahle kokuthulisa umoya kaReishi kunganciphisa ukucindezelwa kwengqondo okubangelwa ubhubhane lwe-COVID-19 futhi kuqinise ukungatheleleki.

I-Ganoderma lucidumfuthi inomphumela we-anti-novel coronavirus.

I-Ganoderma lucidumyaziwa kakhulu ngezakhiwo zayo zokulwa namagciwane.Phakathi nalolu bhubhane, abantu bakhathazeka kakhulu ngokuthiI-Ganoderma luciduminomphumela we-anti-novel coronavirus (SARS-Cov-2).

Ucwaningo olwenziwa yizazi zase-Academia Sinica, eTaiwan olwanyatheliswa ku- “Proceedings of the National Academy of Sciences” Ngo-2021 lwafakazela lokho.I-Ganoderma lucidumI-polysaccharide (RF3) inemiphumela esobala ye-anti-novel coronavirus ku-vivo kanye nokuhlolwa kwe-in vitro antiviral, futhi ayinabo ubuthi.

Ucwaningo lukhombisile ukuthi i-RF3 (2 μg/ml) inomphumela obalulekile wokulwa namagciwane ku-SARS-Cov-2 ekhuliswe ku-vitro, futhi isenomsebenzi ovimbelayo lapho ihlanjululwe izikhathi eziyi-1280, kodwa ayinabo ubuthi kumsingathi wegciwane iVero E6. amaseli.Ukuphathwa ngomlomo kweI-Ganoderma lucidumi-polysaccharide RF3 (ngethamo lansuku zonke lama-30 mg/kg) inganciphisa kakhulu umthamo wegciwane (okuqukethwe) emaphashini ama-hamster atheleleke ngegciwane le-SARS-Cov-2, kodwa isisindo sezilwane ezihlolwayo anciphi, okubonisa ukuthiI-Ganoderma lucidumi-polysaccharide ayinabo ubuthi (njengoba kukhonjisiwe emfanekisweni ongezansi) [1].

Umthelela we-anti-novel coronavirus walokhu okukhulunywe ngakho ngenhlaI-Ganoderma lucidumama-polysaccharides ku-vivo kanye ne-in vitro ahlinzeka ngesisekelo sethiyori "sokuqeda izici ze-pathogenic" ekuvimbeleni kwayo ukutheleleka kwe-coronavirus yenoveli.

Imiphumela yokuhlolwa kweI-Ganoderma lucidumama-polysaccharides ngokumelene ne-coronavirus yenoveli ku-vivo kanye ne-in vitro

I-Ganoderma lucidumkuthuthukisa umphumela womgomo wegciwane.

Imithi yokugomela igciwane amalungiselelo amasosha omzimba enziwa ngokunciphisa ngokwenziwa, angasebenzi noma aguqule izakhi zofuzo amagciwane noma izingxenye zawo ukuze kuvinjelwe izifo ezibangelwa amagciwane.

Umgomo ugcina izici zegciwane noma izingxenye zalo ukuze ukhuthaze amasosha omzimba.Ukugonyelwa amagciwane kungaqeqesha amasosha omzimba ukuba abone amagciwane futhi afake ama-immunoglobulins (njengamasosha omzimba e-IgG kanye ne-IgA) ukuze avikele ezifweni ezibangelwa amagciwane namagciwane.Lapho amagciwane engena emzimbeni esikhathini esizayo, imithi yokugoma ingabona futhi ibulale amagciwane.Imithi yokugoma ingase futhi ikhuthaze ukungatheleleki kwamangqamuzana futhi yakhe inkumbulo ehambisana namasosha omzimba.Lapho amagciwane engena emzimbeni esikhathini esizayo, imithi yokugoma ingakwazi ukubona ngokushesha futhi iwaqede amagciwane.

Kungabonakala kulokhu ukuthi inhloso yokugoma futhi ukuvimbela ukuhlasela kwezici ze-pathogenic nge-qi eyanele enempilo ngaphakathi emzimbeni ukuze kutholakale ukuzivikela okuqondile kwe-antiviral.I-Ganoderma lucidumi-polysaccharide iyodwa ingathuthukisa ukuzivikela komzimba okungaqondile kanye nokuvikeleka okukhethekile kwama-humoral kanye nokuvikeleka kwamaselula.Inhlanganisela yeI-Ganoderma lucidumfuthi umgomo (i-antigen) unomsebenzi we-adjuvant, ongathuthukisa i-immunogenicity ye-antigen futhi uthuthukise umphumela womgomo wegciwane.

Esihlokweni esithi “Izakhiwo ze-Adjuvant zeI-Ganoderma lucidumama-polysaccharides - athuthukisa umphumela wemigomo yegciwane" kumagazini wama-92 weI-Ganodermango-2021, ngethule ngokuningiliziwe lokhoI-Ganoderma lucidumama-polysaccharides akhishwa futhi ahlanzwa kuwoI-Ganoderma lucidumimizimba ethela izithelo ingathuthukisa imiphumela yemithi yokugomela i-porcine circovirus, imigomo yegciwane le-swine fever kanye nenkukhu ye-Newcastle disease virus, ikhuthaze ukukhiqizwa kwamasosha omzimba athile kanye nama-immune cytokines afana ne-interferon-γ, inciphise izimpawu ezibangelwa ukuhlasela kwegciwane ezilwaneni ezihlolwayo futhi kunciphise ukufa.Lezi zifundo zinikeza isisekelo socwaningo nokusebenzisaI-Ganoderma lucidumukuthuthukisa umphumela womgomo wenoveli we-coronavirus.

“I-Ganoderma lucidum+ umgomo” ungathuthukisa ukuvikeleka. 

Igciwane le-Omicron line-pathogenicity ephansi kanye nezinga eliphansi lokufa kwabantu, kodwa liyathelelana kakhulu.Ngemuva kokususwa kokulawulwa kobhubhane lwe-coronavirus yenoveli, imindeni eminingi noma amayunithi ahlolwe ukuthi ane-nucleic acid noma ukuhlolwa okusheshayo kwe-antigen.

Ngakho-ke, isilinganiso esibaluleke kakhulu sokuvimbela kulabo abangazange baphenduke "ukuqinisa i-qi enempilo futhi kuqedwe i-pathogen", okungukuthi ukuthuthukisa ukuzivikela komzimba ukumelana nokutheleleka ngegciwane.I-Ganoderma lucidumingenye yezinketho ezinhle zokuthuthukisa amasosha omzimba.NgeI-Ganodermaukuvikelwa kuhlanganiswe nokugoma, ungase ube nethuba lokubaleka.

Ekugcineni, ngithemba ngobuqotho lokhoI-Ganoderma lucidumokuqinisa i-qi enempilo futhi eqeda amagciwane angasetshenziswa ukuvimbela nokulawula ubhubhane, ukunqoba amagciwane, nokuvikela zonke izinto eziphilayo.

Inkomba: 1. Jia-Tsrong Jan, et al.Ukukhonjwa kwemithi ekhona kanye nemithi ye-herbal njengama-inhibitors okutheleleka kwe-SARS-CoV-2.I-Proc Natl Acad Sci USA.2021;118(5): e2021579118.doi: 10.1073/ pnas.2021579118.

KafushaneUkwethulwa kukaProfessor Zhi-umgqomoLin

Uzinikele ezifundweni zeI-Ganodermacishe ikhulunyaka futhi uyingqalabutho ocwaningweni lweGanoderma eChina.

Usebenze ngokulandelana njengephini likamongameli we-Beijing Medical University, iphini likandunankulu weSikole Sezokwelapha Esiyisisekelo sase-Beijing Medical University, umqondisi we-Institute of Basic Medicine kanye nomqondisi woMnyango Wezesayensi Yezokwelapha waseBeijing Medical University.Njengamanje unguprofesa eMnyangweni Wezemithi, eSikoleni Sezokwelapha Esiyisisekelo saseBeijing Medical University.

Kusukela ngo-1983 kuya ku-1984, ubengumfundi ovakashile e-WHO Traditional Medicine Research Centre eNyuvesi yase-Illinois e-Chicago, e-USA, kanye noprofesa ovakashele eNyuvesi yaseHong Kong kusukela ngo-2000 kuya ku-2002. Kusukela ngo-2006, ube yindondo yokuhlonishwa. uprofesa ePerm State Pharmaceutical Academy eRussia.

Kusukela ngo-1970, usebenzise izindlela zesimanje ze-sci-tech ukuze atadishe imiphumela yezemithi nezindlelaI-Ganodermakanye nezithako zayo ezisebenzayo futhi ishicilele amaphepha ocwaningo angaphezu kwe-100 ku-Ganoderma.

Ngo-2014 nango-2019, wafakwa ohlwini lwabacwaningi baseShayina Abacashunwe Kakhulu olwanyatheliswa ngu-Elsevier iminyaka eyisithupha ilandelana.

Ungumbhali wenombolo yeI-Ganodermaisebenza njengokuthi "Ucwaningo Lwesimanje Nge-Ganoderma" (izinhlelo ezingu-1-4), "I-Lingzhi From Mystery to Science" (1-3 edition), "Adjuvant Treatment of Tumors with Lingzhi eqinisa i-qi enempilo futhi iqede amagciwane", "Khuluma nge-Ganoderma ” kanye ne “Ganoderma and Health”.