◎ Nkhaniyi idasindikizidwa koyamba m'Chitchaina chachikhalidwe mu Gawo 96 la “Ganoderma” (December 2022), ndipo idasindikizidwa koyamba m’Chitchaina chosavuta pa “ganodermanews.com” (Januware 2023), ndipo tsopano yapangidwanso pano ndi chilolezo cha wolemba.

M'nkhani yakuti “Maziko aReishikuteteza chimfine ─ Yokwanira yathanzi qi mkati mwa thupi idzateteza kuukira kwa zinthu zoyambitsa matenda" mu 46th nkhani "Ganoderma"Mu 2009, ndinanena kuti chiphunzitso cha mankhwala achi China chimakhulupirira kuti thanzi ndi matenda zimakhala m'mayiko osiyanasiyana a "mkangano wapakati pa thanzi ndi tizilombo qi".Mwa iwo, "qi yathanzi" imatanthawuza kuthekera kwa thupi la munthu kulimbana ndi matenda, ndipo "pathogenic qi" nthawi zambiri imatanthawuza ma virus ndi mabakiteriya omwe amalowa m'thupi la munthu kapena zotupa zomwe zimatuluka m'thupi.

Ndiko kunena kuti, munthu ali ndi thanzi labwino chifukwa chokwanira chokwanira cha qi mkati mwa thupi chimalepheretsa kuukira kwa zinthu zoyambitsa matenda, ndiko kuti, thupi la munthu limakhala ndi mphamvu yolimbana ndi matenda, zomwe sizikutanthauza kuti palibe pathogenic qi. m'thupi koma zikutanthauza kuti pathogenic qi m'thupi sangathe kugonjetsa qi wathanzi;munthu ali ndi matenda chifukwa tizilombo toyambitsa matenda timalowa m'thupi lopanda thanzi la qi, ndiko kuti, kuchepa kwa qi kufooketsa kukana kwa matenda a thupi, ndipo kudzikundikira kwa zinthu zoyambitsa matenda m'thupi kumabweretsa matenda.Njira yabwino yothandizira ndikuchotseratu zinthu zomwe zimayambitsa matenda.Komabe, mpaka pano, palibe mankhwala akumadzulo kapena mankhwala achi China omwe angathetseretu zinthu zina zoyambitsa matenda.

Kodi sizili choncho ndi matenda amasiku ano a coronavirus?Chifukwa chosowa mankhwala enieni oletsa tizilombo toyambitsa matenda, palibe mankhwala akumadzulo kapena mankhwala achi China omwe angathe kupha mavairasi.Chifukwa chomwe anthu omwe ali ndi kachilomboka amatha kuchira ndikudalira kulimbikitsa chitetezo cha mthupi (thanzi qi) pamaziko a chithandizo chazizindikiro (kuchepetsa zizindikiro zosasangalatsa) kuti pamapeto pake athetse kachilomboka (pathogenic qi).

Chitetezo champhamvu cha mthupi chimapangitsa kuti zikhale zovuta kuti ma virus ayambitse matenda. 

Coronavirus yatsopano (SARS-CoV-2) yapatsira ndikuwononga dziko kwa zaka zitatu.Pofika kumapeto kwa 2022, anthu opitilira 600 miliyoni atenga kachilomboka ndipo anthu opitilira 6 miliyoni amwalira.Pakadali pano, mitundu ya Omicron ya coronavirus yatsopano ikufalikirabe padziko lonse lapansi.Ngakhale kuchuluka kwawo kwa matenda ndi kufa kwawo kumachepetsedwa, kumapatsirana kwambiri ndipo kuchuluka kwa matenda kumakwera kwambiri.

Mankhwala oletsa ma virus omwe alipo kale sangaphe ma virus enieni, koma amatha kuletsa kuchuluka kwa ma virus.Kupatula njira zodzitetezera monga kuvala zigoba, kulabadira ukhondo wa m'manja, kusunga malo ochezera, komanso kupewa misonkhano, chofunikira kwambiri sichina koma "kulimbikitsa qi wathanzi".

Chitetezo cha mthupi chimatanthawuza kuthekera kwa chitetezo chamthupi kukana ndikuchotsa kuukira kwa tizilombo toyambitsa matenda monga mabakiteriya ndi ma virus, kuchotsa ukalamba, maselo akufa kapena osinthika m'thupi ndi zinthu zomwe zimayambitsa kusamvana, kusunga bata lamkati mwa thupi komanso sungani thupi lathanzi.

Zinthu zambiri monga kupsinjika maganizo, nkhawa, kugwira ntchito mopitirira muyeso, kuperewera kwa zakudya m’thupi, vuto la kugona, kusachita masewera olimbitsa thupi, kukalamba, matenda ndi mankhwala osokoneza bongo zingasokoneze chitetezo cha mthupi ndipo zingayambitse kufooka kwa chitetezo cha mthupi kapena kufooka kwa chitetezo cha mthupi.

Panthawi ya mliri, anthu ena omwe adalumikizana kwambiri ndi anthu omwe ali ndi kachilombo ka corona sanadwale ndipo adakhala asymptomatic;anthu ena anadwala koma anali ndi zizindikiro zochepa.

Chifukwa chomwe anthuwa sakhala ndi zizindikiro kapena amakhala ndi zizindikiro zochepa ndikuti chitetezo champhamvu cha thupi (thanzi qi) chimapondereza kachilomboka (pathogenic qi).Pakakhala qi yokwanira yathanzi m'thupi, zinthu zoyambitsa matenda zilibe njira yolowera m'thupi.

Chithunzi chojambula cha Reishi kulimbikitsa qi yathanzi ndikuchotsa tizilombo toyambitsa matenda

Reishikumawonjezera chitetezo chokwanira ndipo linalake ndipo tikulephera mavairasi.

Reishiali ndi mphamvu ya chitetezo cha mthupi.Choyamba, Reishi amatha kupititsa patsogolo chitetezo cha mthupi chomwe sichinatchulidwe, kuphatikizapo kulimbikitsa kusasitsa, kusiyanitsa ndi ntchito ya maselo a dendritic, kupititsa patsogolo ntchito yakupha ya macrophages a mononuclear ndi maselo akupha achilengedwe, ndipo amatha kuchotsa mwachindunji mavairasi omwe akubwera.

Chachiwiri,Reishikumawonjezera ntchito za chitetezo cham'thupi komanso chitetezo cham'ma cell monga kulimbikitsa kuchuluka kwa ma cell a B, kulimbikitsa kupanga immunoglobulin (antibody) IgM ndi IgG, kulimbikitsa kuchuluka kwa ma T cell, kupititsa patsogolo kupha kwa cytotoxic T cell (CTL), ndi kulimbikitsa kupanga ma cytokines monga interleukin-1 (IL-1), interleukin-2 (IL-2) ndi interferon-gamma (IFN-gamma).

Kafukufuku wasonyeza kuti Reishi akhoza kuletsa chitetezo kuthawa kwa chotupa maselo, koma ngati ali ndi zotsatira zofanana pa chitetezo kuthawa mavairasi ayenera kuphunziranso.Komabe, chifukwa cha hypofunction ya chitetezo chamthupi chifukwa cha zifukwa zosiyanasiyana monga nkhawa, nkhawa, kugwira ntchito mopitirira muyeso, ukalamba, matenda ndi mankhwala osokoneza bongo,Reishizatsimikiziridwa kuthandiza kubwezeretsa yachibadwa chitetezo chokwanira.

Mphamvu yolimbitsa chitetezo cha mthupi ya Reishi imapereka maziko amalingaliro opewera matenda a coronavirus.

Reishikumachepetsa mzimu, kumalimbana ndi nkhawa komanso kumawonjezera chitetezo chokwanira.

Munthawi ya mliri wa COVID-19, anthu ena adakhala ndi mantha, nkhawa, nkhawa, kugona, komanso kukhumudwa chifukwa cha kupsinjika kwamaganizidwe komwe kumachitika chifukwa cha matenda a COVID-19 kapena njira zopewera ndi kuwongolera miliri, zonse zomwe zingakhudze chitetezo chathupi.

M'nkhani yakuti "Zoyesera Zanyama ndi Zoyesera Zaumunthu zaGanoderma LucidumAgainst Stress-Induced Immune Function Suppression” mu kope la 63 laGanodermamu 2014, Ndinalankhula za zoyeserera pharmacological kutiGanoderma lucidumkupititsa patsogolo chitetezo chamthupi cha mbewa chifukwa cha nkhawa.Pepalali likuwonetsa kuti kupsinjika kwakuthupi ndi m'maganizo komwe kumapangidwa ndi maphunziro apamwamba kumatha kulepheretsa chitetezo cha othamanga, koma Ganoderma lucidum imatha kupititsa patsogolo chitetezo chamthupi.

Zotsatirazi zimagwirizana ndi kulimbikitsa chitetezo cha mthupi komanso kukhazika mtima pansi kwa mzimuReishi.M'mawu ena, Reishi amathandizira kuchepetsa kupsinjika kwamaganizidwe ndi zotsatira zake monga sedative hypnosis, anti-nkhawa, komanso anti-depression.Chifukwa chake, sikovuta kuganiza kuti kukhazika mtima pansi kwa Reishi kumatha kuchepetsa kupsinjika kwamaganizidwe komwe kumachitika chifukwa cha mliri wa COVID-19 ndikuwonjezera chitetezo chokwanira.

Ganoderma lucidumilinso ndi anti-novel coronavirus effect.

Ganoderma lucidumamadziwika bwino chifukwa cha ma antiviral.Pa nthawi ya mliri, anthu akuda nkhawa kwambiri ngatiGanoderma lucidumali ndi anti-novel coronavirus (SARS-Cov-2) zotsatira.

Kafukufuku wopangidwa ndi akatswiri ochokera ku Academia Sinica, Taiwan omwe adasindikizidwa mu "Proceedings of the National Academy of Sciences" Mu 2021 adatsimikizira izi.Ganoderma lucidumpolysaccharide (RF3) ili ndi zotsatira zodziwikiratu za anti-novel coronavirus mu vivo komanso mu vitro antiviral test, ndipo ilibe poizoni.

Kafukufuku wasonyeza kuti RF3 (2 μg/ml) ili ndi mphamvu yoletsa ma virus pa SARS-Cov-2 yotukuka mu m'galasi, ndipo imakhalabe ndi ntchito yoletsa ikachepetsedwa mpaka nthawi 1280, koma ilibe kawopsedwe kwa omwe ali ndi kachilombo ka Vero E6. maselo.Oral kasamalidwe kaGanoderma lucidumpolysaccharide RF3 (pa mlingo wa tsiku ndi tsiku wa 30 mg/kg) imatha kuchepetsa kwambiri kuchuluka kwa ma virus (zomwe zili) m'mapapo a hamster omwe ali ndi kachilombo ka SARS-Cov-2, koma kulemera kwa nyama zoyeserera sikuchepa, zomwe zikuwonetsa kutiGanoderma lucidumpolysaccharide si poizoni (monga momwe chithunzi chili pansipa) [1].

Zotsatira za anti-novel coronavirus zomwe tazitchula pamwambapaGanoderma lucidumma polysaccharides mu vivo ndi mu vitro amapereka maziko ongoyerekeza a "kuchotsa zinthu zoyambitsa matenda" popewa kupewa matenda atsopano a coronavirus.

Zotsatira zoyeserera zaGanoderma lucidumma polysaccharides motsutsana ndi buku la coronavirus mu vivo ndi mu vitro

Ganoderma lucidumkumawonjezera mphamvu ya katemera HIV.

Katemera wa ma virus ndi kukonzekera kwa autoimmune komwe kumapangidwa pochepetsa, kuyambitsa kapena kusintha ma virus kapena zigawo zake kuti apewe matenda a virus.

Katemerayu amakhalabe ndi mawonekedwe a kachilomboka kapena zigawo zake kuti alimbikitse chitetezo chamthupi.Katemera wolimbana ndi ma virus amatha kuphunzitsa chitetezo chamthupi kuzindikira ma virus ndikupangitsa ma immunoglobulins (monga ma antibodies a IgG ndi IgA) kuti ateteze ku matenda a bakiteriya ndi ma virus.Ma virus akalowa m'thupi m'tsogolomu, katemera amatha kuzindikira ndi kupha tizilombo.Katemera amathanso kulimbikitsa chitetezo chamthupi ndi kupanga kukumbukira kwa chitetezo chokwanira.Ma virus akalowa m'thupi m'tsogolomu, katemera amatha kuzindikira mwachangu ndikuchotsa ma virus.

Zitha kuwoneka kuchokera apa kuti cholinga cha katemera ndikutetezanso kuukira kwa zinthu zoyambitsa matenda ndi qi yokwanira yathanzi mkati mwa thupi kuti mupeze chitetezo chokwanira cha ma virus.Ganoderma lucidumpolysaccharide yokha imatha kupititsa patsogolo chitetezo chamthupi chomwe sichinadziwike bwino komanso chitetezo chenicheni cha humoral komanso chitetezo chamthupi.Kuphatikiza kwaGanoderma lucidumndi katemera (ma antigen) ali ndi ntchito ya adjuvant, amene angathe kumapangitsanso immunogenicity wa Antigen ndi kumapangitsanso zotsatira za katemera HIV.

M'nkhani yakuti "Adjuvant properties ofGanoderma lucidumma polysaccharides - kupititsa patsogolo mphamvu ya katemera wa kachilomboka" mu nkhani ya 92 yaGanodermamu 2021, ndidafotokoza mwatsatanetsatane iziGanoderma lucidumma polysaccharides otengedwa ndikuyeretsedwa kuchokeraGanoderma lucidummatupi a fruiting amatha kupititsa patsogolo zotsatira za katemera wa porcine circovirus, katemera wa nkhumba wa nkhumba ndi nkhuku katemera wa matenda a chitopa, amalimbikitsa kupanga ma antibodies enieni ndi ma cytokines a chitetezo cha mthupi monga interferon-γ, kuchepetsa zizindikiro zomwe zimayambitsidwa ndi kachilombo ka HIV pa zinyama zoyesera ndikuchepetsa imfa.Maphunzirowa amapereka maziko ofufuza ndi kugwiritsa ntchitoGanoderma lucidumkuti muwonjezere mphamvu ya katemera wa coronavirus watsopano.

“Ganoderma lucidum+ katemera” amatha kupititsa patsogolo chitetezo. 

Kachilombo ka Omicron kamakhala ndi kutsika kwapathogenicity komanso kufa kochepa, koma kumapatsirana kwambiri.Kuwongolera kwa mliri wa coronavirus kutachotsedwa, mabanja ambiri kapena mayunitsi adayezetsa kuti ali ndi nucleic acid kapena kuwunika mwachangu kwa antigen.

Choncho, njira yofunika kwambiri yodzitetezera kwa iwo omwe sanatembenuke ndi "kulimbikitsa thanzi la Qi ndikuchotsa tizilombo toyambitsa matenda", ndiko kupititsa patsogolo chitetezo chokwanira kukana matenda a tizilombo.Ganoderma lucidumndi imodzi mwazosankha zabwino zowonjezera chitetezo chokwanira.NdiGanodermachitetezo chophatikizidwa ndi katemera, mutha kukhala ndi mwayi wothawa.

Pomaliza, ndikuyembekeza mowona mtima zimenezoGanoderma lucidumzomwe zimalimbitsa qi yathanzi ndikuchotsa tizilombo toyambitsa matenda titha kugwiritsidwa ntchito popewa ndikuwongolera mliri, kuthana ndi tizilombo toyambitsa matenda, ndikuteteza zamoyo zonse.

Reference: 1. Jia-Tsrong Jan, et al.Kuzindikiritsa mankhwala omwe alipo komanso mankhwala azitsamba ngati zoletsa matenda a SARS-CoV-2.Proc Natl Acad Sci USA.2021;118(5): e2021579118.doi: 10.1073/ pnas.2021579118.

MwachiduleKuyamba kwa Pulofesa Zhi-binLin

Wadzipereka yekha ku maphunziro aGanodermakwa pafupifupi theka la zaka ndipo ndi mpainiya mu maphunziro a Ganoderma ku China.

Adakhala wachiwiri kwa purezidenti wa Beijing Medical University, wachiwiri kwa dipatimenti ya School of Basic Medicine ya Beijing Medical University, director of the Institute of Basic Medicine ndi director of the department of Pharmacology of Beijing Medical University.Panopa ndi pulofesa ku Dipatimenti ya Pharmacology, School of Basic Medicine ya Beijing Medical University.

Kuyambira 1983 mpaka 1984, anali katswiri woyendera pa WHO Traditional Medicine Research Center ku yunivesite ya Illinois ku Chicago, USA, komanso pulofesa wodzacheza ku yunivesite ya Hong Kong kuyambira 2000 mpaka 2002. Kuyambira 2006, wakhala wolemekezeka. pulofesa ku Perm State Pharmaceutical Academy ku Russia.

Kuyambira 1970, wagwiritsa ntchito njira zamakono za sayansi kuti aphunzire zotsatira za mankhwala ndi njira zaGanodermandi zosakaniza zake zogwira ntchito ndipo wasindikiza mapepala ofufuza oposa 100 pa Ganoderma.

Mu 2014 ndi 2019, adaphatikizidwa pamndandanda wa Ofufuza Ambiri Achi China omwe adasindikizidwa ndi Elsevier kwa zaka zisanu ndi chimodzi zotsatizana.

Iye ndi mlembi wa angapoGanodermaamagwira ntchito monga "Kafukufuku Wamakono pa Ganoderma" (mawonekedwe a 1-4), "Lingzhi From Mystery to Science" (1-3 editions), "Adjuvant Treatment of Tumors with Lingzhi yomwe imalimbitsa qi ndi kuthetsa tizilombo toyambitsa matenda", "Lankhulani za Ganoderma ” ndi “Ganoderma ndi Health”.