Izingxenye eziyinhloko zeI-Ganoderma lucidumI-alcohol ekhishwe yi-triterpenoids.KuthiwaI-Ganoderma lucidumama-triterpenoids anemiphumela elwa nesimila, kodwa uyazi ukuthi imiphi imiphumela yangempela yokulwa nesimila engakwaziI-Ganoderma lucidumi-triterpenoids idlala ngemva kokungena emgudwini wamathumbu?

Ithimba likaSolwazi Jianhua Xu kanye noSolwazi Peng Li ovela eSikoleni Sekhemisi saseFujian Medical University bashicilele uchungechunge lwemibiko yocwaningo.Ukusebenzisa imizimba fruiting ofI-Ganoderma luciduminikezwe i-Fujian Xianzhilou Biological Science and Technology Co., Ltd. njengezinto zokusetshenziswa, ngenqubo ethile yokukhipha i-ethanol, bathole izingxenye ezimbili ze-ethanol.I-Ganoderma lucidumi-triterpenoids: I-GLA ne-GLE, enikezwe izilwane zokuhlola ezinamangqamuzana omdlavuza noma izimila ukuze zibone ukuthi kuzokwenzekani.

Kwatholakala ukuthi izingxenye ze-triterpenoid zeI-Ganoderma lucidumokungenani zibe nokubaluleka "kokuvimbela ukukhula kwesimila, ukwandisa isikhathi sokusinda kanye nokwenza ngcono ukusebenza kwe-chemotherapy".

Yehlisa ukukhula kwesimila.

Umphumela uhlotshaniswa kahle nomthamo we-triterpenoids.

Abacwaningi baqale bafaka amagundane ngaphansi kwesikhumba nge-ascitic uhlobo lwe-hepatocellular carcinoma cell line (H22) noma i-sarcoma cell line (S180), futhi ngemva kwamahora angu-24, bondliwa ngemithamo ephansi, ephakathi nendawo nephezulu (0.5, 1, kanye ne-2 g/kg usuku) lwe-GLA izinsuku eziyi-7 ezilandelanayo;iqembu le-chemotherapy lanikezwa i-cyclophosphamide (CTX) (30 mg / kg) njalo ezinsukwini ze-3;iqembu lokulawula alinikezwanga ukwelashwa.

Ngosuku lwesi-8 lokuhlolwa, izisindo zesimila zamagundane eqenjini ngalinye zahlolwa.Imiphumela yabonisa ukuthi i-GLA, ingxenye ye-triterpenoid yeI-Ganoderma lucidum, yehlisa kakhulu ijubane ukukhula kohlobo lwe-ascitic hepatocellular carcinomas kanye nama-sarcomas, futhi umphumela wawuhlotshaniswa kahle nomthamo.

Ukucindezelwa kwe-tumor okuqondile ezimeni ezingenayo i-immunocompromised

Imiphumela yokuhlola engenhla itholwe ngaphansi kwesimo sokusebenza komzimba okuvamile.Ukuze uqonde ukuthi ukuvinjelwa kokukhula kwesimila nge-GLA, ingxenye ye-triterpenoid yeI-Ganoderma lucidum, ihlobene nokusebenza komzimba, abacwaningi benza ucwaningo olulandelayo:

I-colon cancer cell line (i-Colon-26) ifakwe amagundane anqunu umsebenzi wawo wokuzivikela omzimba wawungejwayelekile.Ngemva kokuba isimila sesikhulile, imithamo ephakathi nephezulu ye-GLA yaphinde yondliwe, futhi umphumela wokuvimbela isimila wawusemuhle kakhulu.

Lokhu kubonisa ukuthi i-GLA ingavimbela ngokuqondile ukukhula kwesimila, futhi indlela yokusebenza kwayo ihlukile kuleyo yeI-Ganoderma lucidumama-polysaccharides ukuthuthukisa ikhono lokulwa nomdlavuza wesistimu yomzimba futhi avimbele izimila.

Akuvimbeli nje kuphela ukukhula kwesimila kodwa futhi kwandisa ukuphila

Ngaphezu kwalokho, nge-GLE, enyeI-Ganoderma lucidumtriterpene ingxenye, ithimba likaProf. Jianhua Xu kanye noProf. Peng Li nabo bakubonile lokhoI-Ganoderma lucidumama-triterpenoids awazange avimbele ukukhula kwesimila kuphela kodwa futhi andisa isikhathi sokusinda samagundane aphethe isimila ngemva kokwelashwa.

Ngokombiko wayo oshicilelwe, i-GLE (Khipha ku-I-Ganoderma lucidum) isiqephu esihlukanisiwe futhi esihlanjululwe kusoI-Ganoderma lucidumyi-Institute of New Medicine yaseFujian Medical University.Igremu elingu-1 le-GLE lilingana namagremu angu-93 weI-Ganoderma lucidumizinto zokwelapha eluhlaza, futhi yayoI-Ganoderma lucidumokuqukethwe kwe-triterpenoid kungu-56.7%.

Imiphumela yokuhlola ibonisa ukuthi uma iqhathaniswa ne-GLA eshiwo ngenhla, i-GLE ingaba nomphumela ofanayo omuhle kakhulu wokuvimbela uhlobo lwegundane lwe-hepatocellular carcinomas kanye nama-sarcomas ngethamo eliphansi (ingxenye eyodwa kwezine ye-GLA) ngaphansi kwezimo ezifanayo zokuhlola, futhi zombili zingafinyelela noma zidlule. okuhlosiwe okucaciswe ekuhlolweni kokusebenza komuthi wendabuko waseShayina - izinga lokuvimbela isimila elingaphezu kwama-30%.

Ukuhlola kuphinde kwathola ukuthi ngemva kokumiswa kwazo zonke izindlela zokwelapha (i-GLE noma izidakamizwa ze-chemotherapy azizange zisanikezwa), amagundane e-sarcoma ayedla i-GLE ekuqaleni ayengaphila isikhathi eside, futhi isikhathi sawo sokusinda sasihlobene kahle nomthamo wangaphambilini we-GLE.Phakathi kwabo, isikhathi sokusinda seqembu eliphezulu le-GLE lalide kakhulu kuneqembu elilawulayo elihle elake lathola ukwelashwa ngamakhemikhali.

Ngokombono womcwaningi, nakuba i-chemotherapy inomphumela osobala wokucindezela isimila, isisindo somzimba samagundane e-sarcoma sizothinteka futhi uboya bawo buyoba mpofu ngesikhathi senqubo yemithi;ngakolunye uhlangothi, izinga lokucindezelwa kwesimila seqembu le-GLE ledosi ephezulu liseduze nelokwelapha ngamakhemikhali.Futhi i-GLE ayikhiqizi ukusabela okubi okubangelwa izidakamizwa ze-chemotherapeutic, futhi ingandisa isikhathi sokuphila, okubonisa ukuthi izingxenye ze-triterpenoidI-Ganoderma lucidumube nokuphepha nokusebenza okuthile, futhi ube nosizo oluthile "lwekhwalithi" yokuphilisana nomdlavuza.

Ingasiza i-chemotherapy futhi ithuthukise umphumela wokucindezelwa kwesimila

Ngaphezu kwalokho, ithimba likaProfesa Peng Li liphinde lathola ngolunye ucwaningo lwezilwane ukuthi izingxenye ze-triterpenoidI-Ganoderma lucidumingasiza izidakamizwa ze-chemotherapy.

Baqale bajova i-HER2-positive human breast cancer cell line (SKBR-3) kumagundane anqunu angenawo amasosha omzimba, kwathi ngemuva kokukhula kwamathumba, baphakela lawa magundane anqunu ama-250 mg/kg we-GLE nsuku zonke futhi banikeza ukwelashwa kwe-paclitaxel (PTX) (umjovo nge-intravenous) kanye njalo ezinsukwini ezintathu.

Ngemuva kwezinsuku eziyi-14 zokwelashwa, kwatholakala ukuthi uma kuqhathaniswa ne-GLE noma i-paclitaxel iyodwa, ukuhlanganiswa kwakho kokubili kube nomthelela ongcono kakhulu wokuvimbela izimila.

I-Ganoderma lucidumama-triterpenoid asebenza ngempumelelo kanye nekhwalithi ezinzile asiza ukuhlalisana nomdlavuza nsuku zonke.

Imiphumela yocwaningo engenhla ibonisa izinzuzo zemithombo ethile yezinto ezingavuthiwe, izindlela ezithile zokukhipha, kanye nokwakheka okuthileI-Ganoderma lucidumizingxenye ze-triterpenoid ezilwaneni ezithwala isimila ngemva kokudlula ohlelweni lokugaya ukudla.Ngenxa yezinto zokuhlola ezizinzile zesikhathi eside, abacwaningi bangabona imiphumela emihle yokuhlola ezilwaneni ezihlolwayo kaninginingi.

Eqinisweni, umphumela we-anti-tumor weI-Ganoderma lucidumI-triterpenoids sekuyisikhathi eside iqinisekiswa ngokwesayensi.Inkinga enkulu ukuthi ngabe “I-Ganoderma lucidum” ezikhethwa ngabathengi ngempela zinezithako ezisebenzayo zesikhathi eside.Phela igama elithi “I-Ganoderma lucidum” ebhokisini akusho ukuthi umkhiqizo kufanele uqukatheI-Ganoderma lucidumama-triterpenoids.Ngaphezu kwalokho, imikhiqizo ephawulwe ngegama elithi "triterpenoids" ingase ingakhiqizi imiphumelaI-Ganoderma lucidumama-triterpenoids.

Ukusebenza okuqinisekisiwe ngokwesayensi kuvela ezithakweni, futhi izithako zihlobene eduze nenqubo yokukhipha kanye nomthombo wezinto zokusetshenziswa.Ikhwalithi ezinzile futhi engaguquki idinga ukuphathwa okujwayelekile nokulawula kusixhumanisi ngasinye ukuze kuzuzwe.

Lapho lezi zimo zifinyelelwa, kungenzeka ukuguqula izinzuzo zeI-Ganoderma lucidumama-triterpenoids ethembeni lokuhlala nomdlavuza futhi aphile nomdlavuza isikhathi eside.

Izithenjwa

1.Xiaoxia Wei et al.Ucwaningo ngomphumela we-antitumor we-GLA, ingxenye ye-triterpenoid ye-Ganoderma lucidum, in vitro kanye ne-vivo.Ijenali yaseFujian Medical University, 2010, 44(6): 417-420.
2.Peng et al.Ucwaningo lokuhlola umphumela we-antitumor we-Ganoderma lucidum extract.Ijenali yesiShayina ye-Modern Applied Pharmacy, 2011, 28(9): 798-792.
3.Feng Liu et al.Imiphumela ye-Antitumor ye-GLE, ingxenye ye-triterpenoid ye-Ganoderma lucidum, in vitro kanye ne-vivo.Ijenali yesiShayina Yezidakamizwa Ezintsha, 2012, 21(23): 2790-2793.
4.Zhiqiang Zhang et al.Izingxenye ze-Ganoderma lucidum triterpenoid zithuthukisa i-paclitaxel-induced apoptosis yamaseli omdlavuza webele we-HER2+.Ijenali ye-Fujian Medical University, 2016, 50(1): 1-5.

PHELA

★Le ndatshana ishicilelwe ngaphansi kokugunyazwa okukhethekile kombhali, futhi ubunikazi bungobe-GanoHerb.

★Ungaphrinti kabusha, ucaphune noma usebenzise imisebenzi engenhla ngezinye izindlela ngaphandle kwemvume ye-GanoHerb.

★Uma umsebenzi ugunyaziwe ukuthi usetshenziswe, kufanele usetshenziswe ngaphakathi kobubanzi bokugunyazwa, futhi umthombo kufanele uboniswe: GanoHerb.

★I-GanoHerb izophenya futhi inamathisele izibopho ezingokomthetho ezifanele zalabo abephula izitatimende ezingenhla.

★ Umbhalo wokuqala walesi sihloko ubhalwe ngesiShayina nguWu Tingyao futhi wahunyushelwa esiNgisini ngu-Alfred Liu.Uma kukhona ukungqubuzana phakathi kokuhumusha (isiNgisi) kanye nokwangempela (isiShayina), isiShayina sangempela siyonqoba.Uma abafundi benemibuzo, sicela uthinte umbhali wokuqala, uNksz. Wu Tingyao.

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