Zigawo zazikulu zaGanoderma lucidumKuchotsa mowa ndi triterpenoids.Zimanenedwa kutiGanoderma lucidumtriterpenoids ali ndi anti-chotupa zotsatira, koma mukudziwa zomwe kwenikweni anti-chotupa zotsatira angatheGanoderma lucidumtriterpenoids amasewera atalowa m'mimba?

Gulu la Pulofesa Jianhua Xu ndi Pulofesa Peng Li wochokera ku Sukulu ya Pharmacy ya Fujian Medical University asindikiza malipoti ofufuza.Kugwiritsa ntchito matupi a fruiting aGanoderma lucidumzoperekedwa ndi Fujian Xianzhilou Biological Science and Technology Co., Ltd. monga zopangira, kudzera mu ndondomeko yeniyeni ya ethanol, adapeza zigawo ziwiri zaGanoderma lucidumtriterpenoids: GLA ndi GLE, zomwe zinadyetsedwa kwa zinyama zoyesera ndi maselo a khansa kapena zotupa kuti awone zomwe zingachitike.

Zinapezeka kuti zigawo za triterpenoid zaGanoderma lucidumkukhala ndi tanthauzo la "kuletsa kukula kwa chotupa, kutalikitsa nthawi ya moyo komanso kukonza mphamvu ya mankhwala amphamvu".

Chepetsani kukula kwa chotupacho.

Zotsatira zake zimagwirizana bwino ndi mlingo wa triterpenoids.

Ofufuzawo anayamba kulowetsa mbewa zamtundu wa ascitic mtundu wa hepatocellular carcinoma cell line (H22) kapena sarcoma cell line (S180), ndipo maola a 24 pambuyo pake, adadyetsedwa ndi mlingo wochepa, wapakati komanso wapamwamba (0.5, 1, ndi 2 g / kg pa tsiku) la GLA kwa masiku 7 otsatizana;gulu la chemotherapy linapatsidwa cyclophosphamide (CTX) (30 mg / kg) masiku onse a 3;gulu lolamulira silinapatsidwe chithandizo.

Pa tsiku la 8 la kuyesa, kulemera kwa chotupa cha mbewa pagulu lililonse kunawunikidwa.Zotsatira zinawonetsa kuti GLA, gawo la triterpenoid laGanoderma lucidum, adachepetsa kwambiri kukula kwa ascitic mtundu wa hepatocellular carcinomas ndi sarcoma, ndipo zotsatira zake zinali zogwirizana ndi mlingo.

Direct chotupa kupondereza mu immunocompromised zinthu

Zomwe zili pamwambazi zoyesera zinapezedwa pansi pa chikhalidwe cha chitetezo cha mthupi.Kuti timvetse ngati chopinga cha chotupa kukula ndi GLA, ndi triterpenoid chigawo chimodzi chaGanoderma lucidum, zokhudzana ndi chitetezo cha mthupi, ochita kafukufukuwo adayesa zotsatirazi:

Mzere wa khansa ya m'matumbo (Colon-26) adalowetsedwa mu mbewa zamaliseche zomwe chitetezo cha mthupi sichinali chachilendo.Chotupacho chikakula, mlingo wapakati komanso waukulu wa GLA udadyetsedwanso, ndipo cholepheretsa chotupacho chinali chabwino kwambiri.

Izi zikuwonetsa kuti GLA imatha kuletsa kukula kwa chotupa, ndipo limagwirira ntchito ndi losiyana ndi laGanoderma lucidumma polysaccharides kuti apititse patsogolo mphamvu yolimbana ndi khansa ya chitetezo chamthupi ndikuletsa zotupa.

Sikuti zimangolepheretsa kukula kwa chotupa komanso zimatalikitsa moyo

Kuphatikiza apo, kudzera mu GLE, inaGanoderma lucidumtriterpene gawo, gulu la Prof. Jianhua Xu ndi Prof. Peng Li adawonanso kutiGanoderma lucidumtriterpenoids sanalepheretse kukula kwa chotupa komanso amatalikitsa nthawi yopulumuka ya mbewa zokhala ndi chotupa pambuyo pa chithandizo.

Malinga ndi lipoti lake lofalitsidwa, GLE (Extract fromGanoderma lucidum) ndi chochotsera chopatulidwa ndi choyeretsedwa nachoGanoderma lucidumndi Institute of New Medicine ya Fujian Medical University.1 gramu ya GLE ndi yofanana ndi 93 magalamu aGanoderma lucidumzopangira mankhwala, ndi zakeGanoderma lucidumZomwe zili mu triterpenoid ndi 56.7%.

Zotsatira zoyesera zikuwonetsa kuti poyerekeza ndi GLA yomwe tatchulayi, GLE ikhoza kukhala ndi zotsatira zabwino kwambiri zolepheretsa pa mbewa ascitic mtundu wa hepatocellular carcinomas ndi sarcoma pa mlingo wochepa (gawo limodzi mwa magawo anayi a GLA) pansi pa miyeso yofanana yoyesera, ndipo onse amatha kufika kapena kupitirira. chandamale chomwe chafotokozedwa pakuwunika mphamvu yamankhwala achi China - kuchuluka kwa chotupa choletsa choposa 30%.

Kuyeseraku kunapezanso kuti mankhwala onse atayimitsidwa (GLE kapena mankhwala a chemotherapy sanaperekedwe), mbewa za sarcoma zomwe poyamba zinkadya GLE zikhoza kukhala ndi moyo wautali, ndipo nthawi yawo yopulumuka inali yogwirizana bwino ndi mlingo wapitawo wa GLE.Pakati pawo, nthawi yopulumuka ya gulu lapamwamba la GLE linali lalitali kwambiri kuposa la gulu lolamulira labwino lomwe linalandira kale mankhwala a chemotherapy.

Malinga ndi zomwe wofufuzayo adawona, ngakhale kuti chemotherapy imakhala ndi chotupa chodziwikiratu, kulemera kwa thupi la mbewa za sarcoma kudzakhudzidwa ndipo ubweya wawo udzakhalanso wosauka panthawi ya mankhwala;Kumbali inayi, kuchuluka kwa chotupa kwa gulu la GLE lapamwamba kwambiri kuli pafupi ndi chemotherapy.Ndipo GLE sipanga zovuta zomwe zimachitika chifukwa cha mankhwala a chemotherapeutic, komanso zimatha kutalikitsa nthawi yopulumuka, zomwe zikuwonetsa kuti zigawo za triterpenoidGanoderma lucidumkukhala ndi chitetezo komanso kuchita bwino, komanso kukhala ndi chithandizo china cha "khalidwe" kukhala limodzi ndi khansa.

Itha kuthandizira chemotherapy ndikuwongolera mphamvu ya chotupa

Komanso, gulu Pulofesa Peng Li anapezanso kudzera kuyesera nyama ina kuti zigawo zitatu za triterpenoidGanoderma lucidumangathandize mankhwala a chemotherapy.

Anayamba kulowetsa HER2-positive human breast cancer cell line (SKBR-3) mu mbewa zopanda chitetezo chamthupi, ndipo zotupa zitakula, amadyetsa mbewa zamalisechezi 250 mg/kg ya GLE tsiku lililonse ndikupereka chithandizo cha paclitaxel (PTX). (jekeseni wa mtsempha) kamodzi pa masiku atatu aliwonse.

Pambuyo pa chithandizo cha masiku 14, zidapezeka kuti poyerekeza ndi GLE kapena paclitaxel yokha, kuphatikiza kwa ziwirizi kunali ndi zotsatira zabwino kwambiri zoletsa zotupa.

Ganoderma lucidumtriterpenoids yokhala ndi mphamvu yokhazikika komanso yokhazikika imathandizira kukhala ndi khansa tsiku lililonse.

Zotsatira zafukufuku zomwe zili pamwambazi zikuwonetsa ubwino wa magwero enieni azinthu zopangira, njira zenizeni zochotsera, ndi zolemba zenizeni zaGanoderma lucidumzigawo za triterpenoid kupita ku nyama zokhala ndi chotupa pambuyo podutsa m'mimba.Chifukwa cha zipangizo zoyesera zokhazikika kwa nthawi yaitali, ofufuza amatha kuona zotsatira zabwino zoyesera nyama zoyesera nthawi ndi nthawi.

Ndipotu, anti-chotupa zotsatira zaGanoderma lucidumtriterpenoids zatsimikiziridwa kale mwasayansi.Vuto lalikulu ndilakuti "Ganoderma lucidum” zomwe ogula amasankha zimakhala ndi zinthu zomwe zimagwira ntchito kwa nthawi yayitali.Pambuyo pake, mawu akuti "Ganoderma lucidum” pabokosilo sizikutanthauza kuti chinthucho chiyenera kukhalaGanoderma lucidumtriterpenoids.Komanso, zinthu zolembedwa ndi mawu oti "triterpenoids" sizingabweretse zotsatira zakeGanoderma lucidumtriterpenoids.

Mphamvu yotsimikiziridwa mwasayansi imachokera ku zosakaniza, ndipo zosakaniza zimagwirizana kwambiri ndi ndondomeko yochotsa ndi gwero la zipangizo.Khalidwe lokhazikika komanso lokhazikika limafunikira kasamalidwe kokhazikika ndi kuwongolera mu ulalo uliwonse kuti mukwaniritse.

Izi zikakwaniritsidwa, ndizotheka kusintha mapindu aGanoderma lucidumtriterpenoids mu chiyembekezo chokhala ndi khansa komanso kupulumuka ndi khansa kwa nthawi yayitali.

Maumboni

1.Xiaoxia Wei et al.Phunzirani za antitumor effect ya GLA, gawo la triterpenoid la Ganoderma lucidum, in vitro ndi in vivo.Journal ya Fujian Medical University, 2010, 44 (6): 417-420.
2.Peng ndi al.Kafukufuku woyeserera pa antitumor effect ya Ganoderma lucidum extract.Chinese Journal of Modern Applied Pharmacy, 2011, 28 (9): 798-792.
3.Feng Liu et al.Zotsatira za Antitumor za GLE, gawo la triterpenoid la Ganoderma lucidum, mu vitro ndi mu vivo.Chinese Journal of New Drugs, 2012, 21 (23): 2790-2793.
4.Zhiqiang Zhang et al.Zida za Ganoderma lucidum triterpenoid zimathandizira paclitaxel-induced apoptosis ya HER2+ ma cell a khansa ya m'mawere.Journal ya Fujian Medical University, 2016, 50 (1): 1-5.

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