Isi components nkeGanoderma lucidumihe ọṅụṅụ mmanya bụ triterpenoids.A na-ekwu naGanoderma lucidumtriterpenoids nwere mmetụta mgbochi tumor, mana ị maara ihe mmetụta mgbochi tumo nwere ikeGanoderma lucidumtriterpenoids na-egwu mgbe ọ banyere n'ime eriri afọ?

Otu Prọfesọ Jianhua Xu na Prọfesọ Peng Li sitere na Ụlọ Akwụkwọ Ọgwụ na Mahadum Fujian ebipụtala usoro nyocha.Iji ozu nke fruitingGanoderma lucidumnyere site Fujian Xianzhilou Biological Science and Technology Co., Ltd. dị ka akụrụngwa, site a kpọmkwem ethanol mmịpụta usoro, ha nwetara abụọ components nkeGanoderma lucidumtriterpenoids: GLA na GLE, bụ ndị a na-enye anụmanụ na-anwale nwere mkpụrụ ndụ kansa ma ọ bụ etuto ahụ iji hụ ihe ga-eme.

Achọpụtara na akụkụ nke triterpenoidGanoderma lucidumnwere ma ọ dịkarịa ala ihe ọ pụtara "igbochi uto tumor, ịgbatị oge ndụ na imeziwanye irè nke chemotherapy".

Mee ka uto tumor belata.

Mmetụta a na-ejikọta nke ọma na dose nke triterpenoids.

Ndị nchọpụta ahụ bu ụzọ tinye ụmụ oke na eriri ascitic hepatocellular carcinoma cell line (H22) ma ọ bụ sarcoma cell line (S180), na 24 awa mgbe e mesịrị, a na-enye ha nri dị ala, ọkara na nnukwu doses (0.5, 1, na 2 g / kg kwa). ụbọchị) nke GLA maka ụbọchị 7 n'usoro;Enyere otu chemotherapy cyclophosphamide (CTX) (30 mg / kg) kwa ụbọchị 3;E nyeghị ndị otu njikwa ahụ ọgwụgwọ ọ bụla.

N'ụbọchị 8th nke nnwale ahụ, a na-enyocha ibu arọ nke ụmụ oke na otu ọ bụla.Nsonaazụ gosiri na GLA, akụkụ triterpenoid nkeGanoderma lucidum, nke ukwuu belatara uto nke ascitic ụdị hepatocellular carcinomas hepatocellular carcinomas na sarcomas, yana mmetụta ahụ jikọtara nke ọma na dose ahụ.

Mbelata tumor ozugbo n'ọnọdụ enweghị mgbochi

E nwetara nsonaazụ nnwale ndị dị n'elu n'okpuru ọnọdụ ọrụ mgbochi nkịtị.Iji ghọta ma mgbochi tumor ibu site GLA, a triterpenoid akụrụngwa nkeGanoderma lucidum, metụtara ọrụ mgbochi ọrịa, ndị nchọpụta mere nnwale ndị a:

A gbanyere eriri mkpụrụ ndụ kansa nke eriri afọ (Colon-26) n'ime ụmụ oke gba ọtọ nke ọrụ mgbochi ya na-adịghị mma.Mgbe etuto ahụ tolitere, a na-enye GLA nke ọkara na nnukwu doses nri ọzọ, yana mmetụta mgbochi tumor ka dị mma.

Nke a na-egosi na GLA nwere ike igbochi uto tumor ozugbo, na usoro ọrụ ya dị iche na nkeGanoderma lucidumpolysaccharides iji kwalite ikike mgbochi ọrịa kansa nke usoro ahụ ji alụso ọrịa ọgụ ma gbochie etuto ahụ.

Ọ bụghị naanị na-egbochi uto etuto kamakwa ọ na-agbatị ndụ

Na mgbakwunye, site na GLE, ọzọGanoderma lucidumakụkụ triterpene, otu Prọfesọ Jianhua Xu na Prọfesọ Peng Li hụkwara nke ahụGanoderma lucidumtriterpenoids abụghị nanị na-egbochi uto tumor kamakwa ọ na-agbatị oge ndụ nke ụmụ oke na-ebu akpụ mgbe ọgwụgwọ gasịrị.

Dịka akụkọ ya ebipụtara si kwuo, GLE (Wepụ naGanoderma lucidum) bụ ihe ewepụtara dịpụrụ adịpụ ma sachaa yaGanoderma lucidumsite na Institute of New Medicine nke Fujian Medical University.1 gram GLE dabara na gram 93 nkeGanoderma lucidumakụrụngwa ọgwụ raw, na yaGanoderma lucidumọdịnaya triterpenoid bụ 56.7%.

Nsonaazụ nnwale na-egosi na ma e jiri ya tụnyere GLA ahụ e kwuru n'elu, GLE nwere ike ịkpata otu mmetụta mgbochi ahụ dị mma na ụdị anụ ahụ ascitic hepatocellular carcinomas na sarcomas na obere dose (otu ụzọ n'ụzọ anọ nke GLA) n'okpuru otu ọnọdụ nnwale, ha abụọ nwere ike iru ma ọ bụ gafere. ebumnuche akọwapụtara na nyocha nke ịdị irè nke ọgwụ ndị China ọdịnala - ọnụego mgbochi tumor nke ihe karịrị 30%.

Nnwale ahụ chọpụtakwara na mgbe akwụsịchara ọgwụgwọ niile (A naghị enye GLE ma ọ bụ ọgwụ chemotherapy), ụmụ oke sarcoma ndị riri GLE na mbụ nwere ike ịdị ndụ ogologo oge, oge ndụ ha na-ejikọta ya na ọgwụ GLE gara aga.N'ime ha, oge nlanarị nke ndị otu GLE dị elu dị ogologo karịa nke ndị na-ahụ maka njikwa dị mma bụ ndị natara na mbụ chemotherapy.

Dị ka nchọpụta nke onye nchọpụta si kwuo, ọ bụ ezie na chemotherapy nwere mmetụta doro anya na-egbochi ụbụrụ tumor, a ga-emetụta oke ahụ nke ụmụ oke sarcoma na ajị ha ga-adabawanye n'oge usoro ọgwụ;N'aka nke ọzọ, ọnụ ọgụgụ nkwụsị nke tumor nke ìgwè GLE dị elu dị nso na nke chemotherapy.Na GLE anaghị emepụta mmeghachi omume ọjọọ nke ọgwụ chemotherapeutic kpatara, ọ nwekwara ike ịgbatị oge ndụ, nke na-egosi na akụkụ triterpenoid nkeGanoderma lucidumnwere ụfọdụ nchekwa na ịdị irè, ma nwee ụfọdụ enyemaka maka "ịdị mma" ịdị n'otu na ọrịa kansa.

Ọ nwere ike na-enyere chemotherapy aka ma melite mmetụta nke nkwụsị nke tumor

Ke adianade do, Prọfesọ Peng Li otu nwekwara hụrụ site ọzọ anụmanụ nnwale na triterpenoid components nkeGanoderma lucidumnwere ike inyere ọgwụ chemotherapy aka.

Ha bu ụzọ tinye HER2-positive cancer cancer ara ụmụ oke oke (SKBR-3) n'ime ụmụ oke ndị na-adịghị alụso ọrịa ọgụ, na mgbe etuto ahụ tolitere, ha na-enye ụmụ oke ndị a nri 250 mg / kg nke GLE kwa ụbọchị wee nye ọgwụgwọ paclitaxel (PTX). (intravenous injection) otu ugboro kwa ụbọchị atọ.

Mgbe ụbọchị 14 nke ọgwụgwọ gasịrị, a chọpụtara na e jiri ya tụnyere GLE ma ọ bụ paclitaxel naanị, nchikota nke abụọ ahụ nwere mmetụta nkwụsịtụ ka mma na etuto ahụ.

Ganoderma lucidumtriterpenoids nwere arụmọrụ kwụsiri ike na ịdị mma na-enyere aka ibikọ ọnụ na ọrịa kansa kwa ụbọchị.

Nsonaazụ nyocha ndị a dị n'elu na-egosi uru nke isi mmalite akụrụngwa akọwapụtara, ụzọ mmịpụta akọwapụtara, yana ihe mejupụtara yaGanoderma lucidumihe triterpenoid na anụmanụ ndị na-ebu akpụ mgbe ha gafechara usoro nri nri.N'ihi ihe nnwale kwụsiri ike ogologo oge, ndị nchọpụta nwere ike ịhụ nsonaazụ nnwale dị mma na anụmanụ nnwale ugboro ugboro.

N'ezie, mgbochi tumor mmetụta nkeGanoderma lucidumtriterpenoids ka ejirila sayensị kwadoro ogologo oge.Isi nsogbu bụ ma "Ganoderma lucidum"nke ndị na-azụ ahịa na-ahọrọ nwere ihe ndị dị otú ahụ na-arụsi ọrụ ike maka ogologo oge.E kwuwerị, okwu a "Ganoderma lucidum” na igbe ahụ apụtaghị na ngwaahịa a ga-enwerịrịGanoderma lucidumtriterpenoids.Ọzọkwa, ngwaahịa akara na okwu "triterpenoids" nwere ike ọ gaghị emepụta mmetụta nkeGanoderma lucidumtriterpenoids.

Mmetụta nke sayensị gosipụtara na-esite na ihe ndị na-emepụta ihe, ihe ndị ahụ na-ejikọta ya na usoro mmịpụta na isi iyi nke akụrụngwa.Ọdịmma kwụsiri ike na nke na-agbanwe agbanwe chọrọ njikwa ahaziri ahazi na njikwa na njikọ ọ bụla iji nweta.

Mgbe ọnọdụ ndị a zutere, ọ ga-ekwe omume ịgbanwe uru nkeGanoderma lucidumtriterpenoids n'ime olile anya nke ibikọ ọnụ na ọrịa kansa yana ịlanarị ọrịa kansa ruo ogologo oge.

Ntụaka

1.Xiaoxia Wei et al.Ọmụmụ na mmetụta antitumor nke GLA, akụkụ triterpenoid nke Ganoderma lucidum, in vitro na in vivo.Akwụkwọ akụkọ nke Fujian Medical University, 2010, 44 (6): 417-420.
2.Peng et al.Ọmụmụ ihe nyocha na mmetụta antitumor nke Ganoderma lucidum wepụ.Akwụkwọ akụkọ Chinese nke ụlọ ahịa ọgwụ ọgbara ọhụrụ, 2011, 28 (9): 798-792.
3.Feng Liu et al.Mmetụta antitumor nke GLE, akụkụ triterpenoid nke Ganoderma lucidum, in vitro na in vivo.Akwụkwọ akụkọ Chinese nke ọgwụ ọhụrụ, 2012, 21 (23): 2790-2793.
4.Zhiqiang Zhang et al.Ihe mejupụtara Ganoderma lucidum triterpenoid na-eme ka apoptosis na-akpata paclitaxel nke HER2 + mkpụrụ ndụ kansa ara.Akwụkwọ akụkọ nke Fujian Medical University, 2016, 50 (1): 1-5.

N'ikpeazụ

★ A na-ebipụta akụkọ a n'okpuru ikike nke onye edemede, na ikike ya bụ nke GanoHerb.

★Edoghachila, depụta ma ọ bụ jiri ọrụ ndị a dị n'elu n'ụzọ ndị ọzọ na-enweghị ikike nke GanoHerb.

★Ọ bụrụ na enyerela ọrụ ahụ ikike iji, a ga-eji ya n'ime oke ikike, ma gosipụta isi mmalite ya: GanoHerb.

★GanoHerb ga-enyocha ma tinye ọrụ iwu dị mkpa nke ndị mebiri okwu ndị a dị n'elu.

★ Wu Tingyao dere ederede izizi nke akụkọ a n'asụsụ Chinese wee sụgharịa ya n'asụsụ Bekee site n'aka Alfred Liu.Ọ bụrụ na enwere nghọtahie n'etiti ntụgharị asụsụ (Bekee) na nke izizi (Chinese), Chinese izizi ga-emeri.Ọ bụrụ na ndị na-agụ akwụkwọ nwere ajụjụ ọ bụla, biko kpọtụrụ onye edemede mbụ bụ Oriakụ Wu Tingyao.

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