Zvikamu zvikuru zveGanoderma lucidumdoro rinobvisa ndiro triterpenoids.ZvikanziGanoderma lucidumtriterpenoids ine anti-bundu mhedzisiro, asi unoziva here kuti chii chaicho anti-bundu mhedzisiro inogonaGanoderma lucidumtriterpenoids inotamba mushure mekupinda mudumbu?

Chikwata chaProfessor Jianhua Xu naProfessor Peng Li kubva kuChikoro cheFarmacy cheFujian Medical University vakaburitsa nhevedzano yemishumo yekutsvagisa.Kushandisa michero miviri yeGanoderma lucidumyakapihwa neFujian Xianzhilou Biological Science and Technology Co., Ltd. semidziyo yakabikwa, kuburikidza neimwe nzira yekubvisa ethanol, vakawana zvikamu zviviri zveGanoderma lucidumtriterpenoids: GLA uye GLE, iyo yakadyiswa kumhuka dzekuedza nekenza maseru kana mamota kuti vaone zvaizoitika.

Zvakaonekwa kuti triterpenoid zvikamu zveGanoderma lucidumzvine zvazvinoreva "kudzivisa bundu kukura, kurebesa nguva yekurarama uye kuvandudza kushanda kwechemotherapy".

Deredzai kukura kwebundu.

Mhedzisiro yacho inoenderana neiyo dose ye triterpenoids.

Vatsvakurudzi vanotanga kunyura mbeva ne ascitic type hepatocellular carcinoma cell line (H22) kana sarcoma cell line (S180), uye maawa 24 gare gare, vakadyiswa nemishonga yakaderera, yepakati uye yakakwirira (0.5, 1, uye 2 g / kg pa. zuva) reGLA kwemazuva manomwe akateedzana;boka rechemotherapy rakapiwa cyclophosphamide (CTX) (30 mg / kg) mazuva ose e3;boka rekutonga harina kupiwa kurapwa.

Pazuva rechisere rekuedza, huremu hwebundu hwemakonzo muboka rega rega hwakaongororwa.Mhedzisiro yacho yakaratidza kuti GLA, chikamu chetriterpenoid cheGanoderma lucidum, zvakanyanya kunonoka kukura kweascitic type hepatocellular carcinomas uye sarcomas, uye mhedzisiro yacho yakanyatsoenderana nedosi.

Direct bundu kudzvinyirira mune immunocompromised mamiriro

Migumisiro yekuedza iri pamusoro yakawanikwa pasi pemamiriro ehutano hwekudzivirira muviri.Kuti unzwisise kana iyo inhibition yebundu kukura neGLA, chikamu chetriterpenoid cheGanoderma lucidum, ine hukama nekushanda kwemuviri, vaongorori vakaita zvinotevera zviedzo:

Iyo colon cancer cell line (Colon-26) yakaiswa mune nude mbeva iyo immune system yakanga isiri yakajairika.Mushure mekunge bundu rakura, chiyero chepakati nepamusoro cheGLA chakadyiswa zvakare, uye bundu inhibitory effect yakanga ichiri yakanakisa.

Izvi zvinoratidza kuti GLA inogona kurambidza zvakananga bundu kukura, uye maitiro ayo ekuita akasiyana neayoGanoderma lucidumpolysaccharides kusimudzira kugona kwe-anti-cancer ye immune system uye inhibit tumors.

Haingodziviriri bundu kukura chete asiwo inowedzera hupenyu

Mukuwedzera, kuburikidza neGLE, imweGanoderma lucidumtriterpene chikamu, chikwata chaProf. Jianhua Xu naProf. Peng Li vakacherechedzawo kutiGanoderma lucidumtriterpenoids haina kungotadzisa bundu kukura asiwo yakawedzera nguva yekupona yemakonzo anotakura bundu mushure mekurapwa.

Maererano neshumo rayo rakabudiswa, GLE (Bvisa kubvaGanoderma lucidum) ichidimbu chakatsaurwa uye chakacheneswa kubvaGanoderma lucidumneInstitute of New Medicine yeFujian Medical University.1 giramu reGLE rakaenzana ne93 magiramu eGanoderma lucidummbishi mishonga yemishonga, uye yayoGanoderma lucidumtriterpenoid content is 56.7%.

Migumisiro yekuedza inoratidza kuti kana ichienzaniswa neGLA yambotaurwa, GLE inogona kushandisa zvakafanana zvakanakisisa inhibitory effect pa mouse ascitic type hepatocellular carcinomas uye sarcomas pamwero wakaderera (chikamu chimwe chete muzvina cheGLA) pasi pemamiriro akafanana ekuedza, uye zvose zvinogona kusvika kana kudarika. chinangwa chakatsanangurwa mukuongororwa kwekushanda kwemishonga yechinyakare yeChinese - bundu inhibition rate inopfuura 30%.

Kuedza kwakawanawo kuti mushure mokunge mishonga yose yakamira (GLE kana chemotherapy mishonga yakanga isisapiwi), mbeva dze sarcoma dzakambodya GLE dzaigona kurarama kwenguva refu, uye nguva yavo yekurarama yakanga yakabatana zvakanaka nedoro rekare reGLE.Pakati pavo, nguva yekurarama yeboka repamusoro-soro yeGLE yakanga yakatonyanya kureba kupfuura yeboka rakanaka rekutonga iro rakambogamuchira chemotherapy.

Maererano nekuongorora kwemutsvakurudzi, kunyange zvazvo chemotherapy iine bundu-kuderedza maitiro ari pachena, uremu hwemuviri we sarcoma mbeva huchakanganiswa uye mvere dzadzo dzichavawo hurombo munguva yemishonga;kune rumwe rutivi, bundu kudzvinyirira chiyero chepamusoro-dose GLE boka riri pedyo neiyo chemotherapy.Uye GLE haiburitse maitiro akashata anokonzerwa nemishonga yechemotherapeutic, uye inogona zvakare kurebesa nguva yekupona, iyo inoratidza kuti triterpenoid zvikamu zve.Ganoderma lucidumkuve nekuchengetedzeka uye kushanda zvakanaka, uye uve nerubatsiro rwe "mhando" yekugarisana negomarara.

Inogona kubatsira chemotherapy uye kugadzirisa mhedzisiro yekudzvinyirira bundu

Pamusoro pezvo, timu yaProfessor Peng Li yakawanawo kuburikidza neimwe ongororo yemhuka iyo iyo triterpenoid componentsGanoderma luciduminogona kubatsira chemotherapy mishonga.

Vakatanga kuisa iyo HER2-positive yekenza yemazamu yekenza (SKBR-3) mune immune-inoshomeka nude mbeva, uye mushure mekunge mabundu akura, vakadyisa mbeva idzi dzisina kupfeka 250 mg/kg yeGLE mazuva ese uye vakapa paclitaxel (PTX) kurapwa. (jekiseni remutsinga) kamwe mazuva matatu oga oga.

Mushure memazuva gumi nemana ekurapwa, zvakaonekwa kuti zvichienzaniswa neGLE kana paclitaxel chete, musanganiswa wezviviri izvi waive nekuita zviri nani kuvharisa pamamota.

Ganoderma lucidumtriterpenoids ine yakasimbiswa kushanda uye yakagadzikana mhando inobatsira kugara negomarara zuva rega rega.

Mhedzisiro dzetsvagiridzo dziri pamusoro dzinoratidza mabhenefiti emamwe manyoro ezvinyorwa, nzira dzekubvisa, uye kuumbwa chaiko kweGanoderma lucidumtriterpenoid zvikamu kune mhuka dzinotakura bundu mushure mekupfuura nemudumbu rekudya.Nekuda kwezviyero zvenguva refu zvakatsiga, vaongorori vanogona kuona mibairo yakanaka yekuedza mumhuka dzekuyedza nguva nenguva.

Muchokwadi, iyo anti-tumor mhedzisiro yeGanoderma lucidumtriterpenoids yakagara ichisimbiswa nesainzi.Dambudziko guru nderekuti "Ganoderma lucidum” inosarudzwa nevatengi ine zvinhu zvinoshanda zvenguva refu.Pashure pezvose, izwi rokuti "Ganoderma lucidum” pabhokisi hazvirevi kuti chigadzirwa chacho chinofanira kunge chineGanoderma lucidumtriterpenoids.Uyezve, zvigadzirwa zvakanyorwa neshoko rekuti "triterpenoids" zvinogona kusaburitsa mhedzisiro yeGanoderma lucidumtriterpenoids.

Iyo yesainzi inopupurirwa kushanda kunobva kune zvinongedzo, uye zvimisikidzo zvine hukama zvakanyanya nemaitiro ekubvisa uye kunobva zvigadzirwa.Hunhu hwakagadzikana uye hunoenderana hunoda yakajairika manejimendi uye kutonga mune yega link kuti uwane.

Kana mamiriro aya asangana, zvinokwanisika kushandura mabhenefiti eGanoderma lucidumtriterpenoids mune tariro yekugarisana negomarara uye kurarama negomarara kwenguva yakareba.

References

1.Xiaoxia Wei et al.Kudzidza nezve antitumor mhedzisiro yeGLA, triterpenoid chikamu cheGanoderma lucidum, in vitro uye in vivo.Nyaya yeFujian Medical University, 2010, 44 (6): 417-420.
2.Peng et al.Chidzidzo chekuyedza pane antitumor mhedzisiro yeGanoderma lucidum yakatorwa.Chinese Journal of Modern Applied Pharmacy, 2011, 28(9): 798-792.
3.Feng Liu et al.Antitumor mhedzisiro yeGLE, triterpenoid chikamu cheGanoderma lucidum, in vitro uye in vivo.Chinese Journal of New Drugs, 2012, 21(23): 2790-2793.
4.Zhiqiang Zhang et al.Ganoderma lucidum triterpenoid zvikamu zvinowedzera paclitaxel-induced apoptosis yeHER2+ masero ekenza yemazamu.Nyaya yeFujian Medical University, 2016, 50(1): 1-5.

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