ʻO nā mea nui oʻO Ganoderma lucidumʻO ka waiʻona he triterpenoids.Ua oleloiaʻO Ganoderma lucidumLoaʻa i nā triterpenoids nā hopena anti-tumor, akā ʻike anei ʻoe i nā hopena anti-tumor maoliʻO Ganoderma lucidumpāʻani nā triterpenoids ma hope o ke komo ʻana i ka ʻōpū o ka ʻōpū?

Ua hoʻopuka ka hui o Polofesa Jianhua Xu a me Polofesa Peng Li mai ke kula o ka lāʻau lapaʻau o Fujian Medical University i nā moʻolelo noiʻi.Ke hoʻohana nei i nā kino hua oʻO Ganoderma lucidumhāʻawi ʻia e Fujian Xianzhilou Biological Science and Technology Co., Ltd. ma ke ʻano he kumu waiwai, ma o kahi kaʻina hana ethanol kikoʻī, ua loaʻa iā lākou ʻelua ʻāpana oʻO Ganoderma lucidumtriterpenoids: GLA a me GLE, i hānai ʻia i nā holoholona hoʻokolohua me nā maʻi maʻi ʻaʻai a i ʻole nā ​​​​maʻi koko e ʻike i ka mea e hiki mai ana.

Ua ʻike ʻia nā ʻāpana triterpenoid oʻO Ganoderma lucidumLoaʻa i ka liʻiliʻi o ke koʻikoʻi o "ka pale ʻana i ka ulu ʻana o ka tumora, hoʻolōʻihi i ka manawa ola a hoʻomaikaʻi i ka maikaʻi o ka chemotherapy".

E hoʻolohi i ka ulu ʻana o ke koko.

Hoʻopili maikaʻi ʻia ka hopena i ka nui o nā triterpenoids.

ʻO ka poʻe noiʻi i hoʻopili mua i nā ʻiole me ka ascitic type hepatocellular carcinoma cell line (H22) a i ʻole sarcoma cell line (S180), a me 24 mau hola ma hope, ua hānai ʻia lākou me nā haʻahaʻa haʻahaʻa, waena a kiʻekiʻe (0.5, 1, a me 2 g/kg no kēlā me kēia. lā) o GLA no 7 mau lā;ua hāʻawiʻia ka hui chemotherapy i ka cyclophosphamide (CTX) (30 mg / kg) i kēlā me kēia 3 lā;ʻaʻole i hāʻawi ʻia ka hui hoʻomalu.

Ma ka lā 8 o ka hoʻokolohua, ua loiloi ʻia ke kaumaha o nā ʻiole i kēlā me kēia hui.Hōʻike nā hopena i ka GLA, kahi mea triterpenoid oʻO Ganoderma lucidum, ua ho'ēmi nui i ka uluʻana o nā carcinomas hepatocellular type ascitic a me nā sarcomas, a ua hoʻopili maikaʻiʻia ka hopena me ka hopena.

Hoʻopau pololei i ka tumora ma nā kūlana immunocompromised

Ua loaʻa nā hopena hoʻokolohua ma luna ma lalo o ke kūlana o ka hana immune maʻamau.I mea e hoʻomaopopo ai i ka pale ʻana i ka ulu ʻana o ka maʻi maʻi e GLA, kahi ʻāpana triterpenoid oʻO Ganoderma lucidum, pili i ka hana immune, ua hana nā mea noiʻi i kēia mau hoʻokolohua:

Hoʻokomo ʻia ka laina cell cancer colon (Colon-26) i loko o nā ʻiole olohelohe ka mea ʻaʻole maʻamau ka hana pale.Ma hope o ka ulu ʻana o ka ʻōpū, ua hānai hou ʻia ka GLA a me ka nui o ka nui, a ʻoi aku ka maikaʻi o ka hopena o ka pale ʻana.

Hōʻike kēia i hiki iā GLA ke kāohi pololei i ka ulu ʻana o ka maʻi maʻi, a ʻokoʻa kona ʻano hana mai kaʻO Ganoderma lucidumpolysaccharides e hoʻonui i ka hiki ke kū'ē i ka maʻi kanesa o ka ʻōnaehana pale a keʻakeʻa i nā maʻi koko.

ʻAʻole wale ka pale ʻana i ka ulu ʻana o ka maʻi tumora akā hoʻolōʻihi i ke ola

Eia kekahi, ma o GLE kekahiʻO Ganoderma lucidumtriterpene, ua nānā pū ka hui o Prof. Jianhua Xu a me Prof. Peng LiʻO Ganoderma lucidumtriterpenoids 'a'ole wale i ke'ake'a i ka ulu 'ana o ka ma'i ma'i 'a'ole ho'i i ho'oloihi i ka manawa ola o nā 'iole hāpai 'a'a ma hope o ka mālama 'ana.

Wahi a kāna hōʻike i paʻi ʻia, GLE (Extract fromʻO Ganoderma lucidum) he extract i hoʻokaʻawale ʻia a hoʻomaʻemaʻe ʻia maiʻO Ganoderma lucidumna ka Institute of New Medicine o Fujian Medical University.Ua like ka 1 grams o GLE me 93 grams oʻO Ganoderma lucidumlaau lapaau maka, a me konaʻO Ganoderma lucidumʻO ka maʻiʻo triterpenoid he 56.7%.

Hōʻike nā hopena hoʻokolohua i ka hoʻohālikelike ʻia me ka GLA i ʻōlelo ʻia ma mua, hiki i ka GLE ke hoʻohana i ka hopena hoʻopaʻapaʻa maikaʻi loa i ka ʻiole ascitic type hepatocellular carcinomas a me sarcomas ma kahi haʻahaʻa haʻahaʻa (hoʻokahi hapahā o GLA) ma lalo o nā kūlana hoʻokolohua like, a hiki iā lāua ke hōʻea a ʻoi aku paha. ka pahuhopu i kuhikuhi ʻia i ka loiloi o ka pono o ka lāʻau lapaʻau kuʻuna Kina - ka nui o ka inhibition tumor ma mua o 30%.

Ua ʻike pū ka hoʻokolohua ma hope o ka pau ʻana o nā lāʻau lapaʻau (ʻaʻole i hāʻawi hou ʻia nā lāʻau lapaʻau GLE a i ʻole nā ​​​​lāʻau chemotherapy), hiki i nā ʻiole sarcoma i ʻai mua iā GLE ke ola lōʻihi, a ua hoʻopili maikaʻi ʻia ko lākou manawa ola me ka nui o ka GLE ma mua.Ma waena o lākou, ʻoi aku ka lōʻihi o ka manawa ola o ka hui GLE kiʻekiʻe ma mua o ka hui hoʻomalu maikaʻi i loaʻa mua i ka chemotherapy.

Wahi a ka ʻike a ka mea noiʻi, ʻoiai ʻo ka chemotherapy he hopena kaohi ʻana i ka maʻi tumora, e hoʻopilikia ʻia ke kaumaha o ke kino o nā ʻiole sarcoma a e ʻilihune hoʻi ko lākou hulu i ka wā o ka lāʻau lapaʻau;ma ka ʻaoʻao ʻē aʻe, ʻo ka nui o ka hoʻopau ʻana i ke koko o ka hui GLE kiʻekiʻe e kokoke ana i ka chemotherapy.ʻAʻole hoʻopuka ʻo GLE i nā hopena ʻino i hana ʻia e nā lāʻau chemotherapeutic, a hiki ke hoʻolōʻihi i ka manawa ola, e hōʻike ana i nā ʻāpana triterpenoid oʻO Ganoderma lucidumloaʻa i kekahi palekana a me ka pono, a loaʻa kekahi kōkua no ka "kūpono" noho pū me ka maʻi kanesa.

Hiki ke kōkua i ka chemotherapy a hoʻomaikaʻi i ka hopena o ka hoʻopau ʻana i ka maʻi tumora

Eia hou, ua loaʻa pū i ka hui o Polofesa Peng Li ma o kekahi hoʻokolohua holoholona ʻē aʻe nā mea triterpenoid oʻO Ganoderma lucidumhiki ke kōkua i nā lāʻau lapaʻau chemotherapy.

Ua ino mua lakou i ka HER2-positive human breast cancer cell line (SKBR-3) i loko o ka immune-deficient nude mice, a ma hope o ka ulu ana o na ma'i koko, ua hanai lakou i keia mau iole olohelohe 250 mg/kg o GLE i kela la i keia la a haawi i ka paclitaxel (PTX) lapaau. (injected intravenous) hoʻokahi i kēlā me kēia lā ʻekolu.

Ma hope o 14 mau lā o ka mālama ʻana, ua ʻike ʻia ua hoʻohālikelike ʻia me GLE a i ʻole paclitaxel wale nō, ʻoi aku ka maikaʻi o ka hoʻohui ʻana o nā mea ʻelua i ka hopena inhibitory maikaʻi loa i nā ʻōpū.

ʻO Ganoderma lucidumtriterpenoids me ka ikaika paʻa a me ka maikaʻi paʻa kōkua e noho pū me ka maʻi kanesa i kēlā me kēia lā.

Hōʻike nā hopena noiʻi ma luna nei i nā pono o nā kumu waiwai maka, nā ʻano unuhi kikoʻī, a me nā haku kikoʻī oʻO Ganoderma lucidumnā ʻāpana triterpenoid i nā holoholona hānai maʻi ma hope o ka hele ʻana i loko o ka ʻōnaehana digestive.Mahalo i nā mea hoʻokolohua kūpaʻa lōʻihi, hiki i nā mea noiʻi ke ʻike i nā hopena hoʻokolohua maikaʻi i nā holoholona hoʻokolohua i kēlā me kēia manawa.

ʻOiaʻiʻo, ka hopena anti-tumor oʻO Ganoderma lucidumtriterpenoids ua lōʻihi loa i hōʻoia ʻia i ka ʻepekema.ʻO ka pilikia nui inā paha ka "ʻO Ganoderma lucidum” i koho ʻia e nā mea kūʻai aku he mau mea hana no ka wā lōʻihi.Ma hope o nā mea a pau, ʻo ka huaʻōlelo "ʻO Ganoderma lucidum” ma ka pahu, ʻaʻole ia he pono ke komo i ka huahanaʻO Ganoderma lucidumtriterpenoids.Eia kekahi, ʻaʻole hiki i nā huahana i hōʻailona ʻia me ka huaʻōlelo "triterpenoids" i nā hopena oʻO Ganoderma lucidumtriterpenoids.

ʻO ka ʻepekema i hōʻoia ʻia mai nā mea hoʻohui, a ua pili pono nā mea i ke kaʻina hana unuhi a me ke kumu o nā mea maka.Pono ka maikaʻi kūpaʻa a paʻa i ka hoʻokele maʻamau a me ka mana i kēlā me kēia loulou e hoʻokō.

Ke hoʻokō ʻia kēia mau kūlana, hiki ke hoʻololi i nā pono oʻO Ganoderma lucidumtriterpenoids i loko o ka manaʻolana o ka noho pū ʻana me ka maʻi kanesa a me ke ola ʻana me ka maʻi kanesa no ka manawa lōʻihi.

Nā kuhikuhi

1.Xiaoxia Wei et al.E aʻo i ka hopena antitumor o GLA, kahi mea triterpenoid o Ganoderma lucidum, in vitro a me in vivo.Nūpepa o Fujian Medical University, 2010, 44 (6): 417-420.
2.Peng et al.Ke aʻo hoʻokolohua e pili ana i ka hopena antitumor o Ganoderma lucidum extract.Chinese Journal of Modern Applied Pharmacy, 2011, 28(9): 798-792.
3.Feng Liu et al.Nā hopena antitumor o GLE, kahi mea triterpenoid o Ganoderma lucidum, in vitro a in vivo.Ka Nupepa Haina o na Laau Laau Hou, 2012, 21(23): 2790-2793.
4.Zhiqiang Zhang et al.ʻO nā ʻāpana Ganoderma lucidum triterpenoid e hoʻonui i ka apoptosis i hoʻokomo ʻia i ka paclitaxel o HER2+ mau maʻi kanesa umauma.Nūpepa o Fujian Medical University, 2016, 50 (1): 1-5.

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