Lub ntsiab Cheebtsam ntawmGanoderma lucidumcawv extract yog triterpenoids.Yog hais tiasGanoderma lucidumtriterpenoids muaj cov teebmeem los tiv thaiv qog, tab sis koj puas paub tias cov teebmeem tiv thaiv qog tuaj yeem ua tauGanoderma lucidumtriterpenoids ua si tom qab nkag mus rau hauv txoj hnyuv?

Pab pawg ntawm xibfwb Jianhua Xu thiab xibfwb Peng Li los ntawm Tsev Kawm Ntawv Pharmacy ntawm Fujian Medical University tau tshaj tawm cov ntaub ntawv tshawb fawb.Siv cov txiv hmab txiv ntoo lub cev ntawmGanoderma lucidummuab los ntawm Fujian Xianzhilou Biological Science thiab Technology Co., Ltd. raws li raw cov ntaub ntawv, los ntawm ib tug tshwj xeeb ethanol extraction txheej txheem, lawv tau txais ob yam khoom ntawmGanoderma lucidumtriterpenoids: GLA thiab GLE, uas tau pub rau cov tsiaj sim nrog cov qog nqaij hlav cancer lossis cov qog kom pom tias yuav tshwm sim.

Nws tau pom tias triterpenoid Cheebtsam ntawmGanoderma lucidummuaj tsawg kawg yog qhov tseem ceeb ntawm "inhibiting qog kev loj hlob, ncua sij hawm ciaj sia taus thiab txhim kho cov hauj lwm zoo ntawm chemotherapy".

Ua kom cov qog loj hlob qeeb.

Cov nyhuv zoo sib xws rau cov koob tshuaj triterpenoids.

Cov kws tshawb fawb ua ntej subcutaneously inoculated nas nrog ascitic hom hepatocellular carcinoma cell kab (H22) los yog sarcoma cell kab (S180), thiab 24 teev tom qab, lawv tau noj nrog tsawg, nruab nrab thiab siab koob tshuaj (0.5, 1, thiab 2 g / kg ib. hnub) ntawm GLA rau 7 hnub sib law liag;pawg kws khomob tau muab cyclophosphamide (CTX) (30 mg/kg) txhua 3 hnub;pawg tswj tsis tau kho.

Hnub 8 ntawm qhov kev sim, cov qog hnyav ntawm cov nas hauv txhua pab pawg tau raug soj ntsuam.Cov txiaj ntsig tau pom tias GLA, triterpenoid feem ntawmGanoderma lucidum, ua rau qeeb qeeb ntawm kev loj hlob ntawm ascitic hom hepatocellular carcinomas thiab sarcomas, thiab cov nyhuv tau zoo sib xws nrog cov koob tshuaj.

Direct qog suppression nyob rau hauv immunocompromised tej yam kev mob

Cov kev sim saum toj no tau txais nyob rau hauv cov xwm txheej ntawm lub cev tsis muaj zog.Yuav kom nkag siab seb qhov inhibition ntawm qog loj hlob los ntawm GLA, ib qho triterpenoid tivthaiv ntawmGanoderma lucidum, muaj feem xyuam rau kev tiv thaiv kab mob, cov kws tshawb fawb tau ua cov kev sim hauv qab no:

Cov kab mob qog noj ntshav ntawm txoj hnyuv (Colon-26) tau muab tso rau hauv cov nas liab qab uas nws lub cev tsis muaj zog.Tom qab cov qog loj hlob tuaj, qhov nruab nrab thiab siab koob tshuaj ntawm GLA tau noj dua, thiab cov qog inhibitory tseem zoo heev.

Qhov no qhia tau hais tias GLA tuaj yeem tiv thaiv qog nqaij hlav ncaj qha, thiab nws cov txheej txheem ntawm kev ua yog txawv ntawm qhovGanoderma lucidumpolysaccharides los txhim kho lub peev xwm tiv thaiv kab mob ntawm lub cev tiv thaiv kab mob thiab inhibit qog.

Tsis tsuas yog inhibits qog loj hlob tab sis kuj prolongs lub neej

Tsis tas li ntawd, los ntawm GLE, lwm qhovGanoderma lucidumtriterpene tivthaiv, pab neeg ntawm Prof. Jianhua Xu thiab Prof. Peng Li kuj pom tiasGanoderma lucidumtriterpenoids tsis tsuas yog inhibited qog loj hlob, tab sis kuj ncua lub sij hawm ciaj sia taus ntawm cov qog nqaij hlav nas tom qab kev kho mob.

Raws li nws daim ntawv tshaj tawm, GLE (Extract fromGanoderma lucidum) yog ib qho extract cais thiab purified los ntawmGanoderma lucidumlos ntawm lub koom haum ntawm Cov Tshuaj Tshiab ntawm Fujian Medical University.1 gram ntawm GLE yog sib npaug rau 93 grams ntawmGanoderma lucidumraw cov ntaub ntawv tshuaj, thiab nwsGanoderma lucidumCov ntsiab lus triterpenoid yog 56.7%.

Cov txiaj ntsig kev sim qhia tau hais tias piv nrog GLA tau hais los saum no, GLE tuaj yeem ua rau tib yam zoo heev inhibitory nyhuv ntawm nas ascitic hom hepatocellular carcinomas thiab sarcomas ntawm qhov qis dua (ib feem plaub ntawm GLA) nyob rau hauv tib txoj kev sim, thiab ob qho tib si tuaj yeem ncav cuag lossis tshaj. Lub hom phiaj tau teev tseg nyob rau hauv kev ntsuam xyuas ntawm kev ua tau zoo ntawm cov tshuaj suav tshuaj - cov qog inhibition ntau dua 30%.

Qhov kev sim kuj pom tau tias tom qab tag nrho cov kev kho mob raug tso tseg (GLE lossis cov tshuaj khomob tsis tau muab ntxiv lawm), cov nas sarcoma uas thawj zaug tau noj GLE tuaj yeem nyob ntev dua, thiab lawv lub sijhawm muaj sia nyob tau cuam tshuam nrog cov koob tshuaj yav dhau los ntawm GLE.Ntawm lawv, lub sijhawm muaj sia nyob ntawm pawg GLE koob tshuaj ntau dua yog qhov ntev dua li ntawm pawg tswj hwm zoo uas tau txais kev kho mob yav dhau los.

Raws li tus kws tshawb fawb tau soj ntsuam, txawm hais tias cov tshuaj khomob muaj qhov pom tseeb ntawm cov qog-tshuaj, lub cev hnyav ntawm cov nas sarcoma yuav raug cuam tshuam thiab lawv cov plaub kuj tseem yuav ua rau cov neeg pluag thaum lub sijhawm noj tshuaj;ntawm qhov tod tes, cov qog nqaij hlav ntawm cov koob tshuaj GLE yog ze rau ntawm cov tshuaj kho mob.Thiab GLE ua rau tsis muaj kev phiv tshwm sim los ntawm cov tshuaj chemotherapeutic, thiab nws tseem tuaj yeem ua rau lub sijhawm muaj sia nyob, uas qhia tau tias cov khoom siv triterpenoid ntawmGanoderma lucidummuaj qee yam kev nyab xeeb thiab kev ua tau zoo, thiab muaj qee yam kev pab rau "zoo" kev sib raug zoo nrog mob qog noj ntshav.

Nws tuaj yeem pab kho cov tshuaj tua kab mob thiab txhim kho cov nyhuv ntawm cov qog nqaij hlav

Tsis tas li ntawd, Xib Fwb Peng Li pab pawg kuj pom los ntawm lwm qhov kev sim tsiaj uas cov khoom siv triterpenoid ntawmGanoderma lucidumtuaj yeem pab cov tshuaj kho mob.

Lawv thawj zaug inoculated HER2-zoo tib neeg mob qog noj ntshav cell kab (SKBR-3) nyob rau hauv lub cev tsis muaj zog cov nas liab qab, thiab tom qab cov qog loj hlob tawm, lawv pub cov nas liab qab 250 mg / kg ntawm GLE txhua hnub thiab muab paclitaxel (PTX) kho. (intravenous txhaj) ib zaug txhua peb hnub.

Tom qab 14 hnub ntawm kev kho mob, nws tau pom tias piv nrog GLE lossis paclitaxel ib leeg, kev sib xyaw ntawm ob qho tib si muaj kev cuam tshuam zoo dua rau cov qog.

Ganoderma lucidumtriterpenoids nrog tsim kev ua tau zoo thiab ruaj khov zoo pab ua ke nrog mob qog noj ntshav txhua hnub.

Cov kev tshawb fawb saum toj no qhia tau hais tias cov txiaj ntsig ntawm cov khoom siv raw, cov txheej txheem tshwj xeeb extraction, thiab cov muaj pes tsawg leeg ntawmGanoderma lucidumtriterpenoid Cheebtsam rau qog-cov kabmob tsiaj tom qab dhau los ntawm lub plab zom mov.Ua tsaug rau cov ntaub ntawv sim ruaj khov mus ntev, cov kws tshawb fawb tuaj yeem pom cov txiaj ntsig zoo hauv cov tsiaj sim ib zaug thiab ib zaug ntxiv.

Qhov tseeb, cov nyhuv anti-tumor ntawmGanoderma lucidumtriterpenoids tau ntev tau tshawb pom tseeb.Qhov teeb meem tseem ceeb yog seb qhov "Ganoderma lucidum” tias cov neeg siv khoom xaiv tiag tiag muaj cov khoom xyaw zoo li no rau lub sijhawm ntev.Tom qab tag nrho, lo lus "Ganoderma lucidum” ntawm lub thawv tsis tau txhais hais tias cov khoom yuav tsum muajGanoderma lucidumtriterpenoids.Ntxiv mus, cov khoom uas cim nrog lo lus "triterpenoids" yuav tsis tsim cov teebmeem ntawmGanoderma lucidumtriterpenoids.

Cov kev tshawb fawb pov thawj ua tau zoo los ntawm cov khoom xyaw, thiab cov khoom xyaw muaj feem cuam tshuam nrog cov txheej txheem rho tawm thiab qhov chaw ntawm cov khoom siv raw.Kev ruaj khov thiab zoo ib yam yuav tsum muaj kev tswj hwm thiab kev tswj hwm hauv txhua qhov txuas kom ua tiav.

Thaum cov xwm txheej no tau ntsib, nws muaj peev xwm hloov pauv cov txiaj ntsig ntawmGanoderma lucidumtriterpenoids rau hauv kev cia siab ntawm kev sib koom ua ke nrog mob qog noj ntshav thiab muaj sia nyob nrog mob qog noj ntshav rau lub sijhawm ntev.

Cov ntaub ntawv

1. Xiaoxia Wei et al.Kawm txog cov nyhuv antitumor ntawm GLA, triterpenoid feem ntawm Ganoderma lucidum, hauv vitro thiab hauv vivo.Phau ntawv Journal ntawm Fujian Medical University, 2010, 44(6): 417-420.
2. Peng et al.Kev sim kawm txog cov nyhuv antitumor ntawm Ganoderma lucidum extract.Suav Journal of Modern Applied Pharmacy, 2011, 28(9): 798-792.
3. Feng Liu et al.Antitumor teebmeem ntawm GLE, triterpenoid tivthaiv ntawm Ganoderma lucidum, hauv vitro thiab hauv vivo.Suav Journal of New Drugs, 2012, 21(23): 2790-2793.
4.Zhiqiang Zhang et al.Ganoderma lucidum triterpenoid Cheebtsam txhim kho paclitaxel-induced apoptosis ntawm HER2 + cov qog nqaij hlav cancer mis.Phau ntawv Journal ntawm Fujian Medical University, 2016, 50(1): 1-5.

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★ Kab lus no tau luam tawm raws li kev tso cai tshwj xeeb ntawm tus sau, thiab cov tswv cuab yog GanoHerb.

★Tsis txhob rov luam tawm, txiav tawm lossis siv cov haujlwm saum toj no ua lwm txoj hauv kev yam tsis tau tso cai ntawm GanoHerb.

★ Yog tias txoj haujlwm tau tso cai siv, nws yuav tsum tau siv nyob rau hauv qhov kev tso cai, thiab qhov chaw yuav tsum tau qhia: GanoHerb.

★ GanoHerb yuav tshawb xyuas thiab txheeb xyuas cov luag haujlwm raug cai ntawm cov neeg uas ua txhaum cov lus hais saum toj no.

★ Cov ntawv qub ntawm kab lus no tau sau ua lus Suav los ntawm Wu Tingyao thiab txhais ua lus Askiv los ntawm Alfred Liu.Yog tias muaj qhov tsis sib xws ntawm kev txhais lus (English) thiab tus thawj (Suav), tus thawj Suav yuav yeej.Yog tias cov nyeem muaj lus nug, thov hu rau tus thawj kws sau ntawv, Ms. Wu Tingyao.

Ua raws li Millennia Health Preservation Culture

Kev mob siab rau kev txhim kho Kev Noj Qab Haus Huv ntawm Txhua Tus