Likarolo tse kholo tsaGanoderma lucidumjoala e nkiloeng ke triterpenoids.Ho boleloa joaloGanoderma lucidumtriterpenoids e na le litlamorao tse khahlanong le hlahala, empa na ua tseba hore na litlamorao tsa 'nete tsa anti-tumor li ka etsa engGanoderma lucidumli-triterpenoids li bapala ka mor'a ho kena ka mpeng ea mala?

Sehlopha sa Moprofesa Jianhua Xu le Moprofesa Peng Li oa Sekolo sa Pharmacy sa Fujian Medical University ba phatlalalitse letoto la litlaleho tsa lipatlisiso.Ho sebelisa litho tsa litholoana tsaGanoderma lucidume fanoeng ke Fujian Xianzhilou Biological Science and Technology Co., Ltd. e le lisebelisoa tse tala, ka mokhoa o itseng oa ho ntša ethanol, ba fumane likarolo tse peli tsaGanoderma lucidumtriterpenoids: GLA le GLE, tse ileng tsa fuoa liphoofolo tsa liteko tse nang le lisele tsa mofetše kapa lihlahala ho bona se tla etsahala.

Ho ile ha fumanoa hore likarolo tsa triterpenoid tsaGanoderma lucidumbonyane ho na le bohlokoa ba "ho thibela ho hōla ha hlahala, ho lelefatsa nako ea ho phela le ho ntlafatsa katleho ea chemotherapy".

Fokotsa ho hōla ha hlahala.

Phello e amana hantle le tekanyo ea triterpenoids.

Bafuputsi ba pele ba ile ba kenya litoeba ka subcutaneously ka mofuta oa ascitic hepatocellular carcinoma cell line (H22) kapa sarcoma cell line (S180), le lihora tsa 24 hamorao, ba ne ba fepa ka tekanyo e tlaase, e bohareng le e phahameng (0.5, 1, le 2 g / kg letsatsi) la GLA bakeng sa matsatsi a 7 a latellanang;sehlopha sa chemotherapy se ile sa fuoa cyclophosphamide (CTX) (30 mg / kg) ka matsatsi a 3;sehlopha sa taolo ha sea ka sa fuoa phekolo.

Ka letsatsi la 8th la teko, boima ba hlahala ba litoeba sehlopheng ka seng bo ile ba hlahlojoa.Liphetho li bontšitse hore GLA, karolo ea triterpenoid eaGanoderma lucidum, e ile ea fokotsa haholo ho hōla ha mofuta oa ascitic hepatocellular carcinomas le sarcoma, 'me phello e ne e amana hantle le tekanyo.

Khatello e tobileng ea hlahala maemong a immunocompromised

Liphetho tsa liteko tse ka holimo li ile tsa fumanoa tlas'a boemo ba ts'ebetso e tloaelehileng ea 'mele oa ho itšireletsa mafung.E le hore u utloisise hore na ho thibela ho hōla ha hlahala ka GLA, karolo ea triterpenoid eaGanoderma lucidum, e amana le ts'ebetso ea 'mele ea ho itšireletsa mafung, bafuputsi ba ile ba etsa liteko tse latelang:

Mohala oa lisele tsa mofetše oa colon (Colon-26) o ile oa kenngoa ka har'a litoeba tse hlobotseng tseo tšebetso ea tsona ea 'mele ea ho itšireletsa mafung e neng e sa tloaeleha.Ka mor'a hore hlahala e hōle, litekanyetso tse mahareng le tse phahameng tsa GLA li ile tsa feptjoa hape, 'me phello ea ho thibela hlahala e ne e ntse e le ntle haholo.

Sena se bontša hore GLA e ka thibela ka ho toba ho hōla ha hlahala, 'me mochine oa eona oa ketso o fapane le oaGanoderma lucidumli-polysaccharides ho matlafatsa matla a anti-mofets'e a sesole sa 'mele le ho thibela lihlahala.

Ha e thibele feela ho hōla ha hlahala empa hape e lelefatsa bophelo

Ho phaella moo, ka GLE, e 'ngoeGanoderma lucidumkarolo ea triterpene, sehlopha sa Prof. Jianhua Xu le Prof. Peng Li le bona ba hlokometse horeGanoderma lucidumtriterpenoids ha e thibele feela ho hola ha hlahala empa hape e ile ea lelefatsa nako ea ho phela ha litoeba tse nang le hlahala kamora kalafo.

Ho latela tlaleho ea eona e hatisitsoeng, GLE (Ntša hoGanoderma lucidum) ke moqomo o ka thoko le o hloekisitsoeng ho tsoaGanoderma lucidumke Mokhatlo oa New Medicine oa Fujian Medical University.gram e le 1 ea GLE e lekana le ligrama tse 93 tsaGanoderma lucidumthepa e tala ea meriana, le eonaGanoderma lucidumlitaba tsa triterpenoid ke 56.7%.

Liphetho tsa liteko li bontša hore ha li bapisoa le GLA e boletsoeng ka holimo, GLE e ka fana ka phello e ts'oanang e babatsehang ea ho thibela likokoana-hloko ho mouse ascitic mofuta oa hepatocellular carcinomas le sarcoma ka tekanyo e tlaase (karolo ea bone ea GLA) tlas'a maemo a tšoanang a liteko, 'me ka bobeli li ka fihla kapa tsa feta. sepheo se boletsoeng tlhahlobong ea katleho ea meriana ea setso ea Machaena - sekhahla sa thibelo ea hlahala se fetang 30%.

Teko e ile ea boela ea fumana hore ka mor'a hore phekolo eohle e emisoe (GLE kapa lithethefatsi tsa chemotherapy li ne li se li sa fanoa), litoeba tsa sarcoma tse neng li ja GLE li ne li ka phela nako e telele, 'me nako ea tsona ea ho phela e ne e amana hantle le tekanyo e fetileng ea GLE.Har'a bona, nako ea ho pholoha ha sehlopha se phahameng sa GLE e ne e le nako e telele haholo ho feta ea sehlopha se setle sa taolo se neng se kile sa fumana chemotherapy pele.

Ho ea ka se hlokometsoeng ke mofuputsi, le hoja chemotherapy e na le phello e hlakileng ea ho thibela hlahala, boima ba 'mele ba litoeba tsa sarcoma bo tla ameha' me boea ba bona bo tla boela bo futsanehe nakong ea ts'ebetso ea meriana;ka lehlakoreng le leng, sekhahla sa khatello ea tumor ea sehlopha se phahameng sa GLE se haufi le sa chemotherapy.'Me GLE ha e hlahise maikutlo a mabe a bakoang ke lithethefatsi tsa chemotherapeutic, hape e ka lelefatsa nako ea ho phela, e bontšang hore likarolo tsa triterpenoidGanoderma lucidumho ba le ts'ireletso le ts'ebetso e itseng, 'me u be le thuso e itseng bakeng sa "boleng" ba ho phela hammoho le mofetše.

E ka thusa chemotherapy le ho ntlafatsa phello ea khatello ea tumor

Ho phaella moo, sehlopha sa Moprofesa Peng Li se boetse se fumane ka liteko tse ling tsa liphoofolo tseo likarolo tsa triterpenoid tsaGanoderma lucidume ka thusa litlhare tsa chemotherapy.

Ba ile ba qala ho enta HER2-positive human breast cancer cell line (SKBR-3) ho litoeba tse se nang boits'ireletso ba mmele, mme kamora hore lihlahala li hole, ba fepa litoeba tsena tse hlobotseng 250 mg / kg ea GLE letsatsi le letsatsi mme ba fana ka kalafo ea paclitaxel (PTX). (ente ka methapo) hang ka matsatsi a mararo.

Kamora matsatsi a 14 a kalafo, ho ile ha fumaneha hore ha ho bapisoa le GLE kapa paclitaxel feela, motsoako oa bobeli o bile le phello e ntle haholo ea ho thibela lihlahala.

Ganoderma lucidumli-triterpenoids tse nang le ts'ebetso e tsitsitseng le boleng bo tsitsitseng li thusa ho phela hammoho le mofetše letsatsi le leng le le leng.

Liphetho tsa lipatlisiso tse ka holimo li bonts'a melemo ea mehloli e itseng ea lihlahisoa tse tala, mekhoa e khethehileng ea ho ntša, le sebopeho se itseng saGanoderma lucidumlikarolo tsa triterpenoid ho liphoofolo tse nang le hlahala ka mor'a ho feta tsamaisong ea tšilo ea lijo.Ka lebaka la lisebelisoa tsa liteko tse tsitsitseng tsa nako e telele, bafuputsi ba ka bona liphello tse ntle tsa liteko liphoofolong tsa liteko nako le nako.

Ha e le hantle, phello ea anti-tumor eaGanoderma lucidumtriterpenoids haesale e tiisitsoe ka mahlale.Bothata bo boholo ke hore na "Ganoderma lucidum” eo bareki ba e khethang e na le metsoako e sebetsang ea nako e telele.Etsoe, lentsoe "Ganoderma lucidum” lebokoseng ha ho bolele hore sehlahisoa se tlameha ho ba leGanoderma lucidumtriterpenoids.Ho feta moo, lihlahisoa tse tšoailoeng ka lentsoe "triterpenoids" li ka 'na tsa se ke tsa hlahisa liphello tsaGanoderma lucidumtriterpenoids.

Matla a netefalitsoeng ke saense a tsoa ho metsoako, 'me metsoako e amana haufi-ufi le mokhoa oa ho ntša le mohloli oa lihlahisoa tse tala.Boleng bo tsitsitseng le bo tsitsitseng bo hloka tsamaiso e tsitsitseng le taolo ho sehokelo se seng le se seng ho fihlela.

Ha maemo ana a finyelloa, hoa khoneha ho fetola melemo eaGanoderma lucidumtriterpenoids ka tšepo ea ho phela le mofetše le ho phela le mofetše nako e telele.

Litšupiso

1.Xiaoxia Wei et al.Ho ithuta ka phello ea antitumor ea GLA, karolo ea triterpenoid ea Ganoderma lucidum, in vitro le in vivo.Journal of Fujian Medical University, 2010, 44 (6): 417-420.
2.Peng le ba bang.Boithuto ba liteko mabapi le phello ea antitumor ea Ganoderma lucidum extract.Chinese Journal of Modern Applied Pharmacy, 2011, 28(9): 798-792.
3.Feng Liu et al.Liphello tsa Antitumor tsa GLE, karolo ea triterpenoid ea Ganoderma lucidum, in vitro le in vivo.Chinese Journal of New Drugs, 2012, 21 (23): 2790-2793.
4.Zhiqiang Zhang et al.Likarolo tsa Ganoderma lucidum triterpenoid li ntlafatsa paclitaxel-induced apoptosis ea HER2+ lisele tsa mofetše oa matsoele.Journal of Fujian Medical University, 2016, 50 (1): 1-5.

QETA

★Sengoliloeng sena se hatisitsoe ka tumello e khethehileng ea mongoli, 'me mong'a sona ke oa GanoHerb.

★Se ke oa hatisa hape, oa qotsa kapa oa sebelisa mesebetsi e kaholimo ka litsela tse ling ntle le tumello ea GanoHerb.

★Haeba mosebetsi o lumelletsoe ho sebelisoa, o lokela ho sebelisoa ka har'a sebaka sa tumello, 'me mohloli o lokela ho bontšoa: GanoHerb.

★GanoHerb e tla batlisisa le ho tiisa boikarabelo ba molao bo loketseng ba ba tlolang lipolelo tse ka holimo.

★ Sengoloa sa mantlha sa sengoloa sena se ngotsoe ka Sechaena ke Wu Tingyao mme se fetoleloa ho Senyesemane ke Alfred Liu.Haeba ho na le phapang lipakeng tsa phetolelo (Senyesemane) le ea mantlha (Sechaena), Sechaena sa mantlha se tla ba teng.Haeba babali ba na le lipotso, ka kopo ikopanye le sengoli sa mantlha, Mme Wu Tingyao.

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