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Amacandelo aphambili eI-Ganoderma lucidumutywala isicatshulwa triterpenoids.KuthiwaI-Ganoderma lucidumI-triterpenoids ineempembelelo ezichasene nethumba, kodwa ngaba uyazi ukuba zeziphi iziphumo ezichasene nethumbaI-Ganoderma lucidumi-triterpenoids idlala emva kokungena kwi-gastrointestinal tract?

Iqela likaNjingalwazi uJianhua Xu kunye noNjingalwazi uPeng Li ovela kwiSikolo sePharmacy yaseFujian Medical University baye bapapasha uluhlu lweengxelo zophando.Ukusebenzisa imizimba yeziqhamo zeI-Ganoderma lucidumezibonelelwa yi Fujian Xianzhilou Biological Science and Technology Co., Ltd. njengezinto ekrwada, ngenkqubo ethile yokutsalwa kwe-ethanol, bafumana amacandelo amabiniI-Ganoderma lucidumi-triterpenoids: i-GLA kunye ne-GLE, ezondliwa kwizilwanyana zovavanyo ezineeseli zomhlaza okanye amathumba ukuze zibone ukuba kuya kwenzeka ntoni.

Kwafunyaniswa ukuba amacandelo triterpenoid yeI-Ganoderma lucidumubuncinci bunokubaluleka "kokuthintela ukukhula kwethumba, ukolula ixesha lokusinda kunye nokuphucula ukusebenza kwechemotherapy".

Cothisa ukukhula kwethumba.

Umphumo uhambelana ngokufanelekileyo kwidosi ye-triterpenoids.

Abaphandi baqala ukufakwa kwi-subcutaneously iigundane kunye ne-ascitic uhlobo lwe-hepatocellular carcinoma cell line (H22) okanye i-sarcoma cell line (S180), kunye neeyure ze-24 kamva, zondliwa ngeedosi eziphantsi, eziphakathi kunye eziphezulu (0.5, 1, kunye ne-2 g / kg nganye usuku) lwe-GLA iintsuku ezi-7 ezilandelelanayo;iqela le-chemotherapy linikwe i-cyclophosphamide (CTX) (30 mg / kg) zonke iintsuku ze-3;iqela lolawulo alinikwanga unyango.

Ngomhla we-8 wovavanyo, ubunzima be-tumor yeempuku kwiqela ngalinye bavavanywa.Iziphumo zabonisa ukuba GLA, icandelo triterpenoid ofI-Ganoderma lucidum, yacotha ngokuphawulekayo ukukhula kohlobo lwe-ascitic uhlobo lwe-hepatocellular carcinomas kunye ne-sarcomas, kwaye umphumo wawulungelelaniswe kakuhle kunye nedosi.

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Ukunyanzeliswa kwethumba ngokuthe ngqo kwiimeko ze-immunocompromised

Iziphumo zovavanyo ezingentla zafunyanwa phantsi kwemeko yokusebenza komzimba okuqhelekileyo.Ukuze uqonde ukuba inhibition yokukhula kwethumba yi-GLA, icandelo le-triterpenoid yeI-Ganoderma lucidum, inxulumene nokusebenza komzimba, abaphandi baqhube iimvavanyo ezilandelayo:

Umgca weseli yomhlaza we-colon (i-Colon-26) ifakwe kwiigundane ezinqunu umsebenzi wazo wokuzivikela wawungekho ngokuqhelekileyo.Emva kokuba i-tumor ikhulile, idosi ephakathi kunye nephezulu ye-GLA yondliwa kwakhona, kwaye i-tumor inhibitory effect yayisentle kakhulu.

Oku kubonisa ukuba i-GLA inokunqanda ngokuthe ngqo ukukhula kwethumba, kwaye indlela yokusebenza kwayo yahlukile kuleyo yeI-Ganoderma lucidumiipolysaccharides zokwandisa amandla okulwa nomhlaza wenkqubo yomzimba yokuzikhusela kunye nokuthintela amathumba.

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Ayithinteli kuphela ukukhula kwe-tumor, kodwa kwandisa ubomi

Ukongeza, nge-GLE, enyeI-Ganoderma lucidumicandelo le-triterpene, iqela likaProf. Jianhua Xu kunye noProf. Peng Li nabo baqaphela ukubaI-Ganoderma lucidumI-triterpenoids ayithinteli kuphela ukukhula kwethumba kodwa yandisa ixesha lokusinda kweempuku ezithwele ithumba emva konyango.

Ngokwengxelo epapashiweyo, i-GLE (Thatha kwiI-Ganoderma lucidum) sisicatshulwa esikhethekileyo kwaye sacocwa kusoI-Ganoderma lucidumliZiko leNew Medicine yeFujian Medical University.Igram e-1 ye-GLE ilingana ne-93 grams yeI-Ganoderma lucidumizinto ekrwada amayeza, kunye yayoI-Ganoderma lucidumUmxholo we-triterpenoid yi-56.7%.

Iziphumo zovavanyo zibonisa ukuba xa kuthelekiswa ne-GLA ekhankanywe ngasentla, i-GLE inokusebenzisa impembelelo efanayo yokuthintela i-mouse ascitic uhlobo lwe-hepatocellular carcinomas kunye ne-sarcomas kwidosi ephantsi (isinye-sesine se-GLA) phantsi kweemeko zovavanyo ezifanayo, kwaye zombini zinokufikelela okanye zidlule. ekujoliswe kuko okuchazwe kuvavanyo lwempumelelo yamayeza emveli aseTshayina - izinga lokuthintela ithumba elingaphezulu kwama-30%.

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Uvavanyo luphinde lwafumanisa ukuba emva kokuba zonke iindlela zonyango zimisiwe (i-GLE okanye i-chemotherapy iziyobisi azizange zinikwe), iigundane ze-sarcoma ezazidla i-GLE ekuqaleni zazinokuphila ixesha elide, kwaye ixesha labo lokusinda lalihambelana ngokuqinisekileyo kunye nedosi yangaphambili ye-GLE.Phakathi kwabo, ixesha lokusinda leqela eliphezulu le-GLE lalide kakhulu kunelo qela lokulawula elilungileyo elalifumene i-chemotherapy ngaphambili.

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Ngokutsho kokuqwalaselwa komphandi, nangona i-chemotherapy inesiphumo esicacileyo se-tumor-suppressing, ubunzima bomzimba weempuku ze-sarcoma buya kuchaphazeleka kwaye uboya babo buya kuba buhlwempu ngexesha lenkqubo yamayeza;kwelinye icala, izinga lokunciphisa ithumba ledosi ephezulu yeqela le-GLE lisondele kuleyo ye-chemotherapy.Kwaye i-GLE ayivelisi ziziphumo ezibi ezibangelwa ngamachiza e-chemotherapeutic, kwaye inokwandisa ixesha lokusinda, elibonisa ukuba amacandelo e-triterpenoidI-Ganoderma lucidumube nokhuseleko oluthile kunye nokusebenza kakuhle, kwaye ube noncedo oluthile "lomgangatho" wokuhlalisana nomhlaza.

Inokunceda i-chemotherapy kwaye iphucule umphumo wokunyanzeliswa kwe-tumor

Ukongeza, iqela likaNjingalwazi Peng Li likwafumene ngolunye ulingo lwezilwanyana ukuba amacandelo e-triterpenoidI-Ganoderma luciduminokunceda amayeza echemotherapy.

Baqala bafaka i-HER2-positive human breast cancer line line (SKBR-3) kwi-immune-deficient nude mice, kwaye emva kokuba amathumba ekhulile, bondla ezi mpuku zinqunu 250 mg / kg ye-GLE yonke imihla kwaye banika unyango lwe-paclitaxel (PTX) (isitofu emithanjeni) kanye ngeentsuku ezintathu.

Emva kweentsuku ezili-14 zonyango, kwafunyaniswa ukuba xa kuthelekiswa ne-GLE okanye i-paclitaxel yodwa, indibaniselwano yezi zimbini zinefuthe elingcono kakhulu lokuthintela amathumba.

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I-Ganoderma lucidumI-triterpenoids esebenzayo kunye nomgangatho ozinzileyo inceda ukuhlala nomhlaza yonke imihla.

Ezi ziphumo zophando zingentla zibonisa iinzuzo zemithombo ethile yemathiriyeli ekrwada, iindlela ezithile zokutsalwa, kunye nokwakheka okuthe ngqo kweI-Ganoderma lucidumamacandelo e-triterpenoid kwizilwanyana ezithwala ithumba emva kokudlula kwinkqubo yokugaya.Ngenxa yezixhobo zovavanyo zexesha elide ezizinzileyo, abaphandi banokubona iziphumo ezilungileyo zovavanyo kwizilwanyana zovavanyo amaxesha ngamaxesha.

Enyanisweni, i-anti-tumor effect yeI-Ganoderma lucidumI-triterpenoids kudala yaqinisekiswa ngokwesayensi.Ingxaki enkulu kukuba ingaba "I-Ganoderma lucidum” ezikhethwa ngabathengi ngokwenene zinezithako ezisebenzayo zexesha elide.Ngapha koko, igama elithi "I-Ganoderma lucidum” kwibhokisi akuthethi ukuba imveliso mayiqulatheI-Ganoderma lucidumtriterpenoids.Ngapha koko, iimveliso eziphawulwe ngegama elithi "triterpenoids" zinokungavelisi iziphumo zeI-Ganoderma lucidumtriterpenoids.

Ukusebenza okuqinisekisiweyo ngokwesayensi kuvela kwizithako, kwaye izithako zihambelana ngokusondeleyo nenkqubo yokukhutshwa kunye nomthombo wezinto eziluhlaza.Umgangatho ozinzileyo kunye nohambelanayo ufuna ulawulo olusemgangathweni kunye nolawulo kwikhonkco ngalinye ukufezekisa.

Xa le miqathango idibene, kunokwenzeka ukuguqula inzuzo yeI-Ganoderma lucidumi-triterpenoids kwithemba lokuhlala kunye nomhlaza kunye nokuphila nomhlaza ixesha elide.

Iimbekiselo

1.Xiaoxia Wei et al.Uphononongo ngempembelelo ye-antitumor ye-GLA, icandelo le-triterpenoid ye-Ganoderma lucidum, i-in vitro kunye ne-vivo.Journal of Fujian Medical University, 2010, 44 (6): 417-420.
2.Peng et al.Uphononongo lovavanyo malunga nempembelelo ye-antitumor ye-Ganoderma lucidum extract.Ijenali yaseTshayina ye-Modern Applied Pharmacy, 2011, 28 (9): 798-792.
3.Feng Liu et al.Iziphumo ze-Antitumor ze-GLE, i-triterpenoid component ye-Ganoderma lucidum, in vitro kunye ne-vivo.Ijenali yaseTshayina yeZiyobisi eziNtsha, i-2012, i-21 (23): 2790-2793.
4.Zhiqiang Zhang et al.Amacandelo e-Ganoderma lucidum triterpenoid aphucula i-paclitaxel-induced apoptosis ye-HER2+ iiseli zomhlaza wamabele.Ijenali yeYunivesithi yezoNyango yaseFujian, i-2016, i-50 (1): 1-5.

ISIPHELO

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★Eli nqaku lipapashwe phantsi kogunyaziso olulodwa lombhali, kwaye ubunini bobukaGanoHerb.

★Musa ukuphinda uprinte, ukhuphe okanye usebenzise le misebenzi ingasentla ngezinye iindlela ngaphandle kogunyaziso lweGanoHerb.

★Ukuba umsebenzi ugunyazisiwe ukuba usetyenziswe, kufuneka usetyenziswe ngaphakathi kwendawo yokugunyazisa, kwaye umthombo kufuneka uboniswe: GanoHerb.

★I-GanoHerb iya kuphanda kwaye ifake uxanduva olusemthethweni olufanelekileyo kwabo baphula ezi nkcazo zingentla.

★ Umbhalo wokuqala weli nqaku ubhalwe ngesiTshayina nguWu Tingyao waza waguqulelwa kwisiNgesi nguAlfred Liu.Ukuba kukho nakuphi na ukungangqinelani phakathi kwenguqulelo (isiNgesi) kunye neyoqobo (isiTshayina), isiTshayina sokuqala siya koyisa.Ukuba abafundi banayo nayiphi na imibuzo, nceda uqhagamshelane nombhali wokuqala, uNks. Wu Tingyao.

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Ixesha lokuposa: May-25-2022

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