Babban sassan naGanoderma lucidumAbubuwan barasa sune triterpenoid.Ana cewaGanoderma lucidumtriterpenoids suna da tasirin anti-tumor, amma kun san menene ainihin tasirin cutar kansaGanoderma lucidumtriterpenoids suna wasa bayan shiga cikin sashin gastrointestinal?

Tawagar farfesa Jianhua Xu da Farfesa Peng Li daga makarantar koyar da harhada magunguna ta jami'ar kiwon lafiya ta Fujian sun wallafa wasu rahotannin bincike.Yin amfani da jikin 'ya'yan itaceGanoderma lucidumsamar da Fujian Xianzhilou Biological Science and Technology Co., Ltd. a matsayin albarkatun kasa, ta hanyar wani takamaiman ethanol hakar tsari, sun samu biyu sassa naGanoderma lucidumtriterpenoids: GLA da GLE, waɗanda aka ciyar da su ga dabbobin gwaji masu ciwon daji ko ciwace-ciwace don ganin abin da zai faru.

An gano cewa sassan triterpenoid naGanoderma lucidumsuna da aƙalla mahimmancin "hana ci gaban ƙwayar cuta, tsawaita lokacin rayuwa da inganta tasirin cutar sankara".

Rage haɓakar ƙari.

Sakamakon yana da alaƙa da alaƙa da kashi na triterpenoid.

Masu binciken sun fara yin allurar rigakafin ƙwayoyin ƙwayoyin cuta tare da layin ascitic nau'in hepatocellular carcinoma cell (H22) ko layin salula na sarcoma (S180), kuma bayan sa'o'i 24, an ciyar da su tare da ƙananan, matsakaici da manyan allurai (0.5, 1, da 2 g/kg a kowace. rana) na GLA na kwanaki 7 a jere;An ba da ƙungiyar chemotherapy cyclophosphamide (CTX) (30 mg / kg) kowane kwanaki 3;ba a ba kungiyar kulawa ba.

A ranar 8th na gwajin, an kimanta ma'aunin ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar cuta.Sakamakon ya nuna cewa GLA, wani ɓangaren triterpenoid naGanoderma lucidum, mahimmanci ya rage jinkirin ci gaban nau'in ascitic nau'in hepatocellular carcinomas da sarcomas, kuma tasirin yana da alaƙa da daidaituwa tare da kashi.

Ciwon tumor kai tsaye a cikin yanayin da ba shi da kariya

Sakamakon gwajin da ke sama an samu a ƙarƙashin yanayin aikin rigakafi na yau da kullun.Don fahimtar ko hana haɓakar ƙari ta GLA, ɓangaren triterpenoid naGanoderma lucidum, yana da alaƙa da aikin rigakafi, masu binciken sun gudanar da gwaje-gwaje masu zuwa:

Layin kwayar cutar kansar hanji (Colon-26) an shigar da shi cikin ɓeraye tsirara waɗanda aikin garkuwar jikinsu bai yi daidai ba.Bayan da ƙari ya girma, an sake ciyar da matsakaici da manyan allurai na GLA, kuma tasirin hana ƙwayar ƙwayar cuta yana da kyau.

Wannan yana nuna cewa GLA na iya hana ci gaban ƙari kai tsaye, kuma tsarin aikinsa ya bambanta da naGanoderma lucidumpolysaccharides don haɓaka ikon rigakafin ciwon daji na tsarin rigakafi da hana ciwace-ciwacen daji.

Ba wai kawai yana hana ci gaban ƙari ba har ma yana tsawaita rayuwa

Bugu da kari, ta hanyar GLE, waniGanoderma lucidumbangaren triterpene, tawagar Farfesa Jianhua Xu da Farfesa Peng Li su ma sun lura da hakaGanoderma lucidumtriterpenoids ba kawai hana ci gaban ƙari ba amma kuma ya tsawaita lokacin rayuwa na beraye masu ɗauke da ƙari bayan jiyya.

Dangane da rahoton da aka buga, GLE (Cire dagaGanoderma lucidum) wani tsantsa ne wanda aka keɓe kuma an tsarkake shi daga gare shiGanoderma lucidumta Cibiyar Sabbin Magunguna ta Jami'ar Kiwon Lafiya ta Fujian.gram 1 na GLE yayi daidai da gram 93 naGanoderma lucidumdanyen kayan magani, da taGanoderma lucidumTriterpenoid abun ciki shine 56.7%.

Sakamakon gwaji ya nuna cewa idan aka kwatanta da GLA da aka ambata, GLE na iya yin tasiri iri ɗaya na inhibitory akan linzamin kwamfuta na ascitic nau'in hepatocellular carcinomas da sarcomas a ƙananan kashi (kashi ɗaya cikin huɗu na GLA) a ƙarƙashin yanayin gwaji iri ɗaya, kuma duka biyu na iya kaiwa ko wuce su. Makasudin da aka ƙayyade a cikin kimanta ingancin magungunan gargajiya na kasar Sin - yawan hana ƙwayar cuta fiye da 30%.

Gwajin ya kuma gano cewa bayan an daina ba da duk jiyya (GLE ko magungunan chemotherapy ba a sake ba), berayen sarcoma da suka ci GLE na iya rayuwa mai tsawo, kuma lokacin rayuwarsu yana da alaƙa da ƙimar GLE da ta gabata.Daga cikin su, lokacin rayuwa na ƙungiyar GLE mai girma ya ma fi tsayi fiye da na ƙungiyar kulawa mai kyau waɗanda a baya sun sami ilimin chemotherapy.

Bisa ga binciken mai binciken, ko da yake maganin cutar sankara yana da tasirin da zai iya hana ciwace-ciwacen daji, nauyin jikin berayen sarcoma zai shafi kuma gashin su zai zama mafi talauci yayin aikin magani;a daya bangaren kuma, adadin datsewar ƙwayar cuta na rukunin GLE mai girma yana kusa da na chemotherapy.Kuma GLE ba ya haifar da mummunan halayen da magungunan chemotherapeutic ke haifar, kuma yana iya tsawaita lokacin rayuwa, wanda ke nuna cewa abubuwan triterpenoid naGanoderma lucidumsuna da wasu aminci da tasiri, kuma suna da wasu taimako don "inganci" tare da ciwon daji.

Yana iya taimaka chemotherapy da inganta tasirin danne ƙari

Bugu da kari, tawagar Farfesa Peng Li ta kuma gano ta hanyar wani gwajin dabba wanda sassan triterpenoid naGanoderma lucidumzai iya taimakawa magungunan chemotherapy.

Sun fara allurar HER2-positive human nono cell line (SKBR-3) a cikin tsiraicin beraye masu ƙarancin rigakafi, kuma bayan ciwace-ciwacen sun girma, sun ciyar da waɗannan berayen tsirara 250 mg/kg na GLE kowace rana kuma sun ba da maganin paclitaxel (PTX). (alurar riga kafi) sau ɗaya kowane kwana uku.

Bayan kwanaki 14 na jiyya, an gano cewa idan aka kwatanta da GLE ko paclitaxel kadai, haɗin gwiwar biyu yana da tasiri mai mahimmanci na hana ciwace-ciwacen daji.

Ganoderma lucidumtriterpenoids tare da ingantaccen inganci da ingantaccen inganci yana taimakawa tare da ciwon daji kowace rana.

Sakamakon binciken da ke sama yana nuna fa'idodin ƙayyadaddun tushen kayan albarkatun ƙasa, takamaiman hanyoyin cirewa, da takamaiman abun da ke cikiGanoderma lucidumabubuwan triterpenoid zuwa dabbobi masu ɗauke da ƙari bayan wucewa ta tsarin narkewar abinci.Godiya ga ingantaccen kayan gwaji na dogon lokaci, masu bincike na iya ganin kyakkyawan sakamako na gwaji a cikin dabbobin gwaji sau da yawa.

A gaskiya ma, da anti-tumor sakamako naGanoderma lucidumtriterpenoids an dade da tabbatar da kimiyya.Babban matsalar ita ce ko "Ganoderma lucidum"Waɗanda masu amfani za su zaɓa da gaske suna da irin waɗannan abubuwan da ke aiki na dogon lokaci.Bayan haka, kalmar "Ganoderma lucidum” akan akwatin baya nufin cewa dole ne samfurin ya ƙunshiGanoderma lucidumtriterpenoids.Haka kuma, samfuran da aka yiwa alama da kalmar "triterpenoids" na iya haifar da tasirinGanoderma lucidumtriterpenoids.

Tabbacin da aka tabbatar a kimiyyance ya fito ne daga sinadarai, kuma sinadaran suna da alaƙa da tsarin hakowa da tushen albarkatun ƙasa.Tsayayyen inganci da daidaito yana buƙatar daidaitaccen gudanarwa da sarrafawa a cikin kowane hanyar haɗi don cimma.

Lokacin da waɗannan sharuɗɗan suka cika, yana yiwuwa a canza fa'idodinGanoderma lucidumtriterpenoids a cikin bege na kasancewa tare da ciwon daji da kuma rayuwa tare da ciwon daji na dogon lokaci.

Magana

1.Xiaoxia Wei et al.Nazarin kan tasirin antitumor na GLA, wani ɓangaren triterpenoid na Ganoderma lucidum, in vitro da in vivo.Jaridar Fujian Medical University, 2010, 44 (6): 417-420.
2. Peng et al.Nazarin gwaji akan tasirin antitumor na Ganoderma lucidum tsantsa.Jaridar Sinanci na kantin magani na zamani, 2011, 28 (9): 798-792.
3.Feng Liu et al.Sakamakon Antitumor na GLE, wani ɓangaren triterpenoid na Ganoderma lucidum, in vitro da in vivo.Jaridar Sinawa ta Sabbin Magunguna, 2012, 21 (23): 2790-2793.
4.Zhiqiang Zhang et al.Ganoderma lucidum triterpenoid abubuwan haɓaka haɓaka apoptosis mai haifar da paclitaxel na ƙwayoyin cutar kansar nono HER2+.Jaridar Fujian Medical University, 2016, 50 (1): 1-5.

KARSHE

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