Ibice nyamukuru bigizeGanoderma lucidumibinyobwa bisindisha ni triterpenoide.Bivugwa koGanoderma lucidumtriterpenoide igira ingaruka zo kurwanya ibibyimba, ariko uzi ingaruka nyazo zo kurwanya ibibyimba zishoboraGanoderma lucidumtriterpenoide ikina nyuma yo kwinjira mu nzira ya gastrointestinal?

Itsinda rya Porofeseri Jianhua Xu na Porofeseri Peng Li bo mu Ishuri rya Farumasi rya kaminuza y’ubuvuzi ya Fujian basohoye raporo z’ubushakashatsi.Gukoresha imibiri yera yaGanoderma lucidumyatanzwe na Fujian Xianzhilou Biologiya Science and Technology Co., Ltd. nkibikoresho fatizo, binyuze muburyo bwihariye bwo gukuramo Ethanol, babonye ibice bibiri byaGanoderma lucidumtriterpenoids: GLA na GLE, zagaburiwe inyamaswa zigerageza zifite kanseri ya kanseri cyangwa ibibyimba kugirango turebe uko bizagenda.

Byagaragaye ko ibice bya triterpenoid yaGanoderma lucidumbyibuze bifite akamaro ko "kubuza gukura kw'ibibyimba, kongera igihe cyo kubaho no kunoza imikorere ya chimiotherapie".

Gutinda gukura kw'ikibyimba.

Ingaruka zifitanye isano neza nigipimo cya triterpenoide.

Abashakashatsi babanje gutera inshinge imbeba zifite ubwoko bwa hepatocellular carcinoma selile (H22) cyangwa umurongo wa selile sarcoma (S180), nyuma yamasaha 24, bagaburiwe na dosiye nkeya, ziciriritse kandi ndende (0.5, 1, na 2 g / kg kuri buri umunsi) wa GLA iminsi 7 ikurikiranye;itsinda rya chimiotherapie ryahawe cyclophosphamide (CTX) (30 mg / kg) buri minsi 3;itsinda rishinzwe kugenzura ntiryigeze rivurwa.

Ku munsi wa 8 wubushakashatsi, hasuzumwe uburemere bwibibyimba byimbeba muri buri tsinda.Ibisubizo byerekanaga ko GLA, igice cya triterpenoid yaGanoderma lucidum, byadindije cyane imikurire yubwoko bwa hepatocellular kanseri na sarcomas, kandi ingaruka zari zifitanye isano neza na dose.

Kurwanya ibibyimba bitaziguye mubihe bidakingiwe

Ibisubizo byubushakashatsi byavuzwe haruguru byabonetse muburyo bwimikorere isanzwe yumubiri.Kugirango twumve niba kubuza gukura kwikibyimba na GLA, igice cya triterpenoid yaGanoderma lucidum, bifitanye isano n'imikorere yubudahangarwa, abashakashatsi bakoze ubushakashatsi bukurikira:

Umurongo wa kanseri y'urura runini (Colon-26) watewe mu mbeba zambaye ubusa zidafite ubudahangarwa bw'umubiri.Ikibyimba kimaze gukura, ikigereranyo giciriritse kandi kinini cya GLA cyongeye kugaburirwa, kandi ingaruka zo guhagarika ikibyimba zari nziza cyane.

Ibi birerekana ko GLA ishobora guhagarika byimazeyo gukura kwikibyimba, kandi uburyo bwibikorwa bitandukanye nubwaGanoderma lucidumpolysaccharide kugirango yongere ubushobozi bwo kurwanya kanseri yubudahangarwa bw'umubiri no guhagarika ibibyimba.

Ntabwo ibuza ikibyimba gusa ahubwo inongerera ubuzima

Byongeyeho, binyuze muri GLE, undiGanoderma lucidumigice cya triterpene, itsinda rya Prof. Jianhua Xu na Prof. Peng Li nabo babibonyeGanoderma lucidumtriterpenoide ntabwo yabujije gukura kwikibyimba gusa ahubwo yanongereye igihe cyo kubaho kwimbeba zifite ibibyimba nyuma yo kuvurwa.

Ukurikije raporo yasohotse, GLE (GukuramoGanoderma lucidum) ni igice cyitaruye kandi cyezwa kuvaGanoderma lucidumn'Ikigo gishinzwe Ubuvuzi bushya bwa kaminuza y'ubuvuzi ya Fujian.Garama 1 ya GLE ihwanye na garama 93 zaGanoderma lucidumibikoresho by'imiti mbisi, hamwe na byoGanoderma lucidumibirimo triterpenoid ni 56.7%.

Ibisubizo byubushakashatsi byerekana ko ugereranije na GLA yavuzwe haruguru, GLE irashobora kugira ingaruka nziza cyane yo kubuza imbeba ubwoko bwa kanseri ya hepatocellular kanseri na sarcomasi kumupanga muto (kimwe cya kane cya GLA) mubihe bimwe byubushakashatsi, kandi byombi birashobora kugera cyangwa kurenga intego igaragara mugusuzuma imikorere yubuvuzi gakondo bwubushinwa - igipimo cyo kubuza ibibyimba kurenga 30%.

Ubushakashatsi bwagaragaje kandi ko nyuma y’uko imiti yose ihagaritswe (imiti ya GLE cyangwa imiti ya chimiotherapie itagitangwa), imbeba za sarcoma zahoze zirya GLE zishobora kubaho igihe kirekire, kandi igihe cyo kubaho cyazo kikaba cyari gifitanye isano neza n’ibipimo byabanjirije GLE.Muri bo, igihe cyo kubaho kwitsinda ryinshi rya GLE ryabaye ndende cyane ugereranije n’itsinda rishinzwe kugenzura neza bari barahawe imiti ya chimiotherapie.

Nk’uko umushakashatsi abibona, nubwo chimiotherapie igira ingaruka zigaragara zo guhagarika ibibyimba, uburemere bwumubiri wimbeba za sarcoma bizagira ingaruka kandi ubwoya bwazo nabwo buzabe ubukene mugihe cyo gufata imiti;kurundi ruhande, igipimo cyo guhagarika ikibyimba cyitsinda ryinshi rya GLE ryegereye irya chimiotherapie.Kandi GLE ntabwo itanga ingaruka mbi ziterwa n'imiti ya chimiotherapeutique, kandi irashobora kandi kongera igihe cyo kubaho, cyerekana ko ibice bya triterpenoid bigizeGanoderma lucidumkugira umutekano ningirakamaro, kandi ufite ubufasha runaka kubana "ubuziranenge" kubana na kanseri.

Irashobora gufasha chimiotherapie no kunoza ingaruka zo guhagarika ibibyimba

Byongeye kandi, itsinda rya Porofeseri Peng Li ryasanze kandi mu bundi bushakashatsi bw’inyamaswa ibice bya triterpenoid bigizeGanoderma lucidumirashobora gufasha imiti ya chimiotherapie.

Babanje gukingira HER2-nziza ya kanseri y'ibere ya kanseri y'ibere (SKBR-3) mu mbeba zambaye ubusa zidafite ubudahangarwa, hanyuma ibibyimba bimaze gukura, bagaburira izo mbeba zambaye ubusa mg / kg 250 za GLE buri munsi kandi batanga paclitaxel (PTX) (inshinge zinjira) rimwe muminsi itatu.

Nyuma yiminsi 14 yo kuvurwa, byagaragaye ko ugereranije na GLE cyangwa paclitaxel yonyine, guhuza byombi byagize ingaruka nziza cyane yo kubuza ibibyimba.

Ganoderma lucidumtriterpenoide hamwe nibikorwa byiza kandi bifite ireme bifasha kubana na kanseri burimunsi.

Ibisubizo byubushakashatsi byavuzwe haruguru byerekana inyungu ziva mubikoresho fatizo byihariye, uburyo bwihariye bwo kuvoma, hamwe nibigize byihariyeGanoderma lucidumibice bya triterpenoid kubinyamaswa zifite ibibyimba nyuma yo kunyura muri sisitemu yo kurya.Bitewe nibikoresho birebire byigihe kirekire byubushakashatsi, abashakashatsi barashobora kubona ibisubizo byiza byubushakashatsi ku nyamaswa zigerageza inshuro nyinshi.

Mubyukuri, ingaruka zo kurwanya ibibyimba byaGanoderma lucidumtriterpenoide kuva kera byemejwe mubuhanga.Ikibazo nyamukuru ni ukumenya niba “Ganoderma lucidum”Ko abaguzi bahitamo mubyukuri bifite ibintu bifatika mugihe kirekire.Nakare, ijambo “Ganoderma lucidum”Ku gasanduku ntabwo bivuze ko ibicuruzwa bigomba kubamoGanoderma lucidumtriterpenoids.Byongeye kandi, ibicuruzwa byaranzwe nijambo "triterpenoids" ntibishobora gutanga ingaruka zaGanoderma lucidumtriterpenoids.

Ubuhanga bugaragazwa na siyansi buva mubigize, kandi ibiyigize bifitanye isano rya bugufi nuburyo bwo kuvoma ninkomoko yibikoresho fatizo.Ubwiza buhamye kandi buhoraho busaba imiyoborere nubugenzuzi bisanzwe muri buri murongo kugirango ubigereho.

Iyo ibi bisabwa byujujwe, birashoboka guhindura inyungu zaGanoderma lucidumtriterpenoide mu byiringiro byo kubana na kanseri no kubaho hamwe na kanseri igihe kirekire.

Reba

1.Xiaoxia Wei n'abandi.Kwiga ku ngaruka zirwanya GLA, igice cya triterpenoid ya Ganoderma lucidum, muri vitro no muri vivo.Ikinyamakuru cya kaminuza yubuvuzi ya Fujian, 2010, 44 (6): 417-420.
2.Peng n'abandi.Ubushakashatsi bwubushakashatsi ku ngaruka za antitumor ziva muri Ganoderma lucidum.Ikinyamakuru cyo mu Bushinwa cya Farumasi igezweho ikoreshwa, 2011, 28 (9): 798-792.
3.Feng Liu n'abandi.Ingaruka zirwanya GLE, igice cya triterpenoid ya Ganoderma lucidum, muri vitro no muri vivo.Ikinyamakuru cyo mu Bushinwa cy’ibiyobyabwenge bishya, 2012, 21 (23): 2790-2793.
4.Zhiqiang Zhang n'abandi.Ganoderma lucidum triterpenoid ibice byongera paclitaxel iterwa na apoptose ya HER2 + kanseri yamabere.Ikinyamakuru cya kaminuza yubuvuzi ya Fujian, 2016, 50 (1): 1-5.

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Text Umwandiko wumwimerere wiyi ngingo wanditswe mu gishinwa na Wu Tingyao uhindurwa mu cyongereza na Alfred Liu.Niba hari itandukaniro riri hagati yubuhinduzi (icyongereza) numwimerere (igishinwa), igishinwa cyumwimerere kizatsinda.Niba abasomyi bafite ikibazo, nyamuneka hamagara umwanditsi wambere, Madamu Wu Tingyao.

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