I-Indiya: I-GLAQ ikhusela i-hypobaric hypoxia ebangela ukusilela kwememori

Ngomhla wesi-2 kuJuni, 2020/Iziko loKhuselo leFiziyoloji kunye neNzululwazi eManyanisiweyo (eIndiya)/iNgxelo zeNzululwazi

Umbhalo/Wu Tingyao

Okukhona umphakamo uphezulu, kokukhona usezantsi uxinzelelo lomoya, kokukhona kuncipha ioksijini, kokukhona kuchaphazeleka ngakumbi ukusebenza kwempilo yendalo, kokukhona kunokwenzeka ukuba kubangele imingcipheko yempilo eyahlukeneyo eyaziwa ngokubaisifo sobude.

Le mingcipheko yempilo inokuba yintloko nje, isiyezi, isicaphucaphu, ukuhlanza, ukudinwa kunye nezinye izinto ezingathandekiyo, kwaye zinokukhula zibe yi-edema ye-cerebral echaphazela ukuqonda, iimoto, kunye nemisebenzi yengqondo, okanye i-pulmonary edema echaphazela umsebenzi wokuphefumla.Imbi kangakanani le meko?Ukuba inokuphila ngokuthe ngcembe emva kokuphumla okanye ukuba iya kuba mbi kakhulu ibe ngumonakalo ongenakulungiseka okanye ibe yingozi ebomini kuxhomekeke kumandla weeseli zethishu emzimbeni ukuhlengahlengisa utshintsho kuxinzelelo lweoksijini yangaphandle.

Ukwenzeka kunye nobuzaza besigulo sokuphakama kokuphakama kuyahluka kumntu nomntu, yaye ichaphazeleka kakhulu kukuba sempilweni komntu.Ngokomgaqo, ukuphakama ngaphezu kwe-1,500 yeemitha (ubude obuphakathi) kuya kuqala ukuchaphazela umzimba womntu;nabani na oquka abantu abadala abanempilo ngokukhawuleza bafikelela kwindawo ephakamileyo ye-2,500 yeemitha okanye ngaphezulu (ukuphakama okuphezulu) ngaphambi kokuba umzimba ulungelelanise ulungele iingxaki.

Enoba kukucwangcisa ngocoselelo iindawo eziphakamileyo okanye ukusebenzisa amayeza okuthintela ngaphambi kokuba uhambe, injongo kukuphucula ukuguquguquka komzimba nokuthintela ukubakho kokugula kwindawo ephakamileyo.Kodwa enyanisweni, kukho enye inketho, ethathayoI-Ganoderma lucidum.

Ngokophononongo olupapashwe nguIziko loKhuselo lePhysiology kunye neSayensi eManyano (DIPAS)ngoJuni 2020 kwiiNgxelo zeNzululwazi, kwafunyaniswa ukubaI-Ganoderma lucidumi-aqueous extract (GLAQ) inokunciphisa umonakalo we-hypobaric hypoxia kwi-nerve cranial kunye nokugcina imisebenzi yokuqonda ehambelana nememori yendawo.

Imaze yamanzi - indlela elungileyo yokuvavanya isakhono sokukhumbula iimpuku

Ngaphambi kokuba uvavanyo luqale, abaphandi bachitha iintsuku ezimbalwa beqeqesha iimpuku ukuba bafumane iqonga elifihliweyo elingaphantsi kwamanzi.(Umfanekiso 1).

Iimpuku zikwazi ukuqubha, kodwa aziwathandi amanzi, ngoko ziya kuzama ukufumana indawo yokuphepha amanzi.

Ngokutsho kwerekhodi lokubhukuda kwi-Figure 2, kunokufunyanwa ukuba iigundane zifumene iqonga ngokukhawuleza kwaye ngokukhawuleza ukusuka ekujikelezeni amaxesha amaninzi ngosuku lokuqala ukuya kumgca ochanekileyo ngosuku lwesithandathu (ekunene kwesithathu kwi-Figure 2), ebonisa ukuba iyakwazi ukukhumbula indawo.

Emva kokuba iqonga lisusiwe, indlela yokuqubha yeempuku yayigxile kwindawo elikuyo iqonga (ilungelo lokuqala kuMzobo wesi-2), nto leyo ebonisa ukuba impuku yayinenkumbulo ecacileyo yendawo elikuyo iqonga.

I-Ganoderma luciduminciphisa imiphumo ye-hypobaric hypoxia kwimemori yendawo

Ezi mpuku ziqeqeshiweyo zohlulwe zangamaqela amabini.Elinye iqela laqhubeka lihlala kwindawo enoxinzelelo oluqhelekileyo lomoya kunye neoksijini njengeqela lokulawula (Lawula) ngelixa elinye iqela lithunyelwa kwigumbi eliphantsi loxinzelelo ukuze lilinganise ukuphila kwindawo ephakamileyo yeenyawo ze-25,000 okanye malunga neemitha ze-7620. kwindawo ye-hypobaric hypoxia (HH).

Kwiimpuku ezithunyelwe kwigumbi loxinzelelo oluphantsi, enye inxalenye yazo yondliwa ngesicatshulwa esimanzi seI-Ganoderma lucidum(GLAQ) kwi-dose yemihla ngemihla ye-100, i-200, okanye i-400 mg / kg (HH + GLAQ 100, i-200, okanye i-400) ngelixa enye inxalenye yabo yayingondliwaI-Ganoderma lucidum(iqela le-HH) njengeqela lolawulo.

Olu lingelo lwathatha iveki.Ngosuku olusemva kokuphela kovavanyo, amaqela amahlanu eempuku afakwa kwimaze yamanzi ukuze abone ukuba ayakhumbula na ukuma kweqonga.Isiphumo siboniswe kuMfanekiso 3:

Iqela lolawulo (Ulawulo) lisakhumbula indawo yeqonga ngokucacileyo kwaye linokufumana iqonga ngokukhawuleza;ikhono lokukhumbula i-low-pressure room rats (HH) liphazamiseke kakhulu, kwaye ixesha labo lokufumana iqonga laliphindwe kabini kwiqela lolawulo.Kodwa nokuhlala kwindawo ephantsi-oksijini yegumbi elinoxinzelelo oluphantsi, iigundane ezitye i-GLAQ zinenkumbulo engcono kakhulu yeqonga, kwaye ngakumbi.I-Ganoderma lucidumbadla, ixesha elichithwe likufutshane nelo qela lolawulo eliqhelekileyo.

I-Ganoderma luciduminciphisa imiphumo ye-hypobaric hypoxia kwimemori yendawo

Ezi mpuku ziqeqeshiweyo zohlulwe zangamaqela amabini.Elinye iqela laqhubeka lihlala kwindawo enoxinzelelo oluqhelekileyo lomoya kunye neoksijini njengeqela lokulawula (Lawula) ngelixa elinye iqela lithunyelwa kwigumbi eliphantsi loxinzelelo ukuze lilinganise ukuphila kwindawo ephakamileyo yeenyawo ze-25,000 okanye malunga neemitha ze-7620. kwindawo ye-hypobaric hypoxia (HH).

Kwiimpuku ezithunyelwe kwigumbi loxinzelelo oluphantsi, enye inxalenye yazo yondliwa ngesicatshulwa esimanzi seI-Ganoderma lucidum(GLAQ) kwi-dose yemihla ngemihla ye-100, i-200, okanye i-400 mg / kg (HH + GLAQ 100, i-200, okanye i-400) ngelixa enye inxalenye yabo yayingondliwaI-Ganoderma lucidum(iqela le-HH) njengeqela lolawulo.

Olu lingelo lwathatha iveki.Ngosuku olusemva kokuphela kovavanyo, amaqela amahlanu eempuku afakwa kwimaze yamanzi ukuze abone ukuba ayakhumbula na ukuma kweqonga.Isiphumo siboniswe kuMfanekiso 3:

Iqela lolawulo (Ulawulo) lisakhumbula indawo yeqonga ngokucacileyo kwaye linokufumana iqonga ngokukhawuleza;ikhono lokukhumbula i-low-pressure room rats (HH) liphazamiseke kakhulu, kwaye ixesha labo lokufumana iqonga laliphindwe kabini kwiqela lolawulo.Kodwa nokuhlala kwindawo ephantsi-oksijini yegumbi elinoxinzelelo oluphantsi, iigundane ezitye i-GLAQ zinenkumbulo engcono kakhulu yeqonga, kwaye ngakumbi.I-Ganoderma lucidumbadla, ixesha elichithwe likufutshane nelo qela lolawulo eliqhelekileyo.

I-Ganoderma lucidumikhusela ingqondo kwaye inciphisa i-edema yobuchopho kunye nomonakalo we-hippocampal gyrus.

Iziphumo zovavanyo ezingentla zibonisa ukubaI-Ganoderma lucidumngenene inokunciphisa ingxaki yenkumbulo yendawo ebangelwa yi-hypobaric hypoxia.Umsebenzi wememori yimbonakaliso yokuba isakhiwo kunye nokusebenza kwengqondo kuyinto eqhelekileyo.Ke ngoko, abaphandi baqhubeka basasaza kwaye bahlalutya izicubu zobuchopho zeegundane zovavanyo, kwaye bafumanisa ukuba:

I-Hypobaric hypoxia inokubangela i-angioedema (ukwanda kokungena kwe-capillaries kuvumela ulwelo oluninzi ukuba luvuze kwimithambo yegazi kwaye luqokelele kwiindawo ezidibeneyo zobuchopho) kunye ne-hippocampal gyrus (ejongene nokwakhiwa kwememori) umonakalo, kodwa ezi ngxaki zikhululeka kakhulu. kwiimpuku ezondliwa nge-GLAQ kwangaphambili (Umfanekiso 5 kunye no-6), ebonisa ukubaI-Ganoderma luciduminefuthe lokukhusela ingqondo.

Inkqubo yeI-Ganoderma lucidumngokuchasene ne-hypoxia ye-hypobaric

Kutheni iI-Ganoderma lucidumisicatshulwa esinamanzi sinokumelana nomonakalo obangelwa yi-hypobaric hypoxia?Iziphumo zengxoxo enzulu ngakumbi zishwankathelwe kuMzobo 7. Kukho iindlela ezimbini ngokubanzi:

Ngakolunye uhlangothi, impendulo yomzimba xa uqhelana ne-hypobaric hypoxia iya kulungelelaniswa ngokukhawuleza nangcono ngenxa yokungenelelaI-Ganoderma lucidum;kwelinye icala,I-Ganoderma luciduminokulawula ngokuthe ngqo iimolekyuli ezinxulumeneyo kwiiseli zemithambo-luvo yengqondo ngokuchasa i-oxidation kunye nokuchasana nokudumba, ukugcina ioksijini engaguqukiyo emzimbeni, ukulungelelanisa imijikelezo yemithambo-luvo, kunye nokugcina ukuhanjiswa kwemithambo-luvo egudileyo ukukhusela izicubu zemithambo-luvo kunye nokukwazi ukukhumbula.

Kwixesha elidlulileyo, izifundo ezininzi ziye zabonisa ukubaI-Ganoderma luciduminokukhusela imithambo-luvo yobuchopho kwiinkalo ezahlukeneyo ezifana nesifo sika-Alzheimer, isifo sikaParkinson, ukuxhuzula, i-vascular embolism, ukwenzakala ngengozi kwengqondo, kunye nokwaluphala.Ngoku olu phando luvela eIndiya longeza obunye ubungqinaI-Ganoderma lucidum"Ubulumko obuphuculweyo kunye nenkumbulo" kwimbono yokuphakama okuphezulu, uxinzelelo oluphantsi kunye neoksijini ephantsi.

Ngokukodwa, iyunithi yophando iZiko lezoKhuselo lePhysiology & Allied Sciences (DIPAS) lidibene noMbutho woPhando lwezoKhuselo noPhuhliso lweSizwe (DRDO) loMphathiswa wezoKhuselo waseIndiya.Yenze uphando olunzulu kwinkalo ye-physiology yokuphakama okuphezulu ixesha elide.Indlela yokuphucula ukuguquguquka kwamajoni kunye nokulwa nokusebenza kwiindawo eziphakamileyo eziphakamileyo kunye noxinzelelo bekusoloko kugxininisekile kwingqalelo yayo.Oku kwenza iziphumo zolu phando zibe nentsingiselo ngakumbi.

Izithako ezisebenzayo eziqulethwe kwiI-Ganoderma lucidumI-aqueous extract ye-GLAQ esetyenziswe kolu phononongo ibandakanya i-polysaccharides, i-phenols, i-flavonoids, kunye ne-ganoderic acid A. Ngaphambi kokupapasha olu pho nonongo, umphandi wenze uvavanyo lwe-90-day subchronic toxicity yesicatshulwa kwaye waqinisekisa ukuba nangona umthamo wayo uphezulu njenge-1000. mg / kg, ayiyi kuba nefuthe elibi kwizicubu, izitho kunye nokukhula kweegundane.Ke ngoko, idosi esebenzayo encinci ye-200 mg/kg kolu vavanyo lungentla ngokucacileyo ikhuselekile.

Kuphela xa ulungele ngokupheleleyo unokuyonwabela ubumnandi bokukhwela kwaye ufumane umnxeba wokuba usondele kwi-skyline.Ukuba ukhuselekileI-Ganoderma lucidumukukuvuyisa, kufuneka ukwazi ukuqaphela iminqweno yakho ngokukhuselekileyo.

[Umthombo]

1. Purva Sharma, Rajkumar Tulsawani.I-Ganoderma lucidumisicatshulwa esinamanzi sithintela i-hypobaric hypoxia ebangela ukusilela kwememori ngokumodulating neurotransmission, neuroplasticity kunye nokugcina i-redox homeostasis.Sci Rep. 2020;10: 8944. Ipapashwe kwi-intanethi ye-2020 Jun 2.

2. Purva Sharma, et al.Iziphumo Pharmacological ofI-Ganoderma lucidumisicatshulwa ngokuchasene nezixinzelelo zokuphakama okuphezulu kunye novavanyo lwayo lwetyhefu engaphantsi.J Ukutya kwe-Biochem.2019 Dec;43(12):e13081.

ISIPHELO

Malunga nombhali/ Nksz. Wu Tingyao

UWu Tingyao unike ingxelo ngolwazi lweGanoderma lokuqala ukusukela ngo-1999. Ungumbhali wencwadiUkunyanga ngeGanoderma(ipapashwe kwiNdlu yePeople's Medical Publishing House ngo-Epreli 2017).

★ Eli nqaku lipapashwe phantsi kogunyaziso olulodwa lombhali.★ Le misebenzi ingasentla ayinakuphinda iveliswe, icatshulwe okanye isetyenziswe ngezinye iindlela ngaphandle kokugunyaziswa ngumbhali.★ Ukwaphulwa kwengxelo engentla, umbhali uya kulandela uxanduva olusemthethweni olufanelekileyo.★ Umbhalo wokuqala weli nqaku ubhalwe ngesiTshayina nguWu Tingyao waza waguqulelwa kwisiNgesi nguAlfred Liu.Ukuba kukho nakuphi na ukungangqinelani phakathi kwenguqulelo (isiNgesi) kunye neyoqobo (isiTshayina), isiTshayina sokuqala siya koyisa.Ukuba abafundi banayo nayiphi na imibuzo, nceda uqhagamshelane nombhali wokuqala, uNks. Wu Tingyao.