India: GLAQ na-egbochi hypobaric hypoxia butere deficit ebe nchekwa

June 2, 2020/Ụlọ Ọrụ Nchebe nke Physiology & Sciences Allied (India)/Akụkọ Sayensị

Ederede/Wu Tingyao

Ka elu dị elu, ka ikuku ikuku na-ebelata, ka ikuku oxygen na-emewanyewanye, otú ahụ ka ọ na-emetụta ọrụ nke physiological, otú ahụ ka ọ na-ebute ihe ize ndụ ahụike dị iche iche nke a na-akpọkarị dị ka.elu ọrịa.

Ihe ize ndụ ahụike ndị a nwere ike ịbụ naanị isi ọwụwa, dizziness, ọgbụgbọ, ọgbụgbọ, ike ọgwụgwụ na ahụ erughị ala ndị ọzọ, ha nwekwara ike ịmalite n'ime ụbụrụ ụbụrụ nke na-emetụta cognition, moto, na ọrụ nsụhọ, ma ọ bụ pulmonary edema nke na-emetụta ọrụ iku ume.Olee otú ọnọdụ ahụ dịruru ná njọ?Ma ọ nwere ike jiri nwayọọ nwayọọ gbakee ma ọ gbakechara ma ọ bụ na ọ ga-akawanye njọ na mmebi a na-apụghị ịgbagha agbagha ma ọ bụ ọbụna bụrụ ihe na-eyi ndụ egwu na-adabere n'ikike nke mkpụrụ ndụ anụ ahụ dị n'ime ahụ iji gbanwee n'ime mgbanwe nke ikuku oxygen.

Ihe omume na ogo ọrịa elu dị iche iche dị iche iche site na mmadụ gaa na onye, na ọ kacha emetụta ahụ ike ahụ nke onye ahụ.Na ụkpụrụ, elu n'elu 1,500 mita (ọkara elu) ga-amalite imetụta ahụ mmadụ;onye ọ bụla gụnyere ndị toro eto nwere ahụike nke ji ngwa ngwa rute elu nke mita 2,500 ma ọ bụ karịa (elu elu) tupu ahụ agbanwee na-enwekarị nsogbu.

Ma ọ bụ iji nlezianya mee atụmatụ maka ịrị elu ugwu ma ọ bụ ịṅụ ọgwụ mgbochi tupu ịpụ apụ, ebumnuche ya bụ imeziwanye mgbanwe nke ahụ na igbochi ọnọdụ nke ọrịa elu.Mana n'ezie, enwere nhọrọ ọzọ, nke na-ewereGanoderma lucidum.

Dị ka nnyocha e bipụtara si kwuoỤlọ ọrụ Defence of Physiology and Allied Sciences (DIPAS)na June 2020 na Akụkọ Sayensị, achọpụtara naGanoderma lucidumAqueous wepụ (GLAQ) nwere ike ibelata mmebi nke hypobaric hypoxia na akwara cranial ma nọgide na-arụ ọrụ ọgụgụ isi metụtara ebe nchekwa oghere.

Mmiri mmiri - ụzọ dị mma iji nwalee ikike nchekwa nke oke

Tupu nnwale ahụ amalite, ndị nchọpụta ahụ nọrọ ụbọchị ole na ole na-azụ ụmụ oke ka ha chọta ebe zoro ezo nke dị n'okpuru mmiri.(Foto nke 1).

Oke dị mma n'egwu mmiri, mana mmiri anaghị amasị ha, yabụ na ha ga-agbalị ịchọta ebe ha ga-ezere mmiri.

Dị ka ihe ndekọ nke igwu mmiri na Figure 2, enwere ike ịhụ na oke ahụ chọtara ikpo okwu ngwa ngwa na ngwa ngwa site na ịgagharị ọtụtụ ugboro n'ụbọchị mbụ ruo n'ahịrị kwụ ọtọ n'ụbọchị nke isii (n'aka nri nke atọ na Figure 2), na-egosi na. ọ nwere ikike ebe nchekwa dị mma.

Mgbe e wepụrụ ikpo okwu ahụ, ụzọ igwu mmiri nke oke ahụ gbadoro ụkwụ na mpaghara ebe ikpo okwu dị (nri nke mbụ na Figure 2), na-egosi na oke ahụ nwere ebe nchekwa doro anya ebe ikpo okwu dị.

Ganoderma lucidumna-ebelata mmetụta nke hypobaric hypoxia na ebe nchekwa oghere

E kewara oke ndị a zụrụ azụ ụzọ abụọ.Otu otu gara n'ihu na-ebi na gburugburu ebe ikuku ikuku na ikuku oxygen dị ka ndị na-ahụ maka njikwa (Control) ebe ndị ọzọ na-ezigara n'ime ụlọ nrụgide dị ala iji mee ka ndụ dị elu dị elu nke 25,000 feet ma ọ bụ ihe dị ka mita 7620. na gburugburu ebe obibi nke hypobaric hypoxia (HH).

N'ihi na oke ezigara na ala-nrụgide ụlọ, otu akụkụ nke ha na-nri na aqueous wepụ nkeGanoderma lucidum(GLAQ) na dose kwa ụbọchị nke 100, 200, ma ọ bụ 400 mg / kg (HH+GLAQ 100, 200, ma ọ bụ 400) ebe akụkụ nke ọzọ n'ime ha anaghị eri nri.Ganoderma lucidum(HH otu) dị ka otu njikwa.

Nnwale a were otu izu.Ụbọchị mgbe nnwale ahụ kwụsịrị, a na-etinye ìgwè ise nke oke n'ime mmiri mmiri iji mara ma ha chetara ọnọdụ nke ikpo okwu.E gosipụtara nsonaazụ ya na eserese 3:

Otu njikwa (Control) ka na-echeta ebe ikpo okwu n'ụzọ doro anya ma nwee ike ịchọta ikpo okwu ozugbo;ikike nchekwa nke obere ụlọ oke ọkụ (HH) na-emebi nke ọma, na oge ha ịchọta ikpo okwu karịrị okpukpu abụọ nke otu njikwa.Mana na-ebikwa na gburugburu ikuku oxygen dị ala nke ụlọ obere nrụgide, oke ndị riri GLAQ nwere ebe nchekwa dị mma nke ukwuu, yana ndị ọzọ.Ganoderma lucidumha riri nri, oge ejiri dị nso na nke otu ndị na-achịkwa nkịtị.

Ganoderma lucidumna-ebelata mmetụta nke hypobaric hypoxia na ebe nchekwa oghere

E kewara oke ndị a zụrụ azụ ụzọ abụọ.Otu otu gara n'ihu na-ebi na gburugburu ebe ikuku ikuku na ikuku oxygen dị ka ndị na-ahụ maka njikwa (Control) ebe ndị ọzọ na-ezigara n'ime ụlọ nrụgide dị ala iji mee ka ndụ dị elu dị elu nke 25,000 feet ma ọ bụ ihe dị ka mita 7620. na gburugburu ebe obibi nke hypobaric hypoxia (HH).

N'ihi na oke ezigara na ala-nrụgide ụlọ, otu akụkụ nke ha na-nri na aqueous wepụ nkeGanoderma lucidum(GLAQ) na dose kwa ụbọchị nke 100, 200, ma ọ bụ 400 mg / kg (HH+GLAQ 100, 200, ma ọ bụ 400) ebe akụkụ nke ọzọ n'ime ha anaghị eri nri.Ganoderma lucidum(HH otu) dị ka otu njikwa.

Nnwale a were otu izu.Ụbọchị mgbe nnwale ahụ kwụsịrị, a na-etinye ìgwè ise nke oke n'ime mmiri mmiri iji mara ma ha chetara ọnọdụ nke ikpo okwu.E gosipụtara nsonaazụ ya na eserese 3:

Otu njikwa (Control) ka na-echeta ebe ikpo okwu n'ụzọ doro anya ma nwee ike ịchọta ikpo okwu ozugbo;ikike nchekwa nke obere ụlọ oke ọkụ (HH) na-emebi nke ọma, na oge ha ịchọta ikpo okwu karịrị okpukpu abụọ nke otu njikwa.Mana na-ebikwa na gburugburu ikuku oxygen dị ala nke ụlọ obere nrụgide, oke ndị riri GLAQ nwere ebe nchekwa dị mma nke ukwuu, yana ndị ọzọ.Ganoderma lucidumha riri nri, oge ejiri dị nso na nke otu ndị na-achịkwa nkịtị.

Ganoderma lucidumna-echebe ụbụrụ ma na-ebelata edema ụbụrụ na mmebi gyrus hippocampal.

Nsonaazụ nnwale a dị n'elu gosiri naGanoderma lucidumN'ezie nwere ike ibelata nsogbu ebe nchekwa oghere nke hypobaric hypoxia kpatara.Ọrụ ebe nchekwa bụ ngosipụta nke ma nhazi na ọrụ nke ụbụrụ ọ bụ ihe nkịtị.Ya mere, ndị nchọpụta gara n'ihu gbasaa ma nyochaa ụbụrụ ụbụrụ nke oke nnwale, wee chọpụta na:

Hypobaric hypoxia nwere ike ime ka angioedema (mmụba permeability nke capillaries na-enye ohere ka nnukwu mmiri na-esi na arịa ọbara na-agbakọta na oghere interstitial nke ụbụrụ) na hippocampal gyrus (onye na-ahụ maka nhazi ebe nchekwa), ma nsogbu ndị a na-ebelata nke ukwuu. na oke ndị a na-enye GLAQ nri tupu oge eruo (Foto 5 na 6), na-egosi nke ahụGanoderma lucidumnwere mmetụta nke ichebe ụbụrụ.

Usoro nkeGanoderma lucidummegide hypobaric hypoxia

Ihe kpatara yaGanoderma lucidumaqueous wepụ nwere ike idi mmebi nke hypobaric hypoxia kpatara?A chịkọtara nsonaazụ nke mkparịta ụka miri emi n'ihu na onyonyo 7. E nwere ntụzịaka izugbe abụọ:

N'otu aka ahụ, mmeghachi omume physiological nke anụ ahụ mgbe ị na-eme mgbanwe na hypobaric hypoxia ga-emezi ngwa ngwa ma dị mma n'ihi ntinye aka.Ganoderma lucidum;n'akụkụ aka nke ọzọ,Ganoderma lucidumnwere ike ịhazi ụmụ irighiri ihe ndị metụtara ya na mkpụrụ ndụ akwara ụbụrụ site na mgbochi oxidation na mgbochi mbufụt, na-edobe oxygen mgbe niile n'ime ahụ, na-edozi sekit akwara ụbụrụ, na ịnọgide na-ebufe akwara dị nro iji chebe anụ ahụ akwara na ikike nchekwa.

N'oge gara aga, ọtụtụ nchọpụta egosila naGanoderma lucidumnwere ike ichebe irighiri akwara ụbụrụ site n'akụkụ dị iche iche dị ka ọrịa Alzheimer, ọrịa Parkinson, Akwụkwụ na-adọ, vascular embolism, mmerụ ụbụrụ mberede, na ịka nká.Ugbu a nchọpụta a sitere na India na-agbakwụnye ihe akaebe ọzọ nkeGanoderma lucidum's "ịkwalite amamihe na ebe nchekwa" site n'echiche nke elu elu, obere nrụgide na obere oxygen.

Karịsịa, ngalaba nyocha Defence Institute of Physiology & Allied Sciences (DIPAS) jikọtara ya na National Defence Research and Development Organisation (DRDO) nke Ministry of Defence India.O meela nyocha miri emi n'ọhịa nke physiology dị elu ruo ogologo oge.Otu esi emeziwanye ngbanwe nke ndị agha na ọgụ dị irè na gburugburu ebe dị elu na nrụgide bụ ihe na-elekwasị anya mgbe niile.Nke a na-eme ka nsonaazụ nyocha a bụrụ ihe bara uru karị.

Ihe na-arụ ọrụ dị n'imeGanoderma lucidumAqueous extract GLAQ ejiri mee ihe n'ọmụmụ ihe a gụnyere polysaccharides, phenols, flavonoids, na ganoderic acid A. Tupu e bipụta ọmụmụ ihe a, onye nyocha ahụ mere nyocha nke 90 ụbọchị subchronic toxicity nke wepụ ma kwenye na ọ bụrụgodị na dose ya dị elu dị ka 1000. mg / kg, ọ gaghị enwe mmetụta ọjọọ na anụ ahụ, akụkụ ahụ na uto nke oke.Ya mere, opekempe dị irè nke 200 mg/kg na nnwale a dị n'elu doro anya na ọ dị mma.

Naanị mgbe ị kwadoro nke ọma, ị nwere ike ịnụ ụtọ ịrị elu ma nweta mmetụ nke ịnọ nso na mbara igwe.Ọ bụrụ na ị nwere nchekwaGanoderma lucidumiji mee ka obi dị gị ụtọ, ị ga-enwe ike imezu ọchịchọ gị karịa nke ọma.

[Isi mmalite]

1. Purva Sharma, Rajkumar Tulsawani.Ganoderma lucidumMwepụta mmiri na-egbochi hypobaric hypoxia butere mperi ebe nchekwa site na ịmegharị neurotransmission, neuroplasticity na idowe redox homeostasis.Sci Rep. 2020;10: 8944. Ebipụtara n'ịntanetị 2020 Jun 2.

2. Purva Sharma, et al.Pharmacological mmetụta nkeGanoderma lucidumwepụ megide nrụgide nrụgide dị elu yana nleba anya nsi nsi ya subchronic.J Food Biochem.2019 Disemba; 43 (12): e13081.

N'ikpeazụ

Banyere onye odee/ Oriakụ Wu Tingyao

Wu Tingyao na-akọ akụkọ gbasara Ganoderma nke mbụ kemgbe 1999. Ọ bụ ya bụ onye dere akwụkwọ akụkọ.Ọgwụgwọ na Ganoderma(nke e bipụtara na The People's Medical Publishing House na Eprel 2017).

★ A na-ebipụta akụkọ a n'okpuru ikike nke onye edemede.★ Enweghị ike imepụtagharị ọrụ ndị a dị n'elu, wepụ ma ọ bụ jiri ya mee ihe n'ụzọ ndị ọzọ na-enweghị ikike nke onye edemede.★ Maka mmebi nke nkwupụta a dị n'elu, onye edemede ga-agbaso ọrụ iwu dị mkpa.★ Wu Tingyao dere ederede izizi nke akụkọ a n'asụsụ Chinese wee sụgharịa ya n'asụsụ Bekee site n'aka Alfred Liu.Ọ bụrụ na enwere nghọtahie n'etiti ntụgharị asụsụ (Bekee) na nke izizi (Chinese), Chinese izizi ga-emeri.Ọ bụrụ na ndị na-agụ akwụkwọ nwere ajụjụ ọ bụla, biko kpọtụrụ onye edemede mbụ bụ Oriakụ Wu Tingyao.