India: GLAQ inodzivirira hypobaric hypoxia induced memory deficit

Chikumi 2, 2020/Defence Institute yePhysiology & Allied Sayenzi (India)/Scientific Reports

Chinyorwa/Wu Tingyao

Kukwirira kwepamusoro, kudzika kwemhepo, kunowedzera kunyungudutsa okisijeni, kunowedzera kukanganisa kushanda kwemabasa emuviri, zvinokonzeresa njodzi dzakasiyana dzehutano dzinozivikanwa sekuti.chirwere chepamusoro.

Idzi njodzi dzehutano dzinogona kungova kutemwa nemusoro, dzungu, kusvotwa, kurutsa, kuneta uye kumwe kusagadzikana, uye zvinogona zvakare kukura kuita cerebral edema inokanganisa cognition, mota, uye kuziva mabasa, kana pulmonary edema inokanganisa basa rekufema.Mamiriro acho akaoma sei?Kunyangwe ichigona kupora zvishoma nezvishoma mushure mekuzorora kana kuti ichizowedzera kushata kuita kukuvara kusingagadziriswe kana kutotyisa hupenyu zvinoenderana nekugona kwemasero emunyama emumuviri kuchinjika kune shanduko yekunze kweokisijeni.

Kuitika uye kuoma kwehurwere hwehurefu hunosiyana pamunhu nemunhu, uye inotapurwa zvikuru nokugwinya kwomunhu.Mumusimboti, kureba pamusoro pe1,500 metres (pakati pakakwirira) kunotanga kukanganisa muviri wemunhu;chero ani zvake anosanganisira vanhu vakuru vane hutano vanokurumidza kusvika pakakwirira mamita 2,500 kana kupfuura (yakakwirira yakakwirira) muviri usati wachinja unotarisana nezvinetso.

Kungave kuri kungwarira kuronga kukwira kumusoro kana kutora mishonga yekudzivirira tisati tasimuka, chinangwa ndechekuvandudza kuchinjika kwemuviri uye kudzivirira kuitika kwehurwere hwepamusoro.Asi chokwadi, pane imwe sarudzo, iri kutoraGanoderma lucidum.

Maererano neongororo yakabudiswa neDefence Institute of Physiology uye Allied Sayenzi (DIPAS)munaJune 2020 muScientific Reports, zvakaonekwa kutiGanoderma lucidumaqueous extract (GLAQ) inogona kuderedza kukuvadzwa kwe hypobaric hypoxia kune cranial nerve uye kuchengetedza mabasa ekuziva ane chekuita nekurangarira kwepakati.

Mvura maze - nzira yakanaka yekuyedza kugona kwekurangarira kwemakonzo

Kuedza kusati kwatanga, vatsvakurudzi vakapedza mazuva mashomanana vachidzidzisa makonzo kuti awane nzvimbo yakavanzika yakanyura pasi pemvura.(Mufananidzo 1).

Makonzo akanaka pakutuhwina, asi haadi mvura, saka anoedza kutsvaga pekunzvenga mvura.

Zvinoenderana nekushambira trajectory rekodhi muFigure 2, zvinogona kuwanikwa kuti makonzo akawana chikuva nekukurumidza uye nekukurumidza kubva pakutenderera kakawanda pazuva rekutanga kusvika kumutsara wakatwasuka pazuva rechitanhatu (chetatu kurudyi muMufananidzo 2), zvichiratidza kuti ine ndangariro yakanaka yenzvimbo.

Mushure mekubviswa kwepuratifomu, nzira yekushambira yegonzo yakanyura munzvimbo yaive nepuratifomu (yekutanga kurudyi muMufananidzo 2), zvichiratidza kuti gonzo raive nendangariro yakajeka yenzvimbo yaivepo.

Ganoderma luciduminoderedza mhedzisiro ye hypobaric hypoxia pane spatial memory

Makonzo akadzidziswa aya akakamurwa kuita mapoka maviri.Rimwe boka rakaramba richigara munzvimbo ine mhepo yakajairika uye okisijeni seboka rekutonga (Kudzora) nepo rimwe boka rakatumirwa kune yakaderera-kudzvanywa chamber kuti itevedzere kurarama kune yakakwirira-yakakwirira yakakwirira ye25,000 tsoka kana nezve 7620 metres. munharaunda ye hypobaric hypoxia (HH).

Kune makonzo akatumirwa kune yakaderera-kudzvanywa kamuri, chimwe chikamu chadzo chakadyiswa neaqueous extract ofGanoderma lucidum(GLAQ) pamutengo wezuva nezuva we100, 200, kana 400 mg/kg (HH + GLAQ 100, 200, kana 400) nepo imwe chikamu chavo chisina kudyiswaGanoderma lucidum(HH boka) seboka rinodzora.

Kuedza uku kwakatora kwevhiki.Zuva rakatevera kuyedza kwapera, mapoka mashanu emakonzo akaiswa munzvimbo yemvura kuti aone kana airangarira nzvimbo yepuratifomu.Mhedzisiro yakaratidzwa mumufananidzo 3:

Boka rinodzora (Kudzora) richiri kurangarira nzvimbo yechikuva zvakajeka uye raigona kuwana chikuva pakarepo;kugona kurangarira kwepasi-pressure chamber rats (HH) yakakanganiswa zvakanyanya, uye nguva yavo yekuwana chikuva yaive yakapetwa kaviri yeboka rinodzora.Asi zvakare kugara munzvimbo yakaderera-okisijeni yekamuri yekutsikirira, makonzo aidya GLAQ aive nekurangarira kuri nani kwepuratifomu, uye zvakanyanya.Ganoderma lucidumvakadya, nguva yaishandiswa yakanga yaswedera kune yeboka revanhuwo zvavo.

Ganoderma luciduminoderedza mhedzisiro ye hypobaric hypoxia pane spatial memory

Makonzo akadzidziswa aya akakamurwa kuita mapoka maviri.Rimwe boka rakaramba richigara munzvimbo ine mhepo yakajairika uye okisijeni seboka rekutonga (Kudzora) nepo rimwe boka rakatumirwa kune yakaderera-kudzvanywa chamber kuti itevedzere kurarama kune yakakwirira-yakakwirira yakakwirira ye25,000 tsoka kana nezve 7620 metres. munharaunda ye hypobaric hypoxia (HH).

Kune makonzo akatumirwa kune yakaderera-kudzvanywa kamuri, chimwe chikamu chadzo chakadyiswa neaqueous extract ofGanoderma lucidum(GLAQ) pamutengo wezuva nezuva we100, 200, kana 400 mg/kg (HH + GLAQ 100, 200, kana 400) nepo imwe chikamu chavo chisina kudyiswaGanoderma lucidum(HH boka) seboka rinodzora.

Kuedza uku kwakatora kwevhiki.Zuva rakatevera kuyedza kwapera, mapoka mashanu emakonzo akaiswa munzvimbo yemvura kuti aone kana airangarira nzvimbo yepuratifomu.Mhedzisiro yakaratidzwa mumufananidzo 3:

Boka rinodzora (Kudzora) richiri kurangarira nzvimbo yechikuva zvakajeka uye raigona kuwana chikuva pakarepo;kugona kurangarira kwepasi-pressure chamber rats (HH) yakakanganiswa zvakanyanya, uye nguva yavo yekuwana chikuva yaive yakapetwa kaviri yeboka rinodzora.Asi zvakare kugara munzvimbo yakaderera-okisijeni yekamuri yekutsikirira, makonzo aidya GLAQ aive nekurangarira kuri nani kwepuratifomu, uye zvakanyanya.Ganoderma lucidumvakadya, nguva yaishandiswa yakanga yaswedera kune yeboka revanhuwo zvavo.

Ganoderma luciduminodzivirira huropi uye inoderedza edema yehuropi uye kukuvara kwe hippocampal gyrus.

Migumisiro yekuedza iri pamusoro inoratidza izvozvoGanoderma luciduminogona kunyatso kudzoreredza spatial memory kusagadzikana kunokonzerwa ne hypobaric hypoxia.Memory function chiratidzo chekuti chimiro uye kushanda kwehuropi zvakajairika.Naizvozvo, vaongorori vakawedzera kupatsanura nekuongorora matishu ehuropi emakonzo ekuyedza, ndokuona kuti:

Hypobaric hypoxia inogona kukonzera angioedema (kuwedzerwa permeability kwema capillaries kunobvumira huwandu hukuru hwemvura kubuda kubva mutsinga dzeropa uye kuungana munzvimbo dzehuropi) uye hippocampal gyrus (inotarisira kuumbwa kwendangariro) kukuvadzwa, asi matambudziko aya anorerutswa zvakanyanya. pamakonzo akadyiswa neGLAQ mberi (Mufananidzo 5 uye 6), zvichiratidza kutiGanoderma lucidumine simba rekudzivirira uropi.

The mechanism ofGanoderma lucidumkurwisa hypobaric hypoxia

Why theGanoderma lucidumaqueous extract inogona kumira kukanganisa kunokonzerwa ne hypobaric hypoxia?Mibairo yeimwe nhaurirano yakadzama inopfupikiswa muMufananidzo 7. Pane mativi maviri akajairika:

Kune rimwe divi, mhinduro yemuviri yemuviri kana ichichinjika kune hypobaric hypoxia ichagadziriswa nekukurumidza uye zvirinani nekuda kwekupindira kwe.Ganoderma lucidum;pane rimwe divi,Ganoderma luciduminogona kudzora zvakananga mamorekuru ane hukama mumasero etsinga dzehuropi ne-anti-oxidation uye anti-kuzvimba, kuchengetedza okisijeni inogara iri mumuviri, kugadzirisa uropi neural circuits, uye kuchengetedza yakatsetseka tsinga kutapurirana kuitira kuchengetedza nerve tishu uye kugona ndangariro.

Munguva yakapfuura, zvidzidzo zvakawanda zvakaratidza izvozvoGanoderma luciduminogona kudzivirira tsinga dzehuropi kubva kune dzakasiyana siyana sechirwere cheAlzheimer, chirwere cheParkinson, pfari, vascular embolism, kukuvara kwehuropi netsaona, uye kuchembera.Ikozvino tsvagiridzo iyi kubva kuIndia inowedzera humwe humbowo hweGanoderma lucidum's "humwe hungwaru nekurangarira" kubva pakuona kwekumusoro, kuderera uye kuderera kweokisijeni.

Kunyanya, chikamu chekutsvagisa Defence Institute of Physiology & Allied Sayenzi (DIPAS) yakabatana neNational Defense Research and Development Organisation (DRDO) yeIndia Ministry of Defense.Yakaita ongororo dzakadzama mumunda wepamusoro-soro physiology kwenguva yakareba.Maitiro ekuvandudza kuchinjika kwevarwi uye kurwisa zvinobudirira kune yakakwirira-yakakwirira nharaunda uye kumanikidzwa kwagara kuri iko kutarisisa kwayo.Izvi zvinoita kuti tsvakiridzo iyi ive nerevo.

Izvo zvinoshandiswa zvinoshandiswa zviri muGanoderma lucidumAqueous extract GLAQ inoshandiswa muchidzidzo ichi inosanganisira polysaccharides, phenols, flavonoids, uye ganoderic acid A. Asati abudisa chidzidzo ichi, mutsvakurudzi akanga aita 90-day subchronic toxicity test yezvinyorwa uye akasimbisa kuti kunyange kana dose yaro yakakura se1000. mg/kg, haizove nechakaipa pamatishu, nhengo uye kukura kwemakonzo.Naizvozvo, iyo shoma inoshanda ye200 mg/kg muyedzo iri pamusoro iri pachena yakachengeteka.

Chete kana iwe wakagadzirira zvakakwana iwe unogona kunakidzwa nekunakidzwa kwekukwira uye kuona kubata kwekuve pedyo nedenga.Kana uine safeGanoderma lucidumkuti ufare, iwe unofanirwa kukwanisa kuona zvishuwo zvako zvakachengeteka.

[Kwakabva]

1. Purva Sharma, Rajkumar Tulsawani.Ganoderma lucidumaqueous extract inodzivirira hypobaric hypoxia induced memory deficit bymodulating neurotransmission, neuroplasticity uye kuchengetedza redox homeostasis.Sci Rep. 2020;10: 8944. Rakabudiswa pamhepo 2020 Jun 2.

2. Purva Sharma, nevamwe.Pharmacological migumisiro yeGanoderma luciduminobvisa inopesana ne-high-altitude stressors uye yayo subchronic toxicity yekuongorora.J Chikafu Biochem.2019 Dec;43(12):e13081.

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Nezve munyori/ Ms. Wu Tingyao

Wu Tingyao anga achizivisa nezvekutanga-ruoko ruzivo rweGanoderma kubvira 1999. Ndiye munyori weKuporesa neGanoderma(yakabudiswa muThe People's Medical Publishing House muna Kubvumbi 2017).

★ Chinyorwa ichi chakatsikiswa pasi pemvumo yakasarudzika yemunyori.★ Mabhuku ari pamusoro haagone kutsikiswa, kutorwa kana kushandiswa nedzimwe nzira pasina mvumo yemunyori.★ Nekutyorwa kwechirevo chiri pamusoro, munyori achatevera mabasa akakodzera emutemo.★ Manyoro ekutanga echinyorwa ichi akanyorwa neChinese naWu Tingyao uye akashandurirwa muchiRungu naAlfred Liu.Kana paine mutsauko pakati peshanduro (yeChirungu) neyekutanga (Chinese), iyo yekutanga Chinese ichakunda.Kana vaverengi vaine mibvunzo, tapota taura nemunyori wemabviro, Ms. Wu Tingyao.