India: GLAQ imalepheretsa kuchepa kwa kukumbukira kwa hypobaric hypoxia

June 2, 2020/Defence Institute of Physiology & Allied Sciences (India)/Scientific Reports

Mawu/Wu Tingyao

Kukwera pamwamba, kutsika kwa mpweya, kuchepetsa mpweya wa okosijeni, kumakhudza kwambiri kayendetsedwe ka thupi, m'pamenenso pamakhala ngozi zambiri pa thanzi zomwe zimadziwika kuti.matenda okwera.

Zowopsa za thanzi izi zitha kukhala mutu, chizungulire, nseru, kusanza, kutopa ndi zovuta zina, komanso zimatha kukhala cerebral edema yomwe imakhudza kuzindikira, magalimoto, ndi kuzindikira, kapena pulmonary edema yomwe imakhudza kupuma.Kodi zinthu zavuta bwanji?Kaya imatha kuchira pang'onopang'ono pambuyo popuma kapena ngati ipitilira kuwonongeka kosasinthika kapena kukhala pachiwopsezo cha moyo zimadalira kuthekera kwa maselo am'thupi kuti asinthe kusintha kwa mpweya wakunja.

Kupezeka ndi kuopsa kwa matenda okwera kumasiyana munthu ndi munthu, ndipo zimakhudzidwa kwambiri ndi nyonga ya munthu.M'malo mwake, kukwera pamwamba pa 1,500 metres (kutalika kwapakati) kudzayamba kukhudza thupi la munthu;aliyense kuphatikiza achikulire athanzi omwe amafika pamtunda wa 2,500 metres kapena kupitilira apo (m'mwamba) thupi lisanasinthe amakhala ndi zovuta.

Kaya ndikukonzekereratu kukwera m'mwamba kapena kumwa mankhwala odzitetezera tisananyamuke, cholinga chake ndi kuthandiza thupi kuti lizitha kusintha komanso kupewa matenda.Koma kwenikweni, pali njira ina, yomwe ikutengaGanoderma lucidum.

Malinga ndi kafukufuku wofalitsidwa ndiDefense Institute of Physiology and Allied Sciences (DIPAS)mu June 2020 mu Scientific Reports, zidapezeka kutiGanoderma lucidumKutulutsa kwamadzi (GLAQ) kumatha kuchepetsa kuwonongeka kwa hypobaric hypoxia ku mitsempha ya cranial ndikusunga zidziwitso zokhudzana ndi kukumbukira kwapakati.

Madzi oundana - njira yabwino yoyesera luso la kukumbukira makoswe

Kuyesera kusanayambe, ochita kafukufuku adakhala masiku angapo akuphunzitsa makoswe kuti apeze nsanja yobisika yomwe ili pansi pa madzi.(Chithunzi 1).

Makoswe ndi odziwa kusambira, koma sakonda madzi, choncho amayesa kupeza malo oti apewe madzi.

Malinga ndi mbiri yosambira yosambira mu Chithunzi 2, zitha kupezeka kuti makoswe adapeza nsanja mwachangu komanso mwachangu kuchokera kuzungulira kangapo patsiku loyamba kupita pamzere wowongoka pa tsiku lachisanu ndi chimodzi (chachitatu chakumanja mu Chithunzi 2), kuwonetsa kuti ili ndi luso la kukumbukira bwino kwa malo.

Pulatifomuyo itachotsedwa, njira yosambira ya makoswe inakhazikika m’dera limene nsanjayo inalipo (kumanja koyamba pa Chithunzi 2), kusonyeza kuti khosweyo ankakumbukira bwino lomwe malo amene nsanjayo inali.

Ganoderma lucidumamachepetsa zotsatira za hypobaric hypoxia pa kukumbukira malo

Makoswe ophunzitsidwa bwinowa anagawidwa m'magulu awiri.Gulu lina linapitirizabe kukhala m'malo okhala ndi mpweya wabwino komanso mpweya wa okosijeni monga gulu lolamulira (Control) pamene gulu lina linatumizidwa ku chipinda chochepetsera kuti ayese moyo pamtunda wapamwamba kwambiri wa 25,000 mapazi kapena pafupi mamita 7620. m'malo a hypobaric hypoxia (HH).

Pakuti makoswe anatumiza otsika-anzanu chipinda, gawo limodzi la iwo anadyetsedwa ndi amadzimadzi Tingafinye waGanoderma lucidum(GLAQ) pa mlingo wa tsiku ndi tsiku wa 100, 200, kapena 400 mg / kg (HH + GLAQ 100, 200, kapena 400) pamene gawo lina la iwo silinadyedwe ndiGanoderma lucidum(HH gulu) monga gulu lolamulira.

Kuyesera kumeneku kunatenga sabata.Tsiku lotsatira kuyesera kutha, magulu asanu a makoswe anayikidwa mumsewu wamadzi kuti awone ngati akukumbukira malo a nsanja.Chotsatira chawonetsedwa pa chithunzi 3:

Gulu lolamulira (Control) linakumbukirabe malo a nsanja momveka bwino ndipo likhoza kupeza nsanja nthawi yomweyo;luso la kukumbukira la makoswe otsika kwambiri (HH) anali osokonezeka kwambiri, ndipo nthawi yawo yopeza nsanja inali yoposa kawiri ya gulu lolamulira.Koma pokhalanso m'malo otsika a oxygen m'chipinda chochepetsera mpweya, makoswe omwe amadya GLAQ anali ndi kukumbukira bwino kwambiri pa nsanja, ndi zina zambiri.Ganoderma lucidumadadya, nthawi yomwe idagwiritsidwa ntchito inali pafupi ndi gulu lolamulira bwino.

Ganoderma lucidumamachepetsa zotsatira za hypobaric hypoxia pa kukumbukira malo

Makoswe ophunzitsidwa bwinowa anagawidwa m'magulu awiri.Gulu lina linapitirizabe kukhala m'malo okhala ndi mpweya wabwino komanso mpweya wa okosijeni monga gulu lolamulira (Control) pamene gulu lina linatumizidwa ku chipinda chochepetsera kuti ayese moyo pamtunda wapamwamba kwambiri wa 25,000 mapazi kapena pafupi mamita 7620. m'malo a hypobaric hypoxia (HH).

Pakuti makoswe anatumiza otsika-anzanu chipinda, gawo limodzi la iwo anadyetsedwa ndi amadzimadzi Tingafinye waGanoderma lucidum(GLAQ) pa mlingo wa tsiku ndi tsiku wa 100, 200, kapena 400 mg / kg (HH + GLAQ 100, 200, kapena 400) pamene gawo lina la iwo silinadyedwe ndiGanoderma lucidum(HH gulu) monga gulu lolamulira.

Kuyesera kumeneku kunatenga sabata.Tsiku lotsatira kuyesera kutha, magulu asanu a makoswe anayikidwa mumsewu wamadzi kuti awone ngati akukumbukira malo a nsanja.Chotsatira chawonetsedwa pa chithunzi 3:

Gulu lolamulira (Control) linakumbukirabe malo a nsanja momveka bwino ndipo likhoza kupeza nsanja nthawi yomweyo;luso la kukumbukira la makoswe otsika kwambiri (HH) anali osokonezeka kwambiri, ndipo nthawi yawo yopeza nsanja inali yoposa kawiri ya gulu lolamulira.Koma pokhalanso m'malo otsika a oxygen m'chipinda chochepetsera mpweya, makoswe omwe amadya GLAQ anali ndi kukumbukira bwino kwambiri pa nsanja, ndi zina zambiri.Ganoderma lucidumadadya, nthawi yomwe idagwiritsidwa ntchito inali pafupi ndi gulu lolamulira bwino.

Ganoderma lucidumamateteza ubongo ndi kuchepetsa edema muubongo ndi kuwonongeka kwa hippocampal gyrus.

Zotsatira zoyesera zomwe zili pamwambazi zikuwonetsa zimenezoGanoderma lucidumAngathedi kuchepetsa vuto la kukumbukira malo chifukwa cha hypobaric hypoxia.Memory ntchito ndi chiwonetsero cha ngati kapangidwe ndi ntchito ya ubongo ndi zachilendo.Chifukwa chake, ofufuzawo adagawa ndikuwunikanso minyewa yaubongo ya makoswe oyesera, ndipo adapeza kuti:

Hypobaric hypoxia imatha kuyambitsa angioedema (kuchuluka kwa ma capillaries kumapangitsa kuti madzi ambiri atuluke m'mitsempha yamagazi ndikuwunjikana m'malo olumikizirana muubongo) ndi kuwonongeka kwa hippocampal gyrus (yoyang'anira kukumbukira kukumbukira), koma mavutowa amamasulidwa kwambiri. pa makoswe omwe adadyetsedwa ndi GLAQ pasadakhale (Chithunzi 5 ndi 6), kuwonetsa kutiGanoderma lucidumali ndi mphamvu zoteteza ubongo.

Njira yaGanoderma lucidummotsutsana ndi hypobaric hypoxia

Chifukwa chiyaniGanoderma lucidumKutulutsa kwamadzi kumatha kupirira kuwonongeka koyambitsidwa ndi hypobaric hypoxia?Zotsatira za kukambirana mozama zafotokozedwa mwachidule mu chithunzi 7. Pali njira ziwiri:

Kumbali imodzi, momwe thupi limayankhira posinthira ku hypobaric hypoxia lidzasinthidwa mwachangu komanso bwino chifukwa cha kulowererapo.Ganoderma lucidum;mbali inayi,Ganoderma lucidumimatha kuwongolera mwachindunji mamolekyu okhudzana ndi ma cell a minyewa yaubongo mwa anti-oxidation ndi anti-inflammation, kusunga okosijeni nthawi zonse m'thupi, kukonza minyewa yaubongo, ndikusunga kufalikira kwa minyewa yosalala kuti iteteze minofu ndi kukumbukira kukumbukira.

M'mbuyomu, maphunziro ambiri adawonetsa kutiGanoderma lucidumimatha kuteteza minyewa yaubongo kuzinthu zosiyanasiyana monga matenda a Alzheimer's, Parkinson's disease, khunyu, vascular embolism, kuvulala mwangozi muubongo, ndi ukalamba.Tsopano kafukufukuyu wochokera ku India akuwonjezera umboni wina waGanoderma lucidum's "kupititsa patsogolo nzeru ndi kukumbukira" kuchokera kumadera okwera, kutsika kwapansi ndi mpweya wochepa.

Makamaka, gawo lofufuzira la Defense Institute of Physiology & Allied Sciences (DIPAS) limagwirizana ndi National Defense Research and Development Organisation (DRDO) ya Unduna wa Zachitetezo ku India.Zakhala zikufufuza mozama pazamankhwala apamwamba a physiology kwa nthawi yayitali.Momwe mungasinthire kusinthika kwa asitikali ndikuchita bwino polimbana ndi malo okwera komanso kupanikizika nthawi zonse kwakhala cholinga chake.Izi zimapangitsa kuti zotsatira za kafukufukuyu zikhale zomveka.

The yogwira zosakaniza zili muGanoderma lucidumAmadzimadzi Tingafinye GLAQ ntchito mu phunziro ili monga polysaccharides, phenols, flavonoids, ndi ganoderic asidi A. Asanasindikize phunziroli, wofufuza anachita 90-day subchronic kawopsedwe mayeso a Tingafinye ndipo anatsimikizira kuti ngakhale mlingo wake ndi mkulu monga 1000. mg/kg, sizikhala ndi zotsatirapo zoyipa pamatenda, ziwalo ndi kukula kwa makoswe.Chifukwa chake, mlingo wocheperako wa 200 mg / kg pakuyesa pamwambapa mwachiwonekere ndi wotetezeka.

Pokhapokha mutakonzekera mokwanira mungasangalale ndi chisangalalo chokwera ndikukumana ndi kukhudza kukhala pafupi ndi mlengalenga.Ngati muli ndi chitetezoGanoderma lucidumkuti musangalatse, muyenera kuzindikira zokhumba zanu mosamala kwambiri.

[Chitsime]

1. Purva Sharma, Rajkumar Tulsawani.Ganoderma lucidumKutulutsa kwamadzi kumalepheretsa hypobaric hypoxia yomwe imapangitsa kukumbukira kukumbukira mwakusintha ma neurotransmission, neuroplasticity ndikusunga redox homeostasis.Sci Rep. 2020;10: 8944. Lofalitsidwa pa intaneti 2020 Jun 2.

2. Purva Sharma, et al.Zotsatira za Pharmacological zaGanoderma lucidumKuchotsa motsutsana ndi ma stress okwera kwambiri komanso kuwunika kwake kwa kawopsedwe ka subchronic.J Food Biochem.2019 Dec; 43(12):e13081.

TSIRIZA

Za wolemba/ Mayi Wu Tingyao

Wu Tingyao wakhala akufotokoza zambiri za Ganoderma kuyambira 1999. Iye ndi mlembi wa bukuli.Kuchiza ndi Ganoderma(lofalitsidwa mu The People's Medical Publishing House mu April 2017).

★ Nkhaniyi yasindikizidwa pansi pa chilolezo cha wolemba.★ Ntchito zomwe zili pamwambazi sizingathe kupangidwanso, kuchotsedwa kapena kugwiritsidwa ntchito mwanjira ina popanda chilolezo cha wolemba.★ Pakuphwanya mawu omwe ali pamwambawa, wolemba adzatsata maudindo oyenera azamalamulo.★ Zolemba zoyambirira za nkhaniyi zidalembedwa m'Chitchaina ndi Wu Tingyao ndikumasulira m'Chingerezi ndi Alfred Liu.Ngati pali kusiyana kulikonse pakati pa kumasulira (Chingerezi) ndi choyambirira (Chitchaina), Chitchaina choyambirira chidzapambana.Ngati owerenga ali ndi mafunso, lemberani wolemba woyamba, Mayi Wu Tingyao.