Ubuhinde: GLAQ irinda hypobaric hypoxia iterwa no kubura kwibuka

Ku ya 2 Kamena 2020 / Ikigo cy’Ingabo cya Physiology & Allied Science (Ubuhinde) / Raporo y’ubumenyi

Inyandiko / Wu Tingyao

Iyo ubutumburuke buri hejuru, niko umuvuduko wumwuka ugabanuka, niko bigenda byoroha ogisijeni, niko bigenda bigira ingaruka kumikorere yimikorere ya physiologique, niko bishoboka cyane ko bitera ingaruka mbi zubuzima zikunze kwitwauburwayi bwo mu butumburuke.

Izi ngaruka zubuzima zirashobora kuba kubabara umutwe gusa, kuzunguruka, isesemi, kuruka, umunaniro nibindi bitameze neza, kandi birashobora no gukura mubwonko bwubwonko bugira ingaruka kumikorere, kumenya, ubwenge, cyangwa indwara yibihaha bigira ingaruka kumikorere yubuhumekero.Ibintu birakomeye bite?Niba ishobora gukira buhoro buhoro nyuma yo kuruhuka cyangwa niba izarushaho kwangirika kwangirika ku buryo budasubirwaho cyangwa se bikaba byangiza ubuzima biterwa nubushobozi bwingirabuzimafatizo mu mubiri kugirango zihindure impinduka ziterwa na ogisijeni yo hanze.

Kubaho nuburemere bwindwara zo murwego rwo hejuru biratandukanye kubantu, kandi bigira ingaruka cyane kumubiri kumuntu.Ihame, ubutumburuke buri hejuru ya metero 1.500 (ubutumburuke bwo hagati) buzatangira kugira ingaruka kumubiri wumuntu;umuntu uwo ari we wese harimo n'abantu bakuze bafite ubuzima bwiza bahita bagera ku butumburuke bwa metero 2500 cyangwa zirenga (ubutumburuke) mbere yuko umubiri umenyera usanga ufite ibibazo.

Byaba ari ugutegura neza kuzamuka hejuru cyangwa gufata imiti ikingira mbere yo kugenda, ikigamijwe ni ukunoza imiterere yumubiri no kwirinda indwara ziterwa nubutumburuke.Ariko mubyukuri, hari ubundi buryo, burimo gufataGanoderma lucidum.

Nk’uko ubushakashatsi bwashyizwe ahagaragara naIkigo cy'Ingabo cya Physiology na Science Allied (DIPAS)muri kamena 2020 muri Raporo yubumenyi, byagaragaye koGanoderma lucidumamazi yo mu mazi (GLAQ) arashobora kugabanya kwangirika kwa hypobaric hypoxia kumitsi ya cranial no gukomeza imirimo yubwenge ijyanye no kwibuka ahantu.

Amazi maze - inzira nziza yo kugerageza ubushobozi bwo kwibuka imbeba

Mbere yuko ubushakashatsi butangira, abashakashatsi bamaranye iminsi mike bahugura imbeba kugirango babone urubuga rwihishe munsi y amazi.(Ishusho 1).

Imbeba ninziza koga, ariko ntizikunda amazi, kuburyo bazagerageza gushaka aho birinda amazi.

Ukurikije uburyo bwo koga bwo koga ku gishushanyo cya 2, urashobora gusanga imbeba zabonye urubuga byihuse kandi byihuse kuva kuzenguruka inshuro nyinshi kumunsi wambere kugeza kumurongo ugororotse kumunsi wa gatandatu (iburyo bwa gatatu mubishusho 2), byerekana ko ifite ubushobozi bwiza bwo kwibuka.

Ihuriro rimaze gukurwaho, inzira yo koga yimbeba yibanze mukarere kariho (iburyo bwa mbere ku gishushanyo cya 2), byerekana ko imbeba yari ifite kwibuka neza aho urubuga ruherereye.

Ganoderma lucidumigabanya ingaruka za hypobaric hypoxia kumutwe wibibanza

Izi mbeba zamenyerejwe zagabanijwemo amatsinda abiri.Itsinda rimwe ryakomeje gutura ahantu hamwe n’umuvuduko usanzwe w’umwuka na ogisijeni nkitsinda rishinzwe kugenzura (Igenzura) mu gihe irindi tsinda ryoherejwe mu cyumba cy’umuvuduko ukabije kugira ngo bigane ubuzima ku butumburuke bukabije bwa metero 25.000 cyangwa metero 7620 mubidukikije bya hypobaric hypoxia (HH).

Ku mbeba zoherejwe mu cyumba gifite umuvuduko muke, igice kimwe cyazo cyagaburiwemo amazi yo mu maziGanoderma lucidum(GLAQ) ku gipimo cya buri munsi cya 100, 200, cyangwa 400 mg / kg (HH + GLAQ 100, 200, cyangwa 400) mugihe ikindi gice cyabo kitagaburiweGanoderma lucidum(HH itsinda) nkitsinda rishinzwe kugenzura.

Ubu bushakashatsi bumaze icyumweru.Bukeye bwaho ubushakashatsi burangiye, amatsinda atanu yimbeba yashyizwe mumazi maze kugirango barebe niba bibuka umwanya wa platifomu.Ibisubizo byerekanwe ku gishushanyo cya 3:

Itsinda rishinzwe kugenzura (Igenzura) riracyibuka neza aho urubuga rugeze kandi rushobora kubona icyarimwe icyarimwe;ubushobozi bwo kwibuka bwimbeba ntoya yimbeba (HH) yarangiritse cyane, kandi igihe cyabo cyo kubona urubuga cyari cyikubye kabiri icy'itsinda rishinzwe kugenzura.Ariko nanone kuba mubidukikije bya ogisijeni nkeya yicyumba cyumuvuduko ukabije, imbeba zariye GLAQ zifite kwibuka neza cyane kuri platifomu, nibindi byinshiGanoderma lucidumbariye, umwanya umara wegereye uw'itsinda risanzwe rishinzwe kugenzura.

Ganoderma lucidumigabanya ingaruka za hypobaric hypoxia kumutwe wibibanza

Izi mbeba zamenyerejwe zagabanijwemo amatsinda abiri.Itsinda rimwe ryakomeje gutura ahantu hamwe n’umuvuduko usanzwe w’umwuka na ogisijeni nkitsinda rishinzwe kugenzura (Igenzura) mu gihe irindi tsinda ryoherejwe mu cyumba cy’umuvuduko ukabije kugira ngo bigane ubuzima ku butumburuke bukabije bwa metero 25.000 cyangwa metero 7620 mubidukikije bya hypobaric hypoxia (HH).

Ku mbeba zoherejwe mu cyumba gifite umuvuduko muke, igice kimwe cyazo cyagaburiwemo amazi yo mu maziGanoderma lucidum(GLAQ) ku gipimo cya buri munsi cya 100, 200, cyangwa 400 mg / kg (HH + GLAQ 100, 200, cyangwa 400) mugihe ikindi gice cyabo kitagaburiweGanoderma lucidum(HH itsinda) nkitsinda rishinzwe kugenzura.

Ubu bushakashatsi bumaze icyumweru.Bukeye bwaho ubushakashatsi burangiye, amatsinda atanu yimbeba yashyizwe mumazi maze kugirango barebe niba bibuka umwanya wa platifomu.Ibisubizo byerekanwe ku gishushanyo cya 3:

Itsinda rishinzwe kugenzura (Igenzura) riracyibuka neza aho urubuga rugeze kandi rushobora kubona icyarimwe icyarimwe;ubushobozi bwo kwibuka bwimbeba ntoya yimbeba (HH) yarangiritse cyane, kandi igihe cyabo cyo kubona urubuga cyari cyikubye kabiri icy'itsinda rishinzwe kugenzura.Ariko nanone kuba mubidukikije bya ogisijeni nkeya yicyumba cyumuvuduko ukabije, imbeba zariye GLAQ zifite kwibuka neza cyane kuri platifomu, nibindi byinshiGanoderma lucidumbariye, umwanya umara wegereye uw'itsinda risanzwe rishinzwe kugenzura.

Ganoderma lucidumirinda ubwonko kandi igabanya ubwonko bwubwonko no kwangirika kwa hippocampal.

Ibisubizo byubushakashatsi byavuzwe haruguru byerekana koGanoderma lucidumirashobora rwose kugabanya indwara yibuka yibibanza iterwa na hypobaric hypoxia.Imikorere yo kwibuka nigaragaza niba imiterere n'imikorere y'ubwonko ari ibisanzwe.Kubwibyo, abashakashatsi bakomeje gutandukanya no gusesengura ingirangingo zubwonko bwimbeba zigerageza, basanga:

Hypobaric hypoxia irashobora gutera angioedema (kwiyongera kwimitsi ya capillaries ituma amazi menshi ava mumitsi yamaraso kandi akegeranya mumwanya uhuza ubwonko) hamwe na girus ya hippocampal (ishinzwe kwibukwa), ariko ibyo bibazo byoroheje cyane. ku mbeba zagaburiwe na GLAQ mbere (Ishusho 5 na 6), byerekana koGanoderma lucidumifite ingaruka zo kurinda ubwonko.

Uburyo bwaGanoderma lucidumkurwanya hypobaric hypoxia

KukiGanoderma lucidumamazi yo mumazi arashobora kwihanganira ibyangijwe na hypobaric hypoxia?Ibisubizo by'ibindi biganiro byimbitse byegeranijwe mu gishushanyo cya 7. Hariho ibyerekezo bibiri rusange:

Ku ruhande rumwe, ibisubizo byumubiri byumubiri mugihe bihuye na hypobaric hypoxia bizahinduka byihuse kandi byiza kubera gutabarwa kwaGanoderma lucidum;Ku rundi ruhande,Ganoderma lucidumIrashobora kugenga mu buryo butaziguye molekile zifitanye isano na selile yubwonko ikoresheje anti-okiside na anti-inflammation, igakomeza umwuka wa ogisijeni uhoraho mu mubiri, ugahindura imitsi y’ubwonko, kandi ugakomeza kwanduza imitsi neza kugirango urinde ingirabuzimafatizo nubushobozi bwo kwibuka.

Mu bihe byashize, ubushakashatsi bwinshi bwerekanye koGanoderma lucidumIrashobora kurinda imitsi yubwonko ibintu bitandukanye nkindwara ya Alzheimer, indwara ya Parkinson, igicuri, embolisme yimitsi, gukomeretsa ubwonko kubwimpanuka, no gusaza.Noneho ubu bushakashatsi buva mubuhinde bwongeyeho ikindi kimenyetso cyaGanoderma lucidum'' kongera ubwenge no kwibuka "duhereye ku butumburuke buri hejuru, umuvuduko muke na ogisijeni nkeya.

By'umwihariko, ishami ry’ubushakashatsi Institute Defence Institute of Physiology & Allied Science (DIPAS) rishamikiye ku kigo cy’igihugu gishinzwe ubushakashatsi n’iterambere ry’igihugu (DRDO) cya Minisiteri y’ingabo y’Ubuhinde.Yakoze ubushakashatsi bwimbitse mubijyanye na physiologiya yo hejuru cyane igihe kirekire.Uburyo bwo kunoza imiterere yabasirikare no kurwanya imikorere yubutumburuke bwo hejuru hamwe nigitutu buri gihe nicyo cyibandwaho.Ibi bituma ibisubizo byubushakashatsi bifite ireme.

Ibikoresho bikora bikubiye muriGanoderma lucidumamazi yo mu mazi GLAQ yakoreshejwe muri ubu bushakashatsi arimo polysaccharide, fenol, flavonoide, na aside ganoderic A. Mbere yo gutangaza ubu bushakashatsi, umushakashatsi yari amaze iminsi 90 yipimisha uburozi bw’uburozi bw’ibihingwa kandi yemeza ko niyo igipimo cyacyo kingana na 1000 mg / kg, ntabwo bizagira ingaruka mbi kumubiri, ingingo no gukura kwimbeba.Kubwibyo, ibipimo ntarengwa bya 200 mg / kg mubigeragezo byavuzwe haruguru biragaragara ko bifite umutekano.

Gusa iyo witeguye byuzuye urashobora kwishimira kwishimisha kuzamuka no kwibonera gukoraho kuba hafi ya skyline.Niba ufite umutekanoGanoderma lucidumkugutera inkunga, ugomba gushobora kumenya ibyifuzo byawe neza.

[Inkomoko]

1. Purva Sharma, Rajkumar Tulsawani.Ganoderma lucidumamazi yo mu mazi arinda hypobaric hypoxia iterwa no kubura kwibuka mu guhindura neurotransmission, neuroplastique no kubungabunga redox homeostasis.Sci Rep. 2020;10: 8944. Yatangajwe kumurongo 2020 Jun 2.

2. Purva Sharma, n'abandi.Ingaruka za farumasi yaGanoderma lucidumgukuramo ibirwanya ubutumburuke bwo hejuru hamwe no gusuzuma uburozi bwa subchronic.J Ibiribwa Biochem.Ukuboza 2019; 43 (12): e13081.

IHEREZO

Ibyerekeye umwanditsi / Madamu Wu Tingyao

Wu Tingyao yagiye atanga amakuru ku makuru ya Ganoderma kuva mu 1999. Ni umwanditsi waGukiza hamwe na Ganoderma(byasohotse mu gitabo cy’ubuvuzi cy’abaturage muri Mata 2017).

★ Iyi ngingo yasohowe uruhushya rwihariye rwumwanditsi.Works Ibikorwa byavuzwe haruguru ntibishobora gusubirwamo, gucibwa cyangwa gukoreshwa mubundi buryo utabiherewe uburenganzira n'umwanditsi.★ Kurenga ku magambo yavuzwe haruguru, umwanditsi azakurikirana inshingano zemewe n'amategeko.Text Umwandiko wumwimerere wiyi ngingo wanditswe mu gishinwa na Wu Tingyao uhindurwa mu cyongereza na Alfred Liu.Niba hari itandukaniro riri hagati yubuhinduzi (icyongereza) numwimerere (igishinwa), igishinwa cyumwimerere kizatsinda.Niba abasomyi bafite ikibazo, nyamuneka hamagara umwanditsi wambere, Madamu Wu Tingyao.