Indiya: GLAQ yana hana hypobaric hypoxia induced deficit memory

Yuni 2, 2020/Cibiyar Tsaro ta Ilimin Halittar Halitta da Kimiyyar Ƙwararrun Ƙwararru (Indiya)/Rahotanni na Kimiyya

Rubutu/Wu Tingyao

Mafi girman tsayin daka, rage karfin iska, da yawan dimewar iskar oxygen, mafi tasiri ga ayyukan ayyukan ilimin lissafi, zai iya haifar da haɗarin lafiya daban-daban da aka fi sani da suna.rashin lafiya mai tsayi.

Wadannan haɗarin kiwon lafiya na iya zama kawai ciwon kai, tashin hankali, tashin zuciya, amai, gajiya da sauran rashin jin daɗi, kuma suna iya haɓakawa zuwa ƙwayar ƙwayar cuta wanda ke shafar fahimi, motsi, da ayyukan sani, ko edema na huhu wanda ke shafar aikin numfashi.Yaya girman lamarin yake?Ko zai iya murmurewa sannu a hankali bayan hutawa ko kuma zai kara lalacewa zuwa lalacewar da ba za a iya jurewa ba ko kuma ya zama mai barazana ga rayuwa ya dogara da ikon ƙwayoyin nama a cikin jiki don daidaitawa ga canje-canje a cikin ƙwayar oxygen na waje.

Abin da ya faru da tsananin ciwon tsayi ya bambanta daga mutum zuwa mutum, kuma ya fi shafar lafiyar jikin mutum.A ka'ida, tsayin da ke sama da mita 1,500 (tsawon matsakaici) zai fara shafar jikin mutum;duk wanda ya hada da manya masu koshin lafiya da suka yi saurin kai tsayin mita 2,500 ko sama da haka (tsawo mai tsayi) kafin jikin ya daidaita yana iya fuskantar matsaloli.

Ko shiri na tsanaki ne na hawan tsayi ko shan magungunan rigakafi kafin tashi, manufar ita ce inganta yanayin jikin mutum da kuma hana faruwar ciwon tsayi.Amma a zahiri, akwai wani zaɓi, wanda ke ɗaukaGanoderma lucidum.

A cewar wani bincike da aka bugaCibiyar Tsaro ta Physiology da Kimiyyar Allied (DIPAS)a cikin Yuni 2020 a cikin Rahoton Kimiyya, an gano cewaGanoderma lucidumtsantsa mai ruwa (GLAQ) na iya rage lalacewar hypobaric hypoxia zuwa jijiyoyi na cranial da kuma kula da ayyukan fahimi da ke da alaƙa da ƙwaƙwalwar sararin samaniya.

Maze ruwa - hanya mai kyau don gwada ƙarfin ƙwaƙwalwar ajiyar berayen

Kafin a fara gwajin, masu binciken sun kwashe ‘yan kwanaki suna horar da berayen don gano wani dandali na boye da ke nutse a karkashin ruwa.(Hoto na 1).

Beraye sun kware wajen ninkaya, amma ba sa son ruwa, don haka za su yi kokarin neman wurin da za su guje wa ruwa.

Dangane da rikodin yanayin wasan ninkaya a cikin hoto na 2, ana iya gano cewa berayen sun sami dandamali cikin sauri da sauri daga zagayawa sau da yawa a rana ta farko zuwa madaidaiciyar layi a rana ta shida (na uku na dama a cikin hoto 2), yana nuna cewa. yana da kyakkyawar iyawa ta sararin samaniya.

Bayan an cire dandalin, hanyar ninkaya ta bera ta maida hankali ne a wurin da dandalin yake (dama na farko a cikin hoto na 2), wanda ke nuni da cewa beran yana da cikakkiyar ma'anar inda dandalin yake.

Ganoderma lucidumyana rage tasirin hypobaric hypoxia akan ƙwaƙwalwar sararin samaniya

Waɗannan berayen na yau da kullun da aka horar sun kasu gida biyu.Ƙungiya ɗaya ta ci gaba da rayuwa a cikin wani yanayi tare da matsa lamba na al'ada da oxygen a matsayin ƙungiyar kulawa (Control) yayin da aka aika da sauran rukunin zuwa ɗakin da ba a iya jurewa don kwatanta rayuwa a wani tsayi mai tsayi na ƙafa 25,000 ko kimanin mita 7620. a cikin yanayin hypobaric hypoxia (HH).

Ga berayen da aka aika zuwa ɗakin ƙananan matsa lamba, ɗayan ɓangaren su an ciyar da su tare da tsantsa mai ruwaGanoderma lucidum(GLAQ) a kashi na yau da kullun na 100, 200, ko 400 mg/kg (HH+GLAQ 100, 200, ko 400) yayin da ba a ciyar da ɗayansu tare daGanoderma lucidum(Kungiyar HH) azaman ƙungiyar kulawa.

Wannan gwajin ya dauki mako guda.Washegarin da gwajin ya ƙare, an sa ƙungiyoyin berayen guda biyar a cikin majin ruwan don ganin ko sun tuna matsayin dandalin.An nuna sakamakon a hoto na 3:

Ƙungiyar kulawa (Control) har yanzu tana tunawa da wurin da dandalin yake a fili kuma yana iya samun dandalin a lokaci daya;Kwayar ƙwaƙwalwar ƙwaƙwalwa ta ramuka (HH) ba a iya lalata sosai, kuma lokacinsu don neman dandamali ya wuce sau biyu na rukunin sarrafawa.Amma kuma suna zaune a cikin yanayin ƙarancin oxygen na ɗakin ƙananan matsa lamba, berayen da suka ci GLAQ suna da ingantaccen ƙwaƙwalwar ajiya na dandamali, da ƙari.Ganoderma lucidumsun ci abinci, lokacin da aka kashe ya fi kusa da na ƙungiyar kulawa ta al'ada.

Ganoderma lucidumyana rage tasirin hypobaric hypoxia akan ƙwaƙwalwar sararin samaniya

Waɗannan berayen na yau da kullun da aka horar sun kasu gida biyu.Ƙungiya ɗaya ta ci gaba da rayuwa a cikin wani yanayi tare da matsa lamba na al'ada da oxygen a matsayin ƙungiyar kulawa (Control) yayin da aka aika da sauran rukunin zuwa ɗakin da ba a iya jurewa don kwatanta rayuwa a wani tsayi mai tsayi na ƙafa 25,000 ko kimanin mita 7620. a cikin yanayin hypobaric hypoxia (HH).

Ga berayen da aka aika zuwa ɗakin ƙananan matsa lamba, ɗayan ɓangaren su an ciyar da su tare da tsantsa mai ruwaGanoderma lucidum(GLAQ) a kashi na yau da kullun na 100, 200, ko 400 mg/kg (HH+GLAQ 100, 200, ko 400) yayin da ba a ciyar da ɗayansu tare daGanoderma lucidum(Kungiyar HH) azaman ƙungiyar kulawa.

Wannan gwajin ya dauki mako guda.Washegarin da gwajin ya ƙare, an sa ƙungiyoyin berayen guda biyar a cikin majin ruwan don ganin ko sun tuna matsayin dandalin.An nuna sakamakon a hoto na 3:

Ƙungiyar kulawa (Control) har yanzu tana tunawa da wurin da dandalin yake a fili kuma yana iya samun dandalin a lokaci daya;Kwayar ƙwaƙwalwar ƙwaƙwalwa ta ramuka (HH) ba a iya lalata sosai, kuma lokacinsu don neman dandamali ya wuce sau biyu na rukunin sarrafawa.Amma kuma suna zaune a cikin yanayin ƙarancin oxygen na ɗakin ƙananan matsa lamba, berayen da suka ci GLAQ suna da ingantaccen ƙwaƙwalwar ajiya na dandamali, da ƙari.Ganoderma lucidumsun ci abinci, lokacin da aka kashe ya fi kusa da na ƙungiyar kulawa ta al'ada.

Ganoderma lucidumyana kare kwakwalwa kuma yana rage kumburin kwakwalwa da lalacewar gyrus hippocampal.

Sakamakon gwaji na sama ya nuna hakanGanoderma lucidumHaƙiƙa na iya sauƙaƙa matsalar ƙwaƙwalwar sararin samaniya da ke haifar da hypobaric hypoxia.Ayyukan ƙwaƙwalwar ajiya shine bayyanar ko tsari da aiki na kwakwalwa na al'ada ne.Don haka, masu binciken sun kara rarraba tare da yin nazari akan kyallen kwakwalwa na berayen gwaji, kuma sun gano cewa:

Hypobaric hypoxia na iya haifar da angioedema (ƙara permeability na capillaries yana ba da damar ruwa mai yawa don yabo daga tasoshin jini kuma ya taru a cikin tsaka-tsakin kwakwalwa na kwakwalwa) da gyrus hippocampal (mai kula da ƙwaƙwalwar ajiya) lalacewa, amma waɗannan matsalolin sun sami sauƙi sosai. akan berayen da aka ciyar da GLAQ a gaba (Hoto na 5 da 6), yana nuna hakanGanoderma lucidumyana da tasirin kare kwakwalwa.

Hanyar naGanoderma lucidumda hypobaric hypoxia

Me yasaGanoderma lucidumtsantsa mai ruwa zai iya jure lalacewar da hypobaric hypoxia ya haifar?An taƙaita sakamakon tattaunawa mai zurfi a cikin hoto na 7. Akwai ainihin kwatance guda biyu:

A gefe guda, amsawar ilimin lissafin jiki lokacin da ya dace da hypobaric hypoxia za a daidaita shi da sauri kuma mafi kyau saboda tsoma baki.Ganoderma lucidum;a wannan bangaren,Ganoderma lucidumna iya daidaita kwayoyin da ke da alaƙa kai tsaye a cikin ƙwayoyin jijiya na kwakwalwa ta hanyar anti-oxidation da anti-kumburi, kiyaye iskar oxygen akai-akai a cikin jiki, daidaita ma'aunin jijiyoyi na kwakwalwa, da kiyaye watsawar jijiya mai santsi don kare ƙwayar jijiya da ikon ƙwaƙwalwar ajiya.

A baya, bincike da yawa sun nuna cewaGanoderma lucidumna iya kare jijiyoyi na kwakwalwa daga bangarori daban-daban kamar cutar Alzheimer, cutar Parkinson, farfadiya, bugun jini, raunin kwakwalwar haɗari, da tsufa.Yanzu wannan bincike daga Indiya ya kara da wata hujjaGanoderma lucidum's "haɓaka hikima da ƙwaƙwalwa" daga hangen nesa mai tsayi, ƙananan matsa lamba da ƙarancin iskar oxygen.

Musamman ma, sashin bincike na Cibiyar Tsaro ta Ilimin Halitta da Kimiyyar Kimiyya (DIPAS) tana da alaƙa da Hukumar Bincike da Ci Gaban Tsaro ta ƙasa (DRDO) na Ma'aikatar Tsaro ta Indiya.Ya yi zurfafa bincike a fannin ilimin halittar jiki mai tsayi na dogon lokaci.Yadda za a inganta daidaitawar sojoji da ingancin yaƙi zuwa wurare masu tsayi da matsin lamba ya kasance abin da ya fi maida hankali akai.Wannan ya sa sakamakon wannan bincike ya zama mai ma'ana.

Abubuwan da ke aiki da ke ƙunshe a cikinGanoderma lucidumGLAQ mai ruwa da ruwa da aka yi amfani da shi a cikin wannan binciken ya hada da polysaccharides, phenols, flavonoids, da ganoderic acid A. Kafin buga wannan binciken, mai binciken ya yi gwajin cutarwa na kwanaki 90 na tsantsa kuma ya tabbatar da cewa ko da adadinsa ya kai 1000. mg / kg, ba zai yi mummunan tasiri a kan kyallen takarda, gabobin da girma na berayen ba.Saboda haka, mafi ƙarancin tasiri na 200 mg/kg a cikin gwajin da ke sama ba shakka ba shi da haɗari.

Sai kawai lokacin da kuka shirya sosai za ku iya jin daɗin jin daɗin hawan hawa kuma ku fuskanci taɓawar kasancewa kusa da sararin sama.Idan kana da lafiyaGanoderma lucidumdon faranta muku rai, yakamata ku sami damar cimma burin ku cikin aminci.

[Madogararsa]

1. Purva Sharma, Rajkumar Tulsawani.Ganoderma lucidumtsantsa mai ruwa yana hana hypobaric hypoxia haifar da ƙarancin ƙwaƙwalwar ajiya ta hanyar haɓaka neurotransmission, neuroplasticity da kiyaye redox homeostasis.Sci Rep. 2020;10: 8944. An buga online 2020 Jun 2.

2. Purva Sharma, et al.Pharmacological effects naGanoderma lucidumtsantsa daga matsananciyar matsananciyar tsayin daka da kima mai guba.J Abinci Biochem.Disamba 2019; 43 (12): e13081.

KARSHE

Game da marubucin / Ms. Wu Tingyao

Wu Tingyao ta kasance tana ba da rahoto game da bayanan Ganoderma na farko tun 1999. Ita ce marubucin labarun Ganoderma.Waraka tare da Ganoderma(an buga a The People's Medical Publishing House a Afrilu 2017).

★ An buga wannan labarin ne a ƙarƙashin izini na musamman na marubucin.★ Wadannan ayyukan da ke sama ba za a iya sake su ba, cire su ko amfani da su ta wasu hanyoyi ba tare da izinin marubuci ba.★ Don keta bayanin da ke sama, marubucin zai bi alhakin da ya dace na shari'a.★ Asalin rubutun wannan labarin Wu Tingyao ne ya rubuta shi da Sinanci kuma Alfred Liu ya fassara shi zuwa Turanci.Idan akwai wani sabani tsakanin fassarar (Turanci) da na asali (China), asalin Sinanci zai yi nasara.Idan masu karatu suna da wasu tambayoyi, tuntuɓi marubuciyar asali, Ms. Wu Tingyao.