Inia: Kāohi ʻo GLAQ i ka nele o ka hoʻomanaʻo hypobaric hypoxia

Iune 2, 2020/Defence Institute of Physiology & Allied Sciences (India)/Scientific Reports

Text/Wu Tingyao

ʻO ke kiʻekiʻe o ke kiʻekiʻe, ʻoi aku ka haʻahaʻa o ke ea, ʻoi aku ka hoʻoheheʻe ʻana i ka oxygen, ʻoi aku ka hopena o ka hana o nā hana physiological, ʻoi aku ka nui o ka hopena i nā pilikia olakino i ʻike ʻiamaʻi kiʻekiʻe.

ʻO kēia mau pilikia olakino he poʻo poʻo wale nō, ʻūlū, nausea, luaʻi, luhi a me nā pilikia ʻē aʻe, a hiki iā lākou ke ulu i loko o ka cerebral edema e pili ana i ka cognition, motor, a me ka ʻike, a i ʻole pulmonary edema e pili ana i ka hana hanu.Pehea ke koʻikoʻi o ke kūlana?Inā hiki ke hoʻōla lohi ma hope o ka hoʻomaha ʻana a i ʻole e hōʻino hou ʻia i loko o ka pōʻino hiki ʻole ke hoʻololi ʻia a lilo paha i mea weliweli i ke ola e pili ana i ka hiki o nā ʻiʻo ʻiʻo i loko o ke kino ke hoʻololi i nā loli o ka ʻike oxygen waho.

ʻOkoʻa ka hanana a me ka paʻakikī o ka maʻi kiʻekiʻe mai kēlā me kēia kanaka, a ua pili loa ia e ke kino o ke kanaka.Ma ke kumu, e hoʻomaka ke kiʻekiʻe ma luna o 1,500 mika (medium altitude) i ke kino kanaka;ʻO ka poʻe me nā poʻe mākua olakino e piʻi wikiwiki i kahi kiʻekiʻe o 2,500 mika a ʻoi aku paha (kiʻekiʻe kiʻekiʻe) ma mua o ka hoʻololi ʻana o ke kino e pili ana i nā pilikia.

ʻO ka hoʻolālā akahele o ka piʻi ʻana i kahi kiʻekiʻe a i ʻole ka lawe ʻana i nā lāʻau lapaʻau ma mua o ka haʻalele ʻana, ʻo ke kumu ka hoʻomaikaʻi ʻana i ke ʻano o ke kino a pale i ka hiki ʻana mai o ka maʻi kiʻekiʻe.Akā ʻo ka ʻoiaʻiʻo, aia kekahi koho ʻē aʻe, ʻo ia ka laweʻO Ganoderma lucidum.

Wahi a kahi noiʻi i paʻi ʻia eka Defense Institute of Physiology and Allied Sciences (DIPAS)i Iune 2020 i ka Scientific Reports, ua ʻike ʻiaʻO Ganoderma lucidumHiki i ka wai wai (GLAQ) ke hōʻemi i ka pōʻino o ka hypobaric hypoxia i nā aʻalolo cranial a mālama i nā hana cognitive e pili ana i ka hoʻomanaʻo spatial.

Maze wai - he ala maikaʻi e hoʻāʻo ai i ka hiki ke hoʻomanaʻo o nā ʻiole

Ma mua o ka hoʻomaka ʻana o ka hoʻokolohua, ua hoʻohana nā mea noiʻi i kekahi mau lā e hoʻomaʻamaʻa i nā ʻiole e ʻike i kahi kahua huna i lalo iho o ka wai.(Kiʻi 1).

Maikaʻi ka ʻiole i ka ʻauʻau, akā ʻaʻole lākou makemake i ka wai, no laila e hoʻāʻo lākou e ʻimi i kahi e pale ai i ka wai.

Wahi a ka moʻolelo ʻauʻau ma ke Kiʻi 2, hiki ke ʻike ʻia ua ʻoi aku ka wikiwiki a me ka wikiwiki o ka ʻiole mai ka hele ʻana i nā manawa he nui i ka lā mua a i ka laina pololei i ke ono o ka lā (ʻekolu ʻākau ma ka Figure 2), e hōʻike ana i kēlā. he mana hoʻomanaʻo spatial maikaʻi.

Ma hope o ka wehe ʻia ʻana o ka anuu, ua hoʻopaʻa ʻia ke ala ʻauʻau o ka ʻiole ma kahi i loaʻa ai ka paepae (ʻo ka ʻākau mua ma ke Kiʻi 2), e hōʻike ana ua maopopo ka hoʻomanaʻo ʻana o ka ʻiole i kahi o ka paepae.

ʻO Ganoderma lucidumho'ēmi i ka hopena o ka hypobaric hypoxia ma ka hoʻomanaʻo spatial

Ua māhele ʻia kēia mau ʻiole maʻamau i aʻo ʻia i ʻelua pūʻulu.Ua hoʻomau kekahi pūʻulu i ka noho ʻana i kahi kaiapuni me ka ea maʻamau a me ka oxygen ma ke ʻano he pūʻulu mana (Control) aʻo ka hui ʻē aʻe i hoʻouna ʻia i kahi keʻena haʻahaʻa haʻahaʻa e hoʻohālike i kahi noho ma kahi kiʻekiʻe kiʻekiʻe o 25,000 kapuaʻi a i ʻole 7620 mika. i loko o kahi kaiapuni o ka hypobaric hypoxia (HH).

No nā ʻiole i hoʻouna ʻia i ke keʻena haʻahaʻa haʻahaʻa, ua hānai ʻia kekahi hapa o lākou me ka wai wai oʻO Ganoderma lucidum(GLAQ) i kēlā me kēia lā o 100, 200, a i ʻole 400 mg/kg (HH+GLAQ 100, 200, a i ʻole 400) ʻoiai ʻaʻole i hānai ʻia ka hapa ʻē aʻe o lākou.ʻO Ganoderma lucidum(hui HH) ma ke ano he hui hoomalu.

Hoʻokahi pule kēia hoʻokolohua.I ka lā ma hope o ka pau ʻana o ka hoʻokolohua, ua hoʻokomo ʻia nā pūʻulu ʻiole ʻelima i loko o ka maze wai e ʻike inā hoʻomanaʻo lākou i ke kūlana o ke kahua.Ua hōʻike ʻia ka hopena ma ke Kiʻi 3:

Ua hoʻomanaʻo mau ka pūʻulu hoʻomalu (Control) i kahi o ka paepae a hiki ke loaʻa i ka paepae i ka manawa hoʻokahi;ʻO ka hiki ke hoʻomanaʻo i nā ʻiole keʻena haʻahaʻa haʻahaʻa (HH) ua hoʻopilikia nui ʻia, a ʻo ko lākou manawa e ʻike ai i ka paepae ua ʻoi aku ma mua o ʻelua o ka hui hoʻomalu.Akā, e noho ana i loko o ka haʻahaʻa-oxygen kaiapuni o ka haʻahaʻa-press ke keʻena, nāʻiole iʻai i ka GLAQ i oi aku ka maikaʻi o ka hoʻomanaʻo o ka anuu, a oi aku.ʻO Ganoderma lucidumʻai lākou, ʻoi aku ka kokoke o ka manawa i hoʻohana ʻia i ka hui mana maʻamau.

ʻO Ganoderma lucidumho'ēmi i ka hopena o ka hypobaric hypoxia ma ka hoʻomanaʻo spatial

Ua māhele ʻia kēia mau ʻiole maʻamau i aʻo ʻia i ʻelua pūʻulu.Ua hoʻomau kekahi pūʻulu i ka noho ʻana i kahi kaiapuni me ka ea maʻamau a me ka oxygen ma ke ʻano he pūʻulu mana (Control) aʻo ka hui ʻē aʻe i hoʻouna ʻia i kahi keʻena haʻahaʻa haʻahaʻa e hoʻohālike i kahi noho ma kahi kiʻekiʻe kiʻekiʻe o 25,000 kapuaʻi a i ʻole 7620 mika. i loko o kahi kaiapuni o ka hypobaric hypoxia (HH).

No nā ʻiole i hoʻouna ʻia i ke keʻena haʻahaʻa haʻahaʻa, ua hānai ʻia kekahi hapa o lākou me ka wai wai oʻO Ganoderma lucidum(GLAQ) i kēlā me kēia lā o 100, 200, a i ʻole 400 mg/kg (HH+GLAQ 100, 200, a i ʻole 400) ʻoiai ʻaʻole i hānai ʻia ka hapa ʻē aʻe o lākou.ʻO Ganoderma lucidum(hui HH) ma ke ano he hui hoomalu.

Hoʻokahi pule kēia hoʻokolohua.I ka lā ma hope o ka pau ʻana o ka hoʻokolohua, ua hoʻokomo ʻia nā pūʻulu ʻiole ʻelima i loko o ka maze wai e ʻike inā hoʻomanaʻo lākou i ke kūlana o ke kahua.Ua hōʻike ʻia ka hopena ma ke Kiʻi 3:

Ua hoʻomanaʻo mau ka pūʻulu hoʻomalu (Control) i kahi o ka paepae a hiki ke loaʻa i ka paepae i ka manawa hoʻokahi;ʻO ka hiki ke hoʻomanaʻo i nā ʻiole keʻena haʻahaʻa haʻahaʻa (HH) ua hoʻopilikia nui ʻia, a ʻo ko lākou manawa e ʻike ai i ka paepae ua ʻoi aku ma mua o ʻelua o ka hui hoʻomalu.Akā, e noho ana i loko o ka haʻahaʻa-oxygen kaiapuni o ka haʻahaʻa-press ke keʻena, nāʻiole iʻai i ka GLAQ i oi aku ka maikaʻi o ka hoʻomanaʻo o ka anuu, a oi aku.ʻO Ganoderma lucidumʻai lākou, ʻoi aku ka kokoke o ka manawa i hoʻohana ʻia i ka hui mana maʻamau.

ʻO Ganoderma lucidumpale i ka lolo a hōʻemi i ka edema lolo a me ka pōʻino hippocampal gyrus.

Hōʻike nā hopena hoʻokolohua ma lunaʻO Ganoderma lucidumhiki ke hoʻohaʻahaʻa i ka maʻi hoʻomanaʻo spatial i hoʻokumu ʻia e ka hypobaric hypoxia.ʻO ka hana hoʻomanaʻo he hōʻike ia inā he maʻamau ka hana a me ka hana o ka lolo.No laila, ua hoʻokaʻawale hou nā mea noiʻi i nā ʻiʻo lolo o nā ʻiole hoʻokolohua, a ʻike ʻia:

Hiki i ka hypobaric hypoxia ke hana i ka angioedema (hoʻonui i ka permeability o nā capillaries e hiki ai i ka nui o ka wai e kahe mai nā kīʻaha koko a hōʻiliʻili i loko o nā kikowaena interstitial o ka lolo) a me ka hippocampal gyrus (ke kuleana o ka hoʻokumu ʻana i ka hoʻomanaʻo), akā ua hoʻomaha nui ʻia kēia mau pilikia. i nā ʻiole i hānai ʻia me ka GLAQ ma mua (Figure 5 a me 6), e hōʻike anaʻO Ganoderma lucidumloaʻa ka hopena o ka pale ʻana i ka lolo.

ʻO ka mīkini oʻO Ganoderma lucidumkū'ē i ka hypobaric hypoxia

No ke aha kaʻO Ganoderma lucidumHiki i ka wai wai ke kū i ka pōʻino i hana ʻia e hypobaric hypoxia?Ua hōʻuluʻulu ʻia nā hopena o ke kūkākūkā hohonu ʻana ma ke Kiʻi 7. Aia ma ke kumu ʻelua ʻaoʻao ākea:

Ma ka ʻaoʻao hoʻokahi, e hoʻoponopono wikiwiki ʻia ka pane physiological o ke kino i ka wā e hoʻololi ai i ka hypobaric hypoxia ma muli o ke komo ʻana oʻO Ganoderma lucidum;ma ka lima ʻē aʻe,ʻO Ganoderma lucidumHiki iā ia ke hoʻoponopono pololei i nā molekala pili i loko o ka lolo nerve cell e ka anti-oxidation a me ka anti-inflammation, e mālama mau ana i ka oxygen i loko o ke kino, e hoʻoponopono i nā kaʻa neural o ka lolo, a me ka mālama ʻana i ka neʻe ʻana o ke aʻalolo i mea e pale ai i ka ʻiʻo nerve a me ka hiki ke hoʻomanaʻo.

I ka wā ma mua, nui nā haʻawina i hōʻike i kēlāʻO Ganoderma lucidumhiki ke pale i nā aʻalolo lolo mai nā ʻano like ʻole e like me ka maʻi Alzheimer, ka maʻi Parkinson, epilepsy, vascular embolism, ʻeha lolo, a me ka ʻelemakule.I kēia manawa ua hoʻohui kēia noiʻi mai India i kahi hōʻike ʻē aʻe oʻO Ganoderma lucidumʻO ka "hoʻonui naʻauao a me ka hoʻomanaʻo" mai ka hiʻohiʻona o ke kiʻekiʻe kiʻekiʻe, haʻahaʻa haʻahaʻa a me ka oxygen haʻahaʻa.

Ma keʻano kūikawā, pili ka hui noiʻi ʻo Defense Institute of Physiology & Allied Science (DIPAS) i ka National Defense Research and Development Organization (DRDO) o ke Kuhina Kūʻai o India.Ua hana ʻo ia i nā ʻimi ʻimi hohonu ma ke kahua o ka physiology kiʻekiʻe kiʻekiʻe no ka manawa lōʻihi.Pehea e hoʻomaikaʻi ai i ka hoʻololi ʻana o nā koa a me ka maikaʻi o ka hakakā ʻana i nā wahi kiʻekiʻe kiʻekiʻe a me nā pilikia ʻo ia ka mea nui o kāna nānā.ʻO kēia ka mea i ʻoi aku ka manaʻo o nā hopena o kēia noiʻi.

ʻO nā mea hana i loko o kaʻO Ganoderma lucidumaqueous extract GLAQ hoʻohana 'ia i loko o keia haʻawina e komo polysaccharides, phenols, flavonoids, a me ganoderic acid A. Ma mua o ka paʻi 'ana i kēia haʻawina, ka mea noiʻi ua hana i ka 90-lā subchronic toxicity ho'āʻo o ka extract a ua hōʻoia 'oiai inā he kiʻekiʻe kona nui e like me 1000. mg / kg, ʻaʻole e loaʻa ka hopena maikaʻi ʻole i nā ʻiʻo, nā ʻāpana a me ka ulu ʻana o nā ʻiole.No laila, ʻo ka haʻahaʻa haʻahaʻa haʻahaʻa o 200 mg/kg i ka hoʻokolohua ma luna nei he palekana.

Aia wale ʻoe i ka mākaukau piha e hiki ai iā ʻoe ke hauʻoli i ka leʻaleʻa o ka piʻi ʻana a ʻike i ka hoʻopā o ka pili ʻana i ka lani.Inā he palekana kāuʻO Ganoderma lucidume hoʻohauʻoli iā ʻoe, pono ʻoe e hoʻokō i kāu mau makemake me ka palekana.

[Kumu]

1. Purva Sharma, Rajkumar Tulsawani.ʻO Ganoderma lucidumʻO ka wai wai e pale i ka hypobaric hypoxia i hoʻokomo ʻia i ka hoʻomanaʻo ʻana ma o ka hoʻololi ʻana i ka neurotransmission, neuroplasticity a me ka mālama ʻana i ka homeostasis redox.Sci Rep. 2020;10: 8944. Paʻi ʻia ma ka pūnaewele 2020 Jun 2.

2. Purva Sharma, et al.Nā hopena pharmacological oʻO Ganoderma lucidume kūʻē i nā mea kaumaha kiʻekiʻe a me kāna loiloi subchronic toxicity.J Food Biochem.2019 Dek;43(12):e13081.

HOPE

No ka mea kākau/ Ms. Wu Tingyao

Ua hōʻike ʻo Wu Tingyao i ka ʻike Ganoderma lima mua mai 1999. ʻO ia ka mea kākau oHoola me Ganoderma(i paʻi ʻia ma The People's Medical Publishing House ma ʻApelila 2017).

★ Ua paʻi ʻia kēia ʻatikala ma lalo o ka mana kūʻokoʻa o ka mea kākau.★ ʻAʻole hiki ke paʻi hou ʻia nā hana i luna, ʻokiʻoki a hoʻohana ʻia ma nā ʻano ʻē aʻe me ka ʻole o ka ʻae ʻia e ka mea kākau.★ No ka uhaki ʻana i ka ʻōlelo ma luna, e ʻimi ka mea kākau i nā kuleana pili kānāwai.★ Ua kākau ʻia ka kikokikona kumu o kēia ʻatikala ma ka ʻōlelo Pākē e Wu Tingyao a unuhi ʻia i ka ʻōlelo Pelekania e Alfred Liu.Inā loaʻa kekahi ʻokoʻa ma waena o ka unuhi (English) a me ka unuhi mua (Pake), e lanakila ka Pākē mua.Inā he nīnau ka poʻe heluhelu, e ʻoluʻolu e kelepona i ka mea kākau kumu, ʻo Ms. Wu Tingyao.