Is Nrias teb: GLAQ tiv thaiv hypobaric hypoxia induced memory deficit

Lub Rau Hli 2, 2020 / Kev Tiv Thaiv Lub Tsev Haujlwm ntawm Physiology & Allied Sciences (India) / Kev Tshaj Tawm Txog Kev Tshawb Fawb

Text/Wu Tingyao

Qhov siab dua qhov siab, qhov cua siab qis dua, qhov ntau dilute cov pa oxygen, qhov cuam tshuam ntau dua rau kev ua haujlwm ntawm lub cev, qhov ntau yuav ua rau muaj kev phom sij ntau yam kev noj qab haus huv uas feem ntau hu ua.mob qhov siab.

Cov kev pheej hmoo ntawm kev noj qab haus huv no tuaj yeem tsuas yog mob taub hau, kiv taub hau, xeev siab, ntuav, qaug zog thiab lwm yam tsis xis nyob, thiab lawv tuaj yeem ua rau mob hlwb edema uas cuam tshuam rau kev paub, lub cev muaj zog, thiab kev nco qab, lossis pulmonary edema uas cuam tshuam rau kev ua pa.Qhov xwm txheej hnyav npaum li cas?Txawm hais tias nws tuaj yeem maj mam rov qab los tom qab so lossis seb nws puas yuav ua rau muaj kev puas tsuaj tsis tuaj yeem lossis txawm tias ua rau muaj kev phom sij yog nyob ntawm lub peev xwm ntawm cov ntaub so ntswg hauv lub cev los hloov pauv cov pa oxygen sab nraud.

Qhov tshwm sim thiab qhov mob hnyav ntawm qhov siab sib txawv ntawm ib tus neeg mus rau lwm tus, thiab feem ntau cuam tshuam los ntawm tus neeg lub cev muaj zog.Raws li txoj cai, qhov siab tshaj 1,500 meters (qhov siab nruab nrab) yuav pib cuam tshuam rau tib neeg lub cev;leej twg suav nrog cov neeg laus noj qab haus huv uas rashly nce mus txog qhov siab ntawm 2,500 meters lossis ntau dua (qhov siab siab) ua ntej lub cev hloov mus rau qhov teeb meem.

Txawm hais tias nws tau ceev faj txog kev nce toj siab lossis noj tshuaj tiv thaiv ua ntej tawm mus, lub hom phiaj yog txhawm rau txhim kho lub cev hloov pauv thiab tiv thaiv qhov tshwm sim ntawm qhov chaw siab.Tab sis qhov tseeb, muaj lwm txoj kev xaiv, uas yog nojGanoderma lucidum.

Raws li kev tshawb fawb luam tawm los ntawmLub koom haum tiv thaiv ntawm Physiology thiab Allied Sciences (DIPAS)Thaum Lub Rau Hli 2020 hauv Daim Ntawv Qhia Txog Kev Tshawb Fawb, nws tau pom tiasGanoderma lucidumaqueous extract (GLAQ) tuaj yeem txo qhov kev puas tsuaj ntawm hypobaric hypoxia rau cranial qab haus huv thiab tswj cov kev txawj ntse muaj feem xyuam nrog kev nco.

Dej maze - ib txoj hauv kev zoo los ntsuas lub peev xwm nco ntawm nas

Ua ntej qhov kev sim pib, cov kws tshawb fawb tau siv ob peb hnub los cob qhia cov nas kom pom lub platform zais hauv qab hauv qab dej.(Daim duab 1).

Cov nas ua luam dej zoo, tab sis lawv tsis nyiam dej, yog li lawv yuav sim nrhiav qhov chaw kom tsis txhob muaj dej.

Raws li cov ntaub ntawv ua luam dej hauv daim duab 2, nws tuaj yeem pom tias cov nas pom lub platform sai dua thiab nrawm dua los ntawm kev mus ncig ntau zaus ntawm thawj hnub mus rau txoj kab ncaj nraim rau hnub thib rau (txoj cai thib peb hauv daim duab 2), qhia tias nws muaj peev xwm nco tau zoo spatial.

Tom qab lub platform raug tshem tawm, tus nas txoj kev ua luam dej tau tsom mus rau thaj chaw uas lub platform nyob (thawj txoj cai hauv daim duab 2), qhia tias tus nas tau muaj kev nco meej ntawm qhov chaw nyob.

Ganoderma lucidumalleviates cov teebmeem ntawm hypobaric hypoxia ntawm spatial nco

Cov nas uas raug cob qhia no tau muab faib ua ob pawg.Ib pawg txuas ntxiv mus nyob hauv ib puag ncig nrog huab cua siab thiab oxygen raws li pawg tswj hwm (Control) thaum lwm pab pawg tau raug xa mus rau chav tsev uas tsis tshua muaj siab los simulate ib tug nyob ntawm qhov siab siab ntawm 25,000 ko taw lossis txog 7620 meters. nyob rau hauv ib puag ncig ntawm hypobaric hypoxia (HH).

Rau cov nas xa mus rau chav tsev uas tsis tshua muaj siab, ib feem ntawm lawv tau noj nrog cov kua dej tawm ntawmGanoderma lucidum(GLAQ) ntawm ib hnub koob tshuaj 100, 200, lossis 400 mg / kg (HH + GLAQ 100, 200, lossis 400) thaum lwm qhov ntawm lawv tsis pub nrogGanoderma lucidum(HH pawg) ua pawg tswj hwm.

Qhov kev sim no tau siv sijhawm li ib lub lim tiam.Hnub tom qab qhov kev sim ua tiav, tsib pawg nas tau muab tso rau hauv cov dej tshawb nrhiav seb lawv puas nco qab txoj haujlwm ntawm lub platform.Cov txiaj ntsig tau pom hauv daim duab 3:

Pawg tswj hwm (Control) tseem nco txog qhov chaw ntawm lub platform kom meej thiab tuaj yeem pom lub platform ib zaug;lub cim xeeb muaj peev xwm ntawm qis qis chamber nas (HH) tau poob qis, thiab lawv lub sijhawm los nrhiav lub platform yog ntau tshaj ob zaug ntawm pawg tswj hwm.Tab sis kuj tseem nyob hauv qhov chaw qis-oxygen ntawm chav tsev uas tsis tshua muaj siab, cov nas uas tau noj GLAQ muaj qhov nco zoo dua ntawm lub platform, thiab ntau dua.Ganoderma lucidumlawv tau noj, lub sij hawm siv tau ze rau ntawm pawg tswj hwm ib txwm muaj.

Ganoderma lucidumalleviates cov teebmeem ntawm hypobaric hypoxia ntawm spatial nco

Cov nas uas raug cob qhia no tau muab faib ua ob pawg.Ib pawg txuas ntxiv mus nyob hauv ib puag ncig nrog huab cua siab thiab oxygen raws li pawg tswj hwm (Control) thaum lwm pab pawg tau raug xa mus rau chav tsev uas tsis tshua muaj siab los simulate ib tug nyob ntawm qhov siab siab ntawm 25,000 ko taw lossis txog 7620 meters. nyob rau hauv ib puag ncig ntawm hypobaric hypoxia (HH).

Rau cov nas xa mus rau chav tsev uas tsis tshua muaj siab, ib feem ntawm lawv tau noj nrog cov kua dej tawm ntawmGanoderma lucidum(GLAQ) ntawm ib hnub koob tshuaj 100, 200, lossis 400 mg / kg (HH + GLAQ 100, 200, lossis 400) thaum lwm qhov ntawm lawv tsis pub nrogGanoderma lucidum(HH pawg) ua pawg tswj hwm.

Qhov kev sim no tau siv sijhawm li ib lub lim tiam.Hnub tom qab qhov kev sim ua tiav, tsib pawg nas tau muab tso rau hauv cov dej tshawb nrhiav seb lawv puas nco qab txoj haujlwm ntawm lub platform.Cov txiaj ntsig tau pom hauv daim duab 3:

Pawg tswj hwm (Control) tseem nco txog qhov chaw ntawm lub platform kom meej thiab tuaj yeem pom lub platform ib zaug;lub cim xeeb muaj peev xwm ntawm qis qis chamber nas (HH) tau poob qis, thiab lawv lub sijhawm los nrhiav lub platform yog ntau tshaj ob zaug ntawm pawg tswj hwm.Tab sis kuj tseem nyob hauv qhov chaw qis-oxygen ntawm chav tsev uas tsis tshua muaj siab, cov nas uas tau noj GLAQ muaj qhov nco zoo dua ntawm lub platform, thiab ntau dua.Ganoderma lucidumlawv tau noj, lub sij hawm siv tau ze rau ntawm pawg tswj hwm ib txwm muaj.

Ganoderma lucidumtiv thaiv lub hlwb thiab txo lub hlwb edema thiab hippocampal gyrus puas.

Cov kev sim saum toj no qhia tau tiasGanoderma lucidumQhov tseeb tuaj yeem txo qhov kev nco tsis meej uas tshwm sim los ntawm hypobaric hypoxia.Kev ua haujlwm nco yog qhov tshwm sim ntawm seb cov qauv thiab kev ua haujlwm ntawm lub hlwb puas zoo li qub.Yog li ntawd, cov kws tshawb fawb tau tshawb xyuas ntxiv thiab tshuaj xyuas cov ntaub so ntswg ntawm lub hlwb ntawm cov nas sim, thiab pom tias:

Hypobaric hypoxia tuaj yeem ua rau angioedema (nce permeability ntawm capillaries tso cai rau cov kua dej ntau dhau los ntawm cov hlab ntsha thiab sib sau ua ke hauv qhov chaw nruab nrab ntawm lub hlwb) thiab hippocampal gyrus (tus saib xyuas lub cim xeeb tsim) kev puas tsuaj, tab sis cov teeb meem no tau daws tau ntau heev. ntawm cov nas uas tau noj nrog GLAQ ua ntej (Daim duab 5 thiab 6), qhia tiasGanoderma lucidummuaj cov nyhuv tiv thaiv lub hlwb.

Lub mechanism ntawmGanoderma lucidumtiv thaiv hypobaric hypoxia

Yog vim li cas covGanoderma lucidumaqueous extract tuaj yeem tiv thaiv kev puas tsuaj los ntawm hypobaric hypoxia?Cov txiaj ntsig ntawm kev sib tham tob ntxiv tau muab sau tseg hauv daim duab 7. Muaj ob qho kev qhia dav dav:

Ntawm qhov tod tes, lub cev lub cev cov lus teb thaum hloov mus rau hypobaric hypoxia yuav raug kho sai thiab zoo dua vim muaj kev cuam tshuam ntawmGanoderma lucidum;ntawm qhov tod tes,Ganoderma lucidumtuaj yeem ncaj qha tswj hwm cov molecules hauv lub hlwb paj hlwb los ntawm kev tiv thaiv oxidation thiab tiv thaiv kab mob, tswj cov pa oxygen tsis tu ncua hauv lub cev, kho lub hlwb lub paj hlwb, thiab tswj kev sib kis ntawm cov paj hlwb kom tiv thaiv cov paj hlwb thiab lub peev xwm nco.

Yav dhau los, ntau qhov kev tshawb fawb tau taw qhia tiasGanoderma lucidumtuaj yeem tiv thaiv lub paj hlwb los ntawm ntau yam xws li Alzheimer's disease, Parkinson's disease, qaug dab peg, vascular embolism, raug mob lub hlwb, thiab kev laus.Tam sim no qhov kev tshawb fawb no los ntawm Is Nrias teb ntxiv lwm cov pov thawj ntawmGanoderma lucidum's "txhim kho kev txawj ntse thiab kev nco" los ntawm qhov kev xav ntawm qhov siab siab, tsis tshua muaj siab thiab qis oxygen.

Tshwj xeeb, lub koom haum tshawb fawb Defense Institute of Physiology & Allied Sciences (DIPAS) yog koom nrog National Defense Research thiab Development Organization (DRDO) ntawm Indian Ministry of Defense.Nws tau ua qhov kev tshawb fawb tob hauv thaj chaw siab siab physiology rau lub sijhawm ntev.Yuav ua li cas txhawm rau txhim kho cov tub rog kev hloov pauv thiab kev sib ntaus sib tua kom muaj txiaj ntsig zoo rau qhov chaw siab tshaj plaws thiab kev kub ntxhov ib txwm yog qhov tseem ceeb ntawm nws txoj kev mloog.Qhov no ua rau cov txiaj ntsig ntawm kev tshawb fawb no muaj txiaj ntsig ntau dua.

Cov khoom xyaw nquag muaj nyob rau hauv lubGanoderma lucidumaqueous extract GLAQ siv rau hauv txoj kev tshawb no suav nrog polysaccharides, phenols, flavonoids, thiab ganoderic acid A. Ua ntej tshaj tawm txoj kev tshawb no, tus kws tshawb fawb tau ua 90-hnub subchronic toxicity test ntawm cov extract thiab paub tseeb tias txawm tias nws cov koob tshuaj ntau npaum li 1000. mg / kg, nws yuav tsis muaj kev cuam tshuam tsis zoo rau cov ntaub so ntswg, kabmob thiab kev loj hlob ntawm nas.Yog li, qhov tsawg kawg nkaus koob tshuaj ntawm 200 mg / kg hauv qhov kev sim saum toj no yog pom tseeb muaj kev nyab xeeb.

Tsuas yog thaum koj npaj txhij tuaj yeem txaus siab rau kev lom zem ntawm kev nce toj thiab paub qhov kov ntawm kev nyob ze rau saum ntuj.Yog koj muaj kev nyab xeebGanoderma lucidumua kom zoo siab rau koj, koj yuav tsum muaj peev xwm ua tiav koj txoj kev xav kom nyab xeeb dua.

[Qhov chaw]

1. Purva Sharma, Rajkumar Tulsaani.Ganoderma lucidumaqueous extract tiv thaiv hypobaric hypoxia induced nco deficit bymodulating neurotransmission, neuroplasticity thiab tswj redox homeostasis.Sci Rep. 2020;10: 8944. Tshaj tawm online 2020 Lub Rau Hli 2.

2. Purva Sharma, thiab al.Pharmacological teebmeem ntawmGanoderma lucidumextract tawm tsam high-altitude stressors thiab nws subchronic toxicity ntsuam xyuas.J Food Biochem.2019 Dec; 43(12):e13081.

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Hais txog tus sau/ Ms. Wu Tingyao

Wu Tingyao tau tshaj tawm cov ntaub ntawv Ganoderma thawj zaug txij li xyoo 1999. Nws yog tus sau ntawmKho nrog Ganoderma(tshaj tawm hauv Lub Tsev Kho Mob Tib Neeg Lub Plaub Hlis 2017).

★ Kab lus no tau luam tawm raws li kev tso cai tshwj xeeb ntawm tus sau.★ Cov haujlwm saum toj no tsis tuaj yeem muab luam tawm, txiav tawm lossis siv lwm txoj hauv kev yam tsis muaj kev tso cai los ntawm tus sau.★ Rau kev ua txhaum ntawm cov lus hais saum toj no, tus sau yuav ua raws li cov luag haujlwm raug cai.★ Cov ntawv qub ntawm kab lus no tau sau ua lus Suav los ntawm Wu Tingyao thiab txhais ua lus Askiv los ntawm Alfred Liu.Yog tias muaj qhov tsis sib xws ntawm kev txhais lus (English) thiab tus thawj (Suav), tus thawj Suav yuav yeej.Yog tias cov nyeem muaj lus nug, thov hu rau tus thawj kws sau ntawv, Ms. Wu Tingyao.