Mu Meyi 2021, gulu lotsogozedwa ndi Mohammad Azizur Rahman, Pulofesa Wothandizira wa dipatimenti ya Biochemistry ndi Molecular Biology, Jahangirnagar University, Bangladesh, ndi Mushroom Development Institute, department of Agriculture Extension, Unduna wa Zaulimi, Bangladesh adasindikiza pamodzi pepala loyang'ana m'mbuyomu. The International Journal of Medicinal Mushrooms kuti atsogolere anthu omwe ali ndi mliri wa COVID-19 kuti agwiritse ntchito bwino "chidziwitso chodziwika" ndi "zinthu zomwe zilipo" kuti adziteteze pakapita nthawi yayitali kuti apulumutsidwe ndi mankhwala atsopano.

Kutengera zotsatira zotsimikizika mwasayansi, kudzera pakuwunika zofunikira monga chitetezo chodyedwa komanso kupezeka kwa bowa wodyedwa ndi mankhwala komanso kuwunika gawo lawo mu antivayirasi, chitetezo chamthupi, kuchepetsa kutupa komwe kumachitika chifukwa cha kusalinganika kwa ACE/ACE2 ndikusintha kwanthawi yayitali. matenda monga matenda amtima, shuga, hyperlipidemia, ndi matenda oopsa kwa odwala omwe ali ndi matenda a coronavirus 2019 (COVID-19), pepalalo lidafotokoza zifukwa zomwe anthu ayenera "kudya bowa kuti apewe miliri".

Pepalalo linanena kangapo m’nkhaniyo kutiGanoderma lucidumMosakayikira ndiye chisankho choyenera kwambiri popewa komanso kuchiza matenda a chibayo cha coronavirus pakati pa mafangasi ambiri odyedwa komanso ochiritsa chifukwa cha zosakaniza zake zambiri komanso zosiyanasiyana.

KutiGanoderma lucidumimalepheretsa kubwereza kwa ma virus, imawongolera mayankho ochulukirapo komanso osakwanira a chitetezo chamthupi (anti-inflammation and resistance enhancement) sizodabwitsa kwa aliyense ndipo zakambidwa m'nkhani zambiri:

Nkosavuta kumvetsetsa zimenezoGanoderma lucidum, yomwe ili bwino kale kuteteza mtima ndi chiwindi, kuteteza mapapu ndi kulimbikitsa impso, kulamulira maulendo atatu apamwamba, ndi odana ndi ukalamba, amatha kusintha zovuta za odwala omwe ali ndi matenda aakulu komanso azaka zapakati ndi okalamba polimbana ndi matenda. chibayo cha coronavirus yatsopano.

Koma kusamvana kwa ACE/ACE2 ndi chiyani?Zikugwirizana bwanji ndi kutupa?Zikuyenda bwanjiGanoderma lucidumkulowerera mu mgwirizano?

Kusalinganika kwa ACE/ACE2 kumatha kukulitsa kutupa.

ACE2 (angiotensin converting enzyme 2) sikuti ndi cholandirira cha SARS-CoV-2 chokha kuti chiwukire ma cell komanso chimakhala ndi ntchito yothandiza ya ma enzyme.Udindo wake waukulu ndikuthana ndi ACE (angiotensin converting enzyme) yomwe imawoneka yofanana kwambiri koma imakhala ndi ntchito zosiyanasiyana.

Impso ikazindikira kuchepa kwa kuchuluka kwa magazi kapena kuthamanga kwa magazi (monga magazi kapena kutaya madzi m'thupi), imatulutsa renin m'magazi.Enzyme yotulutsidwa ndi chiwindi imasinthidwa kukhala "angiotensin I" yosagwira ntchito.Angiotensin I ikamayenda ndi magazi m'mapapo posinthana mpweya, ACE mu alveolar capillaries imaisintha kukhala "angiotensin II" yogwira ntchito yomwe imagwira ntchito mthupi lonse.

Mwa kuyankhula kwina, ACE imagwira ntchito yofunika kwambiri mu "renin-angiotensin system" yomwe imasunga kuthamanga kwa magazi nthawi zonse ndi kuchuluka kwa magazi (pokhala ndi madzi am'thupi nthawi zonse ndi electrolytes).

Kungoti simungathe kusunga mitsempha yamagazi kuti ikhale yolimba, yothamanga kwambiri monga chonchi!Zimenezi zingawonjezere ntchito ya mtima yokankhira magazi ndi impso kuti zisefe magazi.Kuphatikiza apo, angiotensin II sikuti imangolimbikitsa vasoconstriction komanso imathandizira kutupa, okosijeni ndi fibrosis.Kuwonongeka kwake kosalekeza kwa thupi sikudzangokhala ndi kuthamanga kwa magazi!

Chifukwa chake, kuti mukhale ndi malire, thupi limapanga mochenjera ACE2 pamwamba pa ma cell endothelial cell, alveolar, mtima, impso, matumbo aang'ono, bile duct, testis ndi ma cell ena amthupi, kuti athe kusintha angiotensin II kukhala ang. 1-7) yomwe imakulitsa mitsempha yamagazi, imachepetsa kuthamanga kwa magazi ndipo imatha kuletsa kutupa, anti-oxidation ndi anti-fibrosis.

Mwanjira ina, ACE2 ndi chiwopsezo chomwe chimagwiritsidwa ntchito m'thupi kuwongolera kupanga kwa angiotensin II kwambiri ndi ACE.Komabe, ACE2 imakhala doko lothandizira kuti buku la coronavirus liwukire ma cell.

ACE2 ikaphatikizidwa ndi puloteni ya spike ya buku la coronavirus, imakokera muselo kapena kukhetsedwa m'magazi chifukwa cha kuwonongeka kwamapangidwe, kotero kuti ACE2 yomwe ili pamwamba pa cell imachepetsedwa kwambiri ndipo imalephera kulimbana ndi angiotensin. II yoyendetsedwa ndi ACE.

Zotsatira zake, kuyankha kotupa komwe kumayambitsidwa ndi kachilomboka kumalumikizana ndi pro-inflammatory effect ya angiotensin II.Kuyankha kwakanthawi kotupa kumalepheretsa kaphatikizidwe ka ACE2 ndi ma cell, ndikupangitsa kuwonongeka kwa unyolo komwe kumachitika chifukwa cha kusalinganika kwa ACE/ACE2 kukhala kowopsa.Zimapangitsanso kuwonongeka kwa okosijeni ndi kuwonongeka kwa fibrosis kwa minofu ndi ziwalo kwambiri.

Kafukufuku wazachipatala adawona kuti angiotensin Ⅱ ya odwala omwe ali ndi matenda a coronavirus 2019 (COVID-19) imachulukitsidwa kwambiri, ndipo imagwirizana bwino ndi kuchuluka kwa kachilomboka, kuchuluka kwa kuvulala kwamapapo, kupezeka kwa chibayo chachikulu komanso kupuma movutikira. .Kafukufuku wasonyezanso kuti kuyankha kwamphamvu kwa kutupa, kuchuluka kwa magazi, komanso kuchuluka kwa magazi chifukwa cha kusalinganika kwa ACE/ACE2 ndi zifukwa zofunika zomwe zimawonjezera katundu pamtima ndi impso za odwala omwe ali ndi chibayo chatsopano cha coronavirus ndikuyambitsa myocardial ndi impso. matenda.

Kuletsa kwa ACE kumatha kusintha kusalinganika kwa ACE/ACE2

Zambiri zomwe zili mkatiGanoderma lucidumimatha kuletsa ACE

Popeza ACE inhibitors omwe amagwiritsidwa ntchito kwambiri pochiza matenda oopsa amatha kuletsa ntchito ya ACE, kuchepetsa kupanga kwa angiotensin II ndikuchepetsa kuwonongeka kwa unyolo chifukwa cha kusalinganika kwa ACE/ACE2, amawonedwa kuti ndi othandiza pochiza chibayo chatsopano cha coronavirus. .

Akatswiri aku Bangladeshi adagwiritsa ntchito mfundo iyi ngati chimodzi mwazifukwa zomwe bowa wodyedwa komanso mankhwala ali oyenera kupewa komanso kuchiza COVID-19.

Chifukwa malinga ndi kafukufuku wam'mbuyomu, bowa ambiri omwe amadyedwa komanso ochiritsa amakhala ndi zosakaniza zomwe zimalepheretsa ACE, pakati pawo.Ganoderma lucidumali ndi zinthu zambiri zogwira ntchito.

Onse ma polypeptides ali mu madzi Tingafinye waGanoderma lucidummatupi a zipatso ndi ma triterpenoids (monga ganoderic acid, ganoderenic acid ndi ganederols) omwe amapezeka mu methanol kapena ethanol Tingafinye.Ganoderma lucidumMatupi opatsa zipatso amatha kuletsa ntchito ya ACE (Table 1) ndipo zoletsa zake ndizabwino kwambiri pakati pa mafangasi ambiri odyedwa komanso amankhwala (Table 2).

Chofunika kwambiri, kuyambira m'ma 1970, maphunziro azachipatala ku China ndi Japan adatsimikizira iziGanoderma lucidumamatha kuchepetsa kuthamanga kwa magazi, kusonyeza kutiGanoderma lucidumKuletsa kwa ACE sikungochitika "chotheka" komanso kumatha kugwira ntchito kudzera m'matumbo.

Kugwiritsa ntchito kwachipatala kwa ACE inhibitors

Malingaliro owongolera kusalinganika kwa ACE/ACE2

Kaya kugwiritsa ntchito zoletsa za ACE kuchiza chibayo chatsopano cha coronavirus kudapangitsa kuti azachipatala azizengereza.

Chifukwa kuletsa ACE kumawonjezera mosadukiza mawu a ACE2.Ngakhale ndichinthu chabwino kulimbana ndi kutupa, oxidation ndi fibrosis, ACE2 ndiye cholandirira buku la coronavirus.Chifukwa chake ngati kuletsa kwa ACE kumateteza minofu kapena kumakulitsa matenda kunali kuda nkhawa.

Masiku ano, pakhala pali maphunziro azachipatala angapo (onani Maupangiri 6-9 kuti mumve zambiri) kuti zoletsa za ACE sizikulitsa mkhalidwe wa odwala omwe ali ndi chibayo cha coronavirus.Chifukwa chake, mabungwe ambiri amtima kapena matenda oopsa ku Europe ndi United States alimbikitsa odwala kuti apitirize kugwiritsa ntchito ACE inhibitor ngati palibe zovuta zachipatala zomwe zimachitika.

Ponena za odwala a COVID-19 omwe sanagwiritse ntchito zoletsa za ACE, makamaka omwe alibe vuto la kuthamanga kwa magazi, matenda amtima kapena matenda a shuga, ngakhale zoletsa za ACE ziyenera kuperekedwa pakali pano sizikudziwika makamaka chifukwa ngakhale maphunziro azachipatala adawona ubwino wogwiritsa ntchito zoletsa za ACE (monga ACE inhibitors). kuchuluka kwa kupulumuka), zotulukapo zake sizikuwoneka zowonekera mokwanira kukhala malingaliro owongolera azachipatala.

Udindo waGanoderma lucidumndizochulukirapo kuposa kuletsa ACE

Ndizosadabwitsa kuti ma inhibitors a ACE sangathe kukhala ndi zotsatirapo zazikulu panthawi yowunikira (nthawi zambiri tsiku limodzi mpaka mwezi umodzi).Kutupa kosalamulirika komwe kumachitika chifukwa cha nkhondo yapakati pa kachilomboka ndi chitetezo chamthupi ndiye gwero la kuwonongeka kwa buku la coronavirus chibayo.Popeza wolakwayo sanachotsedwe, ndizovuta kutembenuza zinthu koyamba popondereza ACE kuti athane ndi omwe amathandizira.

Vuto ndilakuti kusalinganika kwa ACE/ACE2 ndikoyenera kukhala udzu womaliza kuphwanya ngamila, ndipo kutha kukhala chopunthwitsa kuchira mtsogolo.Chifukwa chake, ngati mukuganiza za kufunafuna mwayi ndikupewa tsoka, kugwiritsa ntchito bwino zoletsa za ACE kumathandizira kuchira kwa odwala omwe ali ndi chibayo chatsopano cha coronavirus.

Komabe, poyerekeza ndi zotsatira zoyipa zomwe zitha kuyambitsidwa ndi zoletsa za ACE, monga chifuwa chowuma, allotriogeusti ndi potaziyamu wokwera wamagazi, katswiri waku Bangladeshi yemwe analemba pepalali amakhulupirira kuti zigawo zoletsa ACE mu bowa zomwe zimachitika mwachilengedwe komanso zamankhwala zimatha. osayambitsa kulemedwa kwa thupi.Makamaka,Ganoderma lucidum, yomwe ili ndi zigawo zambiri zoletsa ACE komanso zoletsa zabwino kwambiri, ndizofunikira kwambiri kuziyembekezera.

Zowonjezera, zambiriGanoderma lucidumzowonjezera kapenaGanoderma lucidumZosakaniza zomwe zimalepheretsa ACE zimathanso kulepheretsa kuchulukitsa kwa ma virus, kuwongolera kutupa (kupewa mkuntho wa cytokine), kumalimbitsa chitetezo chamthupi, kuteteza dongosolo lamtima, kuwongolera shuga wamagazi, kuwongolera kuthamanga kwa magazi, kuwongolera lipids m'magazi, kuchepetsa kuvulala kwa chiwindi, kuchepetsa kuvulala kwa impso, kuchepetsa kuvulala kwamapapu, kuteteza kupuma thirakiti, kuteteza matumbo thirakiti.Zopangira zoletsa za ACE kapena zoletsa zina za ACE zochokera ku bowa zodyedwa komanso zamankhwala sizingafanane ndiGanoderma lucidummwa ichi.

Kuchepetsa chiopsezo cha matenda oopsa ndi imfa ndikungochepetsako vutoli.

Kuyambira pomwe buku la coronavirus limasankha ACE2 ngati cholandirira cholowa, amayenera kukhala wosiyana ndi ma virus ena akupha komanso ovuta.

Chifukwa maselo ambiri am'thupi la munthu amakhala ndi ACE2.Coronavirus yatsopanoyo imatha kuwononga alveoli ndikuyambitsa hypoxia mthupi lonse, kutsatira magazi kuti mupeze maziko oyenera m'thupi, kukopa maselo achitetezo kulikonse kuti aukire, kuwononga mayendedwe a ACE / ACE2 kulikonse, kukulitsa kutupa, oxidation ndi fibrosis, kuonjezera magazi. kuthamanga ndi kuchuluka kwa magazi, kumawonjezera kulemedwa kwa mtima ndi impso, kupanga madzi am'thupi ndi kusalinganika kwa ma electrolyte komwe kumakhudza magwiridwe antchito a cell, ndikuyambitsa zotsatira zambiri za domino.

Chifukwa chake, matenda a chibayo cha coronavirus sikutanthauza "kuzizira kwambiri" komwe "kumangokhudza mapapu".Idzakhala ndi zotsatira za nthawi yayitali ku minofu ya thupi, ziwalo ndi ntchito za thupi.

Ngakhale uthenga wabwino wokhudza kupanga mankhwala atsopano oletsa komanso kuchiza COVID-19 ndiwosangalatsa kwambiri, mfundo zina zopanda ungwiro zili pafupi:

Katemera (kuyambitsa ma antibodies) sikutsimikizira kuti sipadzakhala matenda;

Mankhwala oletsa tizilombo toyambitsa matenda (kuletsa kuchulukana kwa ma virus) sangatsimikizire kuchira kwa matendawa;

Steroid anti-inflammation (kuchepetsa chitetezo cha mthupi) ndi lupanga lakuthwa konsekonse;

Zovuta sizingapewedwe ngakhale palibe matenda oopsa;

Kusintha kwa kuyeza kwa ma virus kuchokera ku zabwino kupita ku zoipa sikutanthauza kulimbana kopambana ndi mliri;

Kutuluka m’chipatala wamoyo sikutanthauza kuti mudzachira bwinobwino m’tsogolo.

Pamene mankhwala a coronavirus ndi katemera watithandiza kumvetsetsa "zambiri" zochepetsera kudwala kwambiri, kuchepetsa mwayi wakufa ndikufupikitsa nthawi yogonekedwa m'chipatala, musaiwale kuti pali "zambiri" zambiri zomwe tiyenera tidzidalira tokha kuti tithane nazo.

Anthu akadalira luntha ndi luso lophatikiza mankhwala osiyanasiyana akale ndi atsopano omwe ali ndi zotsatirapo zake kuti akwaniritse bwino, tiyenera kuphunzira kugwiritsa ntchito njira yanthawi zonse yothandizira kuthana ndi matendawa.

Kuchokera pakukulitsa kukana, kuletsa kubwereza kwa ma virus, kuwongolera kutupa kwachilendo, kulinganiza ACE / ACE2 kuteteza dongosolo lamtima, kuwongolera zokwera zitatu ndikuchepetsa kulemetsa kwa matenda osachiritsika m'thupi, izi zitha kunenedwa ngati zofunikira zochepetsera kuchuluka kwa matenda. COVID-19, kuteteza kwambiri COVID-19 ndikuwongolera kuchira kwa COVID-19.

Palibe amene akudziwa ngati pali chiyembekezo m'tsogolo chokwaniritsa zofunika izi panthawi imodzi.Mwinamwake "zophikira zachinsinsi" zomwe ziri kutali kwambiri kumwamba ziridi pamaso panu.Kwa nthawi yaitali Mulungu wachifundo wakonza zophikira zakudya zomwe zili zachilengedwe, zogwiritsidwa ntchito pawiri monga chakudya ndi mankhwala, zomwe zimapezeka mosavuta, komanso zoyenera kwa amuna, akazi ndi ana.Zimangotengera ngati tikudziwa kugwiritsa ntchito.

[Chitsime]

1. Mohammad Azizur Rahman, et al.Int J Med Bowa.2021;23(5):1-11.

2. Aiko Morigiwa, et al.Chem Pharm Bull (Tokyo).1986;34 (7): 3025-3028.

3. Noorlidah Abdullah, ndi al.Evid Based Complement Alternat Med.2012;2012:464238.

4. Tran Hai-Bang, et al.Mamolekyu.2014;19(9):13473-13485.

5. Tran Hai-Bang, et al.Phytochem Lett.2015; 12: 243-247.

6. Chirag Bavishi, ndi al.JAMA Cardiol.2020; 5(7):745-747.

7. Abhinav Grover, et al.2020 Jun 15: pvaa064.doi:10.1093/ehjcvp/pvaa064.

8. Renato D. Lopes, et al.Am Heart J. 2020 Aug; 226: 49–59.

9. Renato D. Lopes, et al.JAMA.2021 Jan 19;325 (3):254–264.

TSIRIZA

Za wolemba/ Mayi Wu Tingyao
Wu Tingyao wakhala akufotokoza zambiri za Ganoderma lucidum kuyambira 1999. Iye ndi mlembi wa bukuli.Kuchiza ndi Ganoderma(lofalitsidwa mu The People's Medical Publishing House mu April 2017).
 
★ Nkhaniyi yasindikizidwa pansi pa chilolezo cha wolemba, ndipo umwini ndi wa GANOHERB.

★ Ntchito zomwe zili pamwambazi sizingapangidwenso, kuchotsedwa kapena kugwiritsidwa ntchito m'njira zina popanda chilolezo cha GanoHerb.

★ Ngati ntchitozo zaloledwa kugwiritsidwa ntchito, ziyenera kugwiritsidwa ntchito molingana ndi chilolezo ndikuwonetsa gwero: GanoHerb.

★ Pakuphwanya kulikonse kwa mawu omwe ali pamwambapa, GanoHerb idzatsata maudindo okhudzana ndi zamalamulo.

★ Zolemba zoyambirira za nkhaniyi zidalembedwa m'Chitchaina ndi Wu Tingyao ndikumasulira m'Chingerezi ndi Alfred Liu.Ngati pali kusiyana kulikonse pakati pa kumasulira (Chingerezi) ndi choyambirira (Chitchaina), Chitchaina choyambirira chidzapambana.Ngati owerenga ali ndi mafunso, lemberani wolemba woyamba, Mayi Wu Tingyao.
 

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