Mashi 1, 2018 / Russian Academy of Sciences / Phytomedicine

Umbhalo / Wu Tingyao

Ngo-March 2018, iphepha elanyatheliswa ku-Phytomedicine yi-Institute of Cytology and Genetics ye-Russian Academy of Sciences laqinisekisa ukuthi ngemva kwamasonto ayisikhombisa okudla.I-Ganoderma lucidum(Reishi) isithelo samanzi somzimba esikhishwa amagundane aphethwe yi-arterial hypertension ezuzwa njengefa, umphumela we-hypotensiveI-Ganoderma lucidumukukhishwa kwamanzi kuqhathaniswa ne-Losartan (bheka Umfanekiso 1).

Ucwaningo lwezilwane luphinde lwathola ukuthi kumagundane ane-hypertensive alashweI-Ganoderma lucidumukukhishwa kwamanzi, umthamo wokugeleza kwegazi womthambo we-carotid wenyuka kakhulu, cishe ngokuphindwe kabili kunalawo angenakwelashwa (bheka Umfanekiso 2).Ngesikhathi esifanayo, ububanzi be-carotid artery kanye nezinga lokugeleza kwegazi nakho kwanda kakhulu.Lokhu kusho ukuthi ukugeleza kwegazi eliya ebuchosheni begundane akuncishiswa ukwehla komfutho wegazi kodwa kunalokho kuba namandla futhi kuvame ngaphansi kwethonyaI-Ganoderma lucidum.Ngokuphambene nalokho, nakuba ububanzi bomthambo we-carotid wamagundane eqenjini lezidakamizwa ze-hypotensive landa, izinga lokugeleza kwegazi alizange lidlule iqembu lokulawula, futhi umthamo wokugeleza kwegazi awuzange uhluke kakhulu kuneqembu lokulawula.

Ngo-March 2018, iphepha elanyatheliswa ku-Phytomedicine yi-Institute of Cytology and Genetics ye-Russian Academy of Sciences laqinisekisa ukuthi ngemva kwamasonto ayisikhombisa okudla.I-Ganoderma lucidum(Reishi) isithelo samanzi somzimba esikhishwa amagundane aphethwe yi-arterial hypertension ezuzwa njengefa, umphumela we-hypotensiveI-Ganoderma lucidumukukhishwa kwamanzi kuqhathaniswa ne-Losartan (bheka Umfanekiso 1).

Ucwaningo lwezilwane luphinde lwathola ukuthi kumagundane ane-hypertensive alashweI-Ganoderma lucidumukukhishwa kwamanzi, umthamo wokugeleza kwegazi womthambo we-carotid wenyuka kakhulu, cishe ngokuphindwe kabili kunalawo angenakwelashwa (bheka Umfanekiso 2).Ngesikhathi esifanayo, ububanzi be-carotid artery kanye nezinga lokugeleza kwegazi nakho kwanda kakhulu.Lokhu kusho ukuthi ukugeleza kwegazi eliya ebuchosheni begundane akuncishiswa ukwehla komfutho wegazi kodwa kunalokho kuba namandla futhi kuvame ngaphansi kwethonyaI-Ganoderma lucidum.Ngokuphambene nalokho, nakuba ububanzi bomthambo we-carotid wamagundane eqenjini lezidakamizwa ze-hypotensive landa, izinga lokugeleza kwegazi alizange lidlule iqembu lokulawula, futhi umthamo wokugeleza kwegazi awuzange uhluke kakhulu kuneqembu lokulawula.

Umfanekiso 2 Umphumela weI-Ganoderma lucidumukukhishwa kwamanzi kumthamo wokugeleza kwegazi we-arterial

[Qaphela] Inqubo yokuhlola iyafana nengenhla.Ngemva kwamasonto ayisikhombisa okwelashwa, umthamo wokugeleza kwegazi we-carotid weqembu le-Reishi wawuphakeme kakhulu kunalawo amanye amaqembu amabili.(Umthombo/Phytomedicine.2018 Mar 1; 41:1-6.)

Ukuhlaziywa okwengeziwe kwama-neurotransmitters ayi-12 akhiqizwe yi-cerebral cortex yeqembu ngalinye lamagundane, kwatholakala ukuthi ukukhishwa kwamanziI-Ganoderma lucidumumzimba wezithelo ungashintsha isilinganiso sama-neurotransmitters athile, okwenza ama-neurotransmitters angavimbeli (njenge-glycine, ebizwa ngokuthi i-Gly) nama-neurotransmitters ajabulisayo (afana ne-glutamine, ebizwa ngokuthi i-Glx) asondele esimweni esinokulinganisela, futhi isimo esinjalo sifanelekile umfutho wegazi ojwayelekile.

Lo mphumela ukhombisa ukuthi uma kuqhathaniswa neLosartan, ephikisana nomphikisi we-AT1 receptors we-angiotensin Ⅱ ukunweba imithambo yegazi nokulawula umfutho wegazi,I-Ganoderma lucidumukukhishwa kwamanzi kuyinkimbinkimbi kakhulu ekulawuleni umfutho wegazi futhi kuhlobene nokulawulwa kwesimiso sezinzwa ze-cranial.

Imodeli yezilwane esetshenziswe ekuhloleni "i-herited stress-induced arterial hypertension", okungukuthi, umthethosisekelo ozuzwe ngofuzo kubaba noma umama obangela kalula umfutho wegazi ophakeme, futhi ukucindezeleka kwengqondo kuyisici esiyinhloko esibangela.Lokhu empeleni kuhambisana nesimo seziguli eziningi ezine-hypertension ye-hereditary ye-etiology engaziwa: ukuphazamiseka kwesistimu yezinzwa ezizimele ezibangelwa ukucindezeleka (ukungalingani komsebenzi olawulayo phakathi kwenzwa enozwela ephethwe ama-neurotransmitters ajabulisayo kanye ne-parasympathetic nerve elawulwa yi-neurotransmitters evimbela) njalo ephezulu futhi kunzima ukubuyela emazingeni ajwayelekile.

Uma ungabuqondi ubudlelwano phakathi kwemizwa ye-autonomic kanye nomfutho wegazi, ungacabanga ukuthi umfutho wegazi uyakhuphuka ngenxa yenjabulo engokomzwelo (ebuswa isimiso sezinzwa esizwelayo) ngenkathi ubuka umdlalo webhola, kodwa umfutho wegazi wehla ubuyela kwesijwayelekile ngemva kwalokho. isikhathi sokuphumula (esibuswa yi-parasympathetic nervous system).Lena indlela evamile yokulawula.Uma umfutho wegazi ungasakwazi ukubuyela esimeni esijwayelekile ngokuphumula, ukulala, nokuphumula ngokomzwelo, kuzoba nenkinga yomfutho wegazi ophakeme.Ngokuqondene nokuthi umfutho wegazi uyafinyelela yini esimweni sesifo esichazwe ngokwezokwelapha esidinga imithi, kuncike ekutheni i-systolic noma i-diastolic blood pressure idlula inani elinqunyiwe - inqobo nje uma enye yazo ingavamile, kubhekwa njengomfutho wegazi ophezulu.

Kunezindawo eziningana zobuchopho ezingathinta umfutho wegazi kanye nesimo sengqondo.Imvamisa, zilawulwa yi-cerebral cortex (“isikhungo sokulawula ikhono eliphezulu lobuchopho”).Ngaphambilini, elinye iqembu labacwaningi abavela e-Russian Academy of Sciences liye laqinisekisa ukuthi kumagundane ane "hypertension ye-arterial hypertension ezuzwe njengefa", i-cerebral cortex ifihla ama-neurotransmitters ajabulisayo, agcina umfutho wegazi uphakeme.Manje, ekuhlolweni ngeI-Ganoderma lucidum, kuye kwaphawulwa ukuthi ukuphathwa ngomlomo kweI-Ganoderma lucidumukukhishwa kwamanzi amasonto ayisikhombisa alandelanayo kungalawula ama-neurotransmitters akhiqizwe yi-cerebral cortex futhi kuthuthukise ngokuyisisekelo umfutho wegazi ophakeme.

Mayelana nalawo magundane ane-hypertensive ayedlaI-Ganoderma lucidumfruiting body extract, ukugeleza kwegazi lobuchopho kwanda futhi izinga lokugeleza kwegazi labo lenyuka.Ngakho-ke, umcwaningi uveze ekugcineni kombiko ukuthiI-Ganoderma lucidumi-extract ingase ibe nomthelela we-nootropic.

Ukuthi uyadlaI-Ganodermalucidumingakhiqiza ngempela imiphumela ye-nootropic, kufanele ifakazelwe ngolunye ucwaningo.Kodwa ezigulini ezinomfutho wegazi ophezulu i-etiology yazo engaziwa (ayibangelwa isifo sikashukela nesifo sezinso),I-Ganoderma lucidumimikhiqizo equketheI-Ganoderma lucidumfruiting umzimba ezikhishwe kufanele kuwufanele ngizame.OkungenaniI-Ganoderma lucidumayikhiqizi imiphumela engemihle efana nesiyezi, ukuminyana kwamakhala, ukukhwehlela, nesicanucanu esivamile emithini evamile ye-antihypertensive.

Kuhle ukusho ukuthi izifundo ezedlule zikuqinisekisile lokhoI-Ganoderma lucidumI-triterpenes ingavimbela umsebenzi we-angiotensin eguqula i-enzyme (ACE) ukuze i-Angiotensin I ekhishwe yizinso ingakwazi ukukhishwa yi-ACE ku-Angiotensin II engakhuthaza i-vasoconstriction.Manje, ukukhishwa kwamanzi kweI-Ganoderma lucidumumzimba wezithelo, owakhiwa ikakhulukazi ama-polysaccharides, kufakazelwe ukuthi uthuthukisa umfutho wegazi ophakeme ngokulawula uhlelo lwezinzwa ze-cranial.Ukuhambisana kwama-triterpenoids nama-polysaccharides kuyaphinda kuqinisekisa lokhoI-Ganoderma lucidumngezithako eziphelele (eziqukethe kokubili i-triterpenoids nama-polysaccharides) kuyisinqumo esifanele.

[Umthombo] Shevelev OB, et al.Imiphumela ye-Hypotensive kanye neurometabolic ye-intragastric Reishi (I-Ganoderma lucidum) ukuphathwa kwe-hypertensive ISIAH rat strain.I-Phytomedicine.2018 Mar 1;41:1-6.

PHELA

Mayelana nombhali/ Nks. Wu Tingyao

UWu Tingyao ubelokhu ebika ngolwazi lwe-Ganoderma lokuqala kusukela ngo-1999. Ungumbhali wencwadiUkwelapha nge-Ganoderma(ishicilelwe ku-People's Medical Publishing House ngo-Ephreli 2017).

★ Lesi sihloko sishicilelwe ngaphansi kokugunyazwa okukhethekile kombhali.★ Le misebenzi engenhla ayinakuphinda ikhiqizwe, ikhishwe noma isetshenziswe ngezinye izindlela ngaphandle kwemvume yombhali.★ Ngokuphulwa kwesitatimende esingenhla, umbhali uzolandela izibopho ezingokomthetho ezifanele.★ Umbhalo wokuqala walesi sihloko ubhalwe ngesiShayina nguWu Tingyao futhi wahunyushelwa esiNgisini ngu-Alfred Liu.Uma kukhona ukungqubuzana phakathi kokuhumusha (isiNgisi) kanye nokwangempela (isiShayina), isiShayina sangempela siyonqoba.Uma abafundi benemibuzo, sicela uthinte umbhali wokuqala, uNksz. Wu Tingyao.