Matshi 1, 2018 / Russian Academy of Sciences / Phytomedicine

Umbhalo / Wu Tingyao

Ngo-Matshi 2018, iphepha elipapashwe kwiPhytomedicine yiZiko leCytology kunye neGenetics ye-Academy yaseRussia yeSayensi yeSayensi yaqinisekisa ukuba emva kweeveki ezisixhenxe zokutya.I-Ganoderma lucidum(Reishi) isiqhamo samanzi aphuma emzimbeni kwiimpuku eziphethwe luxinzelelo lwegazi oluzuzwa njengelifa, isiphumo se-hypotensiveI-Ganoderma lucidumisicatshulwa samanzi sifaniswa nelosartan (jonga umfanekiso 1).

Uvavanyo lwezilwanyana lukwafumanise ukuba iimpuku ezinoxinzelelo lwegazi zinyangwaI-Ganoderma lucidumisicatshulwa samanzi, umthamo wegazi lomthambo we-carotid unyuke kakhulu, malunga nokuphindwe kabini kunabo bangenalo naluphi na unyango (jonga uMfanekiso 2).Kwangaxeshanye, i-carotid artery diameter kunye ne-blood flow rate nayo yanda kakhulu.Oku kuthetha ukuba ukuhamba kwegazi kwingqondo yempuku akuncitshiswa kukuhla koxinzelelo lwegazi kodwa endaweni yoko kuya kusebenza ngakumbi kwaye kuninzi phantsi kweempembelelo zeI-Ganoderma lucidum.Ngokwahlukileyo, nangona umthambo we-carotid ububanzi beegundane kwiqela leziyobisi ze-hypotensive zanda, izinga lokuhamba kwegazi alizange lidlule kwiqela lokulawula, kwaye umthamo wegazi wawungafani kakhulu neqela lokulawula.

Ngo-Matshi 2018, iphepha elipapashwe kwiPhytomedicine yiZiko leCytology kunye neGenetics ye-Academy yaseRussia yeSayensi yeSayensi yaqinisekisa ukuba emva kweeveki ezisixhenxe zokutya.I-Ganoderma lucidum(Reishi) isiqhamo samanzi aphuma emzimbeni kwiimpuku eziphethwe luxinzelelo lwegazi oluzuzwa njengelifa, isiphumo se-hypotensiveI-Ganoderma lucidumisicatshulwa samanzi sifaniswa nelosartan (jonga umfanekiso 1).

Uvavanyo lwezilwanyana lukwafumanise ukuba iimpuku ezinoxinzelelo lwegazi zinyangwaI-Ganoderma lucidumisicatshulwa samanzi, umthamo wegazi lomthambo we-carotid unyuke kakhulu, malunga nokuphindwe kabini kunabo bangenalo naluphi na unyango (jonga uMfanekiso 2).Kwangaxeshanye, i-carotid artery diameter kunye ne-blood flow rate nayo yanda kakhulu.Oku kuthetha ukuba ukuhamba kwegazi kwingqondo yempuku akuncitshiswa kukuhla koxinzelelo lwegazi kodwa endaweni yoko kuya kusebenza ngakumbi kwaye kuninzi phantsi kweempembelelo zeI-Ganoderma lucidum.Ngokwahlukileyo, nangona umthambo we-carotid ububanzi beegundane kwiqela leziyobisi ze-hypotensive zanda, izinga lokuhamba kwegazi alizange lidlule kwiqela lokulawula, kwaye umthamo wegazi wawungafani kakhulu neqela lokulawula.

Umfanekiso wesi-2 Isiphumo seI-Ganoderma lucidumisicatshulwa samanzi kumthamo wegazi lokuhamba kwegazi

[Qaphela] Inkqubo yovavanyo iyafana nale ingasentla.Emva kweeveki ezisixhenxe zonyango, umthamo wegazi we-carotid weqela leReishi wawuphezulu kakhulu kunomnye amaqela amabini.(Umthombo / Phytomedicine.2018 Mar 1; 41: 1-6.)

Uhlalutyo olongezelelweyo lwe-12 eziphambili ze-neurotransmitters ezifihliwe yi-cerebral cortex yeqela ngalinye leempuku, kwafunyaniswa ukuba isicatshulwa samanziI-Ganoderma lucidumumzimba ovelisa iziqhamo unokutshintsha umlinganiselo wee-neurotransmitters ezithile, zenze i-neurotransmitters ezinqandayo (ezifana ne-glycine, ekubhekiselwa kuyo njenge-Gly) kunye ne-neurotransmitters evuselelayo (efana ne-glutamine, ekubhekiselwa kuyo njenge-Glx) kufutshane nemeko elungeleleneyo, kwaye imeko enjalo ifanelekile uxinzelelo lwegazi oluqhelekileyo.

Esi siphumo sibonisa ukuba xa kuthelekiswa ne-Losartan, echasene ne-AT1 receptors ye-angiotensin Ⅱ yokwandisa imithambo yegazi kunye nokulawula uxinzelelo lwegazi,I-Ganoderma lucidumisicatshulwa samanzi siyinkimbinkimbi ngakumbi ekulawuleni uxinzelelo lwegazi kwaye ihambelana nokulawulwa kwenkqubo ye-nervous cranial.

Imodeli yezilwanyana ezisetyenzisiweyo kuvavanyo "yifa loxinzelelo-i-arterial hypertension", oko kukuthi, umgaqo-siseko ozuzwe nguyise okanye umama obangela ngokulula uxinzelelo lwegazi, kunye noxinzelelo lwengqondo yinto ephambili yokubangela.Oku ngokwenene kuhambelana nemeko yezigulane ezininzi ezine-hypertension ye-hereditary ye-etiology engaziwayo: ukuphazamiseka kwenkqubo ye-nervous autonomic ebangelwa uxinzelelo (ukungalingani komsebenzi olawulayo phakathi kwe-nerve yemfesane elawulwa yi-neurotransmitters ye-excitatory kunye ne-parasympathetic nerve elawulwa yi-neurotransmitters evimbelayo) yenza uxinzelelo lwegazi. ihlala iphezulu kwaye inzima ukubuyela kumanqanaba aqhelekileyo.

Ukuba awuyiqondi ubudlelwane phakathi kwemithambo-luvo ye-autonomic kunye noxinzelelo lwegazi, unokucinga ukuba uxinzelelo lwegazi luyanyuka ngenxa yolonwabo lweemvakalelo (olulawulwa yinkqubo ye-nervous novelwano) ngelixa ubukele umdlalo webhola, kodwa uxinzelelo lwegazi lubuyela kwisiqhelo ixesha lokuphumla (elilawulwa yinkqubo ye-nervous parasympathetic).Le yindlela eqhelekileyo yokulawula.Emva kokuba uxinzelelo lwegazi lungakwazi ukubuyela kwisiqhelo ngokuphumla, ukulala, kunye nokuphumla ngokweemvakalelo, kuya kubakho ingxaki yoxinzelelo lwegazi oluphezulu.Ngokuphathelele ukuba uxinzelelo lwegazi lufikelela kwimeko yesifo esichazwe ngokwezonyango esifuna amayeza, kuxhomekeke ekubeni i-systolic okanye i-diastolic yegazi idlula ixabiso elimiselweyo - nje ukuba enye yazo ingaqhelekanga, ithathwa njengoxinzelelo lwegazi oluphezulu.

Kukho iindawo ezininzi zobuchopho ezinokuchaphazela uxinzelelo lwegazi kunye nomoya.Ngokuqhelekileyo, zilawulwa yi-cerebral cortex (“elona ziko lolawulo lokuqonda kwengqondo liphezulu”).Ngaphambili, elinye iqela labaphandi abavela kwi-Academy yaseRashiya yeSayensi liqinisekisile ukuba kwiigundane "ezinoxinzelelo oluzuzwe kwi-arterial hypertension", i-cortex ye-cerebral ifihla i-neurotransmitters enomdla, igcina uxinzelelo lwegazi luphezulu.Ngoku, kwimifuniselo ngeI-Ganoderma lucidum, kuye kwaphawulwa ukuba ulawulo lomlomo lweI-Ganoderma lucidumUkukhutshwa kwamanzi kwiiveki ezisixhenxe ezilandelelanayo kunokulawula i-neurotransmitters ekhutshwe yi-cerebral cortex kwaye iphucule ngokusisiseko uxinzelelo lwegazi.

Ngokuphathelele ezompuku zehypertension ezityileyoI-Ganoderma lucidumfruiting body extract, ukuhamba kwegazi lobuchopho kwanda kwaye izinga lokuhamba kwegazi landa.Ngoko ke, umphandi wabonisa ekupheleni kwengxelo ukubaI-Ganoderma lucidumisicatshulwa sinokuba nefuthe elinokubakho le-nootropic.

Nokuba ukutyaI-Ganodermaluciduminokuvelisa ngokwenene iziphumo ze-nootropic, kufuneka ingqinwe ngolunye uvavanyo.Kodwa kwizigulane ezinoxinzelelo lwegazi olune-etiology engaziwa (engabangelwa sisifo seswekile kunye nesifo sezintso),I-Ganoderma lucidumiimveliso eziqulatheI-Ganoderma lucidumIziqhamo zomzimba ezivelisa iziqhamo kufuneka zizame.KungconoI-Ganoderma lucidumayivelisi ziphumo bezingalindelekanga ezifana nesiyezi, ukuxinana kweempumlo, ukukhohlela, kunye nesicaphucaphu ezixhaphakileyo kumachiza okulwa noxinzelelo olukhulu.

Kufanelekile ukukhankanya ukuba izifundo ezidlulileyo zikuqinisekisile okoI-Ganoderma lucidumI-triterpenes inokuthintela umsebenzi we-angiotensin ukuguqula i-enzyme (ACE) ukwenzela ukuba i-Angiotensin I efihliweyo yintso ayikwazi ukuqhutyelwa yi-ACE kwi-Angiotensin II enokukhuthaza i-vasoconstriction.Ngoku, isicatshulwa samanzi seI-Ganoderma lucidumumzimba ovelisa iziqhamo, owenziwe ikakhulu ziipolysaccharides, ungqinwe ukuba uphucula uxinzelelo lwegazi ngokulawula inkqubo yemithambo-luvo yecranial.Ukuhambelana kwe-triterpenoids kunye ne-polysaccharides kwakhona kuqinisekisa okoI-Ganoderma lucidumkunye nezithako ezipheleleyo (eziqulethe zombini i-triterpenoids kunye ne-polysaccharides) lukhetho olufanelekileyo.

[Umthombo] Shevelev OB, et al.Iziphumo ze-hypotensive kunye neurometabolic ye-intragastric Reishi (I-Ganoderma lucidum) ulawulo kuxinzelelo lwempuku ye-ISIAH ephezulu.IPhytomedicine.2018 Mar 1;41:1-6 .

ISIPHELO

Malunga nombhali/ Nksz. Wu Tingyao

UWu Tingyao unike ingxelo ngolwazi lweGanoderma lokuqala ukusukela ngo-1999. Ungumbhali wencwadiUkunyanga ngeGanoderma(ipapashwe kwiNdlu yePeople's Medical Publishing House ngo-Epreli 2017).

★ Eli nqaku lipapashwe phantsi kogunyaziso olulodwa lombhali.★ Le misebenzi ingasentla ayinakuphinda iveliswe, icatshulwe okanye isetyenziswe ngezinye iindlela ngaphandle kokugunyaziswa ngumbhali.★ Ukwaphulwa kwengxelo engentla, umbhali uya kulandela uxanduva olusemthethweni olufanelekileyo.★ Umbhalo wokuqala weli nqaku ubhalwe ngesiTshayina nguWu Tingyao waza waguqulelwa kwisiNgesi nguAlfred Liu.Ukuba kukho nakuphi na ukungangqinelani phakathi kwenguqulelo (isiNgesi) kunye neyoqobo (isiTshayina), isiTshayina sokuqala siya koyisa.Ukuba abafundi banayo nayiphi na imibuzo, nceda uqhagamshelane nombhali wokuqala, uNks. Wu Tingyao.