March 1, 2018 / Russian Academy of Sciences / Phytomedicine

Zolemba / Wu Tingyao

Mu Marichi 2018, pepala lofalitsidwa mu Phytomedicine ndi Institute of Cytology and Genetics of the Russian Academy of Sciences idatsimikiza kuti patatha milungu isanu ndi iwiri yodyetsa.Ganoderma lucidum(Reishi) kutulutsa madzi amthupi kwa makoswe omwe ali ndi vuto la kuthamanga kwa magazi komwe kumayambitsa kupsinjika, mphamvu ya hypotensive yaGanoderma lucidumKutulutsa kwamadzi kumafanana ndi Losartan (onani Chithunzi 1).

The nyama kuyesera anapezanso kuti makoswe hypertensive mankhwala ndiGanoderma lucidummadzi, kuchuluka kwa magazi kwa mtsempha wawo wa carotid kunakula kwambiri, pafupifupi kuwirikiza kawiri kuposa omwe alibe chithandizo chilichonse (onani Chithunzi 2).Panthawi imodzimodziyo, mitsempha ya carotid ndi kuthamanga kwa magazi kunakula kwambiri.Izi zikutanthauza kuti magazi opita ku ubongo wa makoswe sachepetsedwa ndi kutsika kwa kuthamanga kwa magazi koma m'malo mwake amakhala otanganidwa komanso ochuluka chifukwa chaGanoderma lucidum.Mosiyana ndi zimenezi, ngakhale kuti mitsempha ya carotid ya makoswe mu gulu la mankhwala a hypotensive inawonjezeka, kuchuluka kwa magazi sikunapitirire gulu lolamulira, ndipo kuchuluka kwa magazi sikunali kosiyana kwambiri ndi gulu lolamulira.

Mu Marichi 2018, pepala lofalitsidwa mu Phytomedicine ndi Institute of Cytology and Genetics of the Russian Academy of Sciences idatsimikiza kuti patatha milungu isanu ndi iwiri yodyetsa.Ganoderma lucidum(Reishi) kutulutsa madzi amthupi kwa makoswe omwe ali ndi vuto la kuthamanga kwa magazi komwe kumayambitsa kupsinjika, mphamvu ya hypotensive yaGanoderma lucidumKutulutsa kwamadzi kumafanana ndi Losartan (onani Chithunzi 1).

The nyama kuyesera anapezanso kuti makoswe hypertensive mankhwala ndiGanoderma lucidummadzi, kuchuluka kwa magazi kwa mtsempha wawo wa carotid kunakula kwambiri, pafupifupi kuwirikiza kawiri kuposa omwe alibe chithandizo chilichonse (onani Chithunzi 2).Panthawi imodzimodziyo, mitsempha ya carotid ndi kuthamanga kwa magazi kunakula kwambiri.Izi zikutanthauza kuti magazi opita ku ubongo wa makoswe sachepetsedwa ndi kutsika kwa kuthamanga kwa magazi koma m'malo mwake amakhala otanganidwa komanso ochuluka chifukwa chaGanoderma lucidum.Mosiyana ndi zimenezi, ngakhale kuti mitsempha ya carotid ya makoswe mu gulu la mankhwala a hypotensive inawonjezeka, kuchuluka kwa magazi sikunapitirire gulu lolamulira, ndipo kuchuluka kwa magazi sikunali kosiyana kwambiri ndi gulu lolamulira.

Chithunzi 2 Zotsatira zaGanoderma lucidumchotsitsa chamadzi pamlingo wothamanga wamagazi

[Zindikirani] Njira yoyesera ndi yofanana ndi pamwambapa.Pambuyo pa masabata asanu ndi awiri a chithandizo, kuchuluka kwa magazi a carotid a gulu la Reishi kunali kwakukulu kwambiri kuposa magulu ena awiri.(Gwero/Phytomedicine.2018 Mar 1; 41:1-6.)

Kusanthula kwina kwa ma neurotransmitters akuluakulu a 12 opangidwa ndi cerebral cortex ya gulu lililonse la makoswe, zidapezeka kuti madzi otulutsaGanoderma lucidumthupi la fruiting limatha kusintha chiŵerengero cha ma neurotransmitters ena, kupangitsa kuti ma neurotransmitters oletsa (monga glycine, omwe amatchedwa Gly) ndi ma neurotransmitters osangalatsa (monga glutamine, omwe amatchedwa Glx) akhale pafupi ndi chikhalidwe chokhazikika, ndipo mkhalidwe wotere umakhala wothandiza wamba kuthamanga kwa magazi.

Zotsatirazi zikuwonetsa kuti poyerekeza ndi Losartan, yemwe amatsutsana ndi wotsutsa wa AT1 receptors wa angiotensin Ⅱ kukulitsa mitsempha yamagazi ndikuwongolera kuthamanga kwa magazi,Ganoderma lucidumchotsitsa chamadzi chimakhala chovuta kwambiri pakuwongolera kuthamanga kwa magazi ndipo chimagwirizana ndi kuwongolera kwa dongosolo lamanjenje la cranial.

Chitsanzo cha nyama chomwe chimagwiritsidwa ntchito poyesera ndi "cholowa chotengera kupanikizika kwa magazi", ndiko kuti, malamulo omwe amachokera kwa abambo kapena amayi omwe amayambitsa kuthamanga kwa magazi mosavuta, ndipo kupsinjika maganizo ndizomwe zimayambitsa kwambiri.Izi zikugwirizana ndi zomwe odwala ambiri omwe ali ndi matenda oopsa a cholowa cha etiology yosadziwika: kusokonezeka kwa dongosolo lamanjenje lodziyimira pawokha chifukwa cha kupsinjika (kusagwirizana kwa magwiridwe antchito pakati pa mitsempha yachifundo yomwe imayendetsedwa ndi ma neurotransmitters osangalatsa komanso mitsempha ya parasympathetic yomwe imayendetsedwa ndi ma neurotransmitters oletsa) kumapangitsa kuthamanga kwa magazi. nthawi zonse zimakhala zokwera komanso zovuta kubwerera kumagulu abwinobwino.

Ngati simukumvetsa ubale pakati pa minyewa autonomic ndi kuthamanga kwa magazi, mukhoza kuganiza kuti kuthamanga kwa magazi spikes chifukwa cha chisangalalo maganizo (chomwe chimalamuliridwa ndi wachifundo mantha dongosolo) pamene kuonera masewera mpira, koma kuthamanga kwa magazi kutsika kubwerera mwakale pambuyo. nthawi yopuma (yomwe imayendetsedwa ndi dongosolo lamanjenje la parasympathetic).Iyi ndiye njira yoyendetsera bwino.Kuthamanga kwa magazi kukalephera kubwerera mwakale mwa kupuma, kugona, ndi kumasuka maganizo, padzakhala vuto la kuthamanga kwa magazi.Ngati kuthamanga kwa magazi kumafika ku matenda omwe amatchulidwa ndi mankhwala omwe amafunikira mankhwala, zimadalira ngati systolic kapena diastolic magazi amaposa mtengo wotchulidwa - malinga ngati mmodzi wa iwo ndi wachilendo, amaonedwa kuti ndi kuthamanga kwa magazi.

Pali mbali zingapo za ubongo zomwe zingakhudze kuthamanga kwa magazi ndi maganizo.Nthawi zambiri, amayendetsedwa ndi cerebral cortex ("malo apamwamba kwambiri owongolera luso laubongo").M'mbuyomu, gulu lina la ochita kafukufuku ku Russian Academy of Sciences latsimikizira kuti makoswe omwe ali ndi "kupanikizika kwapamtima komwe kumayambitsa matenda oopsa", ubongo wa cerebral cortex umatulutsa ma neurotransmitters okondweretsa kwambiri, kusunga kuthamanga kwa magazi.Tsopano, mu zoyesera ndiGanoderma lucidum, kwawonedwa kuti kuwongolera pakamwa kwaGanoderma lucidumKutulutsa kwamadzi kwa milungu isanu ndi iwiri yotsatizana kumatha kuwongolera ma neurotransmitters opangidwa ndi cerebral cortex ndikuwongolera kuthamanga kwa magazi.

Koma makoswe a hypertensive aja omwe amadyaGanoderma lucidumfruiting thupi Tingafinye, magazi awo muubongo anakula ndi kuthamanga magazi awo kuchuluka.Choncho, wofufuzayo ananena kumapeto kwa lipoti kutiGanoderma lucidumKutulutsa kumatha kukhala ndi zotsatira za nootropic.

Kaya kudyaGanodermalucidumimatha kutulutsa zotsatira za nootropic, ziyenera kutsimikiziridwa ndi kuyesa kwina.Koma kwa odwala omwe ali ndi kuthamanga kwa magazi omwe etiology yawo siidziwika (osati chifukwa cha matenda a shuga ndi impso),Ganoderma lucidummankhwala okhalaGanoderma lucidumfruiting thupi akupanga ayenera kuyesera.OsacheperaGanoderma lucidumsichibweretsa zotsatira zoyipa monga chizungulire, kupindika kwa m'mphuno, chifuwa, ndi nseru zomwe zimafala m'mamankhwala oletsa kuthamanga kwa magazi.

Ndikoyenera kutchula kuti maphunziro am'mbuyomu adatsimikizira iziGanoderma lucidumtriterpenes imatha kulepheretsa ntchito ya angiotensin converting enzyme (ACE) kotero kuti Angiotensin I yotulutsidwa ndi impso sikanapangike ndi ACE mu Angiotensin II yomwe imatha kulimbikitsa vasoconstriction.Tsopano, Tingafinye madzi aGanoderma lucidumthupi la fruiting, lomwe makamaka limapangidwa ndi ma polysaccharides, latsimikiziridwa kuti limathandizira kuthamanga kwa magazi mwa kuwongolera dongosolo lamanjenje la cranial.Kugwirizana kwa triterpenoids ndi ma polysaccharides kumatsimikiziranso iziGanoderma lucidumndi zosakaniza zonse (zokhala ndi ma triterpenoids ndi ma polysaccharides) ndiye chisankho choyenera.

[Source] Shevelev OB, et al.Hypotensive ndi neurometabolic zotsatira za intragastric Reishi (Ganoderma lucidum) utsogoleri muzovuta za makoswe a ISIAH.Phytomedicine.2018 Marichi 1;41:1-6 .

TSIRIZA

Za wolemba/ Mayi Wu Tingyao

Wu Tingyao wakhala akufotokoza zambiri za Ganoderma kuyambira 1999. Iye ndi mlembi wa bukuli.Kuchiza ndi Ganoderma(lofalitsidwa mu The People's Medical Publishing House mu April 2017).

★ Nkhaniyi yasindikizidwa pansi pa chilolezo cha wolemba.★ Ntchito zomwe zili pamwambazi sizingathe kupangidwanso, kuchotsedwa kapena kugwiritsidwa ntchito mwanjira ina popanda chilolezo cha wolemba.★ Pakuphwanya mawu omwe ali pamwambawa, wolemba adzatsata maudindo oyenera azamalamulo.★ Zolemba zoyambirira za nkhaniyi zidalembedwa m'Chitchaina ndi Wu Tingyao ndikumasulira m'Chingerezi ndi Alfred Liu.Ngati pali kusiyana kulikonse pakati pa kumasulira (Chingerezi) ndi choyambirira (Chitchaina), Chitchaina choyambirira chidzapambana.Ngati owerenga ali ndi mafunso, lemberani wolemba woyamba, Mayi Wu Tingyao.