Kurume 1, 2018 / Russian Academy yeSainzi / Phytomedicine

Chinyorwa / Wu Tingyao

Muna Kurume 2018, bepa rakabudiswa muPhytomedicine neInstitute of Cytology uye Genetics yeRussia Academy yeScience yakasimbisa kuti mushure memavhiki manomwe ekudyisa.Ganoderma lucidum(Reishi) michero yemvura yemuviri inotorwa kumakonzo anotambura kubva kugarwa nhaka-induced arterial hypertension, iyo hypotensive mhedzisiro yeGanoderma lucidummvura inotorwa inofananidzwa neyeLosartan (ona Mufananidzo 1).

Kuedza kwemhuka kwakawanawo kuti kumakonzo ane hypertensive anorapwaGanoderma lucidummvura inotorwa, vhoriyamu yekuyerera kweropa yecarotid artery yavo yakawedzera zvakanyanya, zvakapetwa kaviri kupfuura yeavo vasina kurapwa (ona Mufananidzo 2).Panguva imwecheteyo, iyo carotid artery dhayamita uye chiyero chekuyerera kweropa zvakare yakawedzera zvakanyanya.Izvi zvinoreva kuti kuyerera kweropa kuhuropi hwegonzo hakudzikisirwe nekudonha kweBP asi panzvimbo pezvo kunowedzera kushanda nekuwanda pasi pesimba reGanoderma lucidum.Kusiyana neizvi, kunyange zvazvo carotid artery diameter yemakonzo muboka remishonga ye hypotensive yakawedzera, chiyero chekuyerera kweropa hachina kudarika cheboka rinodzora, uye kuyerera kweropa kwakanga kusina kunyanya kusiyana neboka rekutonga.

Muna Kurume 2018, bepa rakabudiswa muPhytomedicine neInstitute of Cytology uye Genetics yeRussia Academy yeScience yakasimbisa kuti mushure memavhiki manomwe ekudyisa.Ganoderma lucidum(Reishi) michero yemvura yemuviri inotorwa kumakonzo anotambura kubva kugarwa nhaka-induced arterial hypertension, iyo hypotensive mhedzisiro yeGanoderma lucidummvura inotorwa inofananidzwa neyeLosartan (ona Mufananidzo 1).

Kuedza kwemhuka kwakawanawo kuti kumakonzo ane hypertensive anorapwaGanoderma lucidummvura inotorwa, vhoriyamu yekuyerera kweropa yecarotid artery yavo yakawedzera zvakanyanya, zvakapetwa kaviri kupfuura yeavo vasina kurapwa (ona Mufananidzo 2).Panguva imwecheteyo, iyo carotid artery dhayamita uye chiyero chekuyerera kweropa zvakare yakawedzera zvakanyanya.Izvi zvinoreva kuti kuyerera kweropa kuhuropi hwegonzo hakudzikisirwe nekudonha kweBP asi panzvimbo pezvo kunowedzera kushanda nekuwanda pasi pesimba reGanoderma lucidum.Kusiyana neizvi, kunyange zvazvo carotid artery diameter yemakonzo muboka remishonga ye hypotensive yakawedzera, chiyero chekuyerera kweropa hachina kudarika cheboka rinodzora, uye kuyerera kweropa kwakanga kusina kunyanya kusiyana neboka rekutonga.

Mufananidzo 2 Mhedzisiro yeGanoderma lucidummvura inotorwa pane arterial blood flow volume

[Cherechedza] Maitiro ekuyedza akafanana neari pamusoro.Mushure memavhiki manomwe ekurapwa, iyo carotid blood flow volume yeboka reReishi yakanga yakakwirira zvikuru kupfuura yemamwe mapoka maviri.(Kwakabva/Phytomedicine.2018 Mar 1; 41:1-6.)

Kumwezve ongororo ye12 mainurotransmitters yakavanzwa necerebral cortex yeboka rega rega remakonzo, zvakaonekwa kuti mvura inotorwaGanoderma lucidumfruiting muviri unogona kushandura reshiyo yevamwe neurotransmitters, zvichiita kuti inhibitory neurotransmitters (senge glycine, inonzi Gly) uye excitatory neurotransmitters (yakadai se glutamine, inonzi Glx) padyo nenzvimbo yakadzikama, uye nyika yakadaro inokodzera. normal blood pressure.

Ichi chigumisiro chinoratidza kuti kana ichienzaniswa neLosartan, iyo inopikisa mupikisi weAT1 receptors yeangiotensin Ⅱ kuwedzera tsinga dzeropa uye kudzora BP.Ganoderma lucidummvura yemvura inonyanya kuoma mukugadzirisa ropa uye inobatana nekugadzirisa kwecranial nervous system.

Mhuka yemuenzaniso yakashandiswa mukuedza ndeye "inherited stress-induced arterial hypertension", kureva kuti, bumbiro remitemo rinogara nhaka kubva kuna baba kana amai rinokonzera nyore nyore kuwedzera kweropa, uye kushushikana mupfungwa ndicho chinhu chikuru chinokonzera.Izvi zvinonyatsoenderana nemamiriro evarwere vazhinji vane nhaka yehypertension yevasingazivikanwe etiology: autonomic nervous system kusagadzikana kunokonzerwa nekushushikana (iyo regulatory basa kusaenzana pakati petsinga dzinonzwira tsitsi dzinodzorwa neexcitatory neurotransmitters uye parasympathetic nerve inodzorwa neinhibitory neurotransmitters) inoita kuti ropa riwedzere. nguva dzose yakakwirira uye yakaoma kudzokera kumatanho akajairika.

Kana iwe usinganzwisise hukama huripo pakati peautonomic nerve uye blood pressure, unogona kufungidzira kuti BP inokwira nekuda kwekunakidzwa kwepfungwa (iyo inotongwa netsitsi dzetsinga) uchiona mutambo wenhabvu, asi BP inodonha ichidzokera kune yakajairika mushure. nguva yekuzorora (iyo inotungamirirwa neparasympathetic nervous system).Iyi ndiyo yakajairika regulation mechanism.Kana BP isingachakwanisi kudzokera kune yakajairika nekuzorora, kurara, uye kuzorora mupfungwa, pachava nedambudziko reBP.Nekuda kwekuti ropa rinosvika kune chirwere chinotsanangurwa nemishonga chinoda mishonga, zvinoenderana nekuti systolic kana diastolic blood pressure inodarika kukosha kwakatarwa - chero bedzi imwe yadzo isingawanzoitiki, inonzi high blood pressure.

Kune nzvimbo dzakawanda dzehuropi dzinogona kukanganisa BP uye mafungiro.Kazhinji, ivo vanodzorwa necerebral cortex ("uropi hwepamusoro hwekuziva kugona kudzora nzvimbo").Kare, rimwe boka revatsvakurudzi kubva kuRussia Academy of Sciences rakatsigira kuti mumakonzo ane "inhaka yekushushikana-induced arterial hypertension", cerebral cortex inovhara neurotransmitters yakawanda inofadza, kuchengetedza ropa rakakwirira.Zvino, mukuedzwa neGanoderma lucidum, zvakaonekwa kuti kutonga nemuromo kweGanoderma lucidummvura inotorwa kwemavhiki manomwe akatevedzana inogona kudzora ma neurotransmitters akavanzika necerebral cortex uye zvakanyanya kunatsiridza hypertension.

Kana ari iwo makonzo ane hypertensive akadyaGanoderma lucidumfruiting body extract, cerebral blood flow yavo yakawedzera uye kuyerera kweropa kwavo kwakawedzera.Naizvozvo, muongorori akataura pakupera kweshumo kutiGanoderma luciduminobvisa inogona kunge iine nootropic effect.

Kana kudyaGanodermaluciduminogona kunyatso kuburitsa nootropic mhedzisiro, inofanirwa kuratidzwa neimwe kuyedza.Asi kune varwere vane high blood pressure vane etiology isingazivikanwe (isina kukonzerwa nechirwere cheshuga neitsvo),Ganoderma lucidumzvigadzirwa zvineGanoderma lucidumfruiting body extracts inofanirwa kuedza.Dai wangoGanoderma lucidumhaibudisi zvinokonzeresa sedzungu, kubatirana kwemhino, kukosora, uye kuda kusvotwa kunowanikwa nemishonga inoderedza BP.

Zvakakodzera kutaura kuti zvidzidzo zvekare zvakasimbisa izvozvoGanoderma lucidumtriterpenes inogona kutadzisa kuita kweangiotensin inoshandura enzyme (ACE) kuitira kuti Angiotensin I yakavanzwa neitsvo haigone kugadziridzwa neACE muAngiotensin II inogona kukurudzira vasoconstriction.Zvino, kutorwa kwemvura kweGanoderma lucidumfruiting body, iyo inonyanya kuumbwa nepolysaccharides, yakaratidza kuti inovandudza high blood pressure nekugadzirisa cranial nervous system.Kuwirirana kwe triterpenoids uye polysaccharides zvakare kunosimbisa izvozvoGanoderma lucidumine zvinhu zvakakwana (zvine zvese triterpenoids uye polysaccharides) ndiyo yakanakira sarudzo.

[Kwakabva] Shevelev OB, et al.Hypotensive uye neurometabolic mhedzisiro ye intragastric Reishi (Ganoderma lucidum) kutonga mune hypertensive ISIAH rat strain.Phytomedicine.2018 Kurume 1;41:1-6.

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Nezve munyori/ Ms. Wu Tingyao

Wu Tingyao anga achizivisa nezvekutanga-ruoko ruzivo rweGanoderma kubvira 1999. Ndiye munyori weKuporesa neGanoderma(yakabudiswa muThe People's Medical Publishing House muna Kubvumbi 2017).

★ Chinyorwa ichi chakatsikiswa pasi pemvumo yakasarudzika yemunyori.★ Mabhuku ari pamusoro haagone kutsikiswa, kutorwa kana kushandiswa nedzimwe nzira pasina mvumo yemunyori.★ Nekutyorwa kwechirevo chiri pamusoro, munyori achatevera mabasa akakodzera emutemo.★ Manyoro ekutanga echinyorwa ichi akanyorwa neChinese naWu Tingyao uye akashandurirwa muchiRungu naAlfred Liu.Kana paine mutsauko pakati peshanduro (yeChirungu) neyekutanga (Chinese), iyo yekutanga Chinese ichakunda.Kana vaverengi vaine mibvunzo, tapota taura nemunyori wemabviro, Ms. Wu Tingyao.