January 2017/Amala Cancer Research Centre/Mutation Research
Umbhalo/Wu Tingyao

Abantu abaningi abacabangi nge-Ganoderma lucidum baze bagule.Bamane bakhohlwe ukuthi iGanoderma lucidum ingasetshenziswa futhi ekwelapheni ukuvimbela izifo.Ngokombiko oshicilelwe yi-Amala Cancer Research Center yaseNdiya ku- "Mutation Research" ngoJanuwari 2017, i-Ganoderma lucidum triterpenes, engavimbela ngempumelelo ukusinda kwamangqamuzana omdlavuza, inganciphisa ukuvela nokuqina kwezimila, kungakhathaliseki ukuthi zisetshenziswe ngaphandle noma ngaphakathi.
I-Ganoderma lucidum triterpenes yenza amangqamuzana omdlavuza angaphili kahle.
Ucwaningo lusebenzise ukukhishwa okuphelele kwe-triterpenoid yomzimba othela izithelo we-Ganoderma lucidum.Abacwaningi bakuhlanganisa namaseli omdlavuza webele womuntu we-MCF-7 (ancike ku-estrogen) futhi bathola ukuthi lapho kugcwala kakhulu okukhishwayo, kuthatha isikhathi eside ukusebenzisana namaseli omdlavuza, kunganciphisa kakhulu izinga lokusinda komdlavuza. amaseli, futhi kwezinye izimo, kungenza amangqamuzana omdlavuza anyamalale ngokuphelele (njengoba kukhonjisiwe ngezansi).

(Isithombe senziwe kabusha ngu-Wu Tingyao, umthombo wedatha / i-Mutat Res. 2017; 813: 45-51.)

Ukuhlaziywa okwengeziwe kwendlela yokulwa nomdlavuza ye-Ganoderma lucidum total triterpenes kwembula ukuthi ngemuva kokuthi amangqamuzana omdlavuza elungiswa yi-Ganoderma lucidum triterpenes, izakhi zofuzo eziningi nama-molecule wamaprotheni kumaseli azoshintsha kakhulu.Ngokuningiliziwe, i-cyclin yokuqala esebenzayo i-D1 ne-Bcl-2 ne-Bcl-xL izocindezelwa kuyilapho i-Bax ne-Caspase-9 ethule ekuqaleni zizoba nokungahlaliseki.

I-Cyclin D1, Bcl-2 ne-Bcl-xL izogqugquzela ukwanda okuqhubekayo kwamangqamuzana omdlavuza kuyilapho i-Bax ne-caspase-9 izoqala i-apoptosis yamangqamuzana omdlavuza ukuze amangqamuzana omdlavuza akwazi ukuguga futhi afe njengamaseli avamile.

Ukuhlola ukusetshenziswa kwangaphandle: I-Ganoderma lucidum triterpenes ivimbela izimila zesikhumba.
Ukusebenzisa i-Ganoderma lucidum total triterpenes ezilwaneni nakho kungase kube nomthelela wokuvimbela inhibitory kumathumba.Esokuqala siwukuhlolwa kokungeniswa kwe-“cutaneous papilloma” (Inothi lomhleli: Lesi isimila se-papillary esiyingozi esiphumela ngaphandle kwesikhumba. Uma isisekelo saso sidlulela ngaphansi kwe-epidermis, sizowohloka kalula sibe umdlavuza wesikhumba):

I-carcinogen DMBA (i-dimethyl benz[a]anthracene, inhlanganisela ye-polycyclic enamakha e-hydrocarbon engabangela ukuguqulwa kofuzo) yafakwa ngemuva kwegundane lokuhlola (izinwele zalo zazigundiwe) ukuze kudaleke izilonda esikhumbeni.
Ngemuva kwesonto le-1, abacwaningi basebenzise amafutha e-croton, into ekhuthaza ukukhula kwesimila, endaweni efanayo kabili ngesonto, futhi basebenzise i-5, 10, noma i-20 mg ye-Ganoderma lucidum triterpenes imizuzu engu-40 ngaphambi kokusetshenziswa ngakunye kwamafutha e-croton izikhathi ezingu-8 zilandelana. amasonto (isonto lesi-2 kuya kwelesi-9 lokuhlolwa).

Ngemuva kwalokho, abacwaningi bayeka ukusebenzisa izinto eziyingozi kanye ne-Ganoderma lucidum kodwa baqhubeka nokuphakamisa amagundane futhi babheka izimo zabo.Ekupheleni kwesonto le-18 lokuhlolwa, amagundane eqenjini lokulawula elingelashiwe, kungakhathaliseki ukuthi kwenzekani, inani lamathumba akhula, kanye nesikhathi sokukhula kwesimila sokuqala, ayehluke kakhulu kumagundane ayekhona. isetshenziswe ngo-5, 10, no-20 mg we-Ganoderma lucidum triterpenes (njengoba kukhonjisiwe esithombeni esingezansi).(Qaphela: amagundane ayi-12 eqenjini ngalinye.)

Isigameko se-papilloma yesikhumba ngemva kwamaviki angu-18 wokuchayeka kuma-carcinogens
(Isithombe esidwetshwe u-Wu Tingyao, umthombo wedatha / i-Mutat Res. 2017; 813: 45-51.)

Isilinganiso senani lezimila esikhumbeni segundane ngalinye ngemva kwamaviki angu-18 ekuchayekeni amagciwane
(Isithombe esidwetshwe u-Wu Tingyao, umthombo wedatha / i-Mutat Res. 2017; 813: 45-51.)

Isikhathi esithathayo ukukhulisa isimila ngemuva kokuchayeka kuma-carcinogens
(Isithombe esidwetshwe u-Wu Tingyao, umthombo wedatha / i-Mutat Res. 2017; 813: 45-51.)
Ukuhlolwa kokudla: I-Ganoderma lucidum triterpenes ivikela umdlavuza webele.
Okwesibili ukuhlolwa "komdlavuza webele": amagundane anikezwa i-DMBA ye-carcinogen kanye ngesonto amasonto e-3, futhi kusukela ngosuku olulandelayo emva kokudla kokuqala kwe-carcinogen (amahora angu-24 kamuva), i-10, i-50 noma i-100 mg / kg ye-Ganoderma lucidum triterpenes zaziphakelwa nsuku zonke amasonto ama-5 alandelanayo.
Imiphumela icishe ifane nokuhlolwa kwangaphambili kwe-papilloma yesikhumba.Iqembu elilawulayo ngaphandle kokwelashwa linamathuba angu-100% okuba nomdlavuza webele.I-Ganoderma lucidum triterpenes inganciphisa kakhulu ukwenzeka kwezimila;amagundane adle i-Ganoderma lucidum ayehluke kakhulu kumagundane angazange adle i-Ganoderma lucidum enanini lamathumba akhule kanye nesikhathi sokukhulisa isimila sokuqala (njengoba kuboniswe esithombeni esingezansi).
Izisindo zesimila zamagundane ezivikelwe nge-10, 50 noma 100 mg/kg isamba esikhishiwe se-Ganoderma lucidum triterpenes kwakuyizingxenye ezimbili kwezintathu kuphela, ingxenye eyodwa nengxenye eyodwa kwezintathu yezisindo zesimila zamagundane eqenjini lokulawula, ngokulandelana.

Isigameko somdlavuza webele
(Isithombe esidwetshwe u-Wu Tingyao, umthombo wedatha / i-Mutat Res. 2017; 813: 45-51.)

Isilinganiso senani lamathumba esikhumbeni segundane ngalinye evikini le-17 ngemva kokudla amagciwane
(Isithombe esidwetshwe u-Wu Tingyao, umthombo wedatha / i-Mutat Res. 2017; 813: 45-51.)

Isikhathi esithathayo ukuze amagundane akhule izimila ngemva kokudla amagciwane
(Isithombe esidwetshwe u-Wu Tingyao, umthombo wedatha / i-Mutat Res. 2017; 813: 45-51.)

I-Ganoderma lucidum triterpenes inokubili izinzuzo eziphephile nezisebenzayo.

Imiphumela yalokhu kuhlolwa kwezilwane okubili okungenhla kusitshela ngokucacile ukuthi noma ngabe ukuphathwa ngomlomo noma ukusetshenziswa kwangaphandle kwe-Ganoderma lucidum total triterpenes kunganciphisa ngempumelelo izehlakalo zamathumba, kunciphise inani lezimila futhi kubambezele ukubonakala kwezimila.

Indlela ye-Ganoderma lucidum total triterpenes ingase ihlobane nokulawulwa kwezakhi zofuzo nama-molecule amaprotheni kumaseli wesimila okukhulunywe ngawo ekuqaleni kulesi sihloko.Ithimba locwaningo liye laqinisekisa ngaphambilini ukuthi i-Ganoderma lucidum total triterpenes ayilimazi amaseli avamile, okubonisa ukuthi i-Ganoderma lucidum total triterpenes zombili ziphephile futhi ziyasebenza.

Kulo mphakathi wanamuhla ogcwele izinkinga zempilo, kuyiphupho ukugwema amagciwane.Ungacela kanjani izibusiso ngezikhathi ezinzima?Imikhiqizo equkethe i-Ganoderma lucidum total triterpenes ingase ibe isondlo sakho esifanele.

[Umthombo] Smina TP, et al.I-Ganoderma lucidum total triterpenes yenza i-apoptosis kumaseli e-MCF-7 futhi inciphise i-DMBA eyenzelwe i-mammary kanye ne-carcinomas yesikhumba ezilwaneni zokuhlola.I-Mutat Res.2017;813: 45-51.
Mayelana nombhali/ Nks. Wu Tingyao

U-Wu Tingyao ubelokhu ebika ngolwazi lwe-Ganoderma lokuqala kusukela ngo-1999. Ungumbhali wencwadi ethi Healing with Ganoderma (eshicilelwe ku-People's Medical Publishing House ngo-Ephreli 2017).

★ Lesi sihloko sishicilelwe ngaphansi kokugunyazwa okukhethekile kombhali.★ Le misebenzi engenhla ayinakuphinda ikhiqizwe, ikhishwe noma isetshenziswe ngezinye izindlela ngaphandle kwemvume yombhali.★ Ngokuphulwa kwesitatimende esingenhla, umbhali uzolandela izibopho ezingokomthetho ezifanele.★ Umbhalo wokuqala walesi sihloko ubhalwe ngesiShayina nguWu Tingyao futhi wahunyushelwa esiNgisini ngu-Alfred Liu.Uma kukhona ukungqubuzana phakathi kokuhumusha (isiNgisi) kanye nokwangempela (isiShayina), isiShayina sangempela siyonqoba.Uma abafundi benemibuzo, sicela uthinte umbhali wokuqala, uNksz. Wu Tingyao.