Ndira 2017/Amala Cancer Research Center/Mutation Research
Chinyorwa/Wu Tingyao

Vanhu vazhinji havafungi nezveGanoderma lucidum kusvikira varwara.Vanongokanganwa kuti Ganoderma lucidum inogona kushandiswawo kudzivirira kurapwa kwechirwere.Zvinoenderana neshumo rakaburitswa neAmala Cancer Research Center yeIndia mu "Mutation Research" muna Ndira 2017, Ganoderma lucidum triterpenes, iyo inogona kunyatso kuvharidzira kupona kwekenza maseru, inogona kuderedza kuitika uye kuoma kwemamota, angave akashandiswa kunze kana. mukati.
Ganoderma lucidum triterpenes inoita kuti masero egomarara asararame zvakanaka.
Chidzidzo chacho chakashandisa iyo yakazara triterpenoid yakatorwa yechibereko cheGanoderma lucidum.Vatsvagiri vakaiisa pamwe chete neMCF-7 masero egomarara rezamu remunhu (estrogen-inotsamira) uye vakaona kuti iyo yakanyanya kuwanda kweiyo inobvisa, iyo nguva yakareba yainotora kupindirana nekenza maseru, ndiko kuwedzera kwainogona kuderedza huwandu hwekupona kwegomarara. masero, uye kunyange mune dzimwe nguva, zvinogona kuita kuti masero emukenza anyangarika zvachose (sezvinoratidzwa pasi apa).

(Mufananidzo wakagadziridzwa naWu Tingyao, data source / Mutat Res. 2017; 813: 45-51.)

Kumwezve ongororo yeaponti-gomarara mashandiro eGanoderma lucidum yakazara triterpenes yakaratidza kuti mushure mekunge masero egomarara agadziriswa neGanoderma lucidum triterpenes, majini mazhinji uye mapuroteni mamorekuru ari mumasero anozochinja zvikuru.Muchidimbu, iyo yekutanga cyclin D1 uye Bcl-2 neBcl-xL ichadzvanywa uku iyo yekutanga yakanyarara Bax uye Caspase-9 ichave isina kuzorora.

Cyclin D1, Bcl-2 uye Bcl-xL ichasimudzira kuenderera mberi kwemasero egomarara nepo Bax uye caspase-9 ichatanga apoptosis yekenza maseru kuitira kuti maseru egomarara achembe uye afe semaseru akajairwa.

Kuedza kwekushandisa kwekunze: Ganoderma lucidum triterpenes inodzivirira mamota eganda.
Kushandisa Ganoderma lucidum yakazara triterpenes kumhuka kunogona zvakare kuita yekudzivirira inhibitory maitiro pamamota.Chekutanga kuyedza “cutaneous papilloma” (Chinyorwa chemupepeti: Iri ibundu repapilari rinobuda pamusoro peganda. Kana hwaro hwaro hukatambanukira pasi peepidermis, rinokurumidza kuipa kuva kenza yeganda):

Iyo carcinogen DMBA (dimethyl benz[a] anthracene, polycyclic inonhuhwirira hydrocarbon compound iyo inogona kukonzera genetic mutations) yakaiswa kumashure kweyekuyedza mbeva (bvudzi rayo rakaveurwa) kuti riite maronda eganda.
Mushure mevhiki ye1, vatsvakurudzi vakashandisa mafuta e-croton, chinhu chinokurudzira kukura kwebundu, kunzvimbo imwe chete kaviri pavhiki, uye vakashandisa 5, 10, kana 20 mg yeGanoderma lucidum triterpenes 40 maminetsi isati yatanga kushandiswa kwe croton mafuta kwe8 akatevedzana. mavhiki (2nd kusvika 9th vhiki yekuedza).

Mushure meizvozvo, vaongorori vakamira kushandisa zvinhu zvinokuvadza uye Ganoderma lucidum asi vakaramba vachisimudza mbeva nekucherechedza mamiriro avo.Pakupera kwevhiki ye18 yekuedza, mbeva dziri muboka risina kurapwa, pasinei nekuitika kwemamota, nhamba yemamota akakura, uye nguva yekukura bundu rekutanga, akanga akasiyana zvikuru nembeva dzaive. inoshandiswa ne5, 10, uye 20 mg yeGanoderma lucidum triterpenes (sezvinoratidzwa mumufananidzo uri pasi apa).(Cherechedza: 12 mbeva paboka.)

Chiitiko cheganda papilloma mushure memavhiki gumi nemasere ekusangana necarcinogens
(Mufananidzo wakadhonzwa naWu Tingyao, data source / Mutat Res. 2017; 813: 45-51.)

Avhareji yenhamba yemamota paganda rembeva yega yega mushure memavhiki gumi nemasere ekusangana necarcinogens
(Mufananidzo wakadhonzwa naWu Tingyao, data source / Mutat Res. 2017; 813: 45-51.)

Iyo nguva inotora kukura bundu mushure mekusangana necarcinogens
(Mufananidzo wakadhonzwa naWu Tingyao, data source / Mutat Res. 2017; 813: 45-51.)
Kudyisa kuedza: Ganoderma lucidum triterpenes inodzivirira gomarara rezamu.
Yechipiri ndeye "gomarara remazamu" kuedza: mbeva dzakadyiswa carcinogen DMBA kamwe pavhiki kwemavhiki e3, uye kubva zuva rakatevera mushure mekudya kwekutanga kenza (maawa 24 gare gare), 10, 50 kana 100 mg / kg yeGanoderma lucidum triterpenes. vaipiwa zvokudya zuva nezuva kwemavhiki mashanu akatevedzana.
Migumisiro inenge yakafanana neyekare yeganda papilloma miedzo.Boka rekutonga pasina chero kurapwa rine 100% mukana wekuita kenza yemazamu.Ganoderma lucidum triterpenes inogona kuderedza zvakanyanya kuitika kwemamota;mbeva dzaidya Ganoderma lucidum dzakanga dzakasiyana zvakanyanya nembeva dzisina kudya Ganoderma lucidum muhuwandu hwemamota akakura uye nguva yekukura bundu rekutanga (sezvinoratidzwa mumufananidzo uri pasi apa).
Huremu hwebundu hwembeva dzakadzivirirwa ne10, 50 kana 100 mg/kg yakazara yakatorwa yeGanoderma lucidum triterpenes yaingova zvikamu zviviri muzvitatu, hafu uye chikamu chimwe chete muzvitatu zvebundu kurema kwemakonzo muboka rekutonga, zvichiteerana.

Chiitiko chegomarara rezamu
(Mufananidzo wakadhonzwa naWu Tingyao, data source / Mutat Res. 2017; 813: 45-51.)

Avhareji yenhamba yemamota paganda rembeva yega yega pavhiki yegumi nenomwe mushure mekudya kenza
(Mufananidzo wakadhonzwa naWu Tingyao, data source / Mutat Res. 2017; 813: 45-51.)

Iyo nguva inotora kuti mbeva dzikure mapundu mushure mekudya kenza
(Mufananidzo wakadhonzwa naWu Tingyao, data source / Mutat Res. 2017; 813: 45-51.)

Ganoderma lucidum triterpenes ine zvese zvakachengeteka uye zvinoshanda zvakanakira.

Mhedzisiro yezviyedzwa zviviri zvemhuka zviri pamusoro zvinotitaurira zvakajeka kuti kana kutonga nemuromo kana kushandiswa kwekunze kweGanoderma lucidum yakazara triterpenes kunogona kunyatso kudzikisa kuitika kwemamota, kuderedza huwandu hwemamota uye kunonoka kuoneka kwemamota.

Iyo nzira yeGanoderma lucidum yakazara triterpenes inogona kunge ine hukama nekugadzirisa majini uye mapuroteni mamorekuru mu tumor cell ambotaurwa munyaya ino.Chikwata chekutsvagisa chakambosimbisa kuti Ganoderma lucidum yakazara triterpenes haikuvadze maseru akajairwa, zvichiratidza kuti Ganoderma lucidum yakazara triterpenes ese akachengeteka uye anoshanda.

Munzanga yemazuva ano izere nematambudziko ehutano, ifungidziro kudzivirira kenza.Nzira yekukumbira sei maropafadzo munguva dzekutambudzika?Zvigadzirwa zvine Ganoderma lucidum yakazara triterpenes zvinogona kunge zviri zvekudya zvako.

[Kwakabva] Smina TP, et al.Ganoderma lucidum yakazara triterpenes inokonzera apoptosis muMCF-7 masero uye attenuate DMBA inokonzera mammary uye ganda carcinomas mukuedza mhuka.Mutat Res.2017;813: 45-51.
Nezve munyori/ Ms. Wu Tingyao

Wu Tingyao anga achizivisa nezvekutanga-ruoko ruzivo rweGanoderma kubvira 1999. Ndiye munyori weHealing with Ganoderma (yakabudiswa muThe People's Medical Publishing House muna Kubvumbi 2017).

★ Chinyorwa ichi chakatsikiswa pasi pemvumo yakasarudzika yemunyori.★ Mabhuku ari pamusoro haagone kutsikiswa, kutorwa kana kushandiswa nedzimwe nzira pasina mvumo yemunyori.★ Nekutyorwa kwechirevo chiri pamusoro, munyori achatevera mabasa akakodzera emutemo.★ Manyoro ekutanga echinyorwa ichi akanyorwa neChinese naWu Tingyao uye akashandurirwa muchiRungu naAlfred Liu.Kana paine mutsauko pakati peshanduro (yeChirungu) neyekutanga (Chinese), iyo yekutanga Chinese ichakunda.Kana vaverengi vaine mibvunzo, tapota taura nemunyori wemabviro, Ms. Wu Tingyao.