Mutarama 2017 / Ikigo Cy’ubushakashatsi cya Kanseri Amala / Ubushakashatsi bwa Mutation
Inyandiko / Wu Tingyao

Abantu benshi ntibatekereza kuri Ganoderma lucidum kugeza barwaye.Bibagiwe gusa ko Ganoderma lucidum ishobora no gukoreshwa mukuvura indwara.Raporo yashyizwe ahagaragara n’ikigo cy’ubushakashatsi cya kanseri ya Amala yo mu Buhinde muri “Ubushakashatsi bwa Mutation” muri Mutarama 2017, Ganoderma lucidum triterpenes, ishobora kubuza neza kubaho ingirabuzimafatizo za kanseri, ishobora kugabanya ibibyimba n'uburemere bw’ibibyimba, byaba bikoreshwa hanze cyangwa se imbere.
Ganoderma lucidum triterpène ituma selile ya kanseri itabaho neza.
Ubushakashatsi bwakoresheje triterpenoid yuzuye yumubiri wera imbuto ya Ganoderma lucidum.Abashakashatsi babishyize hamwe na selile ya kanseri y'ibere ya MCF-7 (biterwa na estrogene) basanga uko uko ibimera bivamo, ari nako bifata igihe cyo gukorana na selile kanseri, niko bishobora kugabanya ubuzima bwa kanseri. selile, ndetse no mubihe bimwe na bimwe, irashobora gutuma kanseri ya kanseri ibura burundu (nkuko bigaragara hano).

(Ishusho yongeye gukorwa na Wu Tingyao, isoko yamakuru / Mutat Res. 2017; 813: 45-51.)

Isesengura ryakozwe ku buryo bwo kurwanya kanseri ya Ganoderma lucidum yuzuye ya triterpène ryagaragaje ko nyuma yuko kanseri ya kanseri ihinduwe na Ganoderma lucidum triterpène, genes nyinshi na molekile za poroteyine ziri mu ngirabuzimafatizo bizahinduka cyane.Muburyo burambuye, icyambere cyclin D1 na Bcl-2 na Bcl-xL kizahagarikwa mugihe Bax na Caspase-9 byacecetse bizahagarara.

Cyclin D1, Bcl-2 na Bcl-xL bizateza imbere ikwirakwizwa rya selile kanseri mu gihe Bax na caspase-9 bizatangiza apoptose ya selile kanseri kugirango selile kanseri ishobore gusaza kandi ipfa nk'uturemangingo dusanzwe.

Ubushakashatsi bwo gukoresha hanze: Ganoderma lucidum triterpène irinda ibibyimba byuruhu.
Gukoresha Ganoderma lucidum triterpène yose hamwe ninyamaswa birashobora kandi kugira ingaruka zo gukumira ibibyimba.Iya mbere ni igeragezwa rya induction ya “cutaneous papilloma” (Icyitonderwa cy'Ubwanditsi: Iki ni ikibyimba cyiza cya papillary kiva hejuru y'uruhu. Niba ishingiro ryacyo ryagutse munsi ya epidermis, bizagenda byangirika muri kanseri y'uruhu):

Kanseri ya DMBA (dimethyl benz [a] anthracene, uruganda rwa hydrocarubone ya hydrocarubone ya polycyclic aromatic ishobora gutera ihinduka ry’imiterere) yashyizwe inyuma yimbeba yubushakashatsi (umusatsi wayo wari wogoshe) kugirango itere ibikomere byuruhu.
Nyuma yicyumweru 1, abashakashatsi bakoresheje amavuta ya croton, ibintu biteza imbere ikibyimba, mukarere kamwe kabiri mucyumweru, kandi banashyizeho mg 5, 10, cyangwa 20 mg ya Ganoderma lucidum triterpène iminota 40 mbere yo gukoresha amavuta ya croton 8 yikurikiranya. ibyumweru (icyumweru cya 2 kugeza ku cya 9 cy'igerageza).

Nyuma yibyo, abashakashatsi bahagaritse gukoresha ibintu byangiza na Ganoderma lucidum ariko bakomeza kuzamura imbeba no kureba uko zimeze.Mu mpera z'icyumweru cya 18 cy’ubushakashatsi, imbeba zo mu itsinda rishinzwe kugenzura zitavuwe, tutitaye ku kuba hari ibibyimba, umubare w’ibibyimba byakuze, n’igihe cyo gukura ikibyimba cya mbere, byari bitandukanye cyane n’imbeba zari ushyizwemo na 5, 10, na 20 mg za Ganoderma lucidum triterpène (nkuko bigaragara ku gishushanyo gikurikira).(Icyitonderwa: imbeba 12 kuri buri tsinda.)

Indwara ya papilloma y'uruhu nyuma y'ibyumweru 18 ihura na kanseri
(Ishusho yashushanijwe na Wu Tingyao, isoko yamakuru / Mutat Res. 2017; 813: 45-51.)

Impuzandengo y'ibibyimba kuruhu rwa buri mbeba nyuma yibyumweru 18 byo guhura na kanseri
(Ishusho yashushanijwe na Wu Tingyao, isoko yamakuru / Mutat Res. 2017; 813: 45-51.)

Igihe bifata kugirango ukure ikibyimba nyuma yo guhura na kanseri
(Ishusho yashushanijwe na Wu Tingyao, isoko yamakuru / Mutat Res. 2017; 813: 45-51.)
Kugaburira igeragezwa: Ganoderma lucidum triterpène irinda kanseri y'ibere.
Iya kabiri ni igeragezwa rya "kanseri y'ibere": imbeba zagaburiwe kanseri DMBA rimwe mu cyumweru ibyumweru 3, kandi guhera ejobundi nyuma yo kugaburira kanseri ya mbere (nyuma yamasaha 24), 10, 50 cyangwa 100 mg / kg ya Ganoderma lucidum triterpène bagaburiwe buri munsi ibyumweru 5 bikurikiranye.
Ibisubizo birasa nkibigeragezo byabanje kuruhu papilloma.Itsinda rishinzwe kugenzura nta muti rifite amahirwe 100% yo kwandura kanseri y'ibere.Ganoderma lucidum triterpène irashobora kugabanya cyane kwandura ibibyimba;imbeba zariye Ganoderma lucidum zari zitandukanye cyane nimbeba zitariye Ganoderma lucidum mu mubare wibibyimba byakuze nigihe cyo gukura ikibyimba cya mbere (nkuko bigaragara ku gishushanyo gikurikira).
Ibipimo by'ibibyimba by'imbeba birinzwe hamwe na 10, 50 cyangwa 100 mg / kg byose bivamo Ganoderma lucidum triterpène byari bibiri bya gatatu gusa, kimwe cya kabiri na kimwe cya gatatu cyuburemere bwibibyimba byimbeba mu itsinda rishinzwe kugenzura.

Indwara ya kanseri y'ibere
(Ishusho yashushanijwe na Wu Tingyao, isoko yamakuru / Mutat Res. 2017; 813: 45-51.)

Impuzandengo y'ibibyimba kuruhu rwa buri mbeba mucyumweru cya 17 nyuma yo kurya kanseri
(Ishusho yashushanijwe na Wu Tingyao, isoko yamakuru / Mutat Res. 2017; 813: 45-51.)

Igihe bifata kugirango imbeba zikure ibibyimba nyuma yo kurya kanseri
(Ishusho yashushanijwe na Wu Tingyao, isoko yamakuru / Mutat Res. 2017; 813: 45-51.)

Ganoderma lucidum triterpene ifite ibyiza kandi byiza.

Ibyavuye mu bushakashatsi bubiri bw’inyamanswa byavuzwe haruguru bitubwira neza ko niba ubuyobozi bwo mu kanwa cyangwa gukoresha hanze ya Ganoderma lucidum triterpène yose ishobora kugabanya neza ibibyimba, kugabanya umubare w’ibibyimba no gutinda kugaragara kw'ibibyimba.

Uburyo bwa Ganoderma lucidum triterpène yose irashobora kuba ifitanye isano no kugena genes na molekile za poroteyine mu ngirabuzimafatizo zavuzwe haruguru muri iki kiganiro.Itsinda ry’ubushakashatsi ryemeje mbere ko Ganoderma lucidum triterpène yose itangiza ingirabuzimafatizo zisanzwe, byerekana ko Ganoderma lucidum triterpène zose zifite umutekano kandi zifite akamaro.

Muri iyi societe igezweho yuzuye ibibazo byubuzima, ni igitekerezo cyo kwirinda kanseri.Nigute ushobora gusaba imigisha mubihe bigoye?Ibicuruzwa birimo Ganoderma lucidum yuzuye triterpene irashobora kuba intungamubiri nziza.

[Inkomoko] Smina TP, n'abandi.Ganoderma lucidum yuzuye triterpène itera apoptose mungirangingo za MCF-7 kandi igahuza DMBA itera kanseri y’inyamabere n’uruhu mu nyamaswa zigerageza.Mutat Res.2017;813: 45-51.
Ibyerekeye umwanditsi / Madamu Wu Tingyao

Wu Tingyao yagiye atanga amakuru ku makuru ya Ganoderma kuva mu 1999. Ni umwanditsi wa Healing hamwe na Ganoderma (yasohotse mu gitabo cy’ubuvuzi cy’abaturage muri Mata 2017).

★ Iyi ngingo yasohowe uruhushya rwihariye rwumwanditsi.Works Ibikorwa byavuzwe haruguru ntibishobora gusubirwamo, gucibwa cyangwa gukoreshwa mubundi buryo utabiherewe uburenganzira n'umwanditsi.★ Kurenga ku magambo yavuzwe haruguru, umwanditsi azakurikirana inshingano zemewe n'amategeko.Text Umwandiko wumwimerere wiyi ngingo wanditswe mu gishinwa na Wu Tingyao uhindurwa mu cyongereza na Alfred Liu.Niba hari itandukaniro riri hagati yubuhinduzi (icyongereza) numwimerere (igishinwa), igishinwa cyumwimerere kizatsinda.Niba abasomyi bafite ikibazo, nyamuneka hamagara umwanditsi wambere, Madamu Wu Tingyao.