January 2017/Amala Cancer Research Centre/Mutation Research
Mawu/Wu Tingyao

Anthu ambiri samaganizira za Ganoderma lucidum mpaka atadwala.Amangoyiwala kuti Ganoderma lucidum itha kugwiritsidwanso ntchito popewera matenda.Malinga ndi lipoti lofalitsidwa ndi Amala Cancer Research Center of India mu "Mutation Research" mu Januwale 2017, Ganoderma lucidum triterpenes, yomwe ingalepheretse kupulumuka kwa maselo a khansa, ikhoza kuchepetsa zochitika ndi kuopsa kwa zotupa, kaya zikugwiritsidwa ntchito kunja kapena kunja. mkati.
Ganoderma lucidum triterpenes imapangitsa kuti maselo a khansa asakhale bwino.
Kafukufukuyu adagwiritsa ntchito chotsitsa cha triterpenoid chamtundu wa Ganoderma lucidum.Ofufuza adaziyika pamodzi ndi ma cell a khansa ya m'mawere a MCF-7 (odalira estrogen) ndipo adapeza kuti kuchuluka kwa chotsitsacho, nthawi yayitali yolumikizana ndi maselo a khansa, m'pamenenso imatha kuchepetsa kupulumuka kwa khansa. maselo, ndipo ngakhale nthawi zina, amatha kupanga maselo a khansa kutha kwathunthu (monga momwe tawonetsera pansipa).

(Chithunzi chokonzedwanso ndi Wu Tingyao, gwero la data / Mutat Res. 2017; 813: 45-51.)

Kusanthula kwina kwa njira yolimbana ndi khansa ya Ganoderma lucidum total triterpenes kunawonetsa kuti maselo a khansa atasinthidwa ndi Ganoderma lucidum triterpenes, majini ambiri ndi mamolekyu a protein m'maselo asintha kwambiri.Mwatsatanetsatane, cyclin yoyambirira ya D1 ndi Bcl-2 ndi Bcl-xL idzaponderezedwa pomwe Bax ndi Caspase-9 omwe adakhala chete azidzakhala osakhazikika.

Cyclin D1, Bcl-2 ndi Bcl-xL idzalimbikitsa kuchulukirachulukira kwa maselo a khansa pamene Bax ndi caspase-9 adzayambitsa apoptosis ya maselo a khansa kuti maselo a khansa athe kukalamba ndi kufa ngati maselo abwinobwino.

Kuyesera kugwiritsa ntchito kunja: Ganoderma lucidum triterpenes imateteza zotupa zapakhungu.
Kugwiritsa ntchito Ganoderma lucidum total triterpenes kwa nyama kungathenso kuletsa zotupa.Choyamba ndi kuyesa kwa "cutaneous papilloma" (Zolemba za mkonzi: Ichi ndi chotupa choopsa cha papillary chomwe chimatuluka pamwamba pa khungu. Ngati maziko ake apitirira pansi pa epidermis, amatha kuwonongeka mosavuta kukhala khansa yapakhungu):

Carcinogen DMBA (dimethyl benz[a]anthracene, polycyclic onunkhira hydrocarbon compound yomwe ingayambitse kusintha kwa majini) inayikidwa kumbuyo kwa mbewa yoyesera (tsitsi lake linametedwa) kuti apangitse zotupa pakhungu.
Pambuyo pa sabata la 1, ofufuzawo adagwiritsa ntchito mafuta a croton, chinthu chomwe chimalimbikitsa kukula kwa chotupa, kumalo omwewo kawiri pa sabata, komanso kugwiritsa ntchito 5, 10, kapena 20 mg ya Ganoderma lucidum triterpenes mphindi 40 musanagwiritse ntchito mafuta a croton kwa 8 motsatizana. masabata (sabata la 2 mpaka 9 la kuyesa).

Pambuyo pake, ofufuzawo adasiya kugwiritsa ntchito zinthu zovulaza komanso Ganoderma lucidum koma adapitilizabe kukweza mbewa ndikuwona momwe zilili.Kumapeto kwa sabata la 18 la kuyesa, mbewa zomwe zili m'gulu loyang'anira zosasamalidwa, mosasamala kanthu za zochitika za zotupa, chiwerengero cha zotupa zomwe zinakula, ndi nthawi yokulitsa chotupa choyamba, zinali zosiyana kwambiri ndi mbewa zomwe zinali. yogwiritsidwa ntchito ndi 5, 10, ndi 20 mg ya Ganoderma lucidum triterpenes (monga momwe tawonetsera pa chithunzi pansipa).(Dziwani: 12 mbewa pagulu.)

Kuchuluka kwa papilloma pakhungu pambuyo pa milungu 18 yokhudzana ndi ma carcinogens
(Chithunzi chojambulidwa ndi Wu Tingyao, gwero la data / Mutat Res. 2017; 813: 45-51.)

Pafupifupi chiwerengero cha zotupa pakhungu lililonse mbewa pambuyo 18 milungu kukhudzana carcinogens
(Chithunzi chojambulidwa ndi Wu Tingyao, gwero la data / Mutat Res. 2017; 813: 45-51.)

Zimatenga nthawi kuti chikule chotupa pambuyo pokhudzana ndi ma carcinogens
(Chithunzi chojambulidwa ndi Wu Tingyao, gwero la data / Mutat Res. 2017; 813: 45-51.)
Kuyesa kuyesa: Ganoderma lucidum triterpenes amateteza khansa ya m'mawere.
Chachiwiri ndi kuyesa kwa "khansa ya m'mawere": mbewa zinadyetsedwa DMBA kamodzi pa sabata kwa masabata a 3, ndipo kuyambira tsiku lotsatira pambuyo pa kudyetsa koyamba kwa carcinogen (maola 24 pambuyo pake), 10, 50 kapena 100 mg / kg ya Ganoderma lucidum triterpenes ankadyetsedwa tsiku lililonse kwa milungu 5 zotsatizana.
Zotsatira zake zimakhala zofanana ndi zomwe zidachitika kale papilloma yapakhungu.Gulu lolamulira popanda chithandizo chilichonse lili ndi mwayi wa 100% wokhala ndi khansa ya m'mawere.Ganoderma lucidum triterpenes imatha kuchepetsa kwambiri kuchuluka kwa zotupa;mbewa zomwe zinadya Ganoderma lucidum zinali zosiyana kwambiri ndi mbewa zomwe sizinadye Ganoderma lucidum mu chiwerengero cha zotupa zomwe zinakula ndi nthawi yokulitsa chotupa choyamba (monga momwe tawonetsera m'chithunzichi).
Kulemera kwa chotupa cha mbewa kutetezedwa ndi 10, 50 kapena 100 mg/kg yokwana yochokera ku Ganoderma lucidum triterpenes inali magawo awiri pa atatu, theka ndi gawo limodzi mwa magawo atatu a zolemera zotupa za mbewa mu gulu lolamulira, motsatana.

Kupezeka kwa khansa ya m'mawere
(Chithunzi chojambulidwa ndi Wu Tingyao, gwero la data / Mutat Res. 2017; 813: 45-51.)

Pafupifupi kuchuluka kwa zotupa pakhungu la mbewa iliyonse pa sabata la 17 mutadya zowononga
(Chithunzi chojambulidwa ndi Wu Tingyao, gwero la data / Mutat Res. 2017; 813: 45-51.)

Zimatenga nthawi kuti mbewa zikule zotupa pambuyo podya ma carcinogens
(Chithunzi chojambulidwa ndi Wu Tingyao, gwero la data / Mutat Res. 2017; 813: 45-51.)

Ganoderma lucidum triterpenes ali ndi zabwino zonse komanso zothandiza.

Zotsatira za kuyesa kwa nyama ziwiri zomwe zili pamwambazi zimatiuza momveka bwino kuti ngati kugwiritsira ntchito pakamwa kapena kugwiritsa ntchito kunja kwa Ganoderma lucidum okwana triterpenes kungathe kuchepetsa kuchuluka kwa zotupa, kuchepetsa chiwerengero cha zotupa ndi kuchepetsa maonekedwe a zotupa.

Makina a Ganoderma lucidum okwana triterpenes atha kukhala okhudzana ndi kuwongolera kwa majini ndi mamolekyu a protein m'ma cell chotupa omwe tawatchula koyambirira kwa nkhaniyi.Gulu lofufuza latsimikizira kale kuti Ganoderma lucidum okwana triterpenes samawononga maselo abwinobwino, kusonyeza kuti Ganoderma lucidum total triterpenes onse ndi otetezeka komanso othandiza.

M'dziko lamakono lino lodzaza ndi zovuta zaumoyo, ndizongopeka kupeŵa ma carcinogens.Kodi mungapemphe bwanji madalitso panthawi yamavuto?Zogulitsa zomwe zili ndi Ganoderma lucidum total triterpenes zitha kukhala chakudya chanu choyenera.

[Source] Smina TP, et al.Ganoderma lucidum total triterpenes imapangitsa apoptosis m'maselo a MCF-7 ndikuchepetsa DMBA yochititsa mammary ndi khansa yapakhungu mu nyama zoyesera.Mutat Res.2017;813: 45-51.
Za wolemba/ Mayi Wu Tingyao

Wu Tingyao wakhala akufotokoza zambiri za Ganoderma kuyambira 1999. Iye ndi mlembi wa Healing with Ganoderma (yofalitsidwa mu The People's Medical Publishing House mu April 2017).

★ Nkhaniyi yasindikizidwa pansi pa chilolezo cha wolemba.★ Ntchito zomwe zili pamwambazi sizingathe kupangidwanso, kuchotsedwa kapena kugwiritsidwa ntchito mwanjira ina popanda chilolezo cha wolemba.★ Pakuphwanya mawu omwe ali pamwambawa, wolemba adzatsata maudindo oyenera azamalamulo.★ Zolemba zoyambirira za nkhaniyi zidalembedwa m'Chitchaina ndi Wu Tingyao ndikumasulira m'Chingerezi ndi Alfred Liu.Ngati pali kusiyana kulikonse pakati pa kumasulira (Chingerezi) ndi choyambirira (Chitchaina), Chitchaina choyambirira chidzapambana.Ngati owerenga ali ndi mafunso, lemberani wolemba woyamba, Mayi Wu Tingyao.