NgoJanuwari 2017/Iziko loPhando loMhlaza we-Amala/uPhando loGuqulo
Umbhalo/Wu Tingyao

Uninzi lwabantu alucingi ngeGanoderma lucidum de bagule.Balibala nje ukuba iGanoderma lucidum ingasetyenziselwa unyango lothintelo lwezifo.Ngokwengxelo epapashwe yi-Amala Cancer Research Centre yaseIndiya kwi "Mutation Research" ngoJanuwari 2017, i-Ganoderma lucidum triterpenes, enokuthintela ngokufanelekileyo ukusinda kweeseli zomhlaza, inokunciphisa ukwenzeka kunye nobukhulu bamathumba, nokuba isetyenziswe ngaphandle okanye ngaphandle. ngaphakathi.
I-Ganoderma lucidum triterpenes yenza ukuba iiseli zomhlaza zingaphili kakuhle.
Uphononongo lusebenzise isicatshulwa esipheleleyo se-triterpenoid yomzimba weziqhamo weGanoderma lucidum.Abaphandi bayibeke kunye ne-MCF-7 yeeseli zomhlaza webele womntu (ezixhomekeke kwi-estrogen) kwaye bafumanisa ukuba okukhona kugxininiswa kwisicatshulwa, ixesha elide lithatha ukunxibelelana neeseli zomhlaza, kokukhona linokunciphisa izinga lokusinda komhlaza. iiseli, kwaye kwezinye iimeko, ingenza iiseli zomhlaza zinyamalale ngokupheleleyo (njengoko kubonisiwe ngezantsi).

(Umzobo owenziwe nguWu Tingyao, umthombo wedatha / i-Mutat Res. 2017; 813: 45-51.)

Uhlalutyo olongezelelweyo lwendlela yokulwa nomhlaza ye-Ganoderma lucidum iyonke i-triterpenes ibonise ukuba emva kokuba iiseli zomhlaza zihlengahlengiswe yi-Ganoderma lucidum triterpenes, iijini ezininzi kunye neemolekyuli zeprotheyini kwiiseli ziya kutshintsha kakhulu.Ngokweenkcukacha, i-cyclin yokuqala esebenzayo i-D1 kunye ne-Bcl-2 kunye ne-Bcl-xL iya kucinezelwa ngelixa i-Bax yokuqala ethule kunye ne-Caspase-9 iya kungazinzi.

I-Cyclin D1, i-Bcl-2 kunye ne-Bcl-xL iya kukhuthaza ukwanda okuqhubekayo kweeseli zomhlaza ngelixa i-Bax kunye ne-caspase-9 iya kuqalisa i-apoptosis yeeseli zomhlaza ukuze iiseli zomhlaza ziguge kwaye zife njengeeseli eziqhelekileyo.

Uvavanyo lokusetyenziswa kwangaphandle: I-Ganoderma lucidum triterpenes ikhusela amathumba esikhumba.
Ukusebenzisa i-Ganoderma lucidum iyonke i-triterpenes kwizilwanyana kunokusebenzisa isiphumo sothintelo lokuthintela kumathumba.Olokuqala luvavanyo lokungeniswa kwe-“cutaneous papilloma” (Inqaku loMhleli: Eli lithumba elingenabungozi kwipapilari eliphuma kumphezulu wolusu. Ukuba isiseko salo siphumela ngaphantsi kwe-epidermis, siya kuwohloka ngokulula sibe ngumhlaza wolusu):

I-carcinogen DMBA (i-dimethyl benz[a]anthracene, ikhompawundi ye-polycyclic enuka kamnandi ye-hydrocarbon enokubangela utshintsho lwemfuzo) yafakwa ngasemva kwempuku yovavanyo (iinwele zayo bezichetyiwe) ukuze yenze izilonda zolusu.
Emva kweveki ye-1, abaphandi basebenzise ioli ye-croton, into ekhuthaza ukukhula kwe-tumor, kwindawo efanayo kabini ngeveki, kwaye iphinda isebenzise i-5, i-10, okanye i-20 mg ye-Ganoderma lucidum triterpenes imizuzu ye-40 ngaphambi kokusetyenziswa kweoli ye-croton kwi-8 ngokulandelelana. iiveki (i-2nd ukuya kwi-9 yeveki yovavanyo).

Emva koko, abaphandi bayeka ukusebenzisa izinto ezinobungozi kunye neGanoderma lucidum kodwa baqhubeka bephakamisa iigundane kwaye bagcine iimeko zabo.Ekupheleni kweveki ye-18 yovavanyo, iimpuku kwiqela lolawulo elingaphathwanga, kungakhathaliseki ukuba kwenzeka ntoni na, inani lamathumba akhula, kunye nexesha lokukhulisa i-tumor yokuqala, zahluke kakhulu kwiimpuku. isetyenziswe kunye ne-5, i-10, kunye ne-20 mg ye-Ganoderma lucidum triterpenes (njengoko kuboniswe kumzobo ongezantsi).(Qaphela: iimpuku ezili-12 kwiqela ngalinye.)

Isiganeko se-papilloma yesikhumba emva kweeveki ze-18 zokuchayeka kwi-carcinogens
(Umfanekiso ozotywe nguWu Tingyao, umthombo wedatha / i-Mutat Res. 2017; 813: 45-51.)

I-avareji yenani lamathumba eluswini lwempuku nganye emva kweeveki ezili-18 zokuvezwa kwi-carcinogens
(Umfanekiso ozotywe nguWu Tingyao, umthombo wedatha / i-Mutat Res. 2017; 813: 45-51.)

Ixesha elithathayo ukukhula ithumba emva kokuvezwa kwi-carcinogens
(Umfanekiso ozotywe nguWu Tingyao, umthombo wedatha / i-Mutat Res. 2017; 813: 45-51.)
Uvavanyo lokutyisa: I-Ganoderma lucidum triterpenes ikhusela umhlaza wamabele.
Okwesibini "umhlaza wesifuba" ulingelo: iigundane zondliwa i-carcinogen DMBA kanye ngeveki kwiiveki ze-3, kwaye ukususela ngosuku olulandelayo emva kokutya kwe-carcinogen yokuqala (iiyure ezingama-24 kamva), i-10, i-50 okanye i-100 mg / kg ye-Ganoderma lucidum triterpenes zazityiswa yonke imihla iiveki ezi-5 zilandelelana.
Iziphumo ziphantse zifane novavanyo lwangaphambili lwe-papilloma yesikhumba.Iqela lolawulo ngaphandle naluphi na unyango lunethuba le-100% lokuphuhlisa umhlaza webele.I-Ganoderma lucidum triterpenes inokunciphisa kakhulu iziganeko zamathumba;iimpuku ezitye i-Ganoderma lucidum zahluke kakhulu kwiimpuku ezingayityiyo i-Ganoderma lucidum kwinani lamathumba akhule kunye nexesha lokukhulisa ithumba lokuqala (njengoko kubonisiwe kulo mfanekiso ungezantsi).
Ubunzima bethumba leempuku ezikhuselweyo nge-10, i-50 okanye i-100 mg / kg isicatshulwa iyonke ye-Ganoderma lucidum triterpenes yayiyisibini kwisithathu, isiqingatha kunye nesinye kwisithathu sesisindo sobunzima beempuku kwiqela lolawulo, ngokulandelelana.

Isehlo somhlaza webele
(Umfanekiso ozotywe nguWu Tingyao, umthombo wedatha / i-Mutat Res. 2017; 813: 45-51.)

I-avareji yenani lamathumba eluswini lwemouse nganye kwiveki ye-17 emva kokutya i-carcinogens
(Umfanekiso ozotywe nguWu Tingyao, umthombo wedatha / i-Mutat Res. 2017; 813: 45-51.)

Ixesha elithathayo ukuba iimpuku zikhule amathumba emva kokutya i-carcinogens
(Umfanekiso ozotywe nguWu Tingyao, umthombo wedatha / i-Mutat Res. 2017; 813: 45-51.)

I-Ganoderma lucidum triterpenes ineenzuzo ezikhuselekileyo nezisebenzayo.

Iziphumo zezi zimbini zovavanyo lwezilwanyana zisixelela ngokucacileyo ukuba ingaba ulawulo lomlomo okanye ukusetyenziswa kwangaphandle kwe-Ganoderma lucidum iyonke ye-triterpenes inokunciphisa ngokufanelekileyo iziganeko zamathumba, ukunciphisa inani lamathumba kunye nokulibazisa ukubonakala kwamathumba.

Umatshini we-Ganoderma lucidum i-triterpenes iyonke inokunxulumana nokulawulwa kofuzo kunye neemolekyuli zeprotheyini kwiiseli zethumba ezikhankanywe ngaphambili kweli nqaku.Iqela lophando liye laqinisekisa ngaphambili ukuba i-Ganoderma lucidum iyonke i-triterpenes ayilimazi iiseli eziqhelekileyo, ebonisa ukuba i-Ganoderma lucidum iyonke i-triterpenes ikhuselekile kwaye iyasebenza.

Kulo luntu lwanamhlanje olugcwele iingxaki zempilo, kuyintelekelelo ukuphepha i-carcinogens.Indlela yokucela iintsikelelo ngamaxesha anzima?Iimveliso eziqulathe i-Ganoderma lucidum iyonke i-triterpenes inokuba sisondlo sakho esifanelekileyo.

[Umthombo] Smina TP, et al.I-Ganoderma lucidum iyonke i-triterpenes yenza i-apoptosis kwiiseli ze-MCF-7 kwaye ithobe i-DMBA eyenza i-mammary kunye ne-skin carcinomas kwizilwanyana zokulinga.Mutat Res.2017;813: 45-51.
Malunga nombhali/ Nksz. Wu Tingyao

U-Wu Tingyao uye wabika malunga nolwazi lokuqala lwe-Ganoderma ukususela ngo-1999. Ungumbhali we-Healing with Ganoderma (epapashwe kwi-People's Medical Publishing House ngo-Ephreli 2017).

★ Eli nqaku lipapashwe phantsi kogunyaziso olulodwa lombhali.★ Le misebenzi ingasentla ayinakuphinda iveliswe, icatshulwe okanye isetyenziswe ngezinye iindlela ngaphandle kokugunyaziswa ngumbhali.★ Ukwaphulwa kwengxelo engentla, umbhali uya kulandela uxanduva olusemthethweni olufanelekileyo.★ Umbhalo wokuqala weli nqaku ubhalwe ngesiTshayina nguWu Tingyao waza waguqulelwa kwisiNgesi nguAlfred Liu.Ukuba kukho nakuphi na ukungangqinelani phakathi kwenguqulelo (isiNgesi) kunye neyoqobo (isiTshayina), isiTshayina sokuqala siya koyisa.Ukuba abafundi banayo nayiphi na imibuzo, nceda uqhagamshelane nombhali wokuqala, uNks. Wu Tingyao.