Ibhalwe nguWu Tingyao

Umdlavuza kunzima ukuwelapha ngoba amangqamuzana omdlavuza aba nokungazweli emishanguzweni, okusho ukuthi izidakamizwa ebezingasebenza ekubulaleni umdlavuza kufanele zisetshenziswe ngemithamo ephezulu ukuze zisebenze kahle.
Inkinga ukuthi i-chemotherapeutics izophinde ibulale amangqamuzana avamile, ngakho-ke akunakwenzeka ukuphishekela imithamo ephezulu ngaphandle komkhawulo ophezulu ukuze ubulale umdlavuza ngempumelelo.
Kulesi simo, iziguli ngokuvamile kufanele zishintshe izidakamizwa.Ezigulini ezinenhlanhla, umdlavuza wawulawuleka ngemva kokushintsha izidakamizwa.Nokho, iziguli eziningi azinayo enye imithi yomdlavuza.Ngemuva kokuthi amangqamuzana omdlavuza engazweli emishanguzweni yokuqala, iziguli zingakwazi ukuvuma ukudalelwa kwazo.
Akulula ukwakha imithi emisha.Ngakho-ke, indlela yokunciphisa ukumelana kwamangqamuzana omdlavuza emithini ekhona ibe enye indlela yokuphila.
NgoMashi walo nyaka (2021), ithimba labacwaningi likaProfesa Li Peng ovela eSikoleni Sekhemisi, i-Fujian Provincial Key Laboratory ye-Natural Medicine Pharmacology, i-Fujian Medical University yashicilela umbiko ku- “Natural Product Research” esho ukuthi izinhlobonhlobo zama-triterpenoidsI-Ganoderma lucidumabe nomsebenzi "wokunciphisa ukumelana nezidakamizwa kumaseli omdlavuza".
UkuhlanganisaI-Ganodermalucidumama-triterpenoids nge-chemotherapy ukwenza buthaka ukumelana nezidakamizwa kumaseli omdlavuza
Abacwaningi basebenzisa imizimba yezithelo zeI-Ganoderma lucidumetshalwe i-Fujian Xianzhilou Biological Science and Technology Co., Ltd. njengezinto zokwakha, yaqale yayikhipha nge-ethanol, yabe isihlaziya ngokuqhubekayo izingxenye ezikhishwe.Bathole ukuthi okungenani bekukhona izinhlobo ezi-2 zama-sterol kanye nezinhlobo eziyisi-7 zama-triterpenoids (Umfanekiso 1) esikhishwe.
Phakathi kwalezi zingxenye, 6 izinhloboI-Ganoderma lucidumi-triterpenoids (izingxenye 3, 4, 6, 7, 8, 9) ingathuthukisa kakhulu umphumela wokubulala wesidakamizwa sendabuko se-chemotherapy i-doxorubicin (DOX) ku-multidrug resistant oral cell carcinoma, okungukuthi, imithamo ephansi ye-chemotherapeutics ingasetshenziswa ukufeza umphumela. lokubulala ingxenye (50%) yamangqamuzana omdlavuza amelana nezidakamizwa (Umfanekiso 2).
Phakathi kwabo, inhlanganisela ganoderiol F (ingxenye 8) kanye doxorubicin kunomphumela omuhle kakhulu.Ngalesi sikhathi, ingxenye eyodwa kuphela kwesikhombisa yomthamo we-doxorubicin uma isetshenziswa iyodwa inomphumela ofanayo (Umfanekiso 2).

Imithamo evamile ye-chemotherapeutics inzima ukubulala amangqamuzana omdlavuza asethuthuke ukumelana nemithi.
Kunzima kangakanani ukwelapha amangqamuzana omdlavuza lapho eqala ukumelana nezidakamizwa eziningi?Ungafunda ngokukha phezulu kuMfanekiso 3.
Ukwengeza i-0.1μM i-doxorubicin kumaseli omdlavuza womlomo womuntu, ngemva kwamahora angu-72, izinga lokusinda lamangqamuzana omdlavuza ovamile licishe lehle libe cishe ingxenye, kodwa amangqamuzana omdlavuza amelana nezidakamizwa cishe awathinteki (Umdwebo 3 umugqa wamachashazi awolintshi).
Ngokomunye umbono, ukuze kwehliswe amangqamuzana omdlavuza womlomo womuntu aye ku-50%, umthamo we-doxorubicin odingekayo ukubhekana namangqamuzana omdlavuza amelana nezidakamizwa cishe uphindwe izikhathi eziyi-100 kunomthamo we-doxorubicin osetshenziselwa ukubhekana namangqamuzana omdlavuza jikelele (Umdwebo 3 Umugqa wamachashazi aluhlaza. ).

Lo mphumela uthathwe ekuhlolweni kweseli okwenziwe nge-in vitro.Akunakwenzeka ukwenza lokhu lapho welapha iziguli ngoba akunakwenzeka ngathi ukunikela ngamaseli ajwayelekile umzimba oncike kuwo ukuze kuqedwe amangqamuzana omdlavuza.
Ngakho-ke, esingakwenza kuphela ukuvumela amangqamuzana omdlavuza akhule ngokuthanda kwakhe?vele akunjalo.Ngoba imiphumela yocwaningo eyethulwe kuMdwebo 2 isitshele ukuthi uma i-chemotherapeutics nokunyeI-Ganodermalucidumama-triterpenoids angasetshenziswa ndawonye, ​​kunethuba lokuhlehlisa ukumelana nezidakamizwa eziningi okuthuthukiswe amangqamuzana omdlavuza ukwenza i-chemotherapy isebenze futhi.
Kungani kungenzekaI-Ganoderma lucidumama-triterpenes enza buthaka ukumelana namaseli omdlavuza?Ngokokuhlaziywa kwethimba likaSolwazi Li Peng, lihlobene ne-P-glycoprotein (P-gp) kumaseli omdlavuza.
Amangqamuzana omdlavuza aba ukumelana nemithi ngokuxosha izidakamizwa ze-chemotherapy ngenkathiI-Ganoderma lucidum ama-triterpenoidskungabagcinaukwelashwa ngamakhemikhali izidakamizwa ngaphakathi kwamangqamuzana omdlavuza.
I-P-glycoprotein, etholakala kulwelwesi lwamangqamuzana futhi ihamba ngaphakathi nangaphandle kwengqamuzana, ifana nethuluzi lokuvikela iseli, “elihambisa” izinto eziyingozi ekusindeni kwamangqamuzana ngaphandle kwengqamuzana, ngaleyo ndlela ivikele amagciwane. iseli ekulimaleni.Ngakho-ke, amangqamuzana omdlavuza amaningi azokhiqiza i-P-glycoprotein eyengeziwe ngokuqhubeka kokwelashwa ngamakhemikhali, okwenza kube nzima ukuthi izidakamizwa zihlale kumaseli.
Ngakho-ke, ukumelana nezidakamizwa esikubonayo kuyindlela yamangqamuzana omdlavuza ukuthi azivikele.Yingakho ukushintshwa kwezidakamizwa kuze kube sekugcineni kungahluleki nje kuphela ukuqeda izikhali zamangqamuzana omdlavuza kodwa futhi kukhuthaza ukumelana kwawo nezidakamizwa eziningi.
Amangqamuzana omdlavuza, vele, adinga ukuqapha emithini ye-chemotherapy ukuze aphile.Ngenhlanhla,I-Ganoderma lucidumama-triterpenoids anendlela yokudiliza ukuzivikela kwamangqamuzana omdlavuza.Ukuhlaziywa kwabacwaningi nge-Ganoderiol F, enomphumela omuhle kakhulu ekubuyiseleni ukumelana nezidakamizwa, kubonise ukuthi ukuhlakulela amangqamuzana omdlavuza womlomo womuntu ongamelani nezidakamizwa nge-Ganoderiol F (20 μM) amahora angu-3 bese wengeza umuthi we-chemotherapy i-doxorubicin kungakhuphula kakhulu inani. ye-doxorubicin eqoqwe kumaseli omdlavuza.
Kuyathakazelisa ukuthi inani lama-P-glycoprotein kumaseli omdlavuza alizange lincishiswe ngokungenelela kweGanoderiol F, ngakho abacwaningi bacabanga ukuthi i-Ganoderiol F kufanele yenze buthaka "umsebenzi wezokuthutha" walawa ma-P-glycoprotein, okuvumela i-doxorubicin ukuthi ihlale kumaseli omdlavuza futhi ibangele. ukulimala kwamangqamuzana omdlavuza.
Ngaphandle kokukhishwa kotshwala kweI-Ganoderma lucidumukusiza, ngokungangabazeki ukuntuleka kwezikhali eziningi zokulwa nomdlavuza.
Njengoba abacwaningi bahlola kuphela indlela yokuguqulwa kokumelana nezidakamizwa yi-Ganoderiol futhi abazange bahlaziye amanye ama-triterpenoids, abazi ukuthi amanye ama-triterpenoid enza kanjani amangqamuzana omdlavuza womuntu amelana nezidakamizwa abe angamelani nezidakamizwa?
Njengoba lokhu kuhlolwa kuxoxisane ngama-triterpenoid nama-sterol ngokuhlukana, abantu abakwazi ukuzibamba bayazibuza ukuthi ingabe ukusebenzisa ngokuhlanganyela nemithi yokwelapha ngamakhemikhali kungenza umphumela ube ngcono yini.
Kodwa okungenani lolu cwaningo lusitshela ukuthi izingxenye ezisebenzayo zeI-Ganoderma lucidumokwenza buthaka ukumelana nemithi yamangqamuzana omdlavuza aqukethwe ku-ethanol ekhishweI-Ganoderma lucidumimizimba enezithelo.Ukuphepha nokusebenza kwe-ethanol ekhishweI-Ganoderma lucidumimizimba ethela izithelo isidume umhlaba wonke njengoba yayisetshenziselwa izifo ezehlukene ngeminyaka yawo-1970.
Ngakho-ke, ngaphandle kokukhishwa kwe-ethanolI-Ganoderma lucidum, nakanjani kuzoba nezikhali ezimbalwa zokulwa nomdlavuza.Uma ungafuni ukuthi ukwelashwa komdlavuza kuwele embuthanweni ononya wokumelana nezidakamizwa eziningi, ungaqala ngokukhetha okulungile.I-Ganoderma lucidum!
 
[Umthombo Wedatha] UMin Wu, et al.Ama-Sterols nama-triterpenoids avelaI-Ganoderma lucidumkanye nemisebenzi yabo ehlehlisayo yokumelana ne-tumor multidrug.I-Nat Prod Res.2021 Mar 10;1-4.doi: 10.1080/14786419.2021.1878514.
 
 
PHELA
Mayelana nombhali/ Nks. Wu Tingyao
U-Wu Tingyao ubelokhu ebika mathuphaI-Ganoderma lucidumulwazi
kusukela ngo-1999. Ungumbhali weUkwelapha nge-Ganoderma(ishicilelwe ku-People's Medical Publishing House ngo-Ephreli 2017).
 
★ Lesi sihloko sishicilelwe ngaphansi kokugunyazwa okukhethekile kombhali, futhi ubunikazi bungeka-GANOHERB ★ Le misebenzi engenhla ayinakuphinda ikhiqizwe, ikhishwe noma isetshenziswe ngezinye izindlela ngaphandle kokugunyazwa kwe-GanoHerb ★ Uma imisebenzi igunyaziwe ukuthi isetshenziswe, kufanele isetshenziswe ngaphakathi kobubanzi bokugunyazwa futhi ibonise umthombo: GanoHerb ★ Ukwephulwa kwesitatimende esingenhla, i-GanoHerb izoqhuba izibopho zayo ezingokomthetho ezihlobene ★ Umbhalo wokuqala wale ndatshana ubhalwe ngesiShayina nguWu Tingyao futhi wahunyushelwa esiNgisini ngu-Alfred Liu.Uma kukhona ukungqubuzana phakathi kokuhumusha (isiNgisi) kanye nokwangempela (isiShayina), isiShayina sangempela siyonqoba.Uma abafundi benemibuzo, sicela uthinte umbhali wokuqala, uNksz. Wu Tingyao.
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