NguWu Tingyao

Umhlaza kunzima ukunyanga kuba iiseli zomhlaza zikhula ukumelana namachiza, okuthetha ukuba amachiza ebeya kusebenza ekuqaleni ukubulala umhlaza kufuneka asetyenziswe kwiidosi eziphezulu ukuze asebenze.
Ingxaki kukuba i-chemotherapeutics iya kubulala iiseli eziqhelekileyo, ngoko ke akunakwenzeka ukulandela iidosi eziphezulu ngaphandle komda ophezulu ukuze ubulale umhlaza ngokufanelekileyo.
Kule meko, izigulane kufuneka zitshintshe amachiza.Kwizigulane ezinethamsanqa, umhlaza wawulawulwa emva kokuba betshintshe iziyobisi.Nangona kunjalo, uninzi lwezigulana alunawo amanye amayeza omhlaza.Emva kokuba iiseli zomhlaza zinganyangeki kumachiza okuqala, izigulana zinokurhoxa kwikamva labo.
Akulula ukwenza amachiza amatsha.Ke ngoko, indlela yokunciphisa ukuxhathisa kweeseli zomhlaza kumachiza asele ekhona ibe yenye indlela yokuphila.
Ngo-Matshi walo nyaka (2021), iqela lophando likaNjingalwazi uLi Peng ovela kwiSikolo se-Pharmacy, i-Fujian Provincial Key Laboratory ye-Natural Medicine Pharmacology, iYunivesithi yezoNyango yaseFujian yapapasha ingxelo "kwiMveliso yoPhando lweMveliso" echaza ukuba iindidi ze-triterpenoidsI-Ganoderma lucidumbabe nomsebenzi "wokunciphisa ukuxhathisa kumachiza kwiiseli zomhlaza".
UkudibanisaI-Ganodermalucidumi-triterpenoids kunye nechemotherapy ukwenza buthathaka ukuxhathisa ichiza kwiiseli zomhlaza
Abaphandi basebenzise imizimba yeziqhamo zeI-Ganoderma lucidumetyalwe nguFujian Xianzhilou Biological Science and Technology Co., Ltd. njengezinto eziphathekayo, waqala wazikhupha nge-ethanol, waza wahlalutya ngakumbi amacandelo kwisicatshulwa.Baye bafumanisa ukuba ubuncinane be-2 iintlobo ze-sterols kunye ne-7 iindidi ze-triterpenoids (Umfanekiso 1) kwisicatshulwa.
Phakathi kwala macandelo, 6 iintloboI-Ganoderma lucidumi-triterpenoids (icandelo 3, 4, 6, 7, 8, 9) inokuphucula kakhulu isiphumo sokubulala i-chemotherapy yendabuko i-doxorubicin (DOX) kwi-multidrug resistant oral carcinoma, oko kukuthi, iidosi ezisezantsi ze-chemotherapeutics zingasetyenziselwa ukuphumeza umphumo. yokubulala isiqingatha (50%) seeseli zomhlaza ezixhathisa iziyobisi (Umfanekiso 2).
Phakathi kwabo, ukudibanisa kwe-ganoderiol F (icandelo le-8) kunye ne-doxorubicin inefuthe elihle kakhulu.Ngeli xesha, isinye sesixhenxe kuphela sedosi ye-doxorubicin xa isetyenziswe yodwa inefuthe elifanayo (Umfanekiso 2).

Iidosi eziqhelekileyo ze-chemotherapeutics kunzima ukubulala iiseli zomhlaza eziphuhlise ukuxhathisa kumachiza.
Kunzima kangakanani ukunyanga iiseli zomhlaza xa zikhula ukumelana namachiza amaninzi?Unokufunda ngokuthe ngqo kuMfanekiso 3.
Ukongeza i-0.1μM doxorubicin kwiiseli zomhlaza womlomo womntu, emva kweeyure ezingama-72, izinga lokusinda kweeseli zomhlaza jikelele liphantse lincitshiswe malunga nesiqingatha, kodwa iiseli zomhlaza ezixhathisa iziyobisi ziphantse zingachaphazeleki (Umfanekiso 3 umgca ochokozayo orenji).
Ukusuka komnye umbono, ukuze kuncitshiswe iiseli zomhlaza womlomo womntu ukuya kwi-50%, idosi ye-doxorubicin efunekayo ukujongana neeseli zomhlaza ezinganyangekiyo ngamachiza iphantse yaphindwe kali-100 idosi ye-doxorubicin esetyenziselwa ukujongana neeseli zomhlaza ngokubanzi (Umfanekiso 3 Umgca onamachaphaza aluhlaza. ).

Esi siphumo sithathwe kuvavanyo lweeseli olwenziwe kwi-vitro.Akunakwenzeka ukwenza oku xa unyanga izigulane kuba akunakwenzeka ukuba sinikele ngeeseli eziqhelekileyo umzimba oxhomekeke kuzo ukuphelisa iiseli zomhlaza.
Ke, into esinokuyenza kukuvumela kuphela iiseli zomhlaza zikhule ngokuthanda?akunjalongo noko.Ngenxa yokuba iziphumo zophando ezichazwe kuMfanekiso 2 zisixelele ukuba ukuba i-chemotherapeutics kunye ezithileI-Ganodermalucidumi-triterpenoids ingasetyenziswa kunye, kukho ithuba lokubuyisela umva ukuxhathisa amayeza amaninzi aphuhliswe ngamaseli omhlaza ukwenza ichemotherapy isebenze kwakhona.
Kutheni unakoI-Ganoderma lucidumiitriterpenes zenza buthathaka ukuxhathisa kweeseli zomhlaza?Ngokutsho kohlalutyo lweqela likaNjingalwazi uLi Peng, lihambelana ne-P-glycoprotein (P-gp) kwiiseli zomhlaza.
Iiseli zomhlaza ziba ukumelana neziyobisi ngokugxotha amayeza echemotherapy ngelixaI-Ganoderma lucidum triterpenoidsunakogcinaichemotherapy amachiza ngaphakathi kwiiseli zomhlaza.
I-P-glycoprotein, ekwi-membrane yeseli kwaye ihamba ngaphakathi nangaphandle kwiseli, ifana nesixhobo sokukhusela iseli, “esihambisa” izinto eziyingozi kubomi beseli ukuya ngaphandle kweseli, ngaloo ndlela ikhusela iseli. iseli kwingozi.Ke ngoko, iiseli ezininzi zomhlaza ziya kuvelisa ngakumbi i-P-glycoprotein kunye nenkqubela phambili ye-chemotherapy, okwenza kube nzima ukuba amachiza ahlale kwiiseli.
Ke ngoko, ukunganyangeki kwechiza kwimbono yethu yeyona ndlela yeeseli zomhlaza zokuzikhusela.Yiyo loo nto ukutshintshwa kwamachiza kude kube sekupheleni kungaphumeleli nje ukukhupha iiseli zomhlaza kodwa kukwakhuthaza ukuxhathisa kwabo kumachiza amaninzi.
Iiseli zomhlaza, ewe, kufuneka zilumkele amayeza echemotherapy ukuze ziphile.Ngethamsanqa,I-Ganoderma lucidumi-triterpenoids inendlela yokudiliza ukhuseleko lweeseli zomhlaza.Uhlalutyo lwabaphandi kunye ne-Ganoderiol F, enesiphumo esihle ekubuyiseleni ukuxhathisa kumachiza, lubonise ukuba ukulima iiseli zomhlaza womlomo womlomo we-multidrug-resistant kunye ne-Ganoderiol F (20 μM) kwiiyure ezi-3 emva koko ukongeza iyeza le-chemotherapy i-doxorubicin kunokunyusa kakhulu isixa. ye-doxorubicin eqokelelwe kwiiseli zomhlaza.
Kuyathakazelisa ukuba inani le-P-glycoprotein kwiiseli zomhlaza alizange lincitshiswe ngokungenelela kweGanoderiol F, ngoko ke abaphandi bacinga ukuba i-Ganoderiol F kufuneka yenze buthathaka "umsebenzi wezothutho" wale P-glycoproteins, evumela ukuba i-doxorubicin ihlale kwiiseli zomhlaza kwaye ibangele. umonakalo kwiiseli zomhlaza.
Ngaphandle kwesicatshulwa sotywala seI-Ganoderma lucidumukunceda, ngokungathandabuzekiyo kukho ukunqongophala kwezixhobo ezininzi zokulwa nomhlaza.
Ekubeni abaphandi baphonononga kuphela indlela yokuguqulwa kokumelana neziyobisi yiGanoderiol kwaye abazange bahlalutye ezinye i-triterpenoids, abazi ukuba ezinye ii-triterpenoids zenza njani iiseli zomhlaza womntu ezinganyangekiyo ngamachiza ukuba zingaxhathisi kumachiza?
Ekubeni olu vavanyo luxoxe nge-triterpenoids kunye ne-sterols ngokwahlukeneyo, abantu abanakunceda kodwa bazibuze ukuba ukusetyenziswa ngokudibeneyo kunye namachiza e-chemotherapy kunokwenza umphumo ube ngcono.
Kodwa ubuncinci olu phando lusixelela ukuba amacandelo asebenzayo eI-Ganoderma lucidumeyenza buthathaka ukuxhathisa kumachiza kwiiseli zomhlaza eziqulethwe kwiincindi ze-ethanol zeI-Ganoderma lucidumimizimba eneziqhamo.Ukhuseleko kunye nokusebenza kwe-ethanol extract yeI-Ganoderma lucidumimizimba yeziqhamo iye yanconywa kwihlabathi jikelele ukusukela oko yayisetyenziselwa izifo ezahlukeneyo ngeminyaka yoo-1970.
Ngoko ke, ngaphandle kwesicatshulwa se-ethanolI-Ganoderma lucidum, ngokuqinisekileyo ziya kuba mbalwa izixhobo zokulwa nomhlaza.Ukuba awufuni ukuba unyango lomhlaza luwele kwisangqa esikhohlakeleyo sokuxhathisa amayeza amaninzi, ungaqala ngokukhetha okulungileyo.I-Ganoderma lucidum!
 
[Umthombo weDatha] uMin Wu, et al.I-Sterols kunye ne-triterpenoids ukusukaI-Ganoderma lucidumkunye nemisebenzi yabo yokuguqula i-tumor multidrug resistance.Nat Prod Res.2021 Mar 10;1-4.doi: 10.1080/14786419.2021.1878514.
 
 
ISIPHELO
Malunga nombhali/ Nksz. Wu Tingyao
UWu Tingyao unike ingxelo okokuqalaI-Ganoderma lucidumulwazi
ukusukela ngo-1999. Ungumbhali weUkunyanga ngeGanoderma(ipapashwe kwiNdlu yePeople's Medical Publishing House ngo-Epreli 2017).
 
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