By Wu Tingyao

Gomarara rakaomarara kurapa nekuti maseru egomarara anotanga kuramba zvinodhaka, zvichireva kuti mishonga yaizotanga kuuraya gomarara inofanirwa kushandiswa pamitengo yepamusoro kuti ishande.
Dambudziko nderekuti chemotherapeutics inourayawo masero akajairwa, saka hazvigoneke kutevera madosi akakwira pasina muganho wepamusoro kuitira kuti uuraye cancer nemazvo.
Mumamiriro ezvinhu aya, varwere vanowanzofanira kutsiva zvinodhaka.Kune varwere vane rombo rakanaka, gomarara raidzorwa mushure mekuchinja zvinodhaka.Zvisinei, varwere vakawanda havana imwe mishonga yegomarara.Mushure mekunge masero emukenza anopesana nemishonga yepakutanga, varwere vanogona kungozvisiya ivo pachavo kune zvavanoda.
Hazvisi nyore kugadzira mishonga mitsva.Naizvozvo, nzira yekudzikisa kupikisa kwemasero ekenza kumishonga iripo yave imwe nzira yekurarama.
Muna Kurume wegore rino (2021), timu yekutsvagisa yaProfessor Li Peng kubva kuSchool of Pharmacy, Fujian Provincial Key Laboratory ye Natural Medicine Pharmacology, Fujian Medical University yakaburitsa mushumo mu "Natural Product Research" ichitaura kuti akasiyana triterpenoids mu.Ganoderma lucidumvane basa re "kuderedza kusagadzikana kwezvinodhaka kwemasero emukenza".
KubatanidzaGanodermalucidumtriterpenoids ine chemotherapy kuderedza kurwisa kwemishonga kwemasero egomarara
Vatsvakurudzi vakashandisa miviri ye fruiting yeGanoderma lucidumyakasimwa neFujian Xianzhilou Biological Science and Technology Co., Ltd. sezvinhu, yakatanga yaibudisa ne ethanol, ndokuzoongororazve zvikamu zviri muchikamu chacho.Vakaona kuti paive nemhando mbiri dzesterols uye 7 mhando dze triterpenoids (Mufananidzo 1) mune yakatorwa.
Pakati pezvikamu izvi, 6 marudzi eGanoderma lucidumtriterpenoids (zvikamu 3, 4, 6, 7, 8, 9) inogona kuvandudza zvakanyanya kuuraya kwechinyakare chemotherapy drug doxorubicin (DOX) pane multidrug resistant oral cell carcinoma, kureva kuti, yakaderera madhasi echemotherapeutics anogona kushandiswa kuita mhedzisiro. yekuuraya hafu (50%) yemasero emukenza anopesana nemishonga yakawanda (Mufananidzo 2).
Pakati pavo, kusanganiswa kweganoderiol F (chikamu 8) uye doxorubicin kune zvakanakisisa.Panguva ino, chikamu chimwe chete chechinomwe chedosi ye doxorubicin kana ichishandiswa yoga ine mhedzisiro yakafanana (Mufananidzo 2).

Madosi ajairika echemotherapeutics akaoma kuuraya maseru egomarara akagadzira kusanzwa nemishonga.
Zvakaoma sei kurapa masero egomarara kana akura multidrug resistance?Unogona kudzidza zvepamusoro kubva Mufananidzo 3.
Kuwedzera 0.1μM doxorubicin kumasero egomarara remukanwa, mushure memaawa makumi manomwe nemaviri, chiyero chekupona kwesero rekenza yekenza inenge yakaderedzwa kusvika hafu, asi masero emukenza asingarambiki nekenza anenge asina kukanganiswa (Mufananidzo 3 orenji ine doti mutsara).
Kubva kune imwe pfungwa, kuitira kudzikisa maseru ekenza yemukanwa kusvika pa50%, iyo doxorubicin inodiwa kubata nemasero emukenza asingarambiki nemishonga inokwana ka100 iyo doxorubicin inoshandiswa kubata nekenza yesero (Mufananidzo 3 Green dotted line. )

Mhedzisiro iyi inotorwa kubva mukuedza kwesero kwakaitwa in vitro.Hazvibviri kuita izvi kana uchirapa varwere nekuti hazvigoneke kuti isu tipe masero akajairwa ayo muviri unoenderana nawo kubvisa cancer maseru.
Saka, chatinogona kuita chete kurega maseru egomarara kukura pamadiro?zvirokwazvo kwete.Nekuti mhedzisiro yekutsvagisa yakapihwa mumufananidzo 2 yakatiudza kuti kana chemotherapeutics uye zvimweGanodermalucidumtriterpenoids inogona kushandiswa pamwe chete, pane mukana wekudzoreredza kusagadzikana kwemishonga yakawanda yakagadzirwa nekenza maseru kuita kuti chemotherapy ishande zvakare.
Sei zvichigonaGanoderma lucidumtriterpenes inoderedza kushorwa kwekenza maseru?Zvinoenderana nekuongororwa kwechikwata chaProfessor Li Peng, inoenderana neP-glycoprotein (P-gp) mumasero egomarara.
Masero eCancer anova asingatenderi zvinodhaka nekudzinga chemotherapy mishonga panguvaGanoderma lucidum triterpenoidsanogonachengetedzachemotherapy mishonga mukati memasero egomarara.
Iyo P-glycoprotein, iri mu membrane yesero uye inofamba mukati nekunze kwesero, yakafanana nemudziviriro wesero, "inotakura" zvinhu zvinokuvadza kuhupenyu hwesero kuenda kunze kwesero, nekudaro kudzivirira sero kubva mukukuvadza.Naizvozvo, maseru mazhinji ekenza anoburitsa yakawanda P-glycoprotein nekufambira mberi kwechemotherapy, zvichiita kuti zviome kuti mishonga igare mumasero.
Naizvozvo, kuramba kwemishonga mumaonero edu ndiyo nzira yekuti masero egomarara azvidzivirire.Ichi ndicho chikonzero kuchinjwa kwemishonga kusvika kumagumo kwete kungokundikana kubvisa masero egomarara asiwo kunokurudzira kuramba kwavo kwemishonga yakawanda.
Masero eCancer, hongu, anofanirwa kungwarira chemotherapy mishonga kuti vararame.Sezvineiwo,Ganoderma lucidumtriterpenoids ine nzira yekupwanya kudzivirira kwekenza maseru.Ongororo yevatsvakurudzi neGanoderiol F, iyo ine mhedzisiro yakanaka mukudzoreredza kuramba zvinodhaka, yakaratidza kuti kugadzira masero ekenza yemuromo emunhu ane Ganoderiol F (20 μM) kwemaawa matatu nekuwedzera chemotherapy drug doxorubicin inogona kuwedzera huwandu. ye doxorubicin yakaunganidzwa mumasero egomarara.
Zvinofadza kuti nhamba yeP-glycoprotein mumasero emukenza haina kuderedzwa nekupindira kweGanoderiol F, saka vatsvakurudzi vakafungidzira kuti Ganoderiol F inofanira kuderedza "basa rekufambisa" reiyi P-glycoproteins, zvichiita kuti doxorubicin irambe iri mumasero ekenza uye kukonzera. kukuvadzwa kwekenza masero.
Pasina doro rekubvisa reGanoderma lucidumkubatsira, hapana mubvunzo kushayikwa kwezvombo zvakawanda zvekurwisa kenza.
Sezvo vaongorori vakangoongorora maitiro ekudzoreredzwa kwekurwisa zvinodhaka neGanoderiol uye vasina kuongorora mamwe matriterpenoids, havazive kuti mamwe matriterpenoids anoita sei masero emukenza asingarambike emushonga kuti arege kurwisa zvinodhaka?
Sezvo chiyedzo ichi chakakurukura nezve triterpenoids uye sterol zvakasiyana, vanhu havagone kubatsira asi kushamisika kana kushandiswa kwakabatana kwavo uye chemotherapy mishonga kunogona kuita kuti mhedzisiro yacho ive nani.
Asi zvirinani tsvagiridzo iyi inotitaurira kuti zvikamu zvinoshanda zveGanoderma lucidumizvo zvinonetesa kurwisa kwemishonga kwemasero egomarara zviri muzvinyorwa zve ethanol zveGanoderma lucidummichero miviri.Kuchengetedzeka uye kushanda kweiyo ethanol yakatorwa yeGanoderma lucidumMiti inobereka michero yave ichizivikanwa pasi rose kubvira payaishandiswa pazvirwere zvakasiyana muma1970.
Naizvozvo, pasina iyo ethanol inotorwa yeGanoderma lucidum, zvechokwadi pachange paine zvombo zvishoma zvekurwisa kenza.Kana iwe usingade kurapwa kwegomarara kuwira mudenderedzwa rakashata rekuramba zvinodhaka, unogona kutanga nekusarudza iyo chaiyo.Ganoderma lucidum!
 
[Data Source] Min Wu, et al.Sterols uye triterpenoids kubvaGanoderma lucidumuye mabasa avo ekudzoreredza e tumor multidrug resistance.Nat Prod Res.2021 Mar 10;1-4.doi: 10.1080/14786419.2021.1878514.
 
 
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Nezve munyori/ Ms. Wu Tingyao
Wu Tingyao anga achitaura nezvekutanga-ruokoGanoderma lucidumruzivo
kubvira 1999. Ndiye munyori weKuporesa neGanoderma(yakabudiswa muThe People's Medical Publishing House muna Kubvumbi 2017).
 
★ Chinyorwa ichi chakaburitswa pasi pemvumo yakasarudzika yemunyori, uye muridzi ndeweGANOHERB ★ Mabasa ari pamusoro haagone kudhindwa, kutorwa kana kushandiswa nedzimwe nzira pasina mvumo yeGanoHerb ★ Kana mabasa acho akatenderwa kushandiswa, iwo inofanira kushandiswa mukati mechikamu chemvumo uye kuratidza kwakabva: GanoHerb ★ Kutyorwa kwechirevo chiri pamusoro, GanoHerb ichaita mabasa ayo ane chekuita nemutemo ★ Zvinyorwa zvepakutanga zvechinyorwa ichi chakanyorwa muchiChinese naWu Tingyao uye chakashandurirwa muchiChirungu naAlfred Liu.Kana paine mutsauko pakati peshanduro (yeChirungu) neyekutanga (Chinese), iyo yekutanga Chinese ichakunda.Kana vaverengi vaine mibvunzo, tapota taura nemunyori wemabviro, Ms. Wu Tingyao.
Pfuura paMillennia Health Culture
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