Wolemba Wu Tingyao

Khansara ndiyovuta kuchiza chifukwa maselo a khansa amayamba kukana mankhwala, kutanthauza kuti mankhwala omwe akanakhala othandiza popha khansa ayenera kugwiritsidwa ntchito pa mlingo waukulu kuti agwire ntchito.
Vuto ndiloti chemotherapeutics idzaphanso maselo abwinobwino, kotero ndizosatheka kutsata mlingo waukulu popanda malire apamwamba kuti muphe bwino khansa.
Zikatere, odwala nthawi zambiri amayenera kusintha mankhwala.Kwa odwala omwe ali ndi mwayi, khansayo idalamulidwa atasintha mankhwala.Komabe, odwala ambiri alibe mankhwala ena a khansa.Maselo a khansa akayamba kugonjetsedwa ndi mankhwala oyambirira, odwala amatha kudziletsa okha ku zotsatira zake.
Sikophweka kupanga mankhwala atsopano.Choncho, momwe mungachepetsere kukana kwa maselo a khansa ku mankhwala omwe alipo tsopano yakhala njira ina yopulumukira.
Mu Marichi chaka chino (2021), gulu lofufuza la Pulofesa Li Peng wochokera ku School of Pharmacy, Fujian Provincial Key Laboratory of Natural Medicine Pharmacology, Fujian Medical University adafalitsa lipoti mu "Natural Product Research" ponena kuti mitundu yosiyanasiyana ya triterpenoids muGanoderma lucidumkukhala ndi ntchito ya "kuchepetsa kukana mankhwala kwa maselo a khansa".
KuphatikizaGanodermalucidumtriterpenoids ndi chemotherapy kufooketsa kukana kwa mankhwala kwa maselo a khansa
Ofufuzawo adagwiritsa ntchito matupi a fruiting aGanoderma lucidumanabzala ndi Fujian Xianzhilou Biological Science and Technology Co., Ltd. monga zipangizo, poyamba yotengedwa ndi Mowa, ndiyeno anapitiriza kusanthula zigawo zikuluzikulu mu Tingafinye.Adapeza kuti panali mitundu iwiri ya ma sterols ndi mitundu 7 ya triterpenoids (Chithunzi 1) muzochotsa.
Mwa zigawo izi, 6 mitundu yaGanoderma lucidumtriterpenoids (zigawo 3, 4, 6, 7, 8, 9) zitha kusintha kwambiri kupha kwamankhwala achikhalidwe chamankhwala doxorubicin (DOX) pa multidrug resistant oral cell carcinoma, ndiye kuti, Mlingo wocheperako wa chemotherapeutics ungagwiritsidwe ntchito kukwaniritsa zotsatira zake. kupha theka (50%) la maselo a khansa osamva mankhwala ambiri (Chithunzi 2).
Pakati pawo, kuphatikiza ganoderiol F (gawo 8) ndi doxorubicin ali ndi zotsatira zabwino.Panthawiyi, gawo limodzi mwa magawo asanu ndi awiri okha a doxorubicin akagwiritsidwa ntchito payekha amakhala ndi zotsatira zofanana (Chithunzi 2).

Mlingo wabwinobwino wamankhwala amankhwala ndizovuta kupha maselo a khansa omwe ayamba kukana mankhwala.
Ndizovuta bwanji kuchiza ma cell a khansa akayamba kukana mankhwala ambiri?Mutha kuphunzira mwachiphamaso pa Chithunzi 3.
Powonjezera 0.1μM doxorubicin ku maselo a khansa ya m'kamwa, pambuyo pa maola 72, kupulumuka kwa maselo a khansa pafupifupi pafupifupi theka, koma maselo a khansa omwe amalimbana ndi mankhwala ambiri amakhala osakhudzidwa (Chithunzi 3 mzere wa madontho a lalanje).
Kuchokera kumalingaliro ena, kuti muchepetse ma cell a khansa yapakamwa mpaka 50%, mlingo wa doxorubicin wofunikira polimbana ndi maselo a khansa osamva mankhwala ambiri ndi pafupifupi nthawi 100 kuchuluka kwa doxorubicin komwe kumagwiritsidwa ntchito polimbana ndi ma cell a khansa (Chithunzi 3 Mzere wamadontho obiriwira. ).

Zotsatirazi zimachokera ku kuyesa kwa ma cell komwe kumachitika mu vitro.Sizingatheke kuchita zimenezi pochiritsa odwala chifukwa n’zosatheka kuti tipereke nsembe maselo abwinobwino amene thupi limadalira kuti lichotse maselo a khansa.
Ndiye, zomwe tingachite ndikungolola maselo a khansa kukula mwakufuna kwake?Inde sichoncho.Chifukwa zotsatira za kafukufuku zomwe zaperekedwa mu Chithunzi 2 zatiuza kuti ngati chemotherapeutics ndi zinaGanodermalucidumtriterpenoids ikhoza kugwiritsidwa ntchito palimodzi, pali mwayi wosintha kukana kwamankhwala ambiri komwe kumapangidwa ndi maselo a khansa kuti chemotherapy igwirenso ntchito.
Chifukwa chiyani?Ganoderma lucidumtriterpenes imachepetsa kukana kwa maselo a khansa?Malinga ndi kusanthula kwa gulu la Pulofesa Li Peng, zimagwirizana ndi P-glycoprotein (P-gp) m'maselo a khansa.
Maselo a khansa amakhala osamva mankhwala potulutsa mankhwala a chemotherapy pomweGanoderma lucidum triterpenoidsakhozakusungamankhwala a chemotherapy mankhwala mkati mwa maselo a khansa.
P-glycoprotein, yomwe ili mu nembanemba ya selo ndipo imayenda mkati ndi kunja kwa selo, ili ngati chipangizo choteteza maselo, chomwe "chimanyamula" zinthu zomwe zimawononga kupulumuka kwa selo kupita kunja kwa selo, potero zimateteza selo kuvulazidwa.Chifukwa chake, maselo ambiri a khansa amapanga P-glycoprotein yambiri ndikupita patsogolo kwa chemotherapy, zomwe zimapangitsa kuti zikhale zovuta kuti mankhwalawa azikhala m'maselo.
Chifukwa chake, kukana mankhwala m'malingaliro athu ndi njira yomwe maselo a khansa adzitetezere okha.Ichi ndichifukwa chake kulowetsedwa kwa mankhwala mpaka kumapeto sikungolephera kuchotsa zida za khansa komanso kumalimbikitsa kukana kwawo mankhwala ambiri.
Maselo a khansa, ndithudi, ayenera kusamala ndi mankhwala a chemotherapy kuti apulumuke.Mwamwayi,Ganoderma lucidumtriterpenoids ali ndi njira yowonongera chitetezo cha maselo a khansa.Kusanthula kwa ofufuza ndi Ganoderiol F, komwe kumakhala ndi zotsatira zabwino kwambiri pakuchepetsa kukana kwa mankhwala, kunawonetsa kuti kulimbikitsa maselo a khansa yapakamwa ya anthu omwe samva mankhwala ambiri ndi Ganoderiol F (20 μM) kwa maola atatu ndikuwonjezera mankhwala a chemotherapy doxorubicin amatha kukulitsa kuchuluka kwake. a doxorubicin omwe amaunjikana m'maselo a khansa.
Chochititsa chidwi n'chakuti, chiwerengero cha P-glycoproteins m'maselo a khansa sichinachepetsedwe ndi kulowerera kwa Ganoderiol F, kotero ofufuzawo ankaganiza kuti Ganoderiol F iyenera kufooketsa "ntchito yoyendetsa" ya P-glycoproteins iyi, kulola doxorubicin kukhalabe m'maselo a khansa ndikuyambitsa. kuwonongeka kwa maselo a khansa.
Popanda mowa Tingafinye waGanoderma lucidumkuthandiza, mosakayikira pali kusowa kwa zida zambiri zolimbana ndi khansa.
Popeza ofufuzawo adangofufuza njira yosinthira kukana kwa mankhwala ndi Ganoderiol ndipo sanafufuze ma triterpenoids ena, sakudziwa momwe ma triterpenoids ena amapangira maselo a khansa yamunthu osamva mankhwala kukhala osamva mankhwala?
Popeza kuyesaku kunakambirana za triterpenoids ndi sterols mosiyana, anthu sangachitire mwina koma kudabwa ngati kugwiritsa ntchito pamodzi ndi mankhwala a chemotherapy kungapangitse zotsatira zabwino.
Koma osachepera kafukufukuyu amatiuza kuti ogwira zigawo zikuluzikulu zaGanoderma lucidumamene kufooketsa kukana mankhwala a khansa maselo ali Mowa akupanga aGanoderma lucidummatupi a zipatso.Chitetezo ndi mphamvu ya ethanol Tingafinye waGanoderma lucidummatupi a zipatso akhala akuyamikiridwa padziko lonse lapansi kuyambira pomwe adagwiritsidwa ntchito pa matenda osiyanasiyana m'ma 1970.
Choncho, popanda Mowa Tingafinye waGanoderma lucidum, padzakhala zida zochepa zothana ndi khansa.Ngati simukufuna kuti chithandizo cha khansa chigwere m'gulu loyipa la kukana mankhwala ambiri, mutha kuyamba ndi kusankha choyenera.Ganoderma lucidum!
 
[Gwero la Data] Min Wu, et al.Sterols ndi triterpenoids kuchokeraGanoderma lucidumndi ntchito zawo zosinthira za chotupa multidrug resistance.Nat Prod Res.2021 Marichi 10;1-4.doi: 10.1080/14786419.2021.1878514.
 
 
TSIRIZA
Za wolemba/ Mayi Wu Tingyao
Wu Tingyao wakhala akunena za zomwe zikuchitikaGanoderma lucidumzambiri
kuyambira 1999. Iye ndi mlembi waKuchiza ndi Ganoderma(lofalitsidwa mu The People's Medical Publishing House mu April 2017).
 
★ Nkhaniyi yasindikizidwa pansi pa chilolezo cha wolemba, ndipo umwini ndi wa GANOHERB ★ Ntchito zomwe zili pamwambazi sizingapangidwenso, kuchotsedwa kapena kugwiritsidwa ntchito m'njira zina popanda chilolezo cha GanoHerb ★ Ngati ntchitozo zaloledwa kugwiritsidwa ntchito, iwo ziyenera kugwiritsidwa ntchito mkati mwa chilolezo ndikuwonetsa gwero: GanoHerb ★ Kuphwanya mawu omwe ali pamwambawa, GanoHerb idzakwaniritsa udindo wake wokhudzana ndi malamulo ★ Zolemba zoyambirira za nkhaniyi zinalembedwa m'Chitchaina ndi Wu Tingyao ndikumasuliridwa ku Chingerezi ndi Alfred Liu.Ngati pali kusiyana kulikonse pakati pa kumasulira (Chingerezi) ndi choyambirira (Chitchaina), Chitchaina choyambirira chidzapambana.Ngati owerenga ali ndi mafunso, lemberani wolemba woyamba, Mayi Wu Tingyao.
Pitani pa Millennia Health Culture
Thandizani ku Ubwino kwa Onse