Lub Ib Hlis 2017 / Amala Cancer Research Center / Mutation Research
Text/Wu Tingyao

Cov neeg feem coob tsis xav txog Ganoderma lucidum txog thaum lawv mob.Lawv tsuas tsis nco qab tias Ganoderma lucidum kuj tuaj yeem siv rau kev tiv thaiv kab mob.Raws li tsab ntawv ceeb toom luam tawm los ntawm Amala Cancer Research Center ntawm Is Nrias teb hauv "Kev Tshawb Fawb Kev Hloov Pauv" thaum Lub Ib Hlis 2017, Ganoderma lucidum triterpenes, uas tuaj yeem cuam tshuam kev muaj sia nyob ntawm cov qog nqaij hlav cancer, tuaj yeem txo qhov tshwm sim thiab qhov hnyav ntawm cov qog, txawm tias siv sab nraud lossis sab hauv.
Ganoderma lucidum triterpenes ua rau cov qog nqaij hlav cancer tsis nyob zoo.
Txoj kev tshawb no siv tag nrho triterpenoid extract ntawm fruiting lub cev ntawm Ganoderma lucidum.Cov kws tshawb fawb tau muab tso ua ke nrog MCF-7 tib neeg cov qog nqaij hlav qog noj ntshav (estrogen-dependent) thiab pom tias qhov ntau dua cov ntsiab lus ntawm cov extract, lub sij hawm ntev nws yuav siv sij hawm los cuam tshuam nrog cov qog nqaij hlav cancer, qhov ntau nws tuaj yeem txo qhov ciaj sia ntawm cov qog nqaij hlav. hlwb, thiab txawm nyob rau qee kis, nws tuaj yeem ua rau cov qog nqaij hlav cancer ploj tag nrho (raws li qhia hauv qab no).

(Daim duab remade los ntawm Wu Tingyao, cov ntaub ntawv qhov chaw / Mutat Res. 2017; 813: 45-51.)

Kev soj ntsuam ntxiv ntawm kev tiv thaiv kab mob qog noj ntshav ntawm Ganoderma lucidum tag nrho triterpenes tau qhia tias tom qab cov qog nqaij hlav qog noj ntshav tau hloov kho los ntawm Ganoderma lucidum triterpenes, ntau cov noob thiab cov protein molecules hauv cov hlwb yuav raug hloov pauv zoo.Hauv kev nthuav dav, lub hauv paus nquag nquag cyclin D1 thiab Bcl-2 thiab Bcl-xL yuav raug tshem tawm thaum lub sijhawm qub Bax thiab Caspase-9 yuav nyob tsis tswm.

Cyclin D1, Bcl-2 thiab Bcl-xL yuav txhawb nqa kev loj hlob ntawm cov qog nqaij hlav tsis tu ncua thaum Bax thiab caspase-9 yuav pib apoptosis ntawm cov qog nqaij hlav cancer kom cov qog nqaij hlav tuaj yeem muaj hnub nyoog thiab tuag zoo li cov hlwb qub.

Kev sim siv sab nraud: Ganoderma lucidum triterpenes tiv thaiv kab mob ntawm daim tawv nqaij.
Kev siv Ganoderma lucidum tag nrho triterpenes rau cov tsiaj kuj tuaj yeem ua rau muaj kev tiv thaiv kev tiv thaiv ntawm cov qog.Thawj yog qhov kev sim induction ntawm "cutaneous papilloma" (Editor's note: Qhov no yog ib tug benign papillary qog uas protrudes tawm ntawm daim tawv nqaij.

Cov carcinogen DMBA (dimethyl benz [a] anthracene, polycyclic aromatic hydrocarbon compound uas tuaj yeem ua rau kev hloov pauv ntawm caj ces) tau siv rau sab nraub qaum ntawm tus nas sim (nws cov plaub hau tau shaved) ua rau cov tawv nqaij mob.
Tom qab 1 lub lis piam, cov kws tshawb fawb tau siv cov roj croton, ib yam khoom uas txhawb cov qog loj hlob, mus rau tib cheeb tsam ob zaug hauv ib lub lis piam, thiab tseem siv 5, 10, lossis 20 mg ntawm Ganoderma lucidum triterpenes 40 feeb ua ntej txhua daim ntawv thov ntawm cov roj croton rau 8 sib law liag. lub lim tiam (lub lim tiam thib 2 txog 9 ntawm qhov kev sim).

Tom qab ntawd, cov kws tshawb fawb tau tso tseg tsis siv cov tshuaj phem thiab Ganoderma lucidum tab sis txuas ntxiv tsa cov nas thiab saib xyuas lawv cov mob.Thaum kawg ntawm 18th lub lim tiam ntawm kev sim, cov nas nyob rau hauv pab pawg tswj tsis tau kho, tsis hais qhov tshwm sim ntawm cov qog, cov qog uas loj hlob, thiab lub sij hawm loj hlob thawj cov qog, tau txawv txawv ntawm cov nas uas yog. thov nrog 5, 10, thiab 20 mg ntawm Ganoderma lucidum triterpenes (raws li qhia hauv daim duab hauv qab no).(Faj seeb: 12 nas rau ib pab.)

Qhov tshwm sim ntawm daim tawv nqaij papilloma tom qab 18 lub lis piam raug cov carcinogens
(Daim duab kos los ntawm Wu Tingyao, cov ntaub ntawv qhov chaw / Mutat Res. 2017; 813: 45-51.)

Qhov nruab nrab ntawm cov qog nqaij hlav ntawm daim tawv nqaij ntawm txhua tus nas tom qab 18 lub lis piam raug cov kab mob carcinogens
(Daim duab kos los ntawm Wu Tingyao, cov ntaub ntawv qhov chaw / Mutat Res. 2017; 813: 45-51.)

Lub sij hawm nws yuav siv sij hawm los loj hlob qog tom qab raug cov carcinogens
(Daim duab kos los ntawm Wu Tingyao, cov ntaub ntawv qhov chaw / Mutat Res. 2017; 813: 45-51.)
Kev sim pub mis: Ganoderma lucidum triterpenes tiv thaiv mob qog noj ntshav.
Qhov thib ob yog qhov kev sim "mob cancer mis": nas tau noj carcinogen DMBA ib zaug hauv ib lub lis piam rau 3 lub lis piam, thiab hnub tom ntej tom qab thawj zaug pub mis carcinogen (24 teev tom qab), 10, 50 lossis 100 mg / kg ntawm Ganoderma lucidum triterpenes tau noj txhua hnub rau 5 lub lis piam sib law liag.
Cov txiaj ntsig yuav luag zoo ib yam li kev sim ntawm daim tawv nqaij papilloma yav dhau los.Cov pab pawg tswj tsis muaj kev kho mob muaj 100% txoj hauv kev tsim mob qog noj ntshav.Ganoderma lucidum triterpenes tuaj yeem txo qhov tshwm sim ntawm cov qog;cov nas uas noj Ganoderma lucidum txawv txawv ntawm cov nas uas tsis noj Ganoderma lucidum nyob rau hauv tus naj npawb ntawm cov qog uas loj hlob thiab lub sij hawm loj hlob thawj qog (raws li qhia nyob rau hauv daim duab hauv qab no).
Cov qog hnyav ntawm nas tiv thaiv nrog 10, 50 lossis 100 mg / kg tag nrho cov extract ntawm Ganoderma lucidum triterpenes tsuas yog ob feem peb, ib nrab thiab ib feem peb ntawm cov qog hnyav ntawm cov nas hauv pawg tswj hwm, feem.

Kev mob qog noj ntshav mis
(Daim duab kos los ntawm Wu Tingyao, cov ntaub ntawv qhov chaw / Mutat Res. 2017; 813: 45-51.)

Qhov nruab nrab ntawm cov qog nqaij hlav ntawm daim tawv nqaij ntawm txhua tus nas ntawm lub lim tiam 17th tom qab noj carcinogens
(Daim duab kos los ntawm Wu Tingyao, cov ntaub ntawv qhov chaw / Mutat Res. 2017; 813: 45-51.)

Lub sijhawm nws siv rau nas kom loj hlob qog tom qab noj carcinogens
(Daim duab kos los ntawm Wu Tingyao, cov ntaub ntawv qhov chaw / Mutat Res. 2017; 813: 45-51.)

Ganoderma lucidum triterpenes muaj kev nyab xeeb thiab zoo.

Cov txiaj ntsig ntawm ob qho kev sim tsiaj saum toj no qhia meej rau peb tias txawm tias kev tswj hwm qhov ncauj lossis kev siv sab nraud ntawm Ganoderma lucidum tag nrho triterpenes tuaj yeem txo qhov tshwm sim ntawm cov qog, txo cov qog nqaij hlav thiab ncua qhov tshwm sim ntawm cov qog.

Cov txheej txheem ntawm Ganoderma lucidum tag nrho triterpenes tuaj yeem cuam tshuam nrog kev tswj cov noob thiab cov protein molecules hauv cov qog hlwb tau hais ua ntej hauv kab lus no.Pab pawg tshawb fawb yav dhau los tau lees paub tias Ganoderma lucidum tag nrho triterpenes tsis ua mob rau lub cev, qhia tias Ganoderma lucidum tag nrho triterpenes muaj kev nyab xeeb thiab siv tau zoo.

Hauv lub neej niaj hnub no uas muaj teeb meem kev noj qab haus huv, nws yog kev xav kom tsis txhob muaj cov carcinogens.Yuav thov koob hmoov li cas thaum muaj kev nyuaj siab?Cov khoom uas muaj Ganoderma lucidum tag nrho triterpenes tej zaum yuav yog koj qhov zoo tagnrho sustenance.

[Source] Smina TP, et al.Ganoderma lucidum tag nrho triterpenes induce apoptosis hauv MCF-7 hlwb thiab attenuate DMBA induced mammary thiab daim tawv nqaij carcinomas hauv cov tsiaj sim.Mutat Res.2017;813: 45-51.
Hais txog tus sau/ Ms. Wu Tingyao

Wu Tingyao tau tshaj tawm cov ntaub ntawv Ganoderma thawj zaug txij li xyoo 1999. Nws yog tus sau ntawm Kho nrog Ganoderma (tshaj tawm hauv Lub Tsev Kho Mob Cov Neeg Kho Mob thaum Lub Plaub Hlis 2017).

★ Kab lus no tau luam tawm raws li kev tso cai tshwj xeeb ntawm tus sau.★ Cov haujlwm saum toj no tsis tuaj yeem muab luam tawm, txiav tawm lossis siv lwm txoj hauv kev yam tsis muaj kev tso cai los ntawm tus sau.★ Rau kev ua txhaum ntawm cov lus hais saum toj no, tus sau yuav ua raws li cov luag haujlwm raug cai.★ Cov ntawv qub ntawm kab lus no tau sau ua lus Suav los ntawm Wu Tingyao thiab txhais ua lus Askiv los ntawm Alfred Liu.Yog tias muaj qhov tsis sib xws ntawm kev txhais lus (English) thiab tus thawj (Suav), tus thawj Suav yuav yeej.Yog tias cov nyeem muaj lus nug, thov hu rau tus thawj kws sau ntawv, Ms. Wu Tingyao.