Los ntawm Wu Tingyao

Mob qog noj ntshav yog qhov nyuaj rau kev kho mob vim tias cov qog nqaij hlav qog noj ntshav tsim cov tshuaj tiv thaiv, txhais tau hais tias cov tshuaj uas yuav muaj txiaj ntsig zoo hauv kev tua kabmob kheesxaws yuav tsum tau siv ntau dua kom zoo.
Qhov teeb meem yog tias chemotherapeutics tseem yuav tua cov kab mob ib txwm muaj, yog li nws tsis tuaj yeem nrhiav cov koob tshuaj ntau yam tsis muaj kev txwv siab txhawm rau txhawm rau tua cov qog noj ntshav.
Hauv qhov xwm txheej no, cov neeg mob feem ntau yuav tsum tau hloov tshuaj.Rau cov neeg mob muaj hmoo, mob qog noj ntshav tau tswj tau tom qab lawv hloov tshuaj.Txawm li cas los xij, feem ntau cov neeg mob tsis muaj lwm yam tshuaj kho mob cancer.Tom qab cov qog nqaij hlav cancer tiv taus cov tshuaj qub, cov neeg mob tsuas tuaj yeem tawm ntawm lawv tus kheej mus rau lawv txoj hmoo.
Nws tsis yooj yim los tsim cov tshuaj tshiab.Yog li ntawd, yuav ua li cas txo cov qog nqaij hlav cancer rau cov tshuaj uas twb muaj lawm tau dhau los ua lwm txoj hauv kev kom muaj sia nyob.
Nyob rau lub Peb Hlis Ntuj xyoo no (2021), pab neeg tshawb fawb ntawm Xib Fwb Li Peng los ntawm Tsev Kawm Ntawv Pharmacy, Fujian Provincial Key Laboratory ntawm Natural Medicine Pharmacology, Fujian Medical University tau luam tawm tsab ntawv tshaj tawm hauv "Natural Product Research" hais tias ntau yam triterpenoids hauvGanoderma lucidummuaj cov haujlwm ntawm "txo cov tshuaj tiv thaiv kab mob qog noj ntshav".
Ua keGanodermalucidumtriterpenoids nrog tshuaj kho mob kom tsis muaj zog tshuaj tiv thaiv ntawm cov qog nqaij hlav cancer
Cov kws tshawb fawb siv cov txiv hmab txiv ntoo lub cev ntawmGanoderma lucidumcog los ntawm Fujian Xianzhilou Biological Science thiab Technology Co., Ltd. ua cov ntaub ntawv, thawj zaug muab rho tawm nrog ethanol, thiab tom qab ntawd ntxiv tshuaj xyuas cov khoom hauv cov extract.Lawv pom tias muaj tsawg kawg yog 2 hom sterols thiab 7 hom triterpenoids (Daim duab 1) hauv cov extract.
Ntawm cov khoom no, 6 homGanoderma lucidumtriterpenoids (cov khoom siv 3, 4, 6, 7, 8, 9) tuaj yeem txhim kho kev tua cov tshuaj tua kab mob tshuaj doxorubicin (DOX) ntawm ntau cov tshuaj tiv thaiv kab mob hauv qhov ncauj, uas yog, qis dua ntawm cov tshuaj kws khomob tuaj yeem siv los ua kom tiav cov nyhuv. ntawm tua ib nrab (50%) ntawm multidrug resistant hlwb hlwb (Daim duab 2).
Ntawm lawv, kev sib xyaw ua ke ntawm ganoderiol F (cov khoom siv 8) thiab doxorubicin muaj txiaj ntsig zoo tshaj plaws.Lub sijhawm no, tsuas yog ib feem xya ntawm qhov koob tshuaj ntawm doxorubicin thaum siv ib leeg muaj cov nyhuv tib yam (Daim duab 2).

Cov koob tshuaj ntawm chemotherapeutics yog qhov nyuaj los tua cov qog nqaij hlav cancer uas tau tsim cov tshuaj tiv thaiv.
Nws nyuaj npaum li cas los kho cov qog nqaij hlav cancer thaum lawv txhim kho ntau yam tshuaj tiv thaiv?Koj tuaj yeem kawm superficially los ntawm daim duab 3.
Ntxiv 0.1μM doxorubicin rau tib neeg lub qhov ncauj cov hlwb, tom qab 72 teev, cov ciaj sia taus ntawm cov qog nqaij hlav qog nqaij hlav yuav luag raug txo kom txog li ib nrab, tab sis ntau cov tshuaj tiv thaiv kab mob qog noj ntshav yuav luag tsis cuam tshuam (Daim duab 3 txiv kab ntxwv dotted kab).
Los ntawm lwm qhov kev xav, txhawm rau txo cov qog nqaij hlav hauv lub qhov ncauj rau 50%, qhov koob tshuaj ntawm doxorubicin yuav tsum tau ua nrog ntau cov tshuaj tiv thaiv kab mob qog noj ntshav yog yuav luag 100 npaug ntawm cov koob tshuaj doxorubicin siv los cuam tshuam nrog cov kab mob qog noj ntshav (Daim duab 3 Green dotted kab. ).

Cov txiaj ntsig no yog muab los ntawm kev sim ntawm tes ua hauv vitro.Nws yog tsis yooj yim sua ua li no thaum kho cov neeg mob vim hais tias nws yog tsis yooj yim sua rau peb txi cov hlwb li qub uas lub cev nyob ntawm seb yuav tshem tawm cov qog nqaij hlav cancer.
Yog li, peb yuav ua li cas tsuas yog cia cov qog nqaij hlav cancer loj hlob ntawm lub siab nyiam?tau kawg tsis.Vim tias qhov kev tshawb fawb tau nthuav tawm hauv daim duab 2 tau qhia peb tias yog chemotherapeutics thiab qee yamGanodermalucidumtriterpenoids tuaj yeem siv ua ke, muaj txoj hauv kev los thim rov qab cov tshuaj tiv thaiv ntau yam tsim los ntawm cov qog nqaij hlav qog noj ntshav kom ua rau cov tshuaj khomob zoo dua.
Vim li cas thiaj ua tauGanoderma lucidumtriterpenes tsis muaj zog tiv thaiv kab mob qog noj ntshav?Raws li kev soj ntsuam ntawm Xib Fwb Li Peng pab neeg, nws muaj feem xyuam rau P-glycoprotein (P-gp) hauv cov qog nqaij hlav cancer.
Cov qog nqaij hlav cancer dhau los ua tshuaj tiv thaiv los ntawm kev tshem tawm cov tshuaj khomob thaum lub sijhawmGanoderma lucidum triterpenoidsua taukhaws ciacov kws khomob tshuaj nyob rau hauv cov qog nqaij hlav cancer.
P-glycoprotein, uas yog nyob rau hauv lub cell membrane thiab straddles sab hauv thiab sab nraud ntawm lub cell, zoo li ib tug cell tiv thaiv ntaus ntawv, uas "hloov" cov khoom uas muaj teeb meem rau cell ciaj sia taus mus rau sab nraud ntawm lub cell, yog li tiv thaiv lub cell. cell los ntawm kev puas tsuaj.Yog li ntawd, ntau cov qog nqaij hlav cancer yuav tsim P-glycoprotein ntau dua nrog kev ua tiav ntawm kev kho mob, ua rau nws nyuaj rau cov tshuaj nyob hauv cov hlwb.
Yog li ntawd, cov tshuaj tiv thaiv hauv peb lub tswv yim yog txoj hauv kev rau cov qog nqaij hlav cancer los tiv thaiv lawv tus kheej.Qhov no yog vim li cas kev hloov tshuaj mus rau qhov kawg tsis tsuas yog ua tsis tau rau cov qog nqaij hlav cancer tab sis kuj txhawb nqa lawv cov tshuaj tiv thaiv ntau yam.
Cov qog nqaij hlav cancer, tau kawg, yuav tsum tau tiv thaiv cov tshuaj khomob rau lawv tus kheej txoj sia.Hmoov zoo,Ganoderma lucidumtriterpenoids muaj ib txoj hauv kev los rhuav tshem cov kab mob qog noj ntshav.Cov kws tshawb fawb soj ntsuam nrog Ganoderiol F, uas muaj cov txiaj ntsig zoo tshaj plaws hauv kev thim rov qab tshuaj tiv thaiv, pom tias kev coj noj coj ua ntau yam tshuaj tiv thaiv tib neeg lub qhov ncauj hlwb nrog Ganoderiol F (20 μM) rau 3 teev thiab tom qab ntawd ntxiv cov tshuaj tua kab mob doxorubicin tuaj yeem nce tus nqi ntau. doxorubicin sau nyob rau hauv cov qog nqaij hlav cancer.
Interestingly, tus naj npawb ntawm P-glycoproteins hauv cov qog nqaij hlav cancer tsis tau txo qis los ntawm kev cuam tshuam ntawm Ganoderiol F, yog li cov kws tshawb fawb tau kwv yees tias Ganoderiol F yuav tsum tsis muaj zog "kev ua haujlwm" ntawm cov P-glycoproteins, tso cai rau doxorubicin nyob hauv cov qog nqaij hlav thiab ua rau. kev puas tsuaj rau cov qog nqaij hlav cancer.
Tsis muaj cawv extract ntawmGanoderma lucidumlos pab tawm, yog qhov tsis muaj qhov tsis muaj ntau yam riam phom tiv thaiv kab mob.
Txij li thaum cov kws tshawb fawb tsuas yog tshawb nrhiav cov txheej txheem ntawm kev thim rov qab ntawm cov tshuaj tiv thaiv los ntawm Ganoderiol thiab tsis tau txheeb xyuas lwm yam triterpenoids, lawv tsis paub tias lwm cov triterpenoids ua rau cov tshuaj tiv thaiv kab mob qog noj ntshav rau tib neeg li cas los ua cov tshuaj tsis muaj zog?
Txij li qhov kev sim no tau sib tham txog cov triterpenoids thiab sterols sib cais, tib neeg tsis tuaj yeem pab tab sis xav paub yog tias kev sib koom ua ke ntawm lawv thiab cov tshuaj khomob tuaj yeem ua rau cov nyhuv zoo dua.
Tab sis tsawg kawg qhov kev tshawb fawb no qhia peb tias cov khoom siv tau zoo ntawmGanoderma lucidumuas tsis muaj zog tshuaj tiv thaiv kab mob qog noj ntshav muaj nyob rau hauv ethanol rho tawm ntawmGanoderma lucidumtxiv hmab txiv ntoo lub cev.Kev nyab xeeb thiab kev ua tau zoo ntawm ethanol extract ntawmGanoderma lucidumTxiv hmab txiv ntoo lub cev tau txais kev qhuas thoob ntiaj teb txij li nws tau siv rau ntau yam kab mob hauv xyoo 1970s.
Yog li ntawd, tsis muaj ethanol extract ntawmGanoderma lucidum, yeej yuav muaj tsawg dua riam phom tiv thaiv kab mob.Yog tias koj tsis xav tau kev kho mob qog noj ntshav kom poob rau hauv lub voj voog vicious ntawm multidrug resistance, koj tuaj yeem pib los ntawm kev xaiv txoj caiGanoderma lucidum!
 
[Data Source] Min Wu, et al.Sterols thiab triterpenoids los ntawmGanoderma lucidumthiab lawv cov dej num thim rov qab ntawm cov qog ntau yam tshuaj tiv thaiv.Nat Prod Res.2021 Mar 10;1-4.doi: 10.1080/14786419.2021.1878514 ib.
 
 
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Hais txog tus sau/ Ms. Wu Tingyao
Wu Tingyao tau tshaj tawm thawj zaugGanoderma lucidumcov ntaub ntawv
txij li xyoo 1999. Nws yog tus sauKho nrog Ganoderma(tshaj tawm hauv Lub Tsev Kho Mob Tib Neeg Lub Plaub Hlis 2017).
 
★ Kab lus no tau luam tawm raws li kev tso cai tshwj xeeb ntawm tus sau, thiab cov tswv cuab yog GANOHERB ★ Cov haujlwm saum toj no tsis tuaj yeem luam tawm, txiav tawm lossis siv lwm txoj hauv kev yam tsis tau tso cai ntawm GanoHerb ★ Yog tias cov haujlwm tau tso cai siv, lawv yuav tsum tau siv nyob rau hauv lub Scope ntawm kev tso cai thiab qhia lub hauv paus: GanoHerb ★ Kev ua txhaum ntawm cov lus saum toj no, GanoHerb yuav caum nws cov luag hauj lwm raws li txoj cai ★ Thawj cov ntawv nyeem ntawm tsab xov xwm no yog sau ua lus Suav los ntawm Wu Tingyao thiab txhais ua lus Askiv los ntawm Alfred Liu.Yog tias muaj qhov tsis sib xws ntawm kev txhais lus (English) thiab tus thawj (Suav), tus thawj Suav yuav yeej.Yog tias cov nyeem muaj lus nug, thov hu rau tus thawj kws sau ntawv, Ms. Wu Tingyao.
Dhau ntawm Millennia Health Culture
Pab txhawb rau Kev Noj Qab Haus Huv rau Txhua Tus