Na Wu Tingyao

Paʻakikī ka mālama ʻana i ka maʻi maʻi maʻi no ka mea e ulu ana nā maʻi kanesa i ke kūʻē ʻana i ka lāʻau lapaʻau, ʻo ia hoʻi, pono e hoʻohana ʻia nā lāʻau lapaʻau e pono mua i ka pepehi ʻana i ka maʻi maʻi maʻi i nā koina kiʻekiʻe e pono ai.
ʻO ka pilikia ʻo ka chemotherapeutics e pepehi pū i nā cell maʻamau, no laila ʻaʻole hiki ke alualu i nā kau kiʻekiʻe me ka ʻole o ka palena kiʻekiʻe i mea e pepehi pono ai i ka maʻi kanesa.
I kēia kūlana, pono nā mea maʻi e pani i nā lāʻau lapaʻau.No nā poʻe maʻi laki, ua hoʻomalu ʻia ke kanesa ma hope o ka hoʻololi ʻana i nā lāʻau lapaʻau.Eia nō naʻe, ʻaʻole loaʻa i ka hapa nui o nā maʻi nā lāʻau lapaʻau maʻi kanesa ʻē aʻe.Ma hope o ka pale ʻana o nā maʻi kanesa i nā lāʻau lapaʻau mua, hiki i nā mea maʻi ke haʻalele iā lākou iho i ko lākou hopena.
ʻAʻole maʻalahi ka hoʻomohala ʻana i nā lāʻau lapaʻau hou.No laila, pehea e hōʻemi ai i ke kūʻē ʻana o nā maʻi maʻi maʻi i nā lāʻau lapaʻau e noho nei ua lilo i ala ʻē aʻe e ola ai.
I Malaki o kēia makahiki (2021), ua paʻi ka hui noiʻi o Polofesa Li Peng mai ke Kula ʻo Pharmacy, Fujian Provincial Key Laboratory of Natural Medicine Pharmacology, Fujian Medical University i kahi hōʻike ma "Natural Product Research" e ʻōlelo ana he ʻano triterpenoids i loko.ʻO Ganoderma lucidumloaʻa ka hana o ka "hōʻemi i ka pale ʻana i ka lāʻau lapaʻau o nā maʻi kanesa".
HoʻohuiGanodermalucidumtriterpenoids me ka chemotherapy e hoʻonāwaliwali i ka lāʻau kū'ē o nā maʻi maʻi
Ua hoʻohana nā mea noiʻi i nā kino hua oʻO Ganoderma lucidumkanu ʻia e Fujian Xianzhilou Biological Science and Technology Co., Ltd. ma ke ʻano he mau mea, unuhi mua iā lākou me ka ethanol, a laila hoʻopili hou i nā ʻāpana i ka extract.Ua ʻike lākou aia ma kahi o 2 mau ʻano sterols a me 7 ʻano triterpenoids (Figure 1) i loko o ka extract.
Ma waena o kēia mau ʻāpana, 6 mau ʻanoʻO Ganoderma lucidumtriterpenoids ('āpana 3, 4, 6, 7, 8, 9) hiki ke hoʻomaikaʻi maikaʻi i ka hopena pepehi o ka lāʻau lapaʻau lāʻau lapaʻau kuʻuna doxorubicin (DOX) ma luna o ka maʻi maʻi maʻi maʻi waha multidrug, ʻo ia hoʻi, hiki ke hoʻohana ʻia nā haʻahaʻa haʻahaʻa o nā chemotherapeutics e loaʻa ai ka hopena. no ka pepehi ʻana i ka hapalua (50%) o nā pūnaewele maʻi maʻi kūʻē i ka multidrug (Figure 2).
I waena o lākou, ʻo ka hui pū ʻana o ganoderiol F (component 8) a me doxorubicin ka hopena maikaʻi loa.I kēia manawa, hoʻokahi wale nō hapahiku o ka doxorubicin ke hoʻohana wale ʻia ka hopena like (Figure 2).

He paʻakikī ka hoʻopaʻa ʻana o ka chemotherapeutics maʻamau i ka pepehi ʻana i nā maʻi maʻi maʻi i hoʻomohala i ke kūʻē i ka lāʻau.
Pehea ka paʻakikī o ka mālama ʻana i nā maʻi maʻi maʻi ke hoʻomohala lākou i ka pale ʻana i nā lāʻau lapaʻau?Hiki iā ʻoe ke aʻo ma ke kiʻekiʻe mai ka Kiʻi 3.
Hoʻohui 0.1μM doxorubicin i ke kanaka maʻi maʻi ʻaʻai waha, ma hope o 72 hola, ʻaneʻane hoʻemi ʻia ka nui o ke ola ʻana o nā maʻi maʻi maʻi maʻamau ma kahi o ka hapalua, akā ʻaneʻane ʻaʻole i hoʻopilikia ʻia nā pūnana maʻi maʻi multidrug (Figure 3 laina kiko ʻalani).
Mai kahi hiʻohiʻona ʻē aʻe, i mea e hōʻemi ai i nā maʻi maʻi maʻi waha o ke kanaka i 50%, ʻo ka nui o ka doxorubicin i koi ʻia no ka mālama ʻana i nā maʻi maʻi maʻi multidrug-resistant ʻaneʻane 100 ka nui o ka nui o ka doxorubicin i hoʻohana ʻia no ka hoʻohana ʻana i nā cell cancer maʻamau (Figure 3 Green dotted line. ).

Loaʻa kēia hopena mai nā hoʻokolohua cell i hana ʻia in vitro.ʻAʻole hiki ke hana i kēia i ka wā e mālama ai i nā maʻi no ka mea ʻaʻole hiki iā mākou ke kaumaha i nā cell maʻamau i hilinaʻi ʻia e ke kino e hoʻopau i nā maʻi kanesa.
No laila, ʻo ka mea hiki iā mākou ke hana, ʻo ka ʻae wale ʻana i nā maʻi kanesa e ulu i ka makemake?aole loa.No ka mea, ua haʻi mai nā hualoaʻa noiʻi i hōʻike ʻia ma ka Figure 2 inā he chemotherapeutics a me kekahiGanodermalucidumHiki ke hoʻohana pū ʻia nā triterpenoids, aia kahi manawa e hoʻohuli i ke kūpaʻa multidrug i hoʻomohala ʻia e nā maʻi maʻi maʻi e hana hou i ka chemotherapy.
No ke aha e hiki aiʻO Ganoderma lucidumhoʻonāwaliwali nā triterpenes i ke kūʻē ʻana o nā maʻi maʻi?Wahi a ka loiloi a ka hui o Polofesa Li Peng, pili ia i ka P-glycoprotein (P-gp) i loko o nā maʻi kanesa.
Lilo ka maʻi maʻi i ka lāʻau kūʻē ma ke kipaku ʻana i nā lāʻau lapaʻau chemotherapy i ka wāʻO Ganoderma lucidum triterpenoidshikimālamaka chemotherapy nā lāʻau lapaʻau i loko o ka maʻi kanesa.
ʻO ka P-glycoprotein, aia i loko o ka membrane cell a hoʻopaʻa i loko a ma waho o ke kelepona, ua like ia me kahi mea pale o ka cell, ka mea e "lawe" i nā mea ʻino i ke ola ʻana o ka cell i waho o ka cell, no laila e pale ai i ka. cell mai ka pōʻino.No laila, nui ka nui o nā maʻi maʻi maʻi e hoʻohua i ka P-glycoprotein me ka holomua o ka chemotherapy, e paʻakikī ai ka noho ʻana o nā lāʻau i loko o nā keena.
No laila, ʻo ke kūʻē ʻana i ka lāʻau lapaʻau i kā mākou manaʻo ʻo ia ke ala no nā maʻi kanesa e pale aku iā lākou iho.ʻO ia ke kumu o ka hoʻololi ʻana i nā lāʻau lapaʻau a hiki i ka hopena ʻaʻole hiki ke hoʻopau wale i nā pūnaeho maʻi maʻi akā hoʻolaha pū i ko lākou kūʻē multidrug.
ʻO nā maʻi kanesa, ʻoiaʻiʻo, pono e kiaʻi i nā lāʻau lapaʻau chemotherapy no ko lākou ola ponoʻī.ʻO ka pōmaikaʻi,ʻO Ganoderma lucidumHe ala ka triterpenoids e wāwahi ai i nā pale o nā maʻi kanesa.ʻO ka nānā ʻana o ka poʻe noiʻi me Ganoderiol F, ʻo ia ka hopena maikaʻi loa i ka hoʻohuli ʻana i ke kūʻē ʻana i ka lāʻau lapaʻau, ua hōʻike ʻia ʻo ka hoʻoulu ʻana i nā sela maʻi maʻi waha kanaka multidrug-resistant me Ganoderiol F (20 μM) no 3 mau hola a laila hoʻohui i ka lāʻau lapaʻau doxorubicin hiki ke hoʻonui nui i ka nui. ʻO ka doxorubicin i hōʻiliʻili ʻia i loko o nā pūnaeho maʻi maʻi.
ʻO ka mea e mahalo ai, ʻaʻole i hoʻemi ʻia ka helu o nā P-glycoproteins i loko o nā pūnaewele maʻi maʻi ma muli o ke komo ʻana o Ganoderiol F, no laila ua manaʻo ka poʻe noiʻi e hoʻonāwaliwali ʻo Ganoderiol F i ka "hana lawe" o kēia mau P-glycoproteins, e ʻae ana i ka doxorubicin e noho i loko o nā pūnaeho maʻi maʻi a kumu. pōʻino i nā pūnana maʻi kanesa.
Me ka ʻole o ka waiʻona oʻO Ganoderma lucidumno ke kōkua ʻana, ʻaʻole kānalua ka nele o nā mea kaua anti-cancer.
No ka mea ua ʻimi wale ka poʻe noiʻi i ke ʻano o ka hoʻihoʻi ʻana o ke kūʻē ʻana i ka lāʻau e Ganoderiol a ʻaʻole i ʻike i nā triterpenoids ʻē aʻe, ʻaʻole lākou i ʻike pehea e hana ai nā triterpenoids ʻē aʻe i kahi lāʻau lapaʻau kūʻokoʻa kūʻokoʻa ʻole i nā lāʻau lapaʻau?
Ma muli o ke kūkākūkā kaʻawale ʻana o kēia hoʻokolohua i nā triterpenoids a me nā sterols, ʻaʻole hiki i nā kānaka ke noʻonoʻo inā hiki i ka hoʻohana pū ʻana iā lākou a me nā lāʻau lapaʻau chemotherapy ke hoʻomaikaʻi i ka hopena.
Akā ma ka liʻiliʻi e haʻi mai kēia noiʻi iā mākou i nā ʻāpana kūpono oʻO Ganoderma lucidumi hoʻonāwaliwali i ka lāʻau kū'ē o ka maʻi 'aʻai maʻi 'aʻai i loko o ka ethanol extracts oʻO Ganoderma lucidumkino hua.Ka palekana a me ka pono o ka ethanol extract oʻO Ganoderma lucidumUa mahalo nui ʻia nā kino hua ʻai mai ka wā i hoʻohana ʻia ai no nā maʻi like ʻole i nā makahiki 1970.
No laila, me ka ʻole o ka ethanol extract oʻO Ganoderma lucidum, e emi mai ana nā mea kaua anti-cancer.Inā ʻaʻole ʻoe makemake e hāʻule ka mālama ʻana i ka maʻi kanesa i loko o ka pōʻai ʻino o ka pale ʻana i nā lāʻau lehulehu, hiki iā ʻoe ke hoʻomaka ma ke koho ʻana i ka pono.ʻO Ganoderma lucidum!
 
[Kumuʻikepili] Min Wu, et al.Sterols a me triterpenoids maiʻO Ganoderma luciduma me kā lākou hana hoʻohuli ʻana i ke kūʻē ʻana i nā lāʻau lapaʻau nui.Nat Prod Res.2021 Mar 10;1-4.doi: 10.1080/14786419.2021.1878514.
 
 
HOPE
No ka mea kākau/ Ms. Wu Tingyao
Ua hōʻike ʻo Wu Tingyao ma ka lima muaʻO Ganoderma lucidumʻike
mai ka makahiki 1999. ʻO ia ke kumu oHoola me Ganoderma(i paʻi ʻia ma The People's Medical Publishing House ma ʻApelila 2017).
 
★ Ua paʻi ʻia kēia ʻatikala ma lalo o ka mana kūʻokoʻa o ka mea kākau, a no GANOHERB ka mea nona ★ ʻAʻole hiki ke hana hou ʻia nā hana ma luna aʻe, ʻoki ʻia a hoʻohana ʻia ma nā ʻano ʻē aʻe me ka ʻole o ka GanoHerb ★ Inā ua ʻae ʻia nā hana e hoʻohana ʻia, Pono e hoʻohana ʻia i loko o ke ʻano o ka ʻae ʻia a hōʻike i ke kumu: GanoHerb ★ ʻAi ʻole i ka ʻōlelo ma luna, e ʻimi ʻo GanoHerb i kāna mau kuleana pili kānāwai ★ Ua kākau ʻia ka kikokikona kumu o kēia ʻatikala ma ka ʻōlelo Kina e Wu Tingyao a unuhi ʻia i ka ʻōlelo Pelekania e Alfred Liu.Inā loaʻa kekahi ʻokoʻa ma waena o ka unuhi (English) a me ka unuhi mua (Pake), e lanakila ka Pākē mua.Inā he nīnau ka poʻe heluhelu, e ʻoluʻolu e kelepona i ka mea kākau kumu, ʻo Ms. Wu Tingyao.
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