Ucwaningo olushicilelwe ku-“Pharmacological Research” yi-State Key Laboratory of Traditional Chinese Medicine Quality Research yaseNyuvesi yaseMacau (umbhali ohambisana nombiko wocwaningo) kanye nezikhungo eziningi zocwaningo lwasekhaya ngo-Agasti 2020 zathola:

Ukwengeza amagundane namafutha e-Ganoderma lucidum spore (800 mg/kg) nsuku zonke izinsuku ezingama-27 ezilandelanayo kungathuthukisa kakhulu ikhono le-phagocytic lama-macrophage kanye nobuthi bamaseli abulalayo emvelo (NK cells).

Ama-Macrophage kanye namaseli abulalayo emvelo angama-protagonists "wempendulo ye-innate immune immune".Indima yabo esimisweni sokuzivikela ezifweni ifana namasosha amaphoyisa azulazula futhi egcina ukuhleleka emhlabeni wabantu.Bangashiwo ukuthi bahamba phambili ekuvikeleni amagciwane ahlukahlukene, amagciwane, namangqamuzana omdlavuza.

Ngakho-ke, amandla okuphendula ama-macrophages namaseli abulalayo emvelo azokhula ngokufaka uwoyela we-spore, okungase kwandise ithuba lokuzivikela komzimba ukubulala "izitha ezingabonakali" ezihlukahlukene.

Kungani uwoyela we-spore uthuthukisa ukungatheleleki?Ihlobene eduze namagciwane amathumbu.

Amathumbu asatshalaliswa ngamaseli omzimba amaningi futhi aqukethe zonke izinhlobo zamabhaktheriya.Imikhuba yokudla ehlukene izoqinisa noma yenza buthaka izinhlobo ezahlukene zamabhaktheriya amathumbu, futhi izilinganiso ezihlukene zesakhiwo sezitshalo zamathumbu emathunjini kanye nama-metabolite akhiqizwa izinhlobo ezahlukene zamabhaktheriya amathumbu azothinta isiqondiso kanye nezinga lokuphendula komzimba.

Ngokohlaziyo lwalo mbiko wocwaningo, ngemuva kokuthi amagundane edle uwoyela we-spore isikhathi esithile, ukwakheka kanye nama-metabolite ezitshalo zawo zamathumbu kuzoshintsha, njengokuthi:

Ukwanda kwamagciwane azuzisayo njengeLactobacillus, ukuncipha kwamagciwane ayingozi njenge-Staphylococcus ne-Helicobacter, kanye noshintsho lwezinhlobo ezingaphezu kweshumi nambili zama-metabolites njenge-dopamine ne-L-threonine ngobuningi.

Lezi zinguquko zinenzuzo ukukhuthaza i-phagocytosis yama-macrophages futhi kuthuthukise ikhono lokubulala lamangqamuzana abulalayo emvelo.

Eminyakeni embalwa edlule, ucwaningo oluningi luye lwafakazela ukuthi umphumela wokuthuthukisa umzimba we-Ganoderma lucidum fruiting body extract kanye ne-spore powder uhlobene nokulawulwa kwezitshalo zamathumbu kanye nama-metabolites awo.Ezinsukwini zamanje, ucwaningo selugcine selwenzile igebe kulesi sici sawoyela wezinhlamvu.

Nakuba ukwandisa umsebenzi wama-macrophage namangqamuzana abulalayo emvelo kungakhuphula izinga lokuzivikela lokusabela okungokwemvelo komzimba, ukwakheka kwenethiwekhi yokuzivikela komzimba ephelele neminyene kudinga nokusekelwa abanye abaqaphi bangaphambili (njengama-neutrophils namaseli e-dendritic) futhi atholiwe. amasosha omzimba (njengama-T cell, B cells nama-antibodies).

Njengoba i-extract, i-spore powder namafutha e-spore e-Ganoderma lucidum anezinzuzo zawo siqu ekulawuleni ukungatheleleki, kungani ungawasebenzisi kanyekanye ukuze wandise ithuba lokuxosha "isitha esingabonakali"?

[Insiza Yedatha] Xu Wu, et al.Ukuhlaziywa kwe-microbiome okuhlanganisiwe kanye ne-metabolomic kukhomba izici ezithuthukisa ukuzivikela kuwoyela we-Ganoderma lucidum spores kumagundane.I-Pharmacol Res.2020 Aug;158:104937.doi: 10.1016/j.phrs.2020.104937.

Mayelana nombhali/ Nks. Wu Tingyao
U-Wu Tingyao ubelokhu ebika ngolwazi lokuqala lwe-Ganoderma lucidum kusukela ngo-1999. Ungumbhali we-“Ganoderma lucidum: Ingenious Beyond Description” (eshicilelwe ku-People's Medical Publishing House ngo-April 2017).
 

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