Uphononongo olupapashwe "kuPhando lwePharmacological" yiLabhoratri yeSizwe yoPhando lweMigangatho yeMveli yaseTshayina kwiYunivesithi yaseMacau (umbhali ohambelanayo wengxelo yophando) kunye namaziko amaninzi ophando lwasekhaya ngo-Agasti ka-2020 afumene:

Ukongeza iimpuku nge-oyile ye-Ganoderma lucidum spore (800 mg / kg) yonke imihla kangangeentsuku ezingama-27 ezilandelelanayo kunokuphucula kakhulu isakhono se-phagocytic se-macrophages kunye netyhefu yeeseli ezibulalayo zendalo (iiseli ze-NK).

I-Macrophages kunye neeseli ezibulalayo zendalo ziyi-protagonists "yempendulo ye-innate immune immune".Indima yabo kwinkqubo yomzimba yokuzikhusela ifana namajoni amapolisa ajikelezayo yaye egcina ucwangco ehlabathini.Banokuthiwa baphambili ekukhuseleni ngokuchasene neebhaktheriya ezahlukeneyo, iintsholongwane, kunye neeseli zomhlaza.

Ke ngoko, amandla okuphendula ama-macrophages kunye neeseli ezibulalayo zendalo ziya kunyuka kunye ne-oyile ye-spore, enokunyusa ithuba le-immune system yokubulala "iintshaba ezingabonakaliyo" ezahlukeneyo.

Kutheni i-oyile ye-spore iphucula ukugonywa?Inxulumene ngokusondeleyo kwiibhaktheriya zamathumbu.

Amathumbu asasazwa ngeeseli ezininzi zokuzikhusela kwaye iqulethe zonke iintlobo zebhaktheriya.Imikhuba yokutya eyahlukeneyo iya kuqinisa okanye yenze buthathaka iintlobo ezahlukeneyo zeebhaktheriya zamathumbu, kwaye imilinganiselo eyahlukeneyo yesakhiwo se-intestinal flora kunye ne-metabolites eveliswa ziintlobo ezahlukeneyo zebhaktheriya emathunjini ziya kuchaphazela isalathiso kunye nenqanaba lokuphendula komzimba.

Ngokohlalutyo lwale ngxelo yophando, emva kokuba iigundane zidle i-oyile ye-spore ixesha elithile, ukubunjwa kunye ne-metabolites ye-intestinal flora yazo iya kutshintsha, njenge:

Ukwanda kweebhaktheriya eziluncedo ezifana neLactobacillus, ukuncipha kweebhaktheriya ezinobungozi ezifana ne-Staphylococcus kunye ne-Helicobacter, kunye nokutshintsha kweentlobo ezingaphezu kweshumi elinesibini ze-metabolites ezifana ne-dopamine kunye ne-L-threonine ngobuninzi.

Olu tshintsho luluncedo ekukhuthazeni i-phagocytosis ye-macrophages kunye nokuphucula amandla okubulala iiseli ezibulalayo zendalo.

Kwiminyaka embalwa edlulileyo, uphando oluninzi luye lwabonisa ukuba impembelelo yokuphucula umzimba we-Ganoderma lucidum fruiting body extract kunye ne-spore powder inxulumene nokulawulwa kweentyantyambo zamathumbu kunye neemetabolites zayo.Kule mihla, uphando luye lwagqiba ukwenza umsantsa kulo mba we-oyile ye-spore.

Nangona ukwandisa umsebenzi we-macrophages kunye neeseli ezibulalayo zendalo kunokunyusa umgangatho wokukhusela we-innate immune response, ukubunjwa kwenethiwekhi ye-immune epheleleyo kunye nexineneyo kufuna inkxaso yezinye iiseli zangaphambili (ezifana neutrophils kunye neeseli ze-dendritic) kwaye zifunyenwe. amalungu e-immunity impendulo (ezifana neeseli ze-T, iiseli ze-B kunye namajoni omzimba).

Ekubeni i-extract, i-spore powder kunye ne-oyile ye-spore ye-Ganoderma lucidum ineenzuzo zabo ekulawuleni i-immunity, kutheni ungayisebenzisi ngaxeshanye ukunyusa ithuba lokugxotha "utshaba olungabonakaliyo"?

[Uvimba weDatha] Xu Wu, et al.I-microbiome edibeneyo kunye nohlalutyo lwe-metabolomic ichonga iimpawu zokuphucula i-immunoenhancing ye-oyile ye-Ganoderma lucidum spores kwiimpuku.I-Pharmacol Res.2020 Agasti;158:104937.doi: 10.1016/j.phrs.2020.104937.

Malunga nombhali/ Nksz. Wu Tingyao
UWu Tingyao uye wabika malunga nolwazi lokuqala lwe-Ganoderma lucidum ukususela kwi-1999. Ungumbhali we "Ganoderma lucidum: I-Ingenious Beyond Description" (epapashwe kwi-People's Medical Publishing House ngo-Ephreli 2017).
 

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