Ubushakashatsi bwasohotse muri “Ubushakashatsi bwa Farumasi” bwakozwe na Laboratoire ya Leta y’ubushakashatsi bw’ubuvuzi bwa gakondo bw’Abashinwa muri kaminuza ya Macau (umwanditsi uhuye na raporo y’ubushakashatsi) hamwe n’ibigo byinshi by’ubushakashatsi mu gihugu muri Kanama 2020 byagaragaye:

Kuzuza imbeba hamwe na Ganoderma lucidum spore yamavuta (800 mg / kg) burimunsi muminsi 27 ikurikiranye birashobora kunoza cyane ubushobozi bwa fagocyitike ya macrophage nuburozi bwingirabuzimafatizo zica (selile NK).

Macrophage na selile naturel zica nizo ntandaro y "igisubizo kivuka".Uruhare rwabo muri sisitemu yubudahangarwa ni nkabasirikare ba polisi bakora amarondo no kubungabunga umutekano mwisi yabantu.Bashobora kuvugwa ko bari ku isonga mu kwirinda za bagiteri zitandukanye, virusi, na kanseri zitandukanye.

Kubwibyo, ubushobozi bwo gusubiza macrophage na selile naturel ziyongera biziyongera hiyongereyeho amavuta ya spore, ashobora kongera amahirwe yumubiri wumubiri wo kwica "abanzi batagaragara".

Kuki amavuta ya spore atezimbere ubudahangarwa?Ifitanye isano ya hafi na bagiteri zo munda.

Amara akwirakwizwa na selile nyinshi z'umubiri kandi zirimo na bagiteri zose.Ingeso zitandukanye zimirire zizashimangira cyangwa zigabanye ubwoko butandukanye bwa bagiteri zo munda, kandi ibipimo bitandukanye byuburyo bwa flora yo munda na metabolite ikorwa nubwoko butandukanye bwa bagiteri zo munda bizagira ingaruka ku cyerekezo n’urwego rw’ubudahangarwa bw'umubiri.

Dukurikije isesengura ry’iyi raporo y’ubushakashatsi, nyuma yuko imbeba zimaze kurya amavuta ya spore mu gihe runaka, ibigize na metabolite y’ibimera byo mu nda bizahinduka, nka:

Ubwiyongere bwa bagiteri zifite akamaro nka Lactobacillus, kugabanuka kwa bagiteri zangiza nka Staphylococcus na Helicobacter, no guhindura amoko arenga icumi ya metabolite nka dopamine na L-threonine mubwinshi.

Izi mpinduka ningirakamaro mu guteza imbere fagocytose ya macrophage no kongera ubushobozi bwo kwica ingirabuzimafatizo zica.

Mu myaka mike ishize, ubushakashatsi bwinshi bwerekanye ko ingaruka zo kongera ubudahangarwa bw'umubiri wa Ganoderma lucidum yera imbuto zivamo umubiri hamwe nifu ya spore ifitanye isano no kugenzura ibimera byo munda na metabolite.Muri iki gihe, ubushakashatsi bwarangije kuziba icyuho muri aya mavuta ya spore.

Nubwo kongera ibikorwa bya macrophage na selile naturel byica bishobora kongera urwego rwokwirinda igisubizo cyumubiri wavukanye, gushiraho urusobe rwumubiri rwuzuye kandi rwinshi bisaba kandi inkunga yizindi sentare zo mumbere (nka neutrophile na selile dendritic) kandi zabonye abanyamuryango basubiza ubudahangarwa (nka selile T, selile B na antibodies).

Ko ibiyikuramo, ifu ya spore hamwe namavuta ya spore ya Ganoderma lucidum bifite inyungu zabyo muguhuza ubudahangarwa, kuki utabikoresha icyarimwe kugirango ubone amahirwe menshi yo guhashya "umwanzi utagaragara"?

[Data Resource] Xu Wu, n'abandi.Isesengura rya microbiome hamwe na metabolomic isesengura ryerekana ibimenyetso biranga immunoenhancing ya Ganoderma lucidum spores amavuta yimbeba.Pharmacol Res.2020 Kanama; 158: 104937.doi: 10.1016 / j.phrs.2020.104937.

Ibyerekeye umwanditsi / Madamu Wu Tingyao
Wu Tingyao yagiye atanga amakuru ku makuru ya Ganoderma lucidum kuva mu 1999. Ni umwanditsi wa “Ganoderma lucidum: Ingenious Beyond Description” (yasohotse mu gitabo cy’ubuvuzi cy’ubuvuzi muri Mata 2017).
 

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