Kafukufuku wofalitsidwa mu "Pharmacological Research" ndi State Key Laboratory of Traditional Chinese Medicine Quality Research ya University of Macau (mlembi wofanana wa lipoti la kafukufukuyu) ndi mabungwe ambiri ofufuza zapakhomo mu Ogasiti 2020 adapeza:

Kuonjezera mbewa ndi mafuta a Ganoderma lucidum spore (800 mg/kg) tsiku lililonse kwa masiku 27 otsatizana kungathandize kwambiri mphamvu ya phagocytic ya macrophages ndi kawopsedwe ka maselo akupha (NK cells).

Macrophages ndi maselo akupha achilengedwe ndi omwe amatsogolera "kuyankha kwa chitetezo cham'thupi".Udindo wawo pachitetezo cha chitetezo cha mthupi uli ngati asilikali apolisi omwe amayendayenda ndi kusunga bata m'dziko la anthu.Akhoza kunenedwa kuti ali patsogolo pa chitetezo ku mabakiteriya osiyanasiyana, mavairasi, ndi maselo a khansa.

Chifukwa chake, kuthekera koyankha kwa macrophages ndi maselo akupha achilengedwe kumawonjezeka ndi mafuta a spore, omwe amatha kuwonjezera mwayi wa chitetezo chamthupi kupha "adani osawoneka" osiyanasiyana.

Chifukwa chiyani mafuta a spore amawonjezera chitetezo chokwanira?Zimagwirizana kwambiri ndi mabakiteriya a m'mimba.

Matumbo amagawidwa ndi maselo ambiri oteteza thupi komanso amakhala ndi mabakiteriya amitundu yonse.Zakudya zosiyanasiyana zimalimbitsa kapena kufooketsa mitundu yosiyanasiyana ya mabakiteriya a m'mimba, ndipo makonzedwe osiyanasiyana a zomera zam'mimba ndi ma metabolites opangidwa ndi mitundu yosiyanasiyana ya mabakiteriya am'mimba zimakhudza momwe chitetezo cha mthupi chimayendera.

Malinga ndi kuwunika kwa lipoti la kafukufukuyu, mbewa zitadya mafuta a spore kwakanthawi, kapangidwe kake ndi ma metabolites a m'matumbo awo amasintha, monga:

Kuwonjezeka kwa mabakiteriya opindulitsa monga Lactobacillus, kuchepa kwa mabakiteriya owopsa monga Staphylococcus ndi Helicobacter, ndi kusintha kwa mitundu yoposa khumi ndi iwiri ya metabolites monga dopamine ndi L-threonine kuchuluka.

Zosinthazi ndizopindulitsa kulimbikitsa phagocytosis ya macrophages ndikuwonjezera mphamvu yakupha ya maselo akupha achilengedwe.

M'zaka zingapo zapitazi, kafukufuku wambiri watsimikizira kuti mphamvu ya chitetezo cha mthupi ya Ganoderma lucidum fruiting body extract ndi spore powder ikugwirizana ndi kayendetsedwe ka m'mimba ndi ma metabolites ake.Masiku ano, kafukufuku wapanga kusiyana pa mbali iyi ya mafuta a spore.

Ngakhale kuwonjezeka kwa ntchito za macrophages ndi maselo akupha achilengedwe kumatha kukulitsa chitetezo cha chitetezo cham'mimba, kupangidwa kwa chitetezo chokwanira komanso cholimba kumafunanso kuthandizidwa ndi ena amzere akutsogolo (monga neutrophils ndi ma cell a dendritic) ndikupeza. mamembala a chitetezo chamthupi (monga ma T cell, B cell ndi ma antibodies).

Popeza chotsitsacho, spore ufa ndi mafuta a spore a Ganoderma lucidum ali ndi zabwino zawo pakuwongolera chitetezo chokwanira, bwanji osagwiritsa ntchito nthawi imodzi kuti muwonjezere mwayi wothamangitsa "mdani wosawoneka"?

[Data Resource] Xu Wu, et al.Kusanthula kophatikizika kwa ma microbiome ndi metabolomic kumazindikiritsa mawonekedwe a immunoenhancing a Ganoderma lucidum spores mafuta mu mbewa.Zotsatira Pharmacol2020 Aug; 158:104937.doi: 10.1016/j.phrs.2020.104937.

Za wolemba/ Mayi Wu Tingyao
Wu Tingyao wakhala akufotokoza za chidziwitso choyamba cha Ganoderma lucidum kuyambira 1999. Iye ndi mlembi wa "Ganoderma lucidum: Ingenious Beyond Description" (yofalitsidwa mu The People's Medical Publishing House mu April 2017).
 

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