Chidzidzo chakaburitswa mu "Pharmacological Research" neState Key Laboratory yeTraditional Chinese Medicine Quality Research yeYunivhesiti yeMacau (anowirirana munyori wemushumo wekutsvagisa) uye akawanda masangano ekutsvagisa epamba muna Nyamavhuvhu 2020 akawana:

Kuwedzera mbeva neGanoderma lucidum spore oil (800 mg/kg) zuva rega rega kwemazuva makumi maviri nemanomwe akatevedzana kunogona kuvandudza zvakanyanya kugona kwephagocytic yemacrophages uye chepfu yemasero anouraya echisikigo (NK masero).

Macrophages uye masero emuurayi echisikigo ndiwo maratidziro e "innate immune reaction".Basa ravo mukudzivirira muviri kwakafanana nemasoja emapurisa ari kutenderera nekuchengetedza runyararo munyika yevanhu.Vanogona kunzi vari pamberi pekudzivirira kubva kune akasiyana mabhakitiriya, mavhairasi, uye kenza masero.

Nokudaro, kukwanisa kwekupindura kwema macrophages uye masero emuurayi echisikigo achawedzera nekuwedzera kwemafuta e spore, izvo zvinogona kuwedzera mukana wekudzivirira zvirwere zvekuuraya zvakasiyana-siyana "vavengi vasingaoneki".

Nei spore oiri inovandudza kusadzivirirwa?Inonyatsoenderana nehutachiona hwemukati.

Ura hunogoverwa nemasero akawanda ezvirwere zvemuviri uye hunewo marudzi ose ebhakitiriya.Kudya kwakasiyana-siyana kunosimbisa kana kunetesa marudzi akasiyana-siyana emabhakitiriya emudumbu, uye maitiro akasiyana-siyana emaruva emudumbu uye metabolites anogadzirwa nemhando dzakasiyana dzehutachiona hwemukati huchakanganisa kutungamira uye chiyero chemhinduro yekudzivirira.

Zvinoenderana nekuongororwa kweiyi rondedzero yekutsvagisa, mushure mekunge mbeva dzapedza mafuta espore kwenguva yakati, kuumbwa uye metabolites yemaruva emudumbu mavo zvinoshanduka, senge:

Kuwedzera kwebhakitiriya inobatsira yakadai seLactobacillus, kuderera kwebhakitiriya inokuvadza yakadai seStaphylococcus neHelicobacter, uye kuchinja kwemarudzi anopfuura gumi nemaviri ematabolites akadai se dopamine uye L-threonine muhuwandu.

Shanduko idzi dzinobatsira kusimudzira phagocytosis ye macrophages uye kuwedzera kugona kwekuuraya kwemasero anouraya echisikigo.

Mumakore mashoma apfuura, zvidzidzo zvakawanda zvakaratidza kuti immune yekusimudzira mhedzisiro yeGanoderma lucidum fruiting body extract uye spore poda ine chekuita nekudzora maruva emudumbu nemametabolites ayo.Mazuvano, tsvagiridzo yakazoita gaka mune iyi chidimbu chemafuta espore.

Kunyangwe kuwedzera basa remacrophages uye masero emuurayi echisikigo anogona kuwedzera mwero wekudzivirira weiyo innate immune immune network, kuumbwa kweakazara uye dense immune network inodawo rutsigiro rwevamwe vanotungamira-mberi (senge neutrophils uye dendritic masero) uye kuwanikwa. immunity response members (senge T masero, B masero uye masoja ekudzivirira chirwere).

Sezvo yakabviswa, spore poda uye spore mafuta eGanoderma lucidum vane zvakanakira kudzora kusadzivirirwa, wadii kuzvishandisa panguva imwe chete kuti uwedzere mukana wekudzinga "muvengi asingaoneki"?

[Data Resource] Xu Wu, et al.Iyo yakasanganiswa microbiome uye metabolomic ongororo inoratidza immunoenhancing maficha eGanoderma lucidum spores mafuta mumakonzo.Pharmacol Res.2020 Aug;158:104937.doi: 10.1016/j.phrs.2020.104937.

Nezve munyori/ Ms. Wu Tingyao
Wu Tingyao anga achirondedzera nezvekutanga-ruoko Ganoderma lucidum ruzivo kubvira 1999. Ndiye munyori we "Ganoderma lucidum: Ingenious Beyond Description" (yakabudiswa muThe People's Medical Publishing House muna April 2017).
 

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