Umthombo wemifanekiso / iwebhusayithi esemthethweni yoMbutho wezeMpilo weHlabathi

Ngokusebenzisa usasazo “logqatso lwentsholongwane”, i-WHO ikhumbuze ngokufudumeleyo lonke uluntu ukuba ezinye iinguqulelo zenoveli coronavirus “zibaleka” ngokukhawuleza kwaye kulula ukusasazeka phakathi kwabemi kunezinye ii-coronavirus ezintsha.Kodwa nokuba yintsholongwane ebaleka ngokukhawuleza okanye ecothayo, indlela yokubathintela ekufumaneni mna nawe iyafana: hlamba izandla rhoqo, nxiba imaski, ugcine umgama wokuhlala, kwaye uphephe ukuhlanganisana ngokwamaqela.

Ngaphandle kwala manyathelo okhuseleko asisiseko, zeziphi ezinye “ezithembeke ngokwenene,” “ekulula ukuzifumana,” “nekulula ukuziphumeza” iindlela zokomeleza amandla ethu ukuze sihlale siphambili kolu gqatso lwenduli ngeenduli?Singenza ntoni ukongeza umaleko owongezelelekileyo wokhuseleko ukuze sinciphise umonakalo nokuba sosulelwe yintsholongwane ngempazamo?

Kukho iingxelo zophando ezininzi okanye amaphepha ophononongo apapashwe kwiijenali zamazwe ngamazwe, ebonisa ukuba “I-Ganoderma lucidum", etyebileyo kwiipolysaccharides, triterpenes kunye neeproteni ze-immunomodulatory, kufuneka zisincede ekulweni inoveli coronavirus.

Epreli 2020-Ijenali yeMolekyuli:I-Ganoderma luciduminazo zombini ii-anti-virus kunye ne-immune-regulating components

Ngo-Epreli ka-2020, izazinzulu ezivela kwiYunivesithi yaseChiang Mai kunye neRoyal Academy yeSayensi yaseThailand bapapasha iphepha lokubuyela umva kwiiMolekyuli.

Ngokusekwe kwiziphumo zophando ezaziwayo ngoku, baye bavavanya “izitokhwe ezinokubakho” ezinokuthintela i-SARS, i-MERS, i-COVID-19 kunye nezinye ii-coronavirus kwizithako ezininzi zokungunda ngenjongo “yokuthintela ukuphindaphindeka kwentsholongwane” kunye “nokulawula ukuphendula komzimba”.Ngenxa yoko, i-polysaccharides, i-triterpenoids, kunye neeprotheni ze-immunomodulatory ezivelaI-Ganoderma lucidumzonke zibaliwe phakathi kwazo.

Kuba iintsholongwane kufuneka zithembele kwiiseli ukuze ziphile kwaye zande, oko kubizwa ngokuba yi "anti-virus" iziphumo zonke zimalunga "nokuphazamisa inkqubo yophindaphindo lwentsholongwane kwiseli", nto leyo eyenza ukuba intsholongwane ingakwazi ukuvelisa iintsholongwane ezininzi ngeseli. .

Ngokuphathelele ezo ntsholongwane zisajonge ekujoliswe kuzo ngaphandle kweseli - nokuba yintsholongwane esandula ukungena emzimbeni okanye intsholongwane entsha esandula ukukhutshwa kwiseli - ezi ntsholongwane ziya kupheliswa kwimpendulo yokuvuvukala yamajoni omzimba.Emva kokuba intsholongwane ihlanjululwe, ingaba impendulo yokuvuvukala inokupheliswa ngokukhawuleza ukuphepha umonakalo kwiiseli eziqhelekileyo kuxhomekeke kulawulo lwe-immune system.

Ngoko ke,I-Ganoderma lucidum, enamacandelo anqanda ukuphindaphinda kwentsholongwane kunye nokulungelelanisa amajoni omzimba, kubonakala ngathi yindlela yendalo ye-cocktail yokuthintela kunye nokunyanga iintsholongwane, ibonelela nge-inshurensi ephindwe kabini ekufaneleyo ukujonga phambili ekunciphiseni isoyikiso se-coronavirus kubandakanya inoveli coronavirus.

NgoJuni 2020- "Ijenali yaseTshayina ye-Pharmacology kunye neToxicology": Isiphumo seI-Ganodermalucidumekomelezeni amandla abalulekileyo kunye nokuphelisa izinto ze-pathogenic kunye nefuthe layo le-antiviral

Ngokufana nezimvo zabaphengululi baseThai, uNjingalwazi uZhi-Bin Lin weYunivesithi yasePeking ukwapapashe iphepha kwiShayina Journal of Pharmacology and Toxicology ngoJuni ka-2020, exoxa ngamathuba okuthintela kunye nokunyanga i-COVID-19.I-Ganoderma lucidumukusuka kwimbono yomibini ye-TCM ekuqiniseni amandla abalulekileyo kunye nokuphelisa izinto ze-pathogenic kunye nombono weyeza lasentshona kwi-anti-virus.

NgoFebruwari 2021-Iinkqubo zeZiko leSizwe leSayensi: I-Ganoderma polysaccharides inokunciphisa inani le-coronavirus entsha kwimiphunga yezilwanyana.

Ingxelo epapashwe liqela laseTaiwan Academia Sinica kwi-PNAS (Iinkqubo zeNational Academy of Sciences) ngoFebruwari 2021 yaqinisekisa ukuba:

Enye yezinto eziphambili ezisebenzayo kwiI-Ganoderma lucidum,"Ganoderma lucidum polysaccharides", inokuba yi-antiviral zombini kwi-vitro kunye ne-vivo, ibonelela ngobungqina besayensi obuthe ngqoI-Ganoderma luciduminceda ukunqanda kunye nokunyanga inoveli coronavirus.

Okokuqala, iimvavanyo ze-in vitro, abaphandi baqala ukuhlakulela iiseli zeVero E6 kunyeI-Ganoderma lucidumisicatshulwa se-polysaccharide (igama lekhowudi RF3) kunye, kwaye emva koko yongeza inoveli coronavirus ukujonga inani lokuphindaphinda kwentsholongwane kunye nokusinda kweseli emva kweeyure ezingama-48.

Njengoko sonke sisazi, inoveli coronavirus ihlasela umzimba womntu nge-ACE2 receptor kwiseli.Iiseli zeVero E6 ezisuka kwizintso zeenkawu eziluhlaza zaseAfrika zinokuvakalisa inani elikhulu lee-receptors ze-ACE2, ke xa zidibana nenoveli coronavirus, intsholongwane inokungena ngokulula kwiiseli ukuze iphindaphindeke kwaye yande.

Iziphumo zabonisa ukuba iI-Ganoderma lucidumI-polysaccharide extract inokunciphisa inani lokuphindaphinda kwentsholongwane kwisiqingatha kwi-concentration ephantsi ye-2μg / mL ngaphandle kokubangela ukufa kweeseli.

Abaphandi emva koko benza uvavanyo lwezilwanyana: baqala bosulela i-hamsters ngenoveli coronavirus emva koko balawulaI-Ganoderma lucidumI-polysaccharide isicatshulwa ngomlomo kwi-hamster kwi-dose yemihla ngemihla ye-200 mg / kg iintsuku ezi-3.

Kwafunyaniswa ukuba isixa sentsholongwane kwimiphunga ye-hamster sasimalunga nesiqingatha kuphela seqela elingaphathwanga (amanzi anikwe amanzi), kwaye ubunzima bee-hamster bahlala kwinqanaba elifanayo nangaphambi kokusuleleka ngaphandle kokunyuka okubukhali okanye ukunciphisa.Oku kuthetha ukuba iI-Ganoderma lucidumIsicatshulwa se-polysaccharide ayinakunqanda kuphela ngokufanelekileyo ukukhula kwenoveli coronavirus kwiihamster kodwa inenqanaba eliphezulu lokhuseleko olutyiwayo.

Ngokwenene ayilula loo ntoI-Ganoderma lucidumiipolysaccharides zinokugqama kolu phando.Kuba esi sisiphumo sokuthelekisa kunye ne-2,855 yamachiza omntu okanye ezilwanyana avunywe yi-US Food and Drug Administration (FDA) kunye ne-200 ephantse ibe yi-200 yamanzi amachiza e-herbal amayeza asebenzayo ekunyangeni izifo zentsholongwane.

Ekugqibeleni,I-Ganoderma lucidumI-polysaccharides kuphela kwezixhobo zamayeza ezinokuthi zisebenzise ngokwenene iziphumo ze-antiviral emzimbeni ngaphandle kokubangela ukufa kweeseli okanye ukwehla kobunzima.

Ngapha koko, i-polysaccharides sesinye sezithako ezisebenzayoI-Ganoderma lucidum.Ukuba zombini iipolysaccharides kunye ne-triterpenoids eGanoderma lucidum zongezwa ukulwa nentsholongwane, kuya kwenzeka ntoni?

NgoMeyi 2021-"Ijenali yaMazwe ngaMazwe yeNkungu yoNyango":I-Ganoderma lucidumIsiphumo sokulinganisa siyanceda ukuchacha kwaye sinqande ukugula okuqatha

NgoMeyi ka-2021, ngokujonga iimpawu zenyumoniya kunye notshintsho lwemithambo olubangelwa yinoveli coronavirus, iphepha lokubuyela emva elipapashwe kwi "Ijenali yeHlabathi yamaMushrooms amayeza" ngabaphengululi abavela kwiSebe leBiochemistry kunye neMolekyuli yebhayoloji yeYunivesithi yaseJahangirnagar eBangladesh kunye neZolimo. ICandelo loLwandiso lweZiko loPhando lokuPhuhliswa kweMushroom kwiSebe lezoLimo lase-Bangladesh lihlalutye ukuba nokwenzeka kweentlobo ngeentlobo zezithako ezisebenzayo zokungunda ukunyanga nokuthintela ukugula kakhulu kwaye lagqiba kwelokubaI-Ganoderma lucidumkubonakala ngathi lelona chiza lifanelekileyo kubo bonke abantu ukulwa ne-COVID-19 phakathi kweentlobo ezahlukeneyo zamakhowa.

Izigulana ezinenyumoniya entsha ye-coronary ukuze zibuyele kwicala lezempilo kunokuba zibe mandundu kwicala lesifo esibi, kubonakala ngathi kuphelaI-Ganoderma lucidum, enezityebi kwiintlobo ezahlukeneyo zezithako ezisebenzayo, eyona nto ingcono ekugcineni ibhalansi phakathi kwe-ACE (i-Angiotensin Converting Enzyme) kunye ne-ACE2 (i-Angiotensin Converting Enzyme 2) kunye nokulinganisela phakathi kokuphucula impendulo yokuzivikela komzimba (i-anti-viral) kunye nokucinezela ukuvuvukala. impendulo (ukukhusela iiseli).

NgoFebruwari 2020-i-China Nutrition kunye neMpilo yoMbutho woKutya:I-Ganoderma luciduminokunceda ukuthintela kunye nokunyanga usulelo olutsha lwe-coronavirus

"Inqaku lesibini elidumileyo lezesayensi malunga noncedo oluchanekileyo kuthintelo kunye nonyango lwenoveli yosulelo lwe-coronavirus malunga nesondlo - umsebenzi wezongezo zesondlo" epapashwe yi-China Nutrition and Health Food Association yabhengeza kuluntu iintlobo ezili-12 zezondlo ezinceda ukuthintela. kunye nokunyanga inoveli coronavirus, kubandakanywaI-Ganoderma lucidum.

Inqaku lachaza ngokucacileyo:I-Ganoderma luciduminomphumela wokuvuselela umzimba, onokuchaphazela ngokuthe ngqo amandla ayo okulwa nosulelo lwebhaktheriya kunye nentsholongwane.

Kubonakala ngathi ugqatso phakathi kwabantu kunye ne-coronavirus entsha aluzukuphela ngexesha elifutshane.Intsholongwane eguqukayo ebaleka ngokukhawuleza ayibonakali iyiDelta yodwa.

Ukuba ufuna ukuhlala phambili ngaphandle kokubanjwa yintsholongwane, yitya ngakumbiI-Ganoderma lucidumoko “kuqinisekisiwe ngokwenzululwazi”!I-Ganoderma lucidum, elandelwayo, ekhuselekileyo, enokwethenjelwa kwaye iqulethe i-polysaccharides kunye ne-triterpenes, akufanele ikuvumele.

[Umthombo weDatha]

1. Suwannarach N, et al.IiCompounds zeNdalo ze-Bioactive ezivela kwi-Fungi njengaBanokuthi baBagqale kwi-Protease Inhibitors kunye ne-Immunomodulators ukuba bafake isicelo se-Coronaviruses.Iimolekyuli.2020, 25 (8): 1800. doi: 10.3390 / iimolekyuli25081800.

2. Zhi-Bin Lin.Ukomeleza amandla abalulekileyo kunye nokuphelisa izinto ze-pathogenic kunye nefuthe le-antiviral ye-Ganoderma lucidum.Ijenali yaseTshayina ye-Pharmacology kunye neToxicology.2020;34(6): 401-407.

3. Jia-Tsrong Jan, et al.Ukuchongwa kwaMachiza asele eKho kunye namaYeza eeHerbal njengee-Inhibitors zoSulelo lwe-SARS-CoV-2.Proc Natl Acad Sci US A. 2021 Feb 2;118(5):e2021579118.doi: 10.1073/pnas.2021579118.

4. U-Mohammad Azizur Rahman, et al.Ulungelelwaniso lweNdlela eziSekwe kwiMushroom zoThintelo kunye noNyango kwi-COVID-19: Uphononongo.Int J Med Mushrooms.2021;23(5):1-11.doi: 10.1615/IntJMedMushrooms.2021038285.

ISIPHELO 

Malunga nombhali/ Nksz. Wu Tingyao

UWu Tingyao unike ingxelo ngolwazi lokuqala lweGanoderma lucidum ukusukela ngo-1999. Ungumbhali wencwadiUkunyanga ngeGanoderma(ipapashwe kwiNdlu yePeople's Medical Publishing House ngo-Epreli 2017).

★ Eli nqaku lipapashwa phantsi kogunyaziso olukhethekileyo lombhali, kwaye ubunini bubo be-GANOHERB ★ Le misebenzi ingentla ayinakuphinda iphinde iphinde iphinde iphinde isetyenziswe, ikhutshwe okanye isetyenziswe ngezinye iindlela ngaphandle kogunyaziso lweGanoHerb ★ Ukuba imisebenzi igunyazisiwe ukuba isetyenziswe, kufuneka isetyenziswe ngaphakathi kwendawo yogunyaziso kwaye ibonise umthombo: GanoHerb ★ Nakuphi na ukuphulwa kwengxelo engentla, iGanoHerb iya kulandela uxanduva olusemthethweni oluhambelanayo ★ Umbhalo wokuqala weli nqaku ubhalwe ngesiTshayina nguWu Tingyao kwaye waguqulelwa kwisiNgesi nguAlfred. Liu.Ukuba kukho nakuphi na ukungangqinelani phakathi kwenguqulelo (isiNgesi) kunye neyoqobo (isiTshayina), isiTshayina sokuqala siya koyisa.Ukuba abafundi banayo nayiphi na imibuzo, nceda uqhagamshelane nombhali wokuqala, uNks. Wu Tingyao.

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